LOCUS       NM_012839               1228 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome c, somatic (Cycs), mRNA.
ACCESSION   NM_012839
VERSION     NM_012839.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1228)
  AUTHORS   Serrya,M.S., Nader,M.A. and Abdelmageed,M.E.
  TITLE     Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib
            against cyclosporine-A induced liver injury in rats through
            blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway
  JOURNAL   J Biochem Mol Toxicol 35 (6), 1-13 (2021)
   PUBMED   33710703
  REMARK    GeneRIF: Hepatoprotective effect of the tyrosine kinase inhibitor
            nilotinib against cyclosporine-A induced liver injury in rats
            through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling
            pathway.
REFERENCE   2  (bases 1 to 1228)
  AUTHORS   Ye,L. and Yang,S.
  TITLE     [Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome
            C release in myocardiac H9c2 cells with calcium overload]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 (8), 1031-1035 (2015)
   PUBMED   26271974
  REMARK    GeneRIF: Data show that sirtuin 3 could inhibit cell apoptosis by
            reducing cytochrome C (CytC) release and inhibiting caspase-3
            activation in cardiomyocyte models with calcium overload.
REFERENCE   3  (bases 1 to 1228)
  AUTHORS   Gao,G., Yu,Z., Yan,J., Li,J., Shen,S., Jia,B., Guan,K., Gao,X. and
            Kan,Q.
  TITLE     Poly (ADP-ribose) polymerase- and cytochrome c-mediated apoptosis
            induces hepatocyte injury in a rat model of hyperammonia-induced
            hepatic failure
  JOURNAL   Mol Med Rep 11 (6), 4211-4219 (2015)
   PUBMED   25634059
  REMARK    GeneRIF: results suggested that hepatocyte injury and liver
            dysfunction may be caused by inducing apoptosis via the PARP and
            Cyt C pathways.
REFERENCE   4  (bases 1 to 1228)
  AUTHORS   Pu,H., Wang,X., Su,L., Ma,C., Zhang,Y., Zhang,L., Chen,X., Li,X.,
            Wang,H., Liu,X. and Zhang,J.
  TITLE     Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways
            to mediate neuronal apoptosis
  JOURNAL   Med Sci Monit Basic Res 21, 53-62 (2015)
   PUBMED   25848832
  REMARK    GeneRIF: Heroin activates ATF3 and CytC via c-Jun N-terminal kinase
            pathways to mediate neuronal apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1228)
  AUTHORS   Ogneva,I.V., Birjukov,N.S., Veselova,O.M. and Larina,I.M.
  TITLE     [Cytochrome C content and mitochondrial activity in rat's cardiac
            and skeletal muscle cells in the course of 3-day gravitational
            unloading]
  JOURNAL   Aviakosm Ekolog Med 48 (6), 23-29 (2014)
   PUBMED   25928980
REFERENCE   6  (bases 1 to 1228)
  AUTHORS   Virbasius,J.V. and Scarpulla,R.C.
  TITLE     Structure and expression of rodent genes encoding the
            testis-specific cytochrome c. Differences in gene structure and
            evolution between somatic and testicular variants
  JOURNAL   J Biol Chem 263 (14), 6791-6796 (1988)
   PUBMED   2834389
REFERENCE   7  (bases 1 to 1228)
  AUTHORS   Penney,D.G., Zak,R. and Aschenbrenner,V.
  TITLE     Carbon monoxide inhalation: effect on heart cytochrome c in the
            neonatal and adult rat
  JOURNAL   J Toxicol Environ Health 12 (2-3), 395-406 (1983)
   PUBMED   6317876
REFERENCE   8  (bases 1 to 1228)
  AUTHORS   Scarpulla,R.C. and Wu,R.
  TITLE     Nonallelic members of the cytochrome c multigene family of the rat
            may arise through different messenger RNAs
  JOURNAL   Cell 32 (2), 473-482 (1983)
   PUBMED   6130852
REFERENCE   9  (bases 1 to 1228)
  AUTHORS   Scarpulla,R.C., Agne,K.M. and Wu,R.
