LOCUS       NM_012537               2691 bp    mRNA    linear   ROD 23-APR-2012
DEFINITION  Rattus norvegicus cytochrome P450, family 11, subfamily b,
            polypeptide 1 (Cyp11b1), nuclear gene encoding mitochondrial
            protein, mRNA.
ACCESSION   NM_012537 XM_346808
VERSION     NM_012537.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2691)
  AUTHORS   Chen,Y.C., Chen,Y., Huang,S.H. and Wang,S.M.
  TITLE     Protein kinase Cmu mediates adenosine-stimulated steroidogenesis in
            primary rat adrenal cells
  JOURNAL   FEBS Lett. 584 (21), 4442-4448 (2010)
   PUBMED   20937274
REFERENCE   2  (bases 1 to 2691)
  AUTHORS   Bibeau,K., Battista,M.C., Houde,V. and Brochu,M.
  TITLE     Fetal adrenal gland alterations in a rat model of adverse
            intrauterine environment
  JOURNAL   Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 (4), R899-R911
            (2010)
   PUBMED   19923365
REFERENCE   3  (bases 1 to 2691)
  AUTHORS   Gomez-Sanchez,E.P., Gomez-Sanchez,C.M., Plonczynski,M. and
            Gomez-Sanchez,C.E.
  TITLE     Aldosterone synthesis in the brain contributes to Dahl
            salt-sensitive rat hypertension
  JOURNAL   Exp. Physiol. 95 (1), 120-130 (2010)
   PUBMED   19837774
REFERENCE   4  (bases 1 to 2691)
  AUTHORS   Nagaya,M., Arai,M. and Widmaier,E.P.
  TITLE     Ontogeny of immunoreactive and bioactive microsomal steroidogenic
            enzymes during adrenocortical development in rats
  JOURNAL   Mol. Cell. Endocrinol. 114 (1-2), 27-34 (1995)
   PUBMED   8674848
REFERENCE   5  (bases 1 to 2691)
  AUTHORS   Mukai,K., Imai,M., Shimada,H. and Ishimura,Y.
  TITLE     Isolation and characterization of rat CYP11B genes involved in late
            steps of mineralo- and glucocorticoid syntheses
  JOURNAL   J. Biol. Chem. 268 (12), 9130-9137 (1993)
   PUBMED   8473352
REFERENCE   6  (bases 1 to 2691)
  AUTHORS   LeHoux,J.G. and Tremblay,A.
  TITLE     In vivo regulation of gene expression of enzymes controlling
            aldosterone synthesis in rat adrenal
  JOURNAL   J. Steroid Biochem. Mol. Biol. 43 (8), 837-846 (1992)
   PUBMED   22217827
  REMARK    GeneRIF: Data suggest that variations in intake of sodium and
            potassium act on expression of CYP11B2 in adrenal zona glomerulosa,
            but not on expression of CYP11B1.
REFERENCE   7  (bases 1 to 2691)
  AUTHORS   Helmberg,A., Ausserer,B. and Kofler,R.
  TITLE     Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1
            causes congenital adrenal hyperplasia due to steroid 11
            beta-hydroxylase deficiency
  JOURNAL   J. Clin. Endocrinol. Metab. 75 (5), 1278-1281 (1992)
   PUBMED   1430088
REFERENCE   8  (bases 1 to 2691)
  AUTHORS   Lifton,R.P., Dluhy,R.G., Powers,M., Rich,G.M., Cook,S., Ulick,S.
            and Lalouel,J.M.
  TITLE     A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes
            glucocorticoid-remediable aldosteronism and human hypertension
  JOURNAL   Nature 355 (6357), 262-265 (1992)
   PUBMED   1731223
REFERENCE   9  (bases 1 to 2691)
  AUTHORS   Matsukawa,N., Nonaka,Y., Ying,Z., Higaki,J., Ogihara,T. and
            Okamoto,M.
