LOCUS       NM_130744               2138 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus cytoglobin (Cygb), mRNA.
ACCESSION   NM_130744
VERSION     NM_130744.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2138)
  AUTHORS   Liu,X., El-Mahdy,M.A., Boslett,J., Varadharaj,S., Hemann,C.,
            Abdelghany,T.M., Ismail,R.S., Little,S.C., Zhou,D., Thuy,L.T.,
            Kawada,N. and Zweier,J.L.
  TITLE     Cytoglobin regulates blood pressure and vascular tone through
            nitric oxide metabolism in the vascular wall
  JOURNAL   Nat Commun 8, 14807 (2017)
   PUBMED   28393874
  REMARK    GeneRIF: Cygb has a critical role in the regulation of vascular
            tone and disease. We suggest that modulation of the expression and
            NOD activity of Cygb represents a strategy for the treatment of
            cardiovascular disease
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2138)
  AUTHORS   Ferreira,J.C., Marcondes,M.F., Icimoto,M.Y., Cardoso,T.H.,
            Tofanello,A., Pessoto,F.S., Miranda,E.G., Prieto,T.,
            Nascimento,O.R., Oliveira,V. and Nantes,I.L.
  TITLE     Intermediate Tyrosyl Radical and Amyloid Structure in
            Peroxide-Activated Cytoglobin
  JOURNAL   PLoS One 10 (8), e0136554 (2015)
   PUBMED   26312997
  REMARK    GeneRIF: This result suggests that Cygb possibly participates in
            the development of degenerative diseases; our findings also support
            the possible biological role of Cygb related to peroxidase
            activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2138)
  AUTHORS   Tian,S.F., Yang,H.H., Xiao,D.P., Huang,Y.J., He,G.Y., Ma,H.R.,
            Xia,F. and Shi,X.C.
  TITLE     Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain
            injury by up-regulation of cytoglobin (CYGB) in a neonatal rat
            model
  JOURNAL   J Biol Chem 288 (22), 15988-16003 (2013)
   PUBMED   23585565
  REMARK    GeneRIF: The reduction of neonatal HI injury by CYGB may be due in
            part to antioxidant and antiapoptotic mechanisms and by promoting
            angiogenesis.
REFERENCE   4  (bases 1 to 2138)
  AUTHORS   Tanaka,F., Tominaga,K., Sasaki,E., Sogawa,M., Yamagami,H.,
            Tanigawa,T., Shiba,M., Watanabe,K., Watanabe,T., Fujiwara,Y.,
            Kawada,N., Yoshizato,K. and Arakawa,T.
  TITLE     Cytoglobin may be involved in the healing process of gastric
            mucosal injuries in the late phase without angiogenesis
  JOURNAL   Dig Dis Sci 58 (5), 1198-1206 (2013)
   PUBMED   23306842
  REMARK    GeneRIF: may be involved in the healing process of gastric mucosal
            injuries in the late phase without angiogenesis
REFERENCE   5  (bases 1 to 2138)
  AUTHORS   Nishi,H., Inagi,R., Kawada,N., Yoshizato,K., Mimura,I., Fujita,T.
            and Nangaku,M.
  TITLE     Cytoglobin, a novel member of the globin family, protects kidney
            fibroblasts against oxidative stress under ischemic conditions
  JOURNAL   Am J Pathol 178 (1), 128-139 (2011)
   PUBMED   21224051
  REMARK    GeneRIF: These findings show for the first that Cygb serves as a
            defensive mechanism against oxidative stress both in vitro and in
            vivo.
REFERENCE   6  (bases 1 to 2138)
  AUTHORS   Xu,R., Harrison,P.M., Chen,M., Li,L., Tsui,T.Y., Fung,P.C.,
            Cheung,P.T., Wang,G., Li,H., Diao,Y., Krissansen,G.W., Xu,S. and
            Farzaneh,F.
