LOCUS       NM_053342               5486 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus CXXC finger protein 4 (Cxxc4), mRNA.
ACCESSION   NM_053342
VERSION     NM_053342.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5486)
  AUTHORS   Guan,B., Zhan,Z., Wang,L., Wang,L. and Liu,L.
  TITLE     CXXC4 mediates glucose-induced beta-cell proliferation
  JOURNAL   Acta Diabetol 57 (9), 1101-1109 (2020)
   PUBMED   32280999
  REMARK    GeneRIF: CXXC4 mediates glucose-induced beta-cell proliferation.
REFERENCE   2  (bases 1 to 5486)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 5486)
  AUTHORS   Liu,N., Wang,M., Deng,W., Schmidt,C.S., Qin,W., Leonhardt,H. and
            Spada,F.
  TITLE     Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC
            zinc finger modules
  JOURNAL   PLoS One 8 (5), e62755 (2013)
   PUBMED   23690950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5486)
  AUTHORS   London,T.B., Lee,H.J., Shao,Y. and Zheng,J.
  TITLE     Interaction between the internal motif KTXXXI of Idax and mDvl PDZ
            domain
  JOURNAL   Biochem Biophys Res Commun 322 (1), 326-332 (2004)
   PUBMED   15313210
REFERENCE   5  (bases 1 to 5486)
  AUTHORS   Hino,S., Kishida,S., Michiue,T., Fukui,A., Sakamoto,I., Takada,S.,
            Asashima,M. and Kikuchi,A.
  TITLE     Inhibition of the Wnt signaling pathway by Idax, a novel
            Dvl-binding protein
  JOURNAL   Mol Cell Biol 21 (1), 330-342 (2001)
   PUBMED   11113207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 11, 2021 this sequence version replaced NM_053342.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360176.2386672.1, SRR26643298.13617.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760433, SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000002.1  225338589-225338630
            43-118              JAXUCZ010000002.1  225338755-225338830
            119-1428            JAXUCZ010000002.1  225341324-225342633
            1429-5486           JAXUCZ010000002.1  225359290-225363347
FEATURES             Location/Qualifiers
     source          1..5486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..5486
                     /gene="Cxxc4"
                     /gene_synonym="Idax"
                     /note="CXXC finger protein 4"
                     /db_xref="GeneID:83824"
                     /db_xref="RGD:69228"
     exon            1..42
                     /gene="Cxxc4"
                     /gene_synonym="Idax"
                     /inference="alignment:Splign:2.1.0"
     exon            43..118
                     /gene="Cxxc4"
                     /gene_synonym="Idax"
                     /inference="alignment:Splign:2.1.0"
     exon            119..1428
                     /gene="Cxxc4"
                     /gene_synonym="Idax"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1473
                     /gene="Cxxc4"
                     /gene_synonym="Idax"
                     /note="inhibition of the Dvl and axin complex protein;
                     Dvl-binding protein IDAX (inhibition of the Dvl and Axin
                     complex); inhibitor of the Dvl and Axin complex; CXXC
                     finger 4"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 4"
                     /protein_id="NP_445794.4"
                     /db_xref="GeneID:83824"
                     /db_xref="RGD:69228"
                     /translation="MNTNVCVEPGPSPEAPGLPKESHLPEGALNSLVDYNSEMERYRS
