LOCUS       NM_001106996            6253 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cytoplasmic FMR1 interacting protein 2 (Cyfip2),
            mRNA.
ACCESSION   NM_001106996 XM_001068689 XM_001068737 XM_001068787 XM_220333
VERSION     NM_001106996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6253)
  AUTHORS   Xu C, Fu X, Zhu S and Liu JJ.
  TITLE     Retrolinkin recruits the WAVE1 protein complex to facilitate
            BDNF-induced TrkB endocytosis and dendrite outgrowth
  JOURNAL   Mol Biol Cell 27 (21), 3342-3356 (2016)
   PUBMED   27605705
REFERENCE   2  (bases 1 to 6253)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 6253)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 6253)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 6253)
  AUTHORS   Ketteler R, Sun Z, Kovacs KF, He WW and Seed B.
  TITLE     A pathway sensor for genome-wide screens of intracellular
            proteolytic cleavage
  JOURNAL   Genome Biol 9 (4), R64 (2008)
   PUBMED   18387192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6253)
  AUTHORS   Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka
            M, Schenck A, Bardoni B, Bernstein CN and Melanson M.
  TITLE     CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis
            patients and is involved in T cell adhesion
  JOURNAL   Eur J Immunol 34 (4), 1217-1227 (2004)
   PUBMED   15048733
REFERENCE   7  (bases 1 to 6253)
  AUTHORS   Schenck A, Bardoni B, Moro A, Bagni C and Mandel JL.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   8  (bases 1 to 6253)
  AUTHORS   Saller E, Tom E, Brunori M, Otter M, Estreicher A, Mack DH and Iggo
            R.
  TITLE     Increased apoptosis induction by 121F mutant p53
  JOURNAL   EMBO J 18 (16), 4424-4437 (1999)
   PUBMED   10449408
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068689.1, XM_001068787.1, XM_220333.4, XM_001068737.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760393, SAMEA5760396
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..6253
                     /gene="Cyfip2"
                     /note="cytoplasmic FMR1 interacting protein 2"
                     /db_xref="GeneID:303073"
                     /db_xref="RGD:1305048"
     exon            1..67
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..207
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            208..297
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..375
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..477
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..659
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..756
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..885
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..990
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1108
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1228
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1354
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1521
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1669
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1823
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1980
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2081
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1983..3764
                     /gene="Cyfip2"
                     /codon_start=1
                     /product="cytoplasmic FMR1 interacting protein 2"
                     /protein_id="NP_001100466.1"
                     /db_xref="GeneID:303073"
                     /db_xref="RGD:1305048"
                     /translation="MSSTPWICTTTAPTMRSPSSKSSSCMTRSKQRQVNLCFDQFVYK
                     LADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSID
                     LNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSF
                     DAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDK
                     PANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIV
                     KSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQ
                     SLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAK
                     YAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRG
                     PPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIVVLLG
                     QQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMK
                     SVETDSSTVEHVRCFQPPIHQSLATTC"