  TITLE     Cytoglobin overexpression protects against damage-induced fibrosis
  JOURNAL   Mol Ther 13 (6), 1093-1100 (2006)
   PUBMED   16581302
REFERENCE   7  (bases 1 to 2138)
  AUTHORS   Schmidt,M., Gerlach,F., Avivi,A., Laufs,T., Wystub,S.,
            Simpson,J.C., Nevo,E., Saaler-Reinhardt,S., Reuss,S., Hankeln,T.
            and Burmester,T.
  TITLE     Cytoglobin is a respiratory protein in connective tissue and
            neurons, which is up-regulated by hypoxia
  JOURNAL   J Biol Chem 279 (9), 8063-8069 (2004)
   PUBMED   14660570
REFERENCE   8  (bases 1 to 2138)
  AUTHORS   Nakatani,K., Okuyama,H., Shimahara,Y., Saeki,S., Kim,D.H.,
            Nakajima,Y., Seki,S., Kawada,N. and Yoshizato,K.
  TITLE     Cytoglobin/STAP, its unique localization in splanchnic
            fibroblast-like cells and function in organ fibrogenesis
  JOURNAL   Lab Invest 84 (1), 91-101 (2004)
   PUBMED   14647402
REFERENCE   9  (bases 1 to 2138)
  AUTHORS   Burmester,T., Ebner,B., Weich,B. and Hankeln,T.
  TITLE     Cytoglobin: a novel globin type ubiquitously expressed in
            vertebrate tissues
  JOURNAL   Mol Biol Evol 19 (4), 416-421 (2002)
   PUBMED   11919282
REFERENCE   10 (bases 1 to 2138)
  AUTHORS   Kawada,N., Kristensen,D.B., Asahina,K., Nakatani,K., Minamiyama,Y.,
            Seki,S. and Yoshizato,K.
  TITLE     Characterization of a stellate cell activation-associated protein
            (STAP) with peroxidase activity found in rat hepatic stellate cells
  JOURNAL   J Biol Chem 276 (27), 25318-25323 (2001)
   PUBMED   11320098
  REMARK    Erratum:[J Biol Chem 2001 Dec 14;276(50):47744-5]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088455.1.
            
            On Jan 2, 2005 this sequence version replaced NM_130744.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088455.1, AJ245663.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676808 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..2138
                     /gene="Cygb"
                     /gene_synonym="Glnf; Staap; Stap"
                     /note="cytoglobin"
                     /db_xref="GeneID:170520"
                     /db_xref="RGD:69415"
     exon            1..313
                     /gene="Cygb"
                     /gene_synonym="Glnf; Staap; Stap"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..743
                     /gene="Cygb"
                     /gene_synonym="Glnf; Staap; Stap"
                     /EC_number="1.15.1.1"
                     /note="HGb; histoglobin; stellate cell
                     activation-associated protein; globin f; pseudoperoxidase
                     CYGB; nitrite reductase CYGB; superoxide dismutase CYGB;
                     nitric oxygen dioxygenase CYGB"
                     /codon_start=1
                     /product="cytoglobin"
                     /protein_id="NP_570100.1"
                     /db_xref="GeneID:170520"
                     /db_xref="RGD:69415"
                     /translation="MEKVPGDMEIERRERNEELSEAERKAVQATWARLYANCEDVGVA
                     ILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKV
                     SSVLALVGKAHALKHKVEPMYFKILSGVILDVIAEEFANDFPVETQKAWTKLRGLIYS