  TITLE     Molecular cloning and expression of cDNAS encoding rat aldosterone
            synthase: variants of cytochrome P-450(11 beta)
  JOURNAL   Biochem. Biophys. Res. Commun. 169 (1), 245-252 (1990)
   PUBMED   2350348
REFERENCE   10 (bases 1 to 2691)
  AUTHORS   Nonaka,Y., Matsukawa,N., Morohashi, Omura,T., Ogihara,T.,
            Teraoka,H. and Okamoto,M.
  TITLE     Molecular cloning and sequence analysis of cDNA encoding rat
            adrenal cytochrome P-450(11)beta
  JOURNAL   FEBS Lett. 255 (1), 21-26 (1989)
   PUBMED   2551730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AABR03055463.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_012537.4.
            
            On Mar 30, 2010 this sequence version replaced NM_012537.2.
            
            Summary: catalyzes the conversion of 11-deoxycorticosterone to
            corticosterone [RGD, Feb 2006].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AABR03055463.1     6792-7030           c
            240-395             AABR03055463.1     6258-6413           c
            396-595             AABR03055463.1     4697-4896           c
            596-799             AABR03055463.1     4379-4582           c
            800-951             AABR03055463.1     3955-4106           c
            952-1118            AABR03055463.1     2490-2656           c
            1119-1197           AABR03055463.1     2175-2253           c
            1198-1386           AABR03055463.1     1899-2087           c
            1387-2691           AABR03055463.1     345-1649            c
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2691
                     /gene="Cyp11b1"
                     /gene_synonym="Cp11ba; RATCP11BA"
                     /note="cytochrome P450, family 11, subfamily b,
                     polypeptide 1"
                     /db_xref="GeneID:500892"
                     /db_xref="RGD:2453"
     CDS             1..1500
                     /gene="Cyp11b1"
                     /gene_synonym="Cp11ba; RATCP11BA"
                     /EC_number="1.14.15.4"
                     /note="cytochrome P450 11B1, mitochondrial; cytochrome
                     P450, subfamily 11B, polypeptide 1; aldosterone synthase;
                     steroid 11-beta-hydroxylase; CYPXIB1; P450C11; P450(11
                     beta)-DS; cytochrome P450C11; cytochrome P450(11 beta)-DS;
                     Cytochrome P450, subfamily XIB, polypeptide 1 (steroid
                     11-beta-hydroxylase)"
                     /codon_start=1
                     /product="cytochrome P450 11B1, mitochondrial precursor"
                     /protein_id="NP_036669.3"
                     /db_xref="GeneID:500892"
                     /db_xref="RGD:2453"
                     /translation="MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQY
                     SRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQ
                     VESILPHRMPLEPWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPF
                     VDVVARDFVENLKKRMLENVHGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKP
                     ESVTFTHALHSMFKSTTQLMFLPKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYR
                     ELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPD
                     VQQALRQESLAAEASIVANPQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSDLVLQ
                     NYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGMRQCLGRR
                     LAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSSSPFLTFRPVS"
ORIGIN      
        1 atggctctca gggtgacagc agatgtgtgg ctggcaagac cctggcagtg cctgcacagg
       61 acgagggcac tgggcactac ggcaaaagtg gcccccaaga cactgaagcc ctttgaagcc
      121 ataccacaat actccaggaa caagtggctg aagatgatac agatcctgag ggagcagggc
      181 caagagaacc tacacctgga gatgcaccag gccttccaag agctggggcc cattttcagg
      241 cacagtgcag ggggagcaca gattgtgtct gtgatgctgc ctgaggacgc tgagaagctg
      301 caccaggtgg agagtatcct cccgcatcgg atgcccctgg agccgtgggt ggcccacagg
      361 gaactccgtg gcctgagacg tggtgtgttc ttgctaaatg gggcagactg gcgcttcaac
      421 cgactgcagc tgaatccaaa tatgctgtca ccaaaagcca ttcaatcttt tgtccccttt
      481 gtggatgtgg tagcaaggga ctttgtggaa aacctgaaga agagaatgct ggagaatgtt
      541 catggaagca tgtctataaa cattcagtcc aatatgttca actataccat ggaagccagc
      601 cattttgtta tttccggaga gcgtctgggc ctcacaggcc atgacctgaa acctgagagc
      661 gtgacattca ctcatgctct gcactcaatg ttcaagtcca ccacacagct catgttctta
      721 cccaagagct tgactcgttg gacaagcacc cgggtgtgga aagaacactt tgattcctgg
      781 gatatcatct ctgagtatgt cacaaaatgt atcaagaatg tgtatcgcga actggcagag
      841 ggtcgccaac agtcctggag tgtcatatcc gagatggtag cacagagtac tctgtcaatg
      901 gatgccatcc atgccaactc aatggaactt attgctggaa gtgttgacac gacagcaatc
      961 tccttggtaa tgaccctttt tgagctggct cggaacccag atgttcagca ggccctgcgg
     1021 caggagagcc tagcagctga ggccagcatc gttgctaatc cccagaaggc catgtcagac
     1081 ctgcccttgc tgcgggctgc ccttaaagag accttgaggc tctaccctgt tggtagcttt
     1141 gtagagagaa tcgtacactc agacctggtg cttcagaact atcatgtccc tgctgggaca
     1201 ttcgtcataa tttatctgta ctccatgggc cgaaaccctg cagtgttccc aagacctgag
     1261 cgctatatgc ctcagcgctg gctggagagg aaaaggagtt tccagcatct ggccttcggc
     1321 tttgggatgc gccagtgcct ggggcggcgc ctggcagagg tggagatgct gctcctgctt
     1381 caccatatgc tgaaaacctt ccaagtggag acactgagac aagaggatat gcagatggtt
     1441 tttcgctttc ttttgatgcc cagctctagt cctttcctta ctttccggcc tgtgagctag
     1501 tcaccttaca tctggggccc tagtcagtcc accagcctac ctctgtcctg acacccaagg
     1561 tcacacttct ctgccagcag aattttttgt ggggaggagg tcacactgtc atcattcaac
     1621 acaactgtac acagtttaca gctgaagacc tccagcatca ggtacaagca aggccaggga
     1681 agagattagg actatcttca gggcaataag tagtctctcc tgagcggtct tccccattct
     1741 ttccaacggt cactccaggt ggccacggcc tttaaagggt ctcagagtaa agccagaagt
     1801 caactcctcc ttatgtcctc attattatga catgacccac caaaacattt tcacacacag
     1861 atgggaattt ttgggcaaaa gatacataga tgatagatag atatatgata tattacatat
     1921 gatagatgat agatagatag atgatagata gatagataga tagatagata gatagataga
     1981 tagatagata gatgatggat gaccagtcat ttatgtctgt gttttgtttg aagcctttca
     2041 cagtggagct ggcacatacg agctggtgag tctacagtgt tttaagagta gacacagctg
     2101 cacttgctaa ggactgggtg gttgtggtat cagagatgca ggcaggagga cctgctggaa
     2161 cccagatact gtgtgaagtc cccacaggga cagtggtctt ccatgaggtc aaggtgtttc
     2221 ctgacttctg ccagtgcatg ctgcttgggc aaaggtaatt ctcttgactt gtgaaagtgg
     2281 cccagagcat aagatttttt caggtctcct ttcagctgca agtcggtagg gcgaaaagtt
     2341 ttggccaaga acaaccactt cacagggtct cctgtgctca gcactaaagc acaaatctac
     2401 tggagatgtg tgtgccaaat tccaaggtct tagacctttg agtgtgaggc agtatagagt
     2461 cagggccttt aatgatataa ttcgtgtgaa atgagattac tgggttgtgc ctactccagt
     2521 gcccagagag cctcccaaga agagagtgag gtgccaggtc acagagacag acccaagtgg
     2581 aagacaggaa gtcagacttc tgtaagcgga ggaaagcagt tggaactcct acagtcttgg
     2641 ctccatcact caatcacttc cctggctgtg aaaaataaac ttgagttgtt g
//
