LOCUS       NM_001017380            3267 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus CYLD lysine 63 deubiquitinase (Cyld), mRNA.
ACCESSION   NM_001017380 XM_232641
VERSION     NM_001017380.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Wang,H., Wu,B., Wang,H., Jiang,C. and Liu,Z.
  TITLE     LncRNA growth arrest specific transcript 5 inhibits the growth of
            pituitary neuroendocrine tumors via miR-27a-5p/cylindromatosis axis
  JOURNAL   Bioengineered 13 (4), 10274-10286 (2022)
   PUBMED   35435104
  REMARK    GeneRIF: LncRNA growth arrest specific transcript 5 inhibits the
            growth of pituitary neuroendocrine tumors via
            miR-27a-5p/cylindromatosis axis.
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Chen,Q., Lei,Y.Q., Liu,J.F., Wang,Z.C. and Cao,H.
  TITLE     Beneficial effects of chlorogenic acid treatment on
            neuroinflammation after deep hypothermic circulatory arrest may be
            mediated through CYLD/NF-kappaB signaling
  JOURNAL   Brain Res 1767, 147572 (2021)
   PUBMED   34216581
  REMARK    GeneRIF: Beneficial effects of chlorogenic acid treatment on
            neuroinflammation after deep hypothermic circulatory arrest may be
            mediated through CYLD/NF-kappaB signaling.
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Ji,Y.X., Huang,Z., Yang,X., Wang,X., Zhao,L.P., Wang,P.X.,
            Zhang,X.J., Alves-Bezerra,M., Cai,L., Zhang,P., Lu,Y.X., Bai,L.,
            Gao,M.M., Zhao,H., Tian,S., Wang,Y., Huang,Z.X., Zhu,X.Y.,
            Zhang,Y., Gong,J., She,Z.G., Li,F., Cohen,D.E. and Li,H.
  TITLE     The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic
            steatohepatitis
  JOURNAL   Nat Med 24 (2), 213-223 (2018)
   PUBMED   29291351
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Ma,Q., Ruan,H., Peng,L., Zhang,M., Gack,M.U. and Yao,W.D.
  TITLE     Proteasome-independent polyubiquitin linkage regulates synapse
            scaffolding, efficacy, and plasticity
  JOURNAL   Proc Natl Acad Sci U S A 114 (41), E8760-E8769 (2017)
   PUBMED   28973854
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Yu,B., Liu,Z., Fu,Y., Wang,Y., Zhang,L., Cai,Z., Yu,F., Wang,X.,
            Zhou,J. and Kong,W.
  TITLE     CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate
            Oxidase 4 Contributing to Adventitial Remodeling
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (9), 1698-1709 (2017)
   PUBMED   28751569
  REMARK    GeneRIF: CYLD contributes to the transdifferentiation of
            adventitial fibroblasts via deubiquitinating Nox4 and may play a
            role in vascular remodeling.
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Wooten,M.W., Geetha,T., Babu,J.R., Seibenhener,M.L., Peng,J.,
            Cox,N., Diaz-Meco,M.T. and Moscat,J.
  TITLE     Essential role of sequestosome 1/p62 in regulating accumulation of
            Lys63-ubiquitinated proteins
  JOURNAL   J Biol Chem 283 (11), 6783-6789 (2008)
   PUBMED   18174161
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Stegmeier,F., Sowa,M.E., Nalepa,G., Gygi,S.P., Harper,J.W. and
            Elledge,S.J.
  TITLE     The tumor suppressor CYLD regulates entry into mitosis
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 8869-8874 (2007)
   PUBMED   17495026
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Reiley,W.W., Zhang,M., Jin,W., Losiewicz,M., Donohue,K.B.,
            Norbury,C.C. and Sun,S.C.
  TITLE     Regulation of T cell development by the deubiquitinating enzyme
            CYLD
  JOURNAL   Nat Immunol 7 (4), 411-417 (2006)
   PUBMED   16501569
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Saito,K., Kigawa,T., Koshiba,S., Sato,K., Matsuo,Y., Sakamoto,A.,
            Takagi,T., Shirouzu,M., Yabuki,T., Nunokawa,E., Seki,E.,
            Matsuda,T., Aoki,M., Miyata,Y., Hirakawa,N., Inoue,M., Terada,T.,
            Nagase,T., Kikuno,R., Nakayama,M., Ohara,O., Tanaka,A. and
            Yokoyama,S.
