LOCUS       NM_181824               1497 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus cytochrome P450, family 11, subfamily b,
            polypeptide 3 (Cyp11b3), mRNA.
ACCESSION   NM_181824
VERSION     NM_181824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov
            SA and Park HW.
  TITLE     Structural insights into aldosterone synthase substrate specificity
            and targeted inhibition
  JOURNAL   Mol Endocrinol 27 (2), 315-324 (2013)
   PUBMED   23322723
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S,
            Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S, Mochizuki N and
            Saito Y.
  TITLE     Regulation of aldosterone and cortisol production by the
            transcriptional repressor neuron restrictive silencer factor
  JOURNAL   Endocrinology 150 (7), 3110-3117 (2009)
   PUBMED   19342457
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Kuribayashi I, Kuge H, Santa RJ, Mutlaq AZ, Yamasaki N, Furuno T,
            Takahashi A, Chida S, Nakamura T, Endo F, Doi Y, Onishi S and
            Shizuta Y.
  TITLE     A missense mutation (GGC[435Gly]-->AGC[Ser]) in exon 8 of the
            CYP11B2 gene inherited in Japanese patients with congenital
            hypoaldosteronism
  JOURNAL   Horm Res 60 (5), 255-260 (2003)
   PUBMED   14614232
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Tiago AD, Badenhorst D, Skudicky D, Woodiwiss AJ, Candy GP,
            Brooksbank R, Sliwa K, Sareli P and Norton GR.
  TITLE     An aldosterone synthase gene variant is associated with improvement
            in left ventricular ejection fraction in dilated cardiomyopathy
  JOURNAL   Cardiovasc Res 54 (3), 584-589 (2002)
   PUBMED   12031704
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Ranade K, Wu KD, Risch N, Olivier M, Pei D, Hsiao CF, Chuang LM, Ho
            LT, Jorgenson E, Pesich R, Chen YD, Dzau V, Lin A, Olshen RA, Curb
            D, Cox DR and Botstein D.
  TITLE     Genetic variation in aldosterone synthase predicts plasma glucose
            levels
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13219-13224 (2001)
   PUBMED   11687612
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Mellon SH, Bair SR and Monis H.
  TITLE     P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed
            in a tissue-specific, developmentally, and hormonally regulated
            fashion in the rodent adrenal and encodes a protein with both
            11-hydroxylase and 18-hydroxylase activities
  JOURNAL   J Biol Chem 270 (4), 1643-1649 (1995)
   PUBMED   7829497
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Mukai K, Imai M, Shimada H and Ishimura Y.
  TITLE     Isolation and characterization of rat CYP11B genes involved in late
            steps of mineralo- and glucocorticoid syntheses
  JOURNAL   J Biol Chem 268 (12), 9130-9137 (1993)
   PUBMED   8473352
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Kawamoto T, Mitsuuchi Y, Toda K, Yokoyama Y, Miyahara K, Miura S,
            Ohnishi T, Ichikawa Y, Nakao K, Imura H et al.
  TITLE     Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in
            the biosynthesis of glucocorticoids and mineralocorticoids in
            humans
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1458-1462 (1992)
   PUBMED   1741400
REFERENCE   9  (bases 1 to 1497)
  AUTHORS   Domalik LJ, Chaplin DD, Kirkman MS, Wu RC, Liu WW, Howard TA,
            Seldin MF and Parker KL.
  TITLE     Different isozymes of mouse 11 beta-hydroxylase produce
            mineralocorticoids and glucocorticoids
  JOURNAL   Mol Endocrinol 5 (12), 1853-1861 (1991)
   PUBMED   1686470
REFERENCE   10 (bases 1 to 1497)
  AUTHORS   Kawainoto T, Mitsuuchi Y, Ohnishi T, Ichikawa Y, Yokoyama Y,
            Sumimoto H, Toda K, Miyahara K, Kuribayashi I, Nakao K et al.