  TITLE     Isolation and structure of a rat cytochrome c gene
  JOURNAL   J Biol Chem 256 (12), 6480-6486 (1981)
   PUBMED   6263917
REFERENCE   10 (bases 1 to 1228)
  AUTHORS   Carlson,S.S., Mross,G.A., Wilson,A.C., Mead,R.T., Wolin,L.D.,
            Bowers,S.F., Foley,N.T., Muijsers,A.O. and Margoliash,E.
  TITLE     Primary structure of mouse, rat, and guinea pig cytochrome c
  JOURNAL   Biochemistry 16 (7), 1437-1442 (1977)
   PUBMED   191069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081849.1.
            
            On Oct 17, 2004 this sequence version replaced NM_012839.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081849.1, FQ219963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132293, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1228
                     /gene="Cycs"
                     /gene_synonym="CYCSA"
                     /note="cytochrome c, somatic"
                     /db_xref="GeneID:25309"
                     /db_xref="RGD:2451"
     exon            1..67
                     /gene="Cycs"
                     /gene_synonym="CYCSA"
                     /inference="alignment:Splign:2.1.0"
     exon            68..244
                     /gene="Cycs"
                     /gene_synonym="CYCSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..393
                     /gene="Cycs"
                     /gene_synonym="CYCSA"
                     /note="Cytochrome C, expressed in somatic tissues"
                     /codon_start=1
                     /product="cytochrome c, somatic"
                     /protein_id="NP_036971.1"
                     /db_xref="GeneID:25309"
                     /db_xref="RGD:2451"
                     /translation="MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQA
                     AGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKA
                     TNE"
     exon            245..1201
                     /gene="Cycs"
                     /gene_synonym="CYCSA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgggctag agagcgggac gtctccctaa gagtctgatc ctttgtggtg ttgaccagcc
       61 cggaccgaat ttaaaatggg tgatgttgaa aaaggcaaga agatttttgt tcaaaagtgt
      121 gcccagtgcc acactgtgga aaaaggaggc aagcataaga ctggaccaaa cctccatggt
      181 ctgtttgggc ggaagacagg ccaggctgct ggattctctt acacagatgc caacaagaac
      241 aaaggtatca cctggggaga ggataccctg atggagtatt tggaaaatcc caaaaagtac
      301 atccctggaa caaaaatgat cttcgctgga attaagaaga agggagaaag ggcagaccta
      361 atagcttatc ttaaaaaggc tactaatgaa taattccact gccttattta ttacaaaaca
      421 aatgtctcat ggcttttaat gtataccata atttaattca tacaccaaat tcagatcatg
      481 aatggctaac aatgtttttg ttggacagcc ccgatttaag taaaattgac ttgtcataaa
      541 gtggatatga tcttttttaa agtaacactt ccaattgaat acatgttatc actgctttcc
      601 ctttctcaag ataagattgg acttaattag taatattttc ctttccataa atatgagggt
      661 gtcgcctcaa acctattgaa tggttttata cttagattta tataactggg tatatgaata
      721 tgttcaaatc ctgggaaaat tctgtcactg tctcagaaac aagaagactc acccgtgctt
      781 cagtgtgtgt aaactggcct ctgacaggca atgctaaaca ccaggacgga actattcttg
      841 acagtgctgt tttaattaga attccctaca tcaatgatgc tgcctttcac cactgaaagg
      901 catttactgt ggtttatgta tgatatcaaa taaagagtat ttaacacttc tttatagttg
      961 atctacaagt taaaatgctt ttaagaacaa gttagccctt ttaaatcttc tcttatctaa
     1021 gactaagctg taattcagaa ttgtccttaa atgcccattc ggaaagtcat aactggaatt
     1081 tctgttcatg cctgattggg agtggtactc ttttctaact tactagatgg aaagatgaaa
     1141 ataaaggaga taatttgtaa gttatcaaca gtcagaagat aattaaatca atcacaaatc
     1201 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