     exon            2082..2158
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2267
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2387
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2587
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2675
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2819
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2910
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3041
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3114
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3209
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3448
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3596
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..6253
                     /gene="Cyfip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgcgccc cggcgcgggg ccctgcggta gtctcgggtc cctcccctgg acctgtcgct
       61 gaaccagtgt gggagacaga cgccgcagcc atgaccaccc acgtcacttt ggaagatgcc
      121 ctgtccaatg tggacctgct ggaggaactg cccctcccag accagcagcc atgcatcgag
      181 cctccgccgt cctccattat gtaccaggct aacttcgaca caaacttcga ggacaggaat
      241 gcatttgtca cgggcattgc aaggtacatt gagcaggcaa cggtccactc cagcatgaat
      301 gaaatgctgg aggagggtca tgactacgcg gtcatgctgt acacctggcg cagctgctcc
      361 cgggccatcc cgcaggtgaa gtgcaatgag cagcccaatc gggtagagat ctacgagaag
      421 acggtggagg tgctggaacc agaggtcacc aagctcatga agttcatgta ctttcagcgc
      481 aaagccatcg agcgtttctg cagtgaggtg aagcgactgt gccacgcgga gcgcaggaag
      541 gactttgtct ccgaggccta cctgctgacc ctgggcaagt tcatcaacat gtttgccgtc
      601 ttggatgagc tcaaaaacat gaagtgcagt gtcaagaacg accactctgc ctacaagaga
      661 gcggcccagt tcctaaggaa gatggcggac ccccagtcca tccaggaatc tcagaacctg
      721 tccatgttcc tggccaatca caacaggatc acccagtgtc ttcaccagca actggaagtg
      781 atcccgggct atgaggagct gctggcagac attgtcaaca tctgtgttga ttactatgag
      841 aataagatgt acctgacacc cagtgagaag cacatgctcc tcaaggtgat gggctttggc
      901 ctctatctga tggatggaaa tgtcagtaat atttacaagc tggatgccaa gaagagaatc
      961 aaccttagca aaattgataa gttctttaag gtggacgtgc acccagagca gcatcagccc
     1021 ccagtacaac atctgtgagc agatggttca gatccgggac gatcacatcc gcttcatctc
     1081 tgagctggct cgctacagca acagcgaggt ggtgacaggc tcggggctgg acagccagaa
     1141 gtccgatgaa gagtaccggg agctttttga cctggccttg cggggcctgc agctgctatc
     1201 caagtggagt gcccacgtca tggaggtgta ctcttggaag ctggttcacc ccacagacaa
     1261 gttctgcaac aaggactgcc cgggcaccgc ggaagagtac gagagagcca cgcgctataa
     1321 ttacaccagc gaggagaagt ttgcttttgt ggaggtgatc gccatgatca agggtttgca
     1381 ggtgctcatg gggaggatgg agagtgtctt caaccaggcc atccgcaaca ctatctacgc
     1441 agccctgcag gacttcgccc aggtgacgct gcgggagcca ttgcggcaag cagttcgcaa
     1501 gaaaaagaat gtccttatca gtgttctgca ggccattcga aagaccatct gtgactggga
     1561 gggaggccga gagcccccca atgacccatg cttaagaggg gagaaggacc ccaaaggtgg
     1621 ctttgacatc aaggtgcccc gccgtgccgt ggggccatcc agcacacagc tgtacatggt
     1681 gcgcaccatg cttgagtcgc tcatcgcaga caagagcggc tccaagaaga cactcagaag
     1741 cagcctggat ggccctatcg tccttgccat cgaggacttc cacaagcagt ctttcttctt
     1801 cacacacttg ctcaatatca gcgaagctct tcagcagtgc tgtgacctct cccagctctg
     1861 gttccgagaa ttcttcctgg agttgaccat gggccggcga atccagttcc caattgagat
     1921 gtccatgccc tggattctaa cggaccatat tctggaaacc aaagaacctt ccatgatgga
     1981 gtatgtcctc taccccttgg atctgtacaa cgacagcgcc tactatgcgc tcaccaagtt
     2041 caaaaagcag ttcctgtatg acgagatcga agcagaggca agtgaacctg tgctttgatc
     2101 agtttgtcta caagctggct gaccagatct ttgcctacta caaagccatg gccggcagtg
     2161 tcctgttgga caaacgtttt agagctgaat gtaagaacta tggagtgatc attccgtacc
     2221 cgccatctaa ccggtacgag acactgctga aacagagaca cgtccagctg ttgggtagat
     2281 caattgactt gaacagactc atcacgcagc ggatctctgc cgccatgtac aaatccttgg
     2341 accaggcaat cagccgcttt gagagcgaag acctgacctc cattgtggag ctagagtggc
     2401 ttctggagat taaccggctc acacaccgac tcctctgtaa gcacatgacg ctagacagct
     2461 tcgacgccat gttccgagaa gccaatcata atgtgtctgc cccctatggc cgcatcaccc
     2521 tgcatgtctt ctgggagctg aactttgact tcctccccaa ctactgctat aacggctcca
     2581 ccaaccgctt tgtccgcact gccatccctt tcacccaaga accacaacgg gataagcccg
     2641 ccaatgtcca gccttactac ctctacggat ccaagcctct caacattgcc tacagccaca
     2701 tctacagctc ctaccgcaac tttgtggggc cccctcactt caagaccatc tgcagactgc
     2761 tgggctacca gggcatcgcc gtggtcatgg aggaactgct gaaaatcgtc aagagcttgc
