LOCUS       NM_023965               4248 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus cytochrome b-245 beta chain (Cybb), mRNA.
ACCESSION   NM_023965
VERSION     NM_023965.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4248)
  AUTHORS   Dasinger,J.H., Abais-Battad,J.M., Walton,S.D., Burns-Ray,E.C.,
            Cherian-Shaw,M., Baldwin,K.E., Fehrenbach,D.J. and Mattson,D.L.
  TITLE     Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in
            Dahl SS Rats
  JOURNAL   Hypertension 81 (11), 2357-2367 (2024)
   PUBMED   39301728
  REMARK    GeneRIF: Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal
            Damage in Dahl SS Rats.
REFERENCE   2  (bases 1 to 4248)
  AUTHORS   Zhao,M., Lei,J., Deng,F., Zhao,C., Xu,T., Ji,B., Fu,M., Wang,X.,
            Sun,M., Zhang,M. and Gao,Q.
  TITLE     Gestational Hypoxia Impaired Endothelial Nitric Oxide Synthesis Via
            miR-155-5p/NADPH Oxidase/Reactive Oxygen Species Axis in Male
            Offspring Vessels
  JOURNAL   J Am Heart Assoc 13 (3), e032079 (2024)
   PUBMED   38240225
  REMARK    GeneRIF: Gestational Hypoxia Impaired Endothelial Nitric Oxide
            Synthesis Via miR-155-5p/NADPH Oxidase/Reactive Oxygen Species Axis
            in Male Offspring Vessels.
REFERENCE   3  (bases 1 to 4248)
  AUTHORS   Kato,Y., Nishiyama,K., Man Lee,J., Ibuki,Y., Imai,Y., Noda,T.,
            Kamiya,N., Kusakabe,T., Kanda,Y. and Nishida,M.
  TITLE     TRPC3-Nox2 Protein Complex Formation Increases the Risk of
            SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through
            ACE2 Upregulation
  JOURNAL   Int J Mol Sci 24 (1), 102 (2022)
   PUBMED   36613540
  REMARK    GeneRIF: TRPC3-Nox2 Protein Complex Formation Increases the Risk of
            SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through
            ACE2 Upregulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4248)
  AUTHORS   Gasparini,P.V.F., Matias,A.M., Torezani-Sales,S., Kobi,J.B.B.S.,
            Siqueira,J.S., Correa,C.R., Lima-Leopoldo,A.P. and Leopoldo,A.S.
  TITLE     High-Fat and Combined High-Fat and Sucrose Diets Promote Cardiac
            Oxidative Stress Independent of Nox2 Redox Regulation and Obesity
            in Rats
  JOURNAL   Cell Physiol Biochem 55 (5), 618-634 (2021)
   PUBMED   34705355
  REMARK    GeneRIF: High-Fat and Combined High-Fat and Sucrose Diets Promote
            Cardiac Oxidative Stress Independent of Nox2 Redox Regulation and
            Obesity in Rats.
REFERENCE   5  (bases 1 to 4248)
  AUTHORS   Lawler,J.M., Hord,J.M., Ryan,P., Holly,D., Janini Gomes,M.,
            Rodriguez,D., Guzzoni,V., Garcia-Villatoro,E., Green,C., Lee,Y.,
            Little,S., Garcia,M., Hill,L., Brooks,M.C., Lawler,M.S., Keys,N.,
            Mohajeri,A. and Kamal,K.Y.
  TITLE     Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal
            Muscle Fiber Atrophy during Simulated Microgravity
  JOURNAL   Int J Mol Sci 22 (6), 3252 (2021)
   PUBMED   33806917
  REMARK    GeneRIF: Nox2 Inhibition Regulates Stress Response and Mitigates
            Skeletal Muscle Fiber Atrophy during Simulated Microgravity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4248)
  AUTHORS   Kaneda,M., Sakuraba,H., Ohtake,A., Nishida,A., Kiryu,C. and
            Kakinuma,K.
