LOCUS       NM_012538               2695 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 11, subfamily b,
            polypeptide 2 (Cyp11b2), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_012538
VERSION     NM_012538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2695)
  AUTHORS   Takeda,Y., Demura,M., Wang,F., Karashima,S., Yoneda,T.,
            Kometani,M., Hashimoto,A., Aono,D., Horike,S.I., Meguro-Horike,M.,
            Yamagishi,M. and Takeda,Y.
  TITLE     Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and
            Angiotensin II
  JOURNAL   J Am Heart Assoc 7 (10), e008281 (2018)
   PUBMED   29739797
  REMARK    GeneRIF: DNA demethylation may switch the phenotype of CYP11B2
            expression from an inactive to an active state and regulate
            aldosterone biosynthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2695)
  AUTHORS   Yilmaz,M., Sari,I., Bagci,B., Gumus,E. and Ozdemir,O.
  TITLE     Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a
            Turkish Population With Chronic Kidney Disease
  JOURNAL   Iran J Kidney Dis 9 (3), 209-214 (2015)
   PUBMED   25957425
  REMARK    GeneRIF: Data showed that that the CYP11B2 gene -344 C>T
            polymorphism may have an effect on the development of CKD in
            diabetic patients.
REFERENCE   3  (bases 1 to 2695)
  AUTHORS   Li,S.W., Hu,L.J., Wu,Q.H., Huang,P. and Cao,H.Y.
  TITLE     [The influence of suoquan capsule on the mRNA expression of CYP11B2
            in deficiency of the kidney and diuresis rats]
  JOURNAL   Zhong Yao Cai 34 (1), 80-83 (2011)
   PUBMED   21818974
  REMARK    GeneRIF: Suoquan capsule can increase the mRNA expression of
            CYP11B2 in rats with kidney deficiency and diuresis.
REFERENCE   4  (bases 1 to 2695)
  AUTHORS   Tran,P.V., Georgieff,M.K. and Engeland,W.C.
  TITLE     Sodium depletion increases sympathetic neurite outgrowth and
            expression of a novel TMEM35 gene-derived protein (TUF1) in the rat
            adrenal zona glomerulosa
  JOURNAL   Endocrinology 151 (10), 4852-4860 (2010)
   PUBMED   20685870
REFERENCE   5  (bases 1 to 2695)
  AUTHORS   LeHoux,J.G. and Tremblay,A.
  TITLE     In vivo regulation of gene expression of enzymes controlling
            aldosterone synthesis in rat adrenal
  JOURNAL   J Steroid Biochem Mol Biol 43 (8), 837-846 (1992)
   PUBMED   22217827
  REMARK    GeneRIF: Data suggest that variations in intake of sodium and
            potassium act on expression of CYP11B2 in adrenal zona glomerulosa,
            but not on expression of CYP11B1.
REFERENCE   6  (bases 1 to 2695)
  AUTHORS   Pascoe,L., Curnow,K.M., Slutsker,L., Rosler,A. and White,P.C.
  TITLE     Mutations in the human CYP11B2 (aldosterone synthase) gene causing
            corticosterone methyloxidase II deficiency
  JOURNAL   Proc Natl Acad Sci U S A 89 (11), 4996-5000 (1992)
   PUBMED   1594605
REFERENCE   7  (bases 1 to 2695)
  AUTHORS   Okamoto,M. and Nonaka,Y.
  TITLE     Molecular biology of rat steroid 11 beta-hydroxylase [P450(11
            beta)] and aldosterone synthase [P450(11 beta, aldo)]
  JOURNAL   J Steroid Biochem Mol Biol 41 (3-8), 415-419 (1992)
   PUBMED   1562515
REFERENCE   8  (bases 1 to 2695)
  AUTHORS   Domalik,L.J., Chaplin,D.D., Kirkman,M.S., Wu,R.C., Liu,W.W.,
            Howard,T.A., Seldin,M.F. and Parker,K.L.
  TITLE     Different isozymes of mouse 11 beta-hydroxylase produce
            mineralocorticoids and glucocorticoids
  JOURNAL   Mol Endocrinol 5 (12), 1853-1861 (1991)
   PUBMED   1686470
REFERENCE   9  (bases 1 to 2695)
  AUTHORS   White,P.C., Dupont,J., New,M.I., Leiberman,E., Hochberg,Z. and
            Rosler,A.
