LOCUS       NM_001107517            4387 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus cytoplasmic FMR1 interacting protein 1 (Cyfip1),
            mRNA.
ACCESSION   NM_001107517 XM_001054108 XM_218717
VERSION     NM_001107517.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4387)
  AUTHORS   Haddon,J.E., Titherage,D., Heckenast,J.R., Carter,J., Owen,M.J.,
            Hall,J., Wilkinson,L.S. and Jones,M.W.
  TITLE     Linking haploinsufficiency of the autism- and
            schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical
            network dysfunction and cognitive inflexibility
  JOURNAL   Transl Psychiatry 14 (1), 256 (2024)
   PUBMED   38876996
  REMARK    GeneRIF: Linking haploinsufficiency of the autism- and
            schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical
            network dysfunction and cognitive inflexibility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4387)
  AUTHORS   Silva,A.I., Haddon,J.E., Ahmed Syed,Y., Trent,S., Lin,T.E.,
            Patel,Y., Carter,J., Haan,N., Honey,R.C., Humby,T., Assaf,Y.,
            Owen,M.J., Linden,D.E.J., Hall,J. and Wilkinson,L.S.
  TITLE     Cyfip1 haploinsufficient rats show white matter changes, myelin
            thinning, abnormal oligodendrocytes and behavioural inflexibility
  JOURNAL   Nat Commun 10 (1), 3455 (2019)
   PUBMED   31371763
  REMARK    GeneRIF: Cyfip1 haploinsufficient rats show white matter changes,
            myelin thinning, abnormal oligodendrocytes and behavioural
            inflexibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4387)
  AUTHORS   Xu,C., Fu,X., Zhu,S. and Liu,J.J.
  TITLE     Retrolinkin recruits the WAVE1 protein complex to facilitate
            BDNF-induced TrkB endocytosis and dendrite outgrowth
  JOURNAL   Mol Biol Cell 27 (21), 3342-3356 (2016)
   PUBMED   27605705
REFERENCE   4  (bases 1 to 4387)
  AUTHORS   Huang,Y.
  TITLE     Up-regulated cytoplasmic FMRP-interacting protein 1 in intractable
            temporal lobe epilepsy patients and a rat model
  JOURNAL   Int J Neurosci 126 (6), 542-551 (2016)
   PUBMED   26000921
REFERENCE   5  (bases 1 to 4387)
  AUTHORS   Hsiao,K., Harony-Nicolas,H., Buxbaum,J.D., Bozdagi-Gunal,O. and
            Benson,D.L.
  TITLE     Cyfip1 Regulates Presynaptic Activity during Development
  JOURNAL   J Neurosci 36 (5), 1564-1576 (2016)
   PUBMED   26843638
REFERENCE   6  (bases 1 to 4387)
  AUTHORS   Nishimura,Y., Martin,C.L., Vazquez-Lopez,A., Spence,S.J.,
            Alvarez-Retuerto,A.I., Sigman,M., Steindler,C., Pellegrini,S.,
            Schanen,N.C., Warren,S.T. and Geschwind,D.H.
  TITLE     Genome-wide expression profiling of lymphoblastoid cell lines
            distinguishes different forms of autism and reveals shared pathways
  JOURNAL   Hum Mol Genet 16 (14), 1682-1698 (2007)
   PUBMED   17519220
REFERENCE   7  (bases 1 to 4387)
  AUTHORS   Nowicki,S.T., Tassone,F., Ono,M.Y., Ferranti,J., Croquette,M.F.,
            Goodlin-Jones,B. and Hagerman,R.J.
  TITLE     The Prader-Willi phenotype of fragile X syndrome
  JOURNAL   J Dev Behav Pediatr 28 (2), 133-138 (2007)
   PUBMED   17435464
REFERENCE   8  (bases 1 to 4387)
  AUTHORS   Kawano,Y., Yoshimura,T., Tsuboi,D., Kawabata,S., Kaneko-Kawano,T.,
            Shirataki,H., Takenawa,T. and Kaibuchi,K.
  TITLE     CRMP-2 is involved in kinesin-1-dependent transport of the
            Sra-1/WAVE1 complex and axon formation
  JOURNAL   Mol Cell Biol 25 (22), 9920-9935 (2005)
   PUBMED   16260607
REFERENCE   9  (bases 1 to 4387)
  AUTHORS   Steffen,A., Rottner,K., Ehinger,J., Innocenti,M., Scita,G.,
            Wehland,J. and Stradal,T.E.