  TITLE     The CAP-Gly domain of CYLD associates with the proline-rich
            sequence in NEMO/IKKgamma
  JOURNAL   Structure 12 (9), 1719-1728 (2004)
   PUBMED   15341735
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Bignell,G.R., Warren,W., Seal,S., Takahashi,M., Rapley,E.,
            Barfoot,R., Green,H., Brown,C., Biggs,P.J., Lakhani,S.R., Jones,C.,
            Hansen,J., Blair,E., Hofmann,B., Siebert,R., Turner,G., Evans,D.G.,
            Schrander-Stumpel,C., Beemer,F.A., van Den Ouweland,A., Halley,D.,
            Delpech,B., Cleveland,M.G., Leigh,I., Leisti,J. and Rasmussen,S.
  TITLE     Identification of the familial cylindromatosis tumour-suppressor
            gene
  JOURNAL   Nat Genet 25 (2), 160-165 (2000)
   PUBMED   10835629
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082001.1.
            
            On Apr 22, 2005 this sequence version replaced XM_232641.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082001.1, SRR8487231.48683.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3267
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /note="CYLD lysine 63 deubiquitinase"
                     /db_xref="GeneID:312937"
                     /db_xref="RGD:1308346"
     exon            1..45
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            46..699
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..3057
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /EC_number="3.4.19.12"
                     /note="probable ubiquitin carboxyl-terminal hydrolase
                     CYLD; ubiquitin thioesterase CYLD; deubiquitinating enzyme
                     CYLD; ubiquitin-specific-processing protease CYLD;
                     ubiquitin thiolesterase CYLD; retinitis pigmentosa 1
                     homolog; cylindromatosis (turban tumor syndrome); probable
                     ubiquitin carboxyl-terminal hydrolase CYLD-like; 40S
                     ribosomal protein S3a-like"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase CYLD"
                     /protein_id="NP_001017380.1"
                     /db_xref="GeneID:312937"
                     /db_xref="RGD:1308346"
                     /translation="MSSGLWNQEKVTSPYWEERLFYLLLQECSVTDKQTQKLLRVPKG
                     SIGQYIQDRSVGHSRVPSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLA
                     ITNCEERLSLFRNRIRLSKGLQVDVGSPVRVQLRSGEEKFPGVVRFRGPLLAERTVSG
                     IFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDNGLESDFAG
                     PGDTVQVEPPPLEINSRVSLKVGESTESGTVIFCDVLPGKESLGYFVGVDMDNPIGNW
                     DGRFDGVQLCSFASVESTVLLHINDIIPDSVTQERRPPKLAFMSRGVGDKGSSSHNKP
                     KVTGSTSDPGSRNRSELFYTLNGSSVDSQQQSKSKNPWYIDEVAEDPAKSLTEMSSDF
                     GHSSPPPQPPSMNSLSSENRFHSLPFSLTKMPNTNGSMAHSPLSLSVQSVMGELNSTP
                     VQESPPMPSSSGNAHGLEVGSLAEVKENPPFYGVIRWIGQPPGLSDVLAGLELEDECA
                     GCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSE
                     VVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEK
                     NDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEF
                     LNILFHDILRVEPLLKIRSAGQKVQDCNFYQIFMEKNEKVGVPTIQQLLEWSFINSNL
                     KFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRE
                     CYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHTYHPVSLPKDLPDWDWRHGCIPCQKM
                     ELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLK
                     MSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK"
     exon            700..1002
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1108
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1207
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1324
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1704
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1870
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2012
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2135
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2227
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2294
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2427
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2536
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2655
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2872