  TITLE     Missense mutations in the gp91-phox gene encoding cytochrome b558
            in patients with cytochrome b positive and negative X-linked
            chronic granulomatous disease
  JOURNAL   Blood 93 (6), 2098-2104 (1999)
   PUBMED   10068684
REFERENCE   7  (bases 1 to 4248)
  AUTHORS   Yoshida,L.S., Saruta,F., Yoshikawa,K., Tatsuzawa,O. and
            Tsunawaki,S.
  TITLE     Mutation at histidine 338 of gp91(phox) depletes FAD and affects
            expression of cytochrome b558 of the human NADPH oxidase
  JOURNAL   J Biol Chem 273 (43), 27879-27886 (1998)
   PUBMED   9774399
REFERENCE   8  (bases 1 to 4248)
  AUTHORS   Newburger,P.E., Skalnik,D.G., Hopkins,P.J., Eklund,E.A. and
            Curnutte,J.T.
  TITLE     Mutations in the promoter region of the gene for gp91-phox in
            X-linked chronic granulomatous disease with decreased expression of
            cytochrome b558
  JOURNAL   J Clin Invest 94 (3), 1205-1211 (1994)
   PUBMED   8083361
REFERENCE   9  (bases 1 to 4248)
  AUTHORS   Rabbani,H., de Boer,M., Ahlin,A., Sundin,U., Elinder,G.,
            Hammarstrom,L., Palmblad,J., Smith,C.I. and Roos,D.
  TITLE     A 40-base-pair duplication in the gp91-phox gene leading to
            X-linked chronic granulomatous disease
  JOURNAL   Eur J Haematol 51 (4), 218-222 (1993)
   PUBMED   7694872
REFERENCE   10 (bases 1 to 4248)
  AUTHORS   Parkos,C.A., Allen,R.A., Cochrane,C.G. and Jesaitis,A.J.
  TITLE     Purified cytochrome b from human granulocyte plasma membrane is
            comprised of two polypeptides with relative molecular weights of
            91,000 and 22,000
  JOURNAL   J Clin Invest 80 (3), 732-742 (1987)
   PUBMED   3305576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Sep 1, 2022 this sequence version replaced NM_023965.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231233.1, FQ217794.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN11044071,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000021.1  16064968-16065065   c
            99-194              JAXUCZ010000021.1  16062997-16063092   c
            195-305             JAXUCZ010000021.1  16061607-16061717   c
            306-390             JAXUCZ010000021.1  16052545-16052629   c
            391-536             JAXUCZ010000021.1  16050802-16050947   c
            537-727             JAXUCZ010000021.1  16049306-16049496   c
            728-857             JAXUCZ010000021.1  16046431-16046560   c
            858-950             JAXUCZ010000021.1  16045414-16045506   c
            951-1204            JAXUCZ010000021.1  16040500-16040753   c
            1205-1367           JAXUCZ010000021.1  16038933-16039095   c
            1368-1514           JAXUCZ010000021.1  16036990-16037136   c
            1515-1639           JAXUCZ010000021.1  16034309-16034433   c
            1640-4248           JAXUCZ010000021.1  16030596-16033204   c
FEATURES             Location/Qualifiers
     source          1..4248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..4248
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /note="cytochrome b-245 beta chain"
                     /db_xref="GeneID:66021"
                     /db_xref="RGD:620574"
     exon            1..98
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1766
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /note="NADPH oxidase 2; endothelial type gp91-phox;
                     cytochrome b-245, beta polypeptide"
                     /codon_start=1
                     /product="cytochrome b-245 beta chain"
                     /protein_id="NP_076455.2"