                     FATSFYKTNGGAFPQAAKIARITTPIFPSSAAAAAAAARIGMSPWNCDNAATAAATAM
                     LWGSGGGGGGGGGGGGGGGAGRKSSSAAASSSASSSAILPAAGGGGGGGGSGSGGGGG
                     GGGGRTSMHHRNDSQRLGKAGCPPEPSLQMANTNFLSTLSPEHCRPLAGECMNKLKCG
                     AAEAEIMNLPERVGTFSAIPALGGISLPPGVIVMTALHSPAAASAAVTDSAFQIANLA
                     DCPQNHSSSSSSSSGGAGGANPAKKKRKRCGVCVPCKRLINCGVCSSCRNRKTGHQIC
                     KFRKCEELKKKPGTSLERTPVPSAEAFRWFF"
     exon            1429..5486
                     /gene="Cxxc4"
                     /gene_synonym="Idax"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcctcc tctctgcaac aagaaaaaaa agccatttac agggggtgat gtgcaactaa
       61 ttaaaggcag actggcagcg tctgcaaatt ctaaggctcc ccaaataaaa agagactgtt
      121 gtaacagttg gaggataatg caaaggaaga cgctgcctgg gaattcaccg tctgtggaca
      181 tgcgccccag agaggactag agcagccctc accttgctct ccccacccgg atcccacttt
      241 cctgcacggc tcggcccgta ccccgacccc accatcaccc gcttcccttc cccccacctc
      301 tccccctttc ccacccaggt gtcggaccag gcggtcccca cttccaccct gcaccccttc
      361 ttccccccct gcaccatgaa caccaatgtc tgcgtggagc cggggccgag cccggaggcc
      421 ccgggcttgc ccaaggagag ccacctgccc gagggggccc tgaacagcct tgtggattac
      481 aactctgaga tggagcgcta tcgctctttt gccacctcct tctacaagac caacgggggc
      541 gccttcccgc aggcagccaa gatcgcgcgc atcaccaccc ccatcttccc cagcagcgcc
      601 gccgccgccg cggctgctgc gcgcatcggc atgtccccgt ggaactgcga caacgcggcc
      661 accgccgccg ccaccgcgat gctctggggc agcgggggcg gcggcggagg cggtgggggc
      721 gggggtgggg gcggcggagc cggcaggaaa tcctcctcgg ccgccgcctc ctcctccgcc
      781 tcctcctcgg cgatcctccc cgccgccggc ggtggcggtg gcggcggcgg cagtggcagc
      841 ggcggcggcg gcggcggtgg cggcggcagg accagcatgc accaccggaa cgactcccag
      901 cgtctgggga aggctggctg tccgccagag ccgtcgttgc aaatggcaaa tactaatttc
      961 ctctccacct tatcccccga acactgcaga cctttggcgg gggaatgcat gaacaagctc
     1021 aaatgcggcg ctgctgaagc agagataatg aatctccccg agcgggtggg gactttttcc
     1081 gctatcccgg ctttaggggg catctcatta cctccagggg tcatcgtcat gacagccctt
     1141 cactcccccg cagcagcctc agcagccgtc acagacagtg cgtttcaaat tgccaatctg
     1201 gcagactgcc cgcagaatca ttcctcctcc tcctcgtcct cctcgggggg agctggcgga
     1261 gccaacccgg ccaagaagaa gaggaaaagg tgtggggtct gcgtgccctg caagaggctc
     1321 atcaactgtg gcgtctgcag cagttgcagg aaccgcaaaa cgggacacca gatctgcaaa
     1381 tttagaaaat gtgaagagct aaagaaaaaa cctggcactt cgctagagag aacacctgtt
     1441 cccagcgctg aagcattccg atggttcttt taaagctgta gtgtacctta ttttcaaggc
     1501 atttggaaat gaagggcaaa ctaatgtctt gttttaagaa accacttagt ccaccattga
     1561 agaaattatc cagaaattat tttcatttta tgtataggga tttcttcaaa aaaaaaaaaa
     1621 accaagagga aaagaaatca acaacaacaa caacaacaac aacaacaaga cacataaaaa
     1681 taagagggaa gcttggggat tggccggttt atttacgttc aatacactga ttcttccttt
     1741 gatgtatcta gctatactag tgaagctgtt gtctattttg aaagtggctg taaaaaaaaa
     1801 taagtttggg taacccccga ctgtaaaatg atgtatcttt gcaaagtaca tatctatacg
     1861 tcattttcat atatatgtgt tccagtaccg taaactgtac agacagcggc ttgtattttg
     1921 tgtgtttaga cacaaggaga caatcaggtc tgagcaacta tggagattaa cggtttgtac
     1981 acaaaactat ggttctgcaa gttaaaaaat ccggagcaat aaattttagc tttaaatata
     2041 tatatatatt ttttgccagt tgtttttagg agcagaaaca acaccggtgg ttttcatgca
     2101 tccttctgta gagacttgtt ggctggtttt tacgagacga aaagattagc cctgcatcca
     2161 gcaattacct tcagttgtgt tgatatgaga gggaaagcta ctaggaaggt ttccattaat
     2221 cttttgagca ctatattaga gtagtggtta tgcatttgca ttgcttacag acgagctgta
     2281 cagagggtct acctcccaat atttagtgta gttgacttgt ttgggttgca ctgtaaggga