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3237
                     /gene="Cyld"
                     /gene_synonym="LRRGT00003; Rp1; Rp1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccaggta gcaggttcgg ctgcgcgggg gcccgcgcgc ctgaggcact ttgaattgct
       61 gtctttttac aacatggatg ccaggttgct aaaatcttgc tttgggactt acagtgagtt
      121 catttttttg gattttatga cagatttact agtggttcct ttttgccagc taatgttctg
      181 aaagttactg tcacaatgag ttcaggcctg tggaaccaag agaaagttac ttcaccctac
      241 tgggaagaac ggctttttta tctgcttctt caagaatgca gtgtaacaga caaacagaca
      301 cagaagctcc tgagagtacc caaagggagc ataggacagt acatccaaga ccgttccgtg
      361 gggcattcaa gagttccttc tgctaaaggc aagaaaaatc agattggatt aaaaatctta
      421 gagcaaccgc atgcagttct gtttgttgat gaaaaggatg ttgtagaaat aaatgaaaaa
      481 ttcacagagt tactgttggc aattaccaac tgtgaggaga ggctcagcct atttagaaac
      541 agaatccgac taagtaaagg cctccaggta gacgtgggca gtcctgtgag agtacagctg
      601 cgatctgggg aggagaagtt tccaggagtt gtacgcttca gaggaccttt attagcggag
      661 aggacggtgt cggggatttt ctttggagta gaattactgg aagaaggtcg tggccaaggt
      721 ttcactgatg gggtgtatca aggaaaacag ctcttccagt gtgatgagga ctgtggcgtt
      781 tttgttgcat tggacaagct ggagcttata gaagatgatg acaatgggtt ggaaagtgat
      841 tttgcaggcc caggagatac agtccaggtt gaacctcccc ctttggaaat aaactccaga
      901 gtttctttga aggttggaga aagtacagaa tctggaacag tgatattctg tgatgtttta
      961 ccaggaaaag agagtctagg atattttgtt ggtgtggaca tggataaccc tattggcaac
     1021 tgggacggaa ggtttgatgg ggttcagctt tgcagttttg caagtgttga gagtacagtt
     1081 ctcctacaca tcaatgacat catcccagat agcgtgacac aggaaaggag acctcccaaa
     1141 cttgccttta tgtcaagagg tgtaggtgac aaaggttcat ctagtcataa taaaccaaag
     1201 gttacaggat ctacctcaga ccctggaagt agaaacagat ctgaattatt ttatacctta
     1261 aatgggtcat ctgttgactc acaacaacaa tccaagtcca aaaacccatg gtacattgat
     1321 gaagttgcag aagaccctgc aaagtcactt acagagatgt cttcagactt cggacattca
     1381 tcgcctccac cgcaacctcc ttccatgaac tccttgtcta gcgagaacag attccactcc
     1441 ttacccttca gcctgacaaa gatgcccaac actaatggca gcatggctca cagtccactc
     1501 tctctgtcag tgcagtctgt gatgggagag ctgaacagca ctcctgtcca ggagagtcca
     1561 cccatgccca gctcttctgg gaatgcacac gggctagagg tgggctcact ggctgaagta
     1621 aaagagaacc ccccgttcta tggggttatc cgttggattg gccagccacc agggctcagt
     1681 gacgtgcttg ctggattgga actggaagat gaatgcgcag gttgtacgga tggaactttc
     1741 aggggcacgc gctatttcac ctgtgccctg aagaaagcac tgttcgtgaa actgaagagc
     1801 tgcagaccag actctaggtt tgcatccttg cagcctgttt ccaatcagat cgaaaggtgt
     1861 aactctttag catttggggg ctacttaagt gaagtagtag aagaaaatac gccacctaaa
     1921 atggaaaagg aaggtttaga gataatgatt ggaaagaaga aaggcatcca gggccattac
     1981 aattcttgtt acttagactc aactttattc tgcttatttg cttttagttc tgccctggac
     2041 actgtattac ttagacccaa agagaagaat gatgtagagt attacagtga gactcaagag
     2101 ctactgagga cagagatagt caatcctctg agaatatatg gatatgtgtg tgccacaaag
     2161 attatgaagc tgaggaaaat acttgaaaaa gttgaggctg catcaggatt tacctctgag
     2221 gaaaaagatc ctgaagaatt tctaaacatc ctgtttcatg atattttaag ggttgaacca
     2281 ttgttaaaaa taaggtcagc aggtcaaaaa gttcaagact gtaacttcta tcaaattttt
     2341 atggaaaaaa atgagaaagt cggagtaccc acaatccagc agttattaga atggtctttt
     2401 atcaacagca acctgaaatt tgcagaggca ccatcatgct tgattatcca gatgcctcgg
     2461 tttgggaaag actttaaact atttaaaaaa atttttcctt ccctggaatt aaatataaca
     2521 gatttacttg aagacactcc caggcagtgc cgcatctgtg gaggactcgc catgtatgag
     2581 tgtagagagt gctatgatga cccggacatc tcggcaggga agatcaagca gttctgtaag
     2641 acctgcagca ctcaggttca ccttcatccc agaagactga atcacactta ccatccagta
     2701 tcacttccca aagacttgcc cgactgggac tggagacacg gctgcatccc gtgtcagaag
     2761 atggagttat ttgctgtgct ctgcatagaa accagccact atgttgcttt tgtgaagtac
     2821 gggaaggatg actctgcctg gctcttcttt gacagcatgg ctgatcgaga tggtggtcag
     2881 aatggcttca acattccaca agtgacaccc tgcccagaag taggagagta cttgaagatg
     2941 tctctggagg acctgcactc tttggactcc agaaggattc aaggctgtgc gcgcagactt
     3001 ctttgcgatg catacatgtg catgtaccag agtccaacca tgagcttgta caaataacca
     3061 tgccaagacc gagcagactc cagtgctgtg gcttcctcag ctggccattc tgtctggcgc
     3121 ccattgccgg caatgggtgt ctcttgggat gaggcccttc agcaaaggac tcctgtgttt
     3181 ccgaacaaat tgcttttgtg ttcctgaagt atttaataag aagcattttg cactctaaaa
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