                     /db_xref="GeneID:66021"
                     /db_xref="RGD:620574"
                     /translation="MGNWAVNEGLSIFVILVWLGLNVFLFVKYYKVYDDEPKYNYTRK
                     LLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHK
                     MVAWMIALHTAIHTIAHLFNVEWCVNARVGTSDPYSVALSNIGDKENEEYLNFAREKI
                     KNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIG
                     LAIHGAERIVRGQTSDSLKEHNLDVCADKIKEWGKIKECPVPKFAGNPPMTWKWIVGP
                     MFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPQVSK
                     LEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFG
                     TASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLRLKKIYFYWLCRDTHA
                     FEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQK
                     TLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAKTLSKQSISNSESGPRGVHFIFN
                     KENF"
     exon            99..194
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..305
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..390
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..536
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..727
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..857
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..950
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1204
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1367
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1514
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1639
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..4248
                     /gene="Cybb"
                     /gene_synonym="Gp91-phox; Nox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagcaca gtagagaaga gaggcagagg cagcacagtt aacctctgcg aacatgggga
       61 actgggctgt gaatgaggga ctctccatct ttgtcattct ggtgtggttg gggctgaatg
      121 tcttcctctt tgtcaagtat tacaaggttt atgacgatga gcctaaatat aattacactc
      181 gaaaacttct tgggtcagca ctggctctgg cccgggcacc tgcagcctgc ctgaatttca
      241 actgcatgct gatcttgctg ccagtgtgtc ggaatctcct ctccttcctc aggggttcca
      301 gtgcgtgttg ctcaaccaga attcgaagac aactggacag gaaccttact ttccataaga
      361 tggtagcttg gatgatagca cttcacacgg ccattcacac cattgcacat ctgttcaacg
      421 tggagtggtg tgtgaatgcc agagtcggga cttcggaccc atattcagta gcactctcta
      481 acattggaga caaagaaaat gaagagtatc tcaattttgc tagagaaaaa atcaagaacc
      541 ctgaaggggg cctgtatgtg gctgtgactc ggttggctgg catcacagga attgtcatca
      601 cactgtgtct tatattgatc atcacatcct ccaccaaaac cattcggagg tcttactttg
      661 aagtgttctg gtatacacac catctctttg tgatcttctt catcggcctt gccatccatg
      721 gagctgaacg aattgtacgt ggacagactt cggacagttt gaaagagcat aatttagatg
      781 tttgtgcaga caaaatcaaa gaatggggaa aaataaagga gtgcccagta ccaaagtttg
      841 ccggaaaccc tcctatgact tggaaatgga tagtgggtcc catgttcctg tacctttgcg
      901 agaggttggt ccggttttgg cgttctcaac agaaggtggt catcactaag gtggtcacgc
      961 accctttcaa aaccatcgag cttcagatga agaagaaggg attcaagatg gaggtgggac
     1021 agtacatttt tgtcaagtgt ccccaggtat ccaagctaga gtggcaccca ttcacactga
     1081 cctctgctcc tgaggaagac ttttttagca tccatatccg tattgtggga gactggactg
     1141 aggggctatt caatgcttgt ggctgtgata agcaggagtt ccaagatgcc tggaaactac
     1201 ctaagatagc agttgatggg ccctttggta cagccagtga agatgtgttc agctatgagg
     1261 tggtgatgtt agtgggagct gggattggag tcacgccctt tgcctccatt ctcaagtctg
     1321 tctggtacaa atattgtgac aatgccacca gtctgagact caaaaagatc tacttctact
     1381 ggctgtgcag ggacacgcat gcttttgagt ggttcgcaga cctgctgcag ctcctggaga