  TITLE     Cloning and expression of a cDNA for human cytochrome P-450aldo as
            related to primary aldosteronism
  JOURNAL   Biochem Biophys Res Commun 173 (1), 309-316 (1990)
   PUBMED   2256920
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U14907.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_181824.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14907.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1497
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /note="cytochrome P450, family 11, subfamily b,
                     polypeptide 3"
                     /db_xref="GeneID:353498"
                     /db_xref="RGD:727886"
     CDS             1..1497
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /note="cytochrome P450, subfamily 11B, polypeptide 3"
                     /codon_start=1
                     /product="cytochrome P450, family 11, subfamily b,
                     polypeptide 3"
                     /protein_id="NP_861545.1"
                     /db_xref="GeneID:353498"
                     /db_xref="RGD:727886"
                     /translation="MALRVTADVWARPWQCLHRTRALGSTATQAPKTLKPFEAIPQYS
                     RNKWLKMIQILREQSQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQV
                     ESILPRRMTLESWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAVQSFVPFV
                     DVVARDFVENLKKRMLENVHGSMSMDIQSNVFNYTMEASHFVISGERLGLTGHDLNPE
                     SLKFIHALHSMFKSTTQLMFLPKNLTRWTSTQVWKGHFESWDIISEYVTKCIKNVYRE
                     LAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPDV
                     QQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPIGSSLERIVDSDLVLQN
                     YHVPAGTLVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRL
                     AEVEVLLLLHHMLKIFQVETLRQEDVQMAYRFVLMPNPRLVLTIRPVS"
     exon            1..236
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..392
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..592
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..796
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..948
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1115
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1194
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1383
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1497
                     /gene="Cyp11b3"
                     /gene_synonym="CYPXIB3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctctca gggtgacagc agatgtgtgg gcaagaccct ggcagtgcct gcacaggacg
       61 agggcactgg gcagtacggc aacacaggcc cccaagacac tgaagccctt tgaagccata
      121 ccacaatact ccaggaacaa gtggctgaag atgatacaga tcctgaggga gcagagccaa
      181 gagaacctac acctggagat gcaccaggcc ttccaggaac tagggcccat tttcaggcac
      241 agtgcagggg gagcacagat tgtgtctgtg atgctgcctg aggacgctga gaagctgcac
      301 caggtggaga gtatcctccc gcgtcggatg acgctggagt cgtgggtggc ccacagagaa
      361 ctccgtggcc tgagacgtgg tgtgttcttg ctaaatgggg cagactggcg cttcaaccga
      421 ctgcagctga atccaaatat gctgtcacca aaagccgttc aatcttttgt cccctttgtg
      481 gatgtggtag caagggactt tgtggaaaac ctgaagaaga gaatgctgga gaatgttcat
      541 ggaagcatgt ctatggacat tcagtccaat gtgttcaact ataccatgga agccagccat
      601 tttgttattt ccggagagcg actgggcctc acaggccatg acctgaaccc tgagagcctg
      661 aagttcattc atgctctgca ctcaatgttc aagtccacca cacagctcat gttcttaccc
      721 aagaacttga ctcgttggac aagcacccag gtgtggaaag gacactttga gtcctgggat
      781 atcatctctg agtatgtcac aaaatgtatc aagaatgtgt atcgcgaact ggcagagggt
      841 cgccaacagt cctggagtgt catatccgag atggtagcac agagtactct gtcaatggat
      901 gccatccatg ccaactcaat ggaacttatt gctggaagtg ttgacacgac agcaatctcc
      961 ttggtaatga ccctttttga gctggctcgg aacccagatg ttcagcaggc cctgcggcag
     1021 gagagcctgg cagctgaggc cagcatcgct gctaatcccc agaaggccat gtcagacttg
     1081 cccttgctgc gggctgccct taaagagacc ttgaggctct accccattgg tagctctttg
     1141 gagagaatcg tagactcaga cctggtgctt cagaactatc atgtccctgc tgggacgttg
     1201 gtcataattt atctgtactc catgggccga aaccctgcag tgttcccaag acctgagcgc
     1261 tacatgcctc agcgctggct ggagaggaaa aggagtttcc agcatctggc cttcggcttt
     1321 ggggtgcgcc agtgcctggg gcggcgcctg gcagaggtgg aggtgttgct cctgcttcac
     1381 catatgctga aaatcttcca agtcgagaca ctgaggcaag aggatgtgca gatggcctat
     1441 cgctttgttt tgatgcccaa ccctagactc gtcctcacta tccggcctgt gagctag
//