  TITLE     Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia
            formation
  JOURNAL   EMBO J 23 (4), 749-759 (2004)
   PUBMED   14765121
REFERENCE   10 (bases 1 to 4387)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474036.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218717.4, XM_001054108.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4387
                     /gene="Cyfip1"
                     /note="cytoplasmic FMR1 interacting protein 1"
                     /db_xref="GeneID:308666"
                     /db_xref="RGD:1310332"
     exon            1..89
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..207
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3852
                     /gene="Cyfip1"
                     /codon_start=1
                     /product="cytoplasmic FMR1-interacting protein 1"
                     /protein_id="NP_001100987.1"
                     /db_xref="GeneID:308666"
                     /db_xref="RGD:1310332"
                     /translation="MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNT
                     NFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQP
                     NRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLIT
                     LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHN
                     KITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDG
                     SVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTC
                     TSSSSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD
                     LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFA
                     LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQ
                     SVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTML
                     ESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFR
                     EFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKF
                     NKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL
                     PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVEL
                     DGLLEINRMTHKLLSRYLTLDSFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYC
                     YNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHF
                     QVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGI
                     LEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQSLSLEEVCDLLHAAPFQN
                     ILPRVHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCC
                     GLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHE
                     FTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKM
                     VERIRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS"
     exon            208..297
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..375
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..477
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..659
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..756
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..885
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..990
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1082
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1200
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1323
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1449
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1616
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1764
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1918
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2075
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2172
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2249
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2358
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2478
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2678
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2766
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2910
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3001
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3132
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3205
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3300
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3539
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3687
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..4387
                     /gene="Cyfip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctggtgca ttcccgaccc gcccgagtga ctcactgggg taggaaagct cccgggccgc
       61 cctggacaac cgaaggcggc tcagaccagg atggctgccc aagtgacact agaggacgca
      121 ctgtccaatg tggacctcct ggaagagctg cctcttcctg accagcagcc ctgcattgag
      181 cccccacctt cctcgctgct ctatcagcca aatttcaaca ccaactttga agaccgaaat
      241 gcatttgtca ctggcattgc aagatacatt gaacaagcaa ctgtccactc tagcatgaac
      301 gagatgctag aggaaggcca agagtatgct gtcatgctgt atacctggag gagctgctcc
      361 cgtgccatcc ctcaggtgaa gtgcaatgag cagcctaata gggttgaaat ttatgagaaa
