LOCUS       NM_001014244            1349 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome b5 reductase 2 (Cyb5r2), mRNA.
ACCESSION   NM_001014244 XM_344945
VERSION     NM_001014244.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Chen,J., Sun,Y., Chen,L. and Zhou,Y.
  TITLE     NADH-Cytochrome B5 reductase 2 suppresses retinal vascular
            dysfunction through regulation of vascular endothelial growth
            factor A in diabetic retinopathy
  JOURNAL   Exp Eye Res 222, 109186 (2022)
   PUBMED   35820466
  REMARK    GeneRIF: NADH-Cytochrome B5 reductase 2 suppresses retinal vascular
            dysfunction through regulation of vascular endothelial growth
            factor A in diabetic retinopathy.
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Marohnic,C.C., Crowley,L.J., Davis,C.A., Smith,E.T. and Barber,M.J.
  TITLE     Cytochrome b5 reductase: role of the si-face residues, proline 92
            and tyrosine 93, in structure and catalysis
  JOURNAL   Biochemistry 44 (7), 2449-2461 (2005)
   PUBMED   15709757
  REMARK    GeneRIF: Changes in the nature of the side-chain constituents in
            the conserved residues, such as proline-92 and tyrosine-93, exert
            considerable influence on the flavin prosthetic group and
            significantly impact cytochrome B5 reductase turnover.
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Zhu,H., Qiu,H., Yoon,H.W., Huang,S. and Bunn,H.F.
  TITLE     Identification of a cytochrome b-type NAD(P)H oxidoreductase
            ubiquitously expressed in human cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (26), 14742-14747 (1999)
   PUBMED   10611283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079235.1.
            
            On Apr 20, 2005 this sequence version replaced XM_344945.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1349
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /note="cytochrome b5 reductase 2"
                     /db_xref="GeneID:365345"
                     /db_xref="RGD:1308421"
     exon            1..99
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            100..194
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            195..321
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1074
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /EC_number="1.6.2.2"
                     /note="b5R.2"
                     /codon_start=1
                     /product="NADH-cytochrome b5 reductase 2"
                     /protein_id="NP_001014266.1"
                     /db_xref="GeneID:365345"
                     /db_xref="RGD:1308421"
                     /translation="MSVKKKDLITLQDPEAKYPLPLIEKEQINHNTRRFRFGLPSPDH
                     VLGLPVGNYVHLLAQINNELVIRAYTPVSSDDDQGFVDLIIKIYFKNVHPKYPEGGKM
                     TQYLENMKIGDTILFRGPTGRLFYNEPGTLLIKTDKTSEPEKKLVHHLGMIAGGTGIT
                     PMLQLIRHITKDTSDGTRMSLLFANQTEEDILLRKELEEVATTHQNQFSLWYTLDRPP
                     SGWEYSSGFITADMIKEHLPPPGEATLILVCGPPPLIQEAAHPSLEQLGYTKDMIFTY
                     "
     exon            322..394
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            395..501
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            502..631
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            632..715
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            716..801
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            802..901
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1305
                     /gene="Cyb5r2"
                     /gene_synonym="RGD1308421"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcagtgg cctggtcagg attcatgggc ggtttcccag ctgttcggac agtggatctc
       61 tgagccaaag gactacgcag cagacttttc tcaaaacagt cacttgccta tgaaggtgct
      121 agtgagtccc caagccactc acagctccac tgctccagcg gaatccgaag tgagtttggc
      181 aagtctctag agaggaccag acctgtcgcc agggccatcg tgattctctt agccttaaag
      241 aaaatgagcg tcaagaagaa agatcttatc actttacagg accctgaagc caagtacccg
      301 ctgcccttga ttgagaaaga gcaaatcaac cacaacacca gaaggttccg atttggactg
      361 ccctcaccag accatgtcct agggcttcct gtaggtaact atgtccatct cttggcacaa
      421 attaacaatg aattggtgat cagggcttac acgcctgtct ccagtgacga tgatcaagga
      481 tttgtggact taattataaa gatctacttc aaaaatgtgc accctaagta tcctgaagga
      541 ggaaagatga ctcagtactt ggagaatatg aaaattgggg acaccattct ttttcggggg
      601 ccaacggggc gcctgttcta taatgagcca gggacccttt taatcaaaac agacaaaacg
      661 agtgagcctg aaaaaaagct ggttcatcac ctggggatga ttgctggagg cacaggcatt
      721 acgcccatgc tacagctaat tcgccacatc accaaggaca ccagcgatgg gaccaggatg
      781 tccctcctct ttgccaacca gacagaagag gatatcttgc tgagaaagga gctagaagaa
      841 gtggccacaa cgcatcagaa ccagttcagc ctgtggtata ccctggacag gccccccagt
      901 ggttgggagt acagctcagg cttcattact gcagacatga tcaaggagca cctccctcct
      961 cctggggagg ccacactcat cctggtatgt ggcccaccac ctctgatcca ggaggcagct
     1021 caccccagcc tggagcagct tggctacacc aaggacatga tttttaccta ctaacacctc
     1081 ccacgatacc tagtgggtcc ctgtgtcaca gtgagtttga cttcatgctg ttcaactaag
     1141 gtgtcactcc aggcaccatt aggcatggca ttcttttcat tgtgggccta agaagagaaa
     1201 ggggctgaag agaaaaatga tttttgagct tctaggcttg gaggctggga aggaagccac
     1261 tttctccatg gcttagtgga ataaactaga ctactctgca tttaaaaaaa aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
