LOCUS       NM_012753               1926 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 17, subfamily a,
            polypeptide 1 (Cyp17a1), mRNA.
ACCESSION   NM_012753 XM_006231434
VERSION     NM_012753.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1926)
  AUTHORS   Suleiman,J.B., Nna,V.U., Othman,Z.A., Zakaria,Z., Bakar,A.B.A. and
            Mohamed,M.
  TITLE     Orlistat attenuates obesity-induced decline in steroidogenesis and
            spermatogenesis by up-regulating steroidogenic genes
  JOURNAL   Andrology 8 (5), 1471-1485 (2020)
   PUBMED   32438512
REFERENCE   2  (bases 1 to 1926)
  AUTHORS   Kim,Y.M., Kang,M., Choi,J.H., Lee,B.H., Kim,G.H., Ohn,J.H.,
            Kim,S.Y., Park,M.S. and Yoo,H.W.
  TITLE     A review of the literature on common CYP17A1 mutations in adults
            with 17-hydroxylase/17,20-lyase deficiency, a case series of such
            mutations among Koreans and functional characteristics of a novel
            mutation
  JOURNAL   Metabolism 63 (1), 42-49 (2014)
   PUBMED   24140098
  REMARK    Review article
REFERENCE   3  (bases 1 to 1926)
  AUTHORS   Munetsuna,E., Hattori,M. and Yamazaki,T.
  TITLE     Stimulation of estradiol biosynthesis by tributyltin in rat
            hippocampal slices
  JOURNAL   Endocr Res 39 (4), 168-172 (2014)
   PUBMED   24679120
  REMARK    GeneRIF: Data suggest that CYP17A1 and aromatase/Cyp19a1 are
            induced in hippocampus by the environmental pollutant/retinoid X
            receptor agonist tributyltin; thus, tributyltin appears to
            stimulate estradiol biosynthesis.
REFERENCE   4  (bases 1 to 1926)
  AUTHORS   Li,H., Chen,Y., Yan,L.Y. and Qiao,J.
  TITLE     Increased expression of P450scc and CYP17 in development of
            endogenous hyperandrogenism in a rat model of PCOS
  JOURNAL   Endocrine 43 (1), 184-190 (2013)
   PUBMED   22798247
  REMARK    GeneRIF: Data from a rat model of polycystic ovary syndrome suggest
            that hyperandrogenism develops and this may partially up-regulate
            expression of steroidogenic enzymes (CYP17 and P450scc [cholesterol
            side-chain cleavage enzyme]) in ovarian tissue.
REFERENCE   5  (bases 1 to 1926)
  AUTHORS   Manca,P., Caria,M.A., Blasi,J., Martin-Satue,M. and Mameli,O.
  TITLE     Cytochrome P450 17alpha-hydroxylase/C(17,20)-lyase immunoreactivity
            and molecular expression in the cerebellar nuclei of adult male
            rats
  JOURNAL   J Chem Neuroanat 45 (1-2), 18-25 (2012)
   PUBMED   22800812
  REMARK    GeneRIF: these data demonstrate the occurrence of P450C(17) in the
            deep cerebellar nuclei of the rat
REFERENCE   6  (bases 1 to 1926)
  AUTHORS   Zhang,P., Nason,T.F., Han,X.G. and Hall,P.F.
  TITLE     Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete
            nucleotide sequence of the porcine gene and 5' upstream sequence of
            the rat gene
  JOURNAL   Biochim Biophys Acta 1131 (3), 345-348 (1992)
   PUBMED   1627653
REFERENCE   7  (bases 1 to 1926)
  AUTHORS   Yanase,T., Simpson,E.R. and Waterman,M.R.
  TITLE     17 alpha-hydroxylase/17,20-lyase deficiency: from clinical
            investigation to molecular definition
  JOURNAL   Endocr Rev 12 (1), 91-108 (1991)
   PUBMED   2026124
  REMARK    Review article
REFERENCE   8  (bases 1 to 1926)
  AUTHORS   Mellon,S.H. and Vaisse,C.
  TITLE     cAMP regulates P450scc gene expression by a
            cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10
            cells
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7775-7779 (1989)
   PUBMED   2554289
REFERENCE   9  (bases 1 to 1926)
  AUTHORS   Fevold,H.R., Lorence,M.C., McCarthy,J.L., Trant,J.M., Kagimoto,M.,
            Waterman,M.R. and Mason,J.I.
  TITLE     Rat P450(17 alpha) from testis: characterization of a full-length
            cDNA encoding a unique steroid hydroxylase capable of catalyzing
            both delta 4- and delta 5-steroid-17,20-lyase reactions
  JOURNAL   Mol Endocrinol 3 (6), 968-975 (1989)
   PUBMED   2786990
REFERENCE   10 (bases 1 to 1926)
  AUTHORS   Nishihara,M., Winters,C.A., Buzko,E., Waterman,M.R. and Dufau,M.L.