                     HVTAAYKEVGWVQQVPNTTTLPATLPSSGP"
     exon            314..545
                     /gene="Cygb"
                     /gene_synonym="Glnf; Staap; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            546..709
                     /gene="Cygb"
                     /gene_synonym="Glnf; Staap; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            710..2112
                     /gene="Cygb"
                     /gene_synonym="Glnf; Staap; Stap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagacaca cacacacaca cacacacaca cacacacaca cacgctccct ccctccggcg
       61 ctctactccg cgcccgcccg cccgctcgcc cgcccgcccg cctcgcacgc accggcctcg
      121 gctccccgcg cccgccgccg agcgaagctg ctctgggatc ggagcagctc atggagaaag
      181 tgccgggcga catggagata gagcgcaggg agaggaacga ggagctgtcc gaggcggaga
      241 ggaaggcggt tcaggctacg tgggcccggc tgtatgccaa ctgcgaggac gtgggggtgg
      301 ccatcctggt gaggttcttt gtgaacttcc cgtcggccaa gcagtacttc agccagttta
      361 aacacatgga ggatccgttg gagatggaga ggagtcctca gctgcggaaa catgcctgcc
      421 gggtcatggg ggccctcaac acggtcgtgg agaacctgca tgacccagac aaggtatcct
      481 ctgtgctcgc gctggttggc aaggcccacg ccctcaagca caaggtggaa cctatgtact
      541 ttaagattct ctctggggtc attctggacg tgatcgccga ggagtttgcc aatgacttcc
      601 ccgtcgagac gcagaaagcc tggaccaagc tgcgcggtct catctacagc catgtgaccg
      661 cggcctacaa ggaagtgggc tgggtacagc aggtccccaa caccaccacc ctaccagcca
      721 cactgccctc ttcagggcca taggacccct cccagctccc ccctccctgg cagcactttg
      781 ggcagaaggc tgacttctga agacactcct tgaccttcca tttctgggtg ccaaggaagc
      841 tggaggaacc cctgactgga cttcccgaaa ggaggccttc atcatggctg tggtctccca
      901 cgttactggg aggtggggct ggctacctgg atgctgaatt tagcagaggg gaacccttct
      961 gcctcgcagc agagggcaca ccctccttag ctttcactgt caagagaggg acctggcatg
     1021 tggccggtgg gaagcaagga caagcctttg agtcacttca gaaaggaact agccctgctt
     1081 cactctgccc taccagcatg caggttctcc tcaccatctc tgagcattgc gcacacacac
     1141 gtctaccata tacacagata tattctatat acgagctcta tataaatata tatacacaca
     1201 cacacgtaca tatctgtcgc gtgcacctgc aggcccagaa gcctaggcct cgcacagctg
     1261 tgggagaccc ggaagagtcc tggccgtact tcagggcagc tctaccggga gcagggagaa
     1321 agcttgcaac agcacgagag ggcggggccg ggtgggagag tcggggtgac tcagctcacc
     1381 ccgcacagct cagtgccctg caatcttccc cttccgcccc ccaaaagaga acacttggtt
     1441 tgcccggtgt cggggcgcac acctgtaatc cccgagtttg ggacgcagag gaaggacaat
     1501 ctttgcaagt ctgaggtcag gtggtctaca cttggtctcc atcttggtga gtttccggct
     1561 agctggggtc gactcaggga gaccccgtgt caaacaaaac aagaagcgaa gagaagatct
     1621 ggctcccctc ccctccccaa gggtttgccc gactgacttg ctccggaaag gggcacaccg
     1681 agaattcagg agaccccagt ggggtgctgg ccagtgtagg tgtccggcgt ttgggggtgg
     1741 ggtgaggggc agcttcagcg tggagcccta gaatgtcagc ctcacccgct cacttcagac
     1801 agcagccagg ccacaggacc aggggccata ctcaaacccc tcagcagaga ccagggcgcc
     1861 tctctcctgc cctcctcggg gccacctgcc catcctctcc aactagtctc cgtaacattc
     1921 gctggggacc ccgtgtgtac cccttggtca cgtgtactgt cctggaggac gtcttactgc
     1981 tgtggctacc gtgcctgcgt cccctctggt cccaccctca cgcagccttc ctgtaactgc
     2041 ctgtcttttt gtagtttctg atgtttgtaa ccagacccag ctgtgtcatt aaacaggtct
     2101 gttcttcctg taaaaaaaaa aaaaaaaaaa aaaaaaaa
//