      421 actgtggaag tccttgaacc cgaggtcaca aaactgatga attttatgta cttccagaga
      481 aatgccatcg agcgtttctg tggggaggtg agacgcctgt gtcatgctga gaggagaaag
      541 gacttcgtgt ctgaagccta cttgatcacc ttgggcaagt ttatcaacat gtttgctgtg
      601 ttggatgagc tgaagaacat gaagtgcagt gtgaagaatg accactcagc gtataagagg
      661 gctgctcagt ttttacgtaa aatggcagat ccacaatcca tccaggagtc acagaatttg
      721 tccatgttcc tggccaacca caacaagatt acacaatctc tacagcaaca gcttgaggtc
      781 atttctggct atgaagaact cctggcagac atagtgaatc tgtgtgtgga ctactatgag
      841 aacagaatgt acttgacgcc cagcgaaaaa cacatgcttc tcaaagtcat gggatttggt
      901 ctgtacctga tggatgggag tgtgagtaac atctacaaac tagatgccaa gaaaagaata
      961 aatttatcca aaatagacaa gtatttcaag cagctgcagg tggttccact ctttggagat
     1021 atgcagatag aactggcaag atacatcaag accagcgcac actatgagga gaataagtcc
     1081 cggtggacct gtacgtcctc gagcagcagc ccacagtaca acatctgtga gcagatgatc
     1141 cagatccgtg aggaccacat gcgtttcatt tctgagctgg cacgctacag caatagcgag
     1201 gtagtcacag ggtctggccg gcaggaggcc cagaagacag atgctgagta ccggaagctc
     1261 tttgacctgg cgctgcaggg cctgcagctt ctgtcgcagt ggagcgcgca tgtgatggaa
     1321 gtgtattcct ggaaacttgt acatccaaca gacaagtact ccaacaagga ctgcccagac
     1381 aatgctgagg agtatgaacg tgccacgcgt tacaactaca ccactgagga gaagtttgct
     1441 ctggtggagg tgattgccat gatcaaaggc ctgcaggtgc tgatgggcag gatggagagt
     1501 gtgttcaatc acgccatcag acacacagtt tatgctgcac ttcaggactt ctcccaggtg
     1561 accctcaggg aaccactgcg acaggccatc aagaagaaaa agaatgtcat ccagagtgtc
     1621 ctacaggcca tcaggaagac tgtgtgtgac tgggagactg ggcatgaacc ctttaacgac
     1681 ccagctctgc ggggagagaa ggaccctaag agcggctttg acatcaaggt gccacgccgt
     1741 gctgtaggac cctccagcac acagctttac atggtgagaa ctatgctaga gtccctcatt
     1801 gcagacaaaa gtggttccaa gaaaaccttg agaagtagcc ttgaggggcc caccatattg
     1861 gacatagaaa aatttcatcg agaatcattc ttctacactc acttgataaa tttcagtgaa
     1921 acactgcagc agtgctgtga cctttcccag ctgtggttcc gagagttctt cctggagctg
     1981 accatgggca ggaggatcca gttccccatt gagatgtcta tgccctggat tctgactgac
     2041 cacatcctag agaccaagga ggcatcaatg atggagtacg tcctctactc cttggacctg
     2101 tacaatgaca gtgctcacta tgcgctcacc aagttcaaca agcagtttct ctatgatgaa
     2161 attgaagcag aggtgaatct gtgttttgac caatttgttt ataaactggc agaccagata
     2221 tttgcatatt acaaggttat ggcaggaagt ttgcttcttg acaaacggtt acgatcagaa
     2281 tgcaaaaatc agggagccac gattcacctc ccaccgtcta accgctatga gacgttgttg
     2341 aagcaaaggc acgtgcagct gcttgggaga tccatcgatc tcaatcgtct gattacacag
     2401 cgtgtttcag cagccatgta caaatctcta gaactggcaa ttggacgatt tgaaagtgaa
     2461 gatttaacat cagtagtcga gctagatggg ctcttagaaa tcaaccgtat gacgcacaag
     2521 ctgctgagta ggtacctcac actagacagc tttgatgcca tgttccggga agccaaccac
     2581 aacgtgtctg caccttatgg aagaatcacc ctccatgtct tctgggagct aaactatgac
     2641 ttcttgccca actactgcta taatggctcc accaaccggt ttgttcggac agtactacca
     2701 ttttctcagg aatttcaacg agacaaacaa cctaatgcac agccccagta tttgcacggc
     2761 tccaaggctt tgaacctagc ctactcaagc atttatggca gctaccggaa ctttgtgggg
     2821 cctcctcact tccaggtcat ctgccggctg cttggctacc agggcattgc agtcgtcatg
     2881 gaagaactgc tgaaggttgt caagagcctg cttcaaggca caatcctgca gtatgtgaaa
     2941 actctgatgg aagtgatgcc taagatctgc cgccttcccc gacatgagta cggctctcct
     3001 ggcatcctag agttcttcca ccaccagctg aaggacattg tggagtatgc agagctgaaa
     3061 acagtatgct tccagaacct gcgggaggtg ggaaatgctg ttctcttctg cctgctcatc
     3121 gagcaaagcc tgtctttaga agaagtctgt gacctgttgc atgcagctcc ttttcagaat
     3181 atcctgcctc gagtccacgt aaaagagggg gagagagttg atgccaaaat gaaaagacta
     3241 gaatccaagt atgctccact gcatcttgtt ccgctgattg aaaggctggg gaccccacag
     3301 caaattgcaa tcgcaagaga gggggacttg ctgaccaagg agcggctctg ttgtggtctg
     3361 tccatgtttg aagtcatcct cacacggatc cggacctttc tggatgatcc catctggcgt
     3421 gggcccctgc ccagcaatgg ggtcatgcat gtggatgagt gtgtggagtt tcacagacta
     3481 tggagtgcca tgcagtttgt ttactgcatt cctgtaggga cacacgagtt tacagtggag
     3541 cagtgttttg gcgatgggct ccactgggct ggctgcatga tcattgtact tctgggacag
     3601 cagcggcgct ttgctgtgtt ggatttctgc tatcatcttc tcaaagttca gaaacacgat
     3661 ggcaaggatg agatcatcaa aaatgtgcca ttgaagaaga tggtggagag gattcgcaag
     3721 ttccagattc tcaatgatga gatcatcact atcctggaca agtacttgaa atctggagat
     3781 ggggagagca cacctgtgga acatgtacgc tgcttccagc cacccatcca ccagtcccta
     3841 gccagcagct gagggctaag ctcatcagat cccagtaact gatggcatgt ttgtctttat
     3901 gtaaactata ttgaaatttt taggggctat tttccattat gtctaaacct aataattaag
     3961 ggggtacttt ttgatctgaa agcttaactt tataaaactt acatattttt ctatactaaa
     4021 attgtatatg cctttggaat tgggaagtct gagaatatgg ttactagttg ttgccattat
     4081 ggtcttaaca aatattttca tgctaaatat tccagtagct agttataaaa tgcaaaattc
     4141 actcattatc ctataagagc ataataccaa ctaattgtat ttaaaaaaaa aaaccctacc
     4201 aattacttta aatttaatga ctagtttagg gatttttctg atggcctttt aggaaatctt
     4261 ttctaagtca ttgttccctt ttatgccaat atagtgaaat tgtttcccct gttcaagtaa
     4321 atcaaactgt gagtctgatt cgtgagatat gacttaacga ttagagaaat aaaaatcaat
     4381 ggaatct
//