  TITLE     A mutation in CYP11B1 (Arg-448----His) associated with steroid 11
            beta-hydroxylase deficiency in Jews of Moroccan origin
  JOURNAL   J Clin Invest 87 (5), 1664-1667 (1991)
   PUBMED   2022736
REFERENCE   10 (bases 1 to 2695)
  AUTHORS   Imai,M., Shimada,H., Okada,Y., Matsushima-Hibiya,Y., Ogishima,T.
            and Ishimura,Y.
  TITLE     Molecular cloning of a cDNA encoding aldosterone synthase
            cytochrome P-450 in rat adrenal cortex
  JOURNAL   FEBS Lett 263 (2), 299-302 (1990)
   PUBMED   2129527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 15, 2009 this sequence version replaced NM_012538.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52766.1, D00568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050746, SAMN17050747
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               JAXUCZ010000007.1  108725519-108725763 c
            246-401             JAXUCZ010000007.1  108724993-108725148 c
            402-601             JAXUCZ010000007.1  108723300-108723499 c
            602-805             JAXUCZ010000007.1  108722981-108723184 c
            806-960             JAXUCZ010000007.1  108722569-108722723 c
            961-1127            JAXUCZ010000007.1  108721490-108721656 c
            1128-1206           JAXUCZ010000007.1  108721174-108721252 c
            1207-1395           JAXUCZ010000007.1  108720898-108721086 c
            1396-2695           JAXUCZ010000007.1  108719349-108720648 c
FEATURES             Location/Qualifiers
     source          1..2695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2695
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /note="cytochrome P450, family 11, subfamily b,
                     polypeptide 2"
                     /db_xref="GeneID:24294"
                     /db_xref="RGD:2454"
     CDS             1..1509
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /EC_number="1.14.15.4"
                     /EC_number="1.14.15.5"
                     /note="cytochrome P450 11B3, mitochondrial; aldosterone
                     synthase; CYPXIB2; CYPXIB3; P450-Aldo-1; P450-Aldo-2;
                     cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; cytochrome
                     P450, subfamily 11B, polypeptide 2; Cytochrome P450,
                     subfamily XIB, polypeptide 2 (aldosterone synthase);
                     cytochrome P-450C18; cytochrome P-450Aldo; steroid
                     18-hydroxylase; aldosterone-synthesizing enzyme; steroid
                     11-beta-hydroxylase, CYP11B2; corticosterone
                     18-monooxygenase, CYP11B2; P450(11beta,aldo); cytochrome
                     P-450 11B3; cytochrome P450(11beta,aldo)"
                     /codon_start=1
                     /product="cytochrome P450 11B2, mitochondrial"
                     /protein_id="NP_036670.2"
                     /db_xref="GeneID:24294"
                     /db_xref="RGD:2454"
                     /translation="MAMALRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIP
                     QYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKL
                     HQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGADWRFNRLKLNPNVLSPKAVQNFV
                     PMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDL
                     NPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTRVWKEHFDAWDVISEYANRCIWKV
                     HQELRLGSSQTYSGIVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELAR
                     NPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDL
                     VLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCL
                     GRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPVS"
     exon            1..245
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            246..401
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            402..601