  TITLE     Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha
            mRNA levels and characterization of a partial length rat P-45017
            alpha cDNA
  JOURNAL   Biochem Biophys Res Commun 154 (1), 151-158 (1988)
   PUBMED   3260774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Nov 20, 2020 this sequence version replaced
            XM_006231434.3, NM_012753.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.7015.1,
                                           SRR26643288.7462.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000001.1  255484452-255484547 c
            97-521              JAXUCZ010000001.1  255482550-255482974 c
            522-657             JAXUCZ010000001.1  255480831-255480966 c
            658-887             JAXUCZ010000001.1  255480446-255480675 c
            888-974             JAXUCZ010000001.1  255479493-255479579 c
            975-1190            JAXUCZ010000001.1  255478953-255479168 c
            1191-1360           JAXUCZ010000001.1  255478475-255478644 c
            1361-1464           JAXUCZ010000001.1  255477725-255477828 c
            1465-1926           JAXUCZ010000001.1  255476861-255477322 c
FEATURES             Location/Qualifiers
     source          1..1926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1926
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /note="cytochrome P450, family 17, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:25146"
                     /db_xref="RGD:2456"
     exon            1..96
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            97..521
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1748
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /EC_number="1.14.14.19"
                     /EC_number="1.14.14.32"
                     /note="CYPXVII; P450c17; P450-C17; cytochrome P450 17A1;
                     steroid 17-alpha-monooxygenase; cytochrome P450c17;
                     cytochrome P450-C17; Cytochrome P450, subfamily XVII;
                     P45017alpha; cytochrome P450, subfamily 17;
                     17-alpha-hydroxyprogesterone aldolase"
                     /codon_start=1
                     /product="steroid 17-alpha-hydroxylase/17,20 lyase"
                     /protein_id="NP_036885.2"
                     /db_xref="GeneID:25146"
                     /db_xref="RGD:2456"
                     /translation="MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLP
                     RRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQ
                     SLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHD
                     KESIDLSTPIFMSVTNIICAICFNISYEKKDPKLTAIKTFTEGIVDATGDRNLVDIFP
                     WLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNN
                     SCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQY
                     VGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVV
                     VNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQE
                     LFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST"
     exon            522..657
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            658..887
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            888..974
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1190
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1360
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1464
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1926
                     /gene="Cyp17a1"
                     /gene_synonym="Cyp17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccatcga gtgtcactca ctgctcaatg gttttcgctt cagccgctgc ctgcaggttc
       61 ctgccttggc ttctcagtga ctgtgacctg ggaagtgata aacttcttca ggccaagaga
      121 taactcgacg tcaaggtgac aatcagaaac gccctttaaa agtcctcctt cttggttgaa
      181 gttgctccgc tccacagctg gccatctgcc tacacctggc tgccatgtgg gaacttgtgg
      241 gtctcttgct gctcatccta gcctatttct tttgggtcaa gtcaaagacg cccggtgcca
      301 agctccccag gagccttcca tccctgcccc tggtgggcag tctgccgttt ctccccagac
      361 gtggtcatat gcatgtcaac ttcttcaagc tacaggaaaa gtatggtccc atctattctc
      421 ttcgcctggg taccacaact acagtgatca tcggccacta tcagctggcc agggaggtgc
      481 tcatcaagaa gggaaaagaa ttctctggtc ggccccagat ggtgactcaa agcctcttgt
      541 cggaccaagg gaaaggcgtg gcctttgcag atgctggtag ctcctggcac ctgcaccgga
      601 agttggtgtt cagcaccttt tccctgttca aggatggcca gaaactggag aagctaatct
      661 gtcaggaagc caagtcactg tgtgatatga tgctggcaca cgacaaggag tccatagacc
      721 tgtccacgcc tatcttcatg tcagtaacca acatcatctg tgctatctgc ttcaacatct
      781 cttatgagaa aaaggatcca aaactgaccg ccataaagac ctttactgag ggtatcgtgg
      841 atgccacggg cgacagaaat ctggtggaca tattcccatg gttgacgatt tttcccaaca
      901 aaggcttgga ggtgataaag ggttatgcca aagttcgaaa tgaagtactg actggaatat
      961 ttgaaaagtg cagggagaag ttcgacagtc agtctatctc cagcctgacg gacattctga
     1021 ttcaagccaa gatgaattca gacaacaaca acagctgtga aggccgggac ccagatgtgt
     1081 tttcagatag gcacatcctt gccacggtgg gagacatctt tggggcgggc atagagacaa
     1141 ctaccactgt gctcaagtgg atcctggctt tcctggtgca caatcctgag gtgaagaaga
     1201 agatccaaaa ggagattgac cagtacgtag gcttcagccg aacaccaact ttcaatgacc
     1261 ggtctcacct cctcatgctg gaggccacta tccgagaagt gctgcgtatc aggccggtgg
     1321 ctcccatgct catcccccac aaggctaacg ttgactccag cattggagag tttactgtcc
     1381 ccaaggacac acatgtggtc gtcaatctct gggcactgca tcacgatgag aatgaatggg
     1441 accagccaga tcagttcatg cctgaacgct tcttagatcc aacgggaagc catctcatta
     1501 cacccacgca gagttacttg cccttcggag ctggtccccg atcctgcatc ggagaggctc
     1561 tggcccgtca ggagctcttt gtcttcacgg ccttgctact gcagaggttt gacttggatg
     1621 tgtcagatga taaacaactg ccccgcctgg agggtgatcc caaggtagtc tttctgatcg
     1681 accctttcaa agtaaagatc acggtgcgcc aggcatggat ggatgcacag gctgaggtta
     1741 gcacctagag gccacaacta acatccccga tccatacctc aacacccaca gtacaatctt
     1801 agaggtgcta gtcccagtgc ctcctacggt cctcctccct cctaccccat tttctagttg
     1861 gcagcaatgg ggggtgatac acataaatta aagttttttc aataaacatc tctgagccgc
     1921 ctttca
//
