LOCUS       NM_001013126            1695 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus cytochrome b5 reductase 1 (Cyb5r1), mRNA.
ACCESSION   NM_001013126 XM_222644
VERSION     NM_001013126.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Samhan-Arias,A.K., Marques-da-Silva,D., Yanamala,N. and
            Gutierrez-Merino,C.
  TITLE     Stimulation and clustering of cytochrome b5 reductase in
            caveolin-rich lipid microdomains is an early event in oxidative
            stress-mediated apoptosis of cerebellar granule neurons
  JOURNAL   J Proteomics 75 (10), 2934-2949 (2012)
   PUBMED   22200675
  REMARK    GeneRIF: Stimulation and clustering of cytochrome b5 reductase in
            caveolin-rich lipid microdomains is an early event in oxidative
            stress-mediated apoptosis.
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089945.1.
            
            On Apr 20, 2005 this sequence version replaced XM_222644.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089945.1, SRR8487227.28346.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1695
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /note="cytochrome b5 reductase 1"
                     /db_xref="GeneID:304805"
                     /db_xref="RGD:1306084"
     exon            1..59
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..962
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /EC_number="1.6.2.2"
                     /note="b5R.1; NAD(P)H:quinone oxidoreductase type 3,
                     polypeptide A2"
                     /codon_start=1
                     /product="NADH-cytochrome b5 reductase 1"
                     /protein_id="NP_001013144.1"
                     /db_xref="GeneID:304805"
                     /db_xref="RGD:1306084"
                     /translation="MGIQPSPVLLASLGVGLFTLFGLALGTYLVRRSRRPQVTLQDPD
                     EKYLLRLLDKTTVSHNTRRFRFALPTAHHILGLPVGKHVYLSARIDGSQVIRPYTPVT
                     SDEDQGYVDLVIKVYLKGVHPKFSEGGKMSQYLDSLKIGDVVEFRGPSGLLSYAGKGN
                     FNIQPNKKSPPELRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEK
                     DIILREDLEELQAQYPIRFKLWFTLDYPPEDWTYSKGFVTADMIQEHLPAPAEDVLLL
                     LCGPPPMVQLACHPNLDKLGYSQKMRFTY"
     exon            60..209
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..282
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..389
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..519
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..603
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..689
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..789
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1665
                     /gene="Cyb5r1"
                     /gene_synonym="Nqo3a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtgggat ctgtccgccc tagcggagcc gaacggcgct agtcatgggg atccagccga
       61 gcccggtctt gctagcctct ctgggggtgg ggctgtttac cctgttcggc ctggctctgg
      121 gtacctactt ggttcgaaga tcccgccggc cacaggtcac tctccaggac ccggatgaga
      181 agtacctgct gcgattgctg gacaagacga cagtgagcca caacaccagg aggttccgct
      241 ttgccctgcc caccgcccac cacattctgg ggctgcctgt gggtaagcac gtctacctct
      301 ctgcccgaat tgatggcagt caggtcatca ggccttacac tcctgtcacc agcgatgaag
      361 accagggcta tgtagatctt gtcatcaagg tttatctgaa aggtgtgcac cccaaatttt
      421 ctgaaggagg gaagatgtct cagtacctgg atagcctgaa gattggggat gtggtggagt
      481 tccgggggcc gagtgggttg ctcagttatg ctgggaaagg gaattttaac attcagccca
      541 acaaaaaatc cccacctgaa ctgcgagtgg ctaagaaatt gggaatgatt gctggcggga
      601 caggaatcac cccaatgctg cagctgatcc gggccatctt gaaagtccct gaagatccaa
      661 cccagtgctt tctgcttttt gccaaccaga ctgaaaagga cataatcctg cgggaggacc
      721 tagaggagct gcaggcccaa tatcctatcc gctttaagct ctggttcacc ctggactacc
      781 ctccagaaga ctggacctac agcaagggct ttgttaccgc cgacatgatc caggagcacc
      841 tgcctgcccc agcagaggat gtgctgctgc tgctttgtgg gccaccacct atggtacagc
      901 tggcctgcca cccgaacctg gataagctgg gctattcaca gaagatgcga ttcacctact
      961 gagcaccgag aggcctccct atcccgtgtg tgcagttgtc cctagtcgat tctccaacac
     1021 caagaggccg cctagggccc ttgctgagag catcagccct tggtgtctca tcccggaatc
     1081 tgggtgcttg cagaagcaac actcccccag ctatggtaga agcaggtcaa ggctaagtca
     1141 ctcccttgca acttccctta tcgtaatctc cttgtgataa aaggtccaga tgaggctcaa
     1201 ggagcagtct ctagggccag aaagaaggga gcatttgtta caaggctacc tagtttttga
     1261 gagcgtcatg gtcacctctg tgaccgtggt gaaatggatg gactggacag catattttgc
     1321 tctatcctca gcatttcacc cactacttaa atgagtacag gctgagcagg cttatataca
     1381 cagtcctaca gaaaccgtag aaaagcaatt atttgccaga attctaaacc tcagaggttt
     1441 agggatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1501 gtggagagag agagagagag agagagagag agagagagag agagagagtg atcagcccct
     1561 gcccaggctg gagtgaaatg gttacccgca acttaagatt actgcttgta caaggagtat
     1621 ctggctgtta aataaatgga gctaaggccc tgatgatctc aaggaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaa
//