     1441 cccagatgca agaaagaaac aatgccaact tcctcagcta caacatctac cttactggct
     1501 gggatgaatc tcaggccaat cactttgctg tgcaccacga tgaggagaaa gatgtgatta
     1561 caggcctaaa acagaagact ctgtatggac ggcccaactg ggataacgag ttcaagacca
     1621 ttgcaagtca acaccccaac accagaatag gagtttttct gtgtggcccc gaagccttgg
     1681 ctaaaactct cagtaaacag agcatctcca actctgagtc cggcccacgt ggagtccact
     1741 tcatcttcaa caaggaaaac ttctaactca gctctttccc aaggaaacca gcgtatgcag
     1801 ccaaatgccc tgatattgcc ggttgattgt gggagaggag gaggaaagga aactgtactc
     1861 gcacaggccc cctaaaaaga attccaaaga ttgttcgcta gtcataggtc atctttacac
     1921 ggagcgtcat ggtttcagag cgccttttac aaacattgtt atgttgcatt gtttcatatt
     1981 tccctctgcc atgcgagaag agggtaaggc aaaagcattt tccgggactt gttctaagat
     2041 aaataatagg aacacaaatg agttcaacac cttcttcctt tcaattcaga agctgaaacc
     2101 agatctaagc catctgactc tgggtatggc catttttttc acatttaata ccaagttatc
     2161 tcaagagtca gttcttatac tctccccgag caaatcaaag agtagcttat ctttcttcat
     2221 tttttttgtt tcatctttaa ccttagcatc atgctaaagg agactttttt ttaataggag
     2281 atagtgacac tgacagtgac ttaatactta ctaatgacag tattgataca agtattttcc
     2341 agtttaccag cacaacagcg taactgggtc agagactatt cctactaagg aatattagac
     2401 tgattggagg caggagggtt gaatttagag acctatcctc ctatgatgat gctggctaac
     2461 acttctcgtc tactctgtaa gctggaaaag aaaaacattc atttactaac tggtctgctc
     2521 cagccaaccc ttgtgaattt tgaactgaat tctagcaaat gtatacctga taatacgtaa
     2581 cctgcttaga atgcatttct cctttggctt aaattcctac acaaatagat cttatgtgta
     2641 tagacaatga tgttttttat tacagcattt tcatcaccac tggaatcagt atcacaatca
     2701 tcctgaaata taagtcctag aaactgtaat ccccaaataa ctgggtacat agtaaaatca
     2761 cacccaatat tttatgggta ttcagaagtg aaggacagag tctagatcac tgctagagta
     2821 gtcagatgtg aaaagcatcc ctcaggggct ggggatttag ctcagtggta gagcgcttac
     2881 ctaggaagcg caaggccctg ggttcggtcc ccagctccga aaaaaagatc caaaaaaaaa
     2941 aaaaagaaaa gcatccctcc tcccatttct ggggactaaa agcatttctg ttaccccacc
     3001 actagggata caaatgactc ttcagcttta gtaatgagga aggaagagta gagagagggc
     3061 agaggccttg ttggagagaa agcatggaga taacaggaga caaaggaaag cacaacactc
     3121 aaaaggaaaa aggcggggga aaggatctca cagtgttggc attcaccctc tatttttctt
     3181 tggtatgtac cacatgtaac tgaaggatgc atgcactcat cttgttttga cttcatgtag
     3241 tattgcatag tttcaatgct ggtcacaaat tttgctattg taggggcatt tttgaaggga
     3301 ctagatgaag tgtgagccca gattctcctt atattcctgc tatacccttg ttctcttacc
     3361 atccttagag cactgaaggc tggttctggc aaataaggcc ttcctagaaa tgcatatgca
     3421 ccacaaggat tgttgccctt ggagaaaggt ccagcccctt tgtgttgtgc cccaggcatt
     3481 agttcattca ttctttcagt cacaaggaat ctgaaaatac ctttctaaca aagatggtaa
     3541 tgagtctgtt tgttgttcca agaatgtttc tccagttttc tggggttttt tttcttcctt
     3601 ttttctttat tattctcaca cacaatagat ccagactgca gcctccctcc tccctctctc
     3661 taagccctac ctctgcacct cctcttcccc aggtccattg ttcctctgtt tcccttaaaa
     3721 aaaaaaaaga gcaggcctcc cagggatatc agctgaacac agcataacaa gatgcaataa
     3781 gaacaggcac aaaccctctt atcaagtctg gatgaggcaa cccagtagga ggaaaaggat
     3841 cccataagca ggcaatagtt gatatcaaca tagttcccaa aatagagatc tacactgagt
     3901 tattctggtt atgagatgga aaatgagtgc agtgcgcatg tgcttcttgt ttgagaactt
     3961 ccttcttttt cctcccaagt tcctggctcc cagccaccag ctgccagcac aactctctcc
     4021 acagttagtt cttagaattt agtaacagat actgagatct gtctttagta acaaatataa
     4081 aatgagaata taagtctaga aacgattttc ctgggttttt ccgcttttgc agtatcatgt
     4141 ttatggaatt tgaattcttg cagccattgt atatgaatag tctggggtag aagatgatct
     4201 ggagacaatt tttagaaata actattaaag cttgctttga tgctgaaa
//