     2821 tccagggtac cattctgcag tacgtgaaga cactcataga ggtgatgcct aaaatatgcc
     2881 gtttgcctcg tcacgagtat ggctctccag ggatcctgga gttcttccac caccaactga
     2941 aggacatcat cgagtatgca gaactcaaaa cagacgtgtt ccagagtctc agagaggtgg
     3001 gcaatgccat cctgttctgc ctcctcatag agcaagctct gtctcaagag gaagtctgtg
     3061 atttgctcca tgccgcaccc ttccaaaaca ttctgcctcg ggtctatatc aaagaggggg
     3121 agcgtctgga agtccggatg aaacgcctcg aggccaagta cgccccactt cacctggtcc
     3181 ccctgataga gcgactgggg acgcctcagc aaattgccat cgctcgggag ggtgacctgc
     3241 tgaccaagga gcggctctgc tgtggcctgt ccatgttcga ggttatcctg acccgaattc
     3301 ggagctacct gcaggacccc atctggaggg gcccgccacc caccaatggc gtcatgcacg
     3361 tggatgagtg tgttgagttt caccggctgt ggagcgccat gcagtttgtc tactgcatcc
     3421 ctgtggggac caacgagttc acagctgagc agtgcttcgg tgatggcttg aactgggctg
     3481 gctgctctat cgttgtcttg ctgggccagc aacggcgctt tgacctgttt gatttctgtt
     3541 atcatctgct gaaggtgcag aggcaggacg ggaaggatga gatcattaag aatgtgcccc
     3601 tgaagaagat ggctgaccgc atcaggaagt accagatctt gaacaatgag gtttttgcca
     3661 ttctgaacaa gtacatgaag tccgtagaga cagacagctc cacggtagag cacgtacgct
     3721 gcttccagcc cccaatccac cagtccctgg ccaccacctg ctaggtagga aatcctgcag
     3781 accttcaacc cagaggagga ggaggaggag aagcaggaga gggaacacag tggtcagcct
     3841 gcagcaggtc cagctgacag tgtgggggac aggcctggaa ggaaaagaaa aacctcccca
     3901 acacatctat accactccca agggctgggc tcccgcatgc tctcccatga tatctccatg
     3961 gtgggtttct ccatagtgta aatgaaaaaa acaacaaaaa cacagggcag tgtgtgcttt
     4021 cttctttctt tttttttcca ccttaactgt gtttaagaag tactgtttcc accctgcagc
     4081 tgcccacccc atctgtgatt acttcccaag accacctccc aaaattgtaa cttcctaccc
     4141 agtgtctgta tttgatccag caccacagtc ttagagacat aggagaggag agtggagcca
     4201 taacagagat atcagcctgg cccaattgta tgcccgagct tactcaccca tcttctgtgg
     4261 cttctccctc cagtgtcctg gtcacttcac ttcctgctct tgatattagg gactccacta
     4321 ccaaagttag atccctggag agccaggaag aggttgctaa ctgtcaagac aacaaatgat
     4381 gctgaaaagg gatcttttac agccccccta ccacccaccc tagaccgtcc tggcaggaca
     4441 gccccagaga gaagaaaata agatttgtga aaccacactg agtggaagta ggggagaaga
     4501 tgccagggcc tgctgtgagg aaaagatata tccgtcagca aagggcacaa ctccagattt
     4561 ctcccaaagg aaaaatgtta ggccttgtca atggtgtggg aaggtaaggc acccctgctc
     4621 ctcatacaga gtcttagccc ttggccacat gggagtgcac acggtcagtc atagcgctgc
     4681 acatcacatt agcgagtgac caatcggtga ctgcttaaca cagaacctga tctaggaaaa
     4741 tcccccaaga aagaaaatct aaaggggtta cttcaaatgg agacagggta gcagggagga
     4801 aagaaatctt tatcaacaag ctttcgatct caagacccct ccacccaaaa agaagtcttc
     4861 tttaagcaga ctggaatgtt catcatgttg gctactaaaa gattcttgga acgttttatt
     4921 cttttgctct caacttcctg gtctcttcct tttgctcaag ccccgtgctg gggtagagct
     4981 tctttcacag gggtgtatta acgtccgtgt tctagactaa ctaaaacacc cctgcacagt
     5041 ctccacgtac agcagatctt taaggagact gcccatgtct ccacacagag ctagtcatct
     5101 gacccacaga gagaggacat agccctgagc ccccaaaaca taggaaagaa tgagagatgc
     5161 tcctctgcca gcctggggag gaggagagca gacaggagta accactccct cccccagtaa
     5221 ggtgactgtt atccgtcacc gtgttttaac cacacagagc tggagaggtg tgtgtaacca
     5281 gcactttgac agacacggcc acgtacccca gggaagtcat gtaaattaga acccttgagg
     5341 atggtacact agagtgttca tttctggaca ctaactctca atctctggga acagggccag
     5401 aagatcagcc ttttcccagt taaacgttac tgcataccac agactcagag cctttgctgt
     5461 agcttggatt gctctgtagt ctctctgagc acgaatggga gtcatttgta gggggcgtgg
     5521 cttgcaaggg aaactgtcca gtcctcccgt ctggcactgt taattcttag tctgattatt
     5581 tttcaatgac cagagatgta tcccagaagc agatcccacc ttccagctct tcagctccgg
     5641 ctggggatag tgtgtgatta acagacttct ctcctaatcc tccctcgctg ctctgtagaa
     5701 atgtgggctg tttacttcat aaggccgcct tcctggcagc tcatccctcc tcccctgtac
     5761 tcctgacccc aacagttgac cctctgggaa gagtcacagt ctcaagagat ttgatcccaa
     5821 taaaccaagg tcctcacttt gaggacagag attccatttc tgcagcactt gtctgcagac
     5881 actgaacaac tttaatgctc tttcctctct agtgatcctt gtttcccacc ccacacccct
     5941 ctttgatttt ttttaatgta tttaaaaatc aagaaaaaag cttagatttt aaaatgtttt
     6001 aaaaagaatt ctgtttcaga gactgtcaaa tgtgtaccat atttgtatta agagttgttg
     6061 gggatttttt gtacaatgaa tttacattat ttatggtgaa cttatattta cgcttgtgat
     6121 cgaataatga tgttaaattc ttaaatcata tttgctatgc agctgaagat gatattttga
     6181 tttgtatttt gggggtacct gtgttgagtt gataaaacat tttcatctcc attaaaactg
     6241 cttccaaacc agt
//