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            602..805
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            806..960
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1127
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1206
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1395
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..2695
                     /gene="Cyp11b2"
                     /gene_synonym="ALDOS; Cp45as; Cyp11b3; RNCP45AS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcaatgg ctctcagggt gacagcagat gtgtggctgg caagaccctg gcagtgcctg
       61 cacaggacga gggcactggg cactacggca acactggccc ccaagacact gaagcccttt
      121 gaagccatac cacaatactc caggaacaag tggctgaaga tgatacagat cctgagggag
      181 cagggccaag agaacctaca cctggagatg caccaggcct tccaggagct ggggcccatt
      241 ttcaggcaca gtgcaggggg agcacagatt gtgtctgtga tgctgcctga ggacgctgag
      301 aagctgcacc aggtggagag tatcctcccg cgtcggatgc acctggagcc gtgggtggcc
      361 cacagggaac tccgtggcct gagacgtggt gtgttcttgc taaatggggc tgactggcgc
      421 ttcaaccgac tgaaactgaa cccaaacgtg ctgtcaccaa aagctgttca aaattttgtc
      481 cccatggtgg acgaggtagc aagggacttc ttggaggccc tgaaaaagaa ggtgcgtcag
      541 aatgctcgag ggagccttac catggatgtc cagcaaagtc tcttcaacta cactatagaa
      601 gccagcaact ttgcactttt tggagagagg ctgggcctcc ttggtcatga cctgaaccct
      661 ggtagcctga agttcatcca tgccctacat tcaatgttca agtccaccac acagctcctg
      721 ttcttaccca gaagcttgac tcgctggaca agcacccggg tgtggaaaga acattttgat
      781 gcctgggatg tcatctctga gtatgccaac agatgtatct ggaaggtgca ccaggaactc
      841 agactcggca gctctcagac ctacagtggc attgtggcag cactaataac tcagggagct
      901 ttacctctgg acgccatcaa agccaactct atggagctca ctgctgggag cgttgacacg
      961 acagcaatcc ccttggtaat gacccttttt gagctggctc ggaacccaga tgttcagcag
     1021 gccctgcggc aggagaccct ggcagctgag gccagcatcg ctgctaatcc ccagaaggcc
     1081 atgtcagacc tgcccttgct gcgggctgcc cttaaagaga ccttgagact ctaccctgtt
     1141 ggtggctttt tggagagaat cctaaactca gacctggtgc ttcagaacta tcatgtccct
     1201 gctgggacgt tggtcctact ttatctgtac tccatgggcc gaaaccctgc agtgttccca
     1261 agacctgagc gctatatgcc tcagcgctgg ctggagagga aaaggagttt ccagcatctg
     1321 gccttcggct ttggggtgcg ccagtgcctg gggcggcgcc tggcagaggt ggagatgctg
     1381 ctcctgcttc accatatgct gaaaaccttc caggtggaga cactgagaca agaggatgtg
     1441 cagatggcct atcgctttgt tttgatgccc agctctagtc ctgtcctcac tttccggccc
     1501 gtcagctagt caccttacat ctggggccct aatcagtcca ccggcctact tctgtcctga
     1561 cgcccaaggt cacgcttctc tgccagcaga aatcttgggg ggggggaaga ggtcacattg
     1621 tcatcattca acacaactgt acacagttta cagctgaaga cctccagcat caggtacaag
     1681 caaggccagg gaagagatta ggagtatctt cagggcaata ggtagtctct cctgagcggt
     1741 cttccccatt ctttccaacg gtcactccag gtggccacgg ccttcaaagg gtctcagagt
     1801 aaagccagaa gtaatctcct ccttatggat ccattatttt gacatgaccc acaaaaacat
     1861 tttcacacac agatgggttt ttggggggca aaagatacat agatgataga tatgatatat
     1921 gatattgata gatagataga tgatagatag atagatagat agatagatag atagatagat
     1981 agatagatga tggatgacca gtcatttatg tctgtgtttt gtttgaagcc tttcacagtg
     2041 gagctggcac atatgagttg gtgactctac agtgttttaa gagtagacac agctgcactt
     2101 gctaaggact gggtggttgt ggtatcagag atgcaggcag gaggacctgc tggaacccag
     2161 atactgtgtg aagtccccac agggacggtg gtcttccatg aggtcaaggt gtttcctgac
     2221 ttctgccagt gcatgctgct tgggcaaagg taattctctt gacttgtgaa agtggcccaa
     2281 agcataagaa ttttttcagg tatcctttca gctgcaagtc ggtagggcga aaagttttgg
     2341 ccaagaacaa ccacttcaca ggatctcctg tgctcagcac caaagcacaa atctactgga
     2401 gatgtgtgtg ccaaattcca aggtcttagg cctttgagtg tgaggcagta tagagtcagg
     2461 gcctttaatg atataattcg tgtgaaatga gattactggg ttgtgcctac tccaatgccc
     2521 agagagcacc caagaagaga gtgaggtgcc aggtcacaga gacagacccc atgtggaaga
     2581 caggaagtca gacttctgta agccgaggaa agcagttgga actcctgtag tcttggctcc
     2641 atcactcaat cacttccctg gctgtgaaaa ataaacttgt gttgttgaag tccca
//