     2341 gtacgctgaa tagttggaaa atgcagaatc agttgtatct tttttttttt tttaaattgg
     2401 aaaagcgtgt tctaggctaa cgatatccga tcatagaaag agaaattcat gcctgactcc
     2461 actttttttc cccctcctag ccgtacacag gttgttcaag cttttttatt cttatttttt
     2521 tttgcttcgg ggaggggtag aaaaaaataa aaacaaaaac agaagagtat tcaaaatgtt
     2581 ttaattccat gtgtggcgtt gaatgggtag gtttcaaaca atactcaaat gcattgaagc
     2641 ctactttaag gcttggttgg gcttattttc aagttcaaaa taattaaaca cattcattaa
     2701 aagtgggacc tttttgtttc tttaccttcc cttcctcagt ctctcagtgg gacacctact
     2761 gcttccattc cctttcttac cactggaagc tttcttttca tgaagcaagg ccacattgta
     2821 aggaatttca taaaaaaaaa aaaccaacac agcccatctg ccccccagga tgctttatag
     2881 aacccgggct gcgttactcg gtaaggtttg attttcctag gactgtcatg cttctcaaat
     2941 gatgcctgtc ccaataagac aaacactttc attgatttat ttttaagact agcctaaacg
     3001 aaccagtttc aggaataaaa catagtttag gaaagacacg tagaataaca aagttgccat
     3061 gttaaattac atctccgttt tttatgcctg tcagacaggt tagcaagatg ggtgagaagg
     3121 aaaacaacag cagagtgata agtcagcgag gactttagag tctaaagagc ttcaaaggct
     3181 ggttggggaa tattttttaa atctcatttt agatttaagt ggaggaggga tgacattatt
     3241 ttttttccaa aggcaggtca ggtacgccat cattggtcac ctggatgaga gcatagtagg
     3301 tttgtatgat gccagtgtag ggtaccagcg ggatggatga gcctagctag cagaccagtg
     3361 ctgagtctgc agtatggtca agcagcctgt gaggaaaacg ctttatgtat cacacctgcc
     3421 cgggcttaaa gagaggaatg agctcatcaa aaagtaaaat gcgctgtata ttactttcga
     3481 gatagctttc tactccatgt gtatccctta gagtgttcgt agctataatt tctgtttctg
     3541 ctgtaggacc aatgagaggt atatgagttc tctattgctt tatatcctct ctctctctct
     3601 ctctctctct ctctctctct ccaattttta ttttacttta ttcttatttt ggacaatttg
     3661 ttagtgaact atgagtatgc aaaaatttat tttcacactt gaatgggact tcccttgcta
     3721 ttgtaaaaaa atgattataa aacttttctt caggctgtat taggcacacc ataaggacat
     3781 catagcaata tatggaaagt caaaaactca aggtggcgtt gcatgtcctg atgtattttt
     3841 ttgtttgttt gtttcatggt ttttgtttta agacaatgaa tctgggtatt gtaaatgtgt
     3901 cgtttcacat ggcagttcat ttatttttag tgaaaggaat gtttgtcacc atgatgaaca
     3961 gtgtggcctt tcttttttta aaaaaatatt ttcttacatt ttcattattg acattatttt
     4021 cattatgcca cactcttctt atatttccct ttaaacccaa tttacaaaat gtagggtaca
     4081 gatagagttc tcactggtga tggtgaagaa attacccttc tagattccct ctagttttca
     4141 ttctcaagta tctacgtacc aacaacttgt agccttaagt cagtgaaggt gtgcttgtgt
     4201 attttttctc tattccaaaa tagaaatgaa acgtaactct taacagcttg ctcactgagt
     4261 gtctcgtttt ccatatcaat aaaatttaga atttagcaat cagactgtag gttgtatata
     4321 tacaacttaa aaattacaca ctggtgtttc taaagctgct agagaagtcc gcacacagga
     4381 atccagtctt cagcagatgc attccctggc agcatttgag gggagtacag gaggatacgt
     4441 ggaccactgg catacaggat gtccaacaga tgctcccttt agctctccag aagaccaaat
     4501 actgtaatgc agacctccgt ctttattgac ctttcagact aaagtgactt tctgttggac
     4561 tcctcttgcc ttcatacaag cagaggcaca acacgctcac aaagtagtac tgaatccatc
     4621 caagttccat aaacaataaa catcttcccc tgacgtatga atatataaaa cgtctcctgt
     4681 ttgcttaccc ccaaaccttc cctttcagac taagcagtca cagggagtga taggcaacaa
     4741 ggttgttatg aattaatatt aagtaatcat gaaaggaacg gaatgtccca tcctttgtca
     4801 gaacccctgg catggatgtt gttcaattag tgctggagcc tagaaagctc ttaagctgat
     4861 agtatcagta atcaaagagt gaaaagagag acacagttaa atggggcaca attcagggtc
     4921 aaatatgttg agcagagagc tgtagtgggt ctttgatcat ggcgagattc acggcgagat
     4981 ccaacagctg gttctcgtgt agcagctaaa tgtttcagat tttgtttttt attaaatttg
     5041 gcatttcaca ctgagatctg tattcctagc gagtaaaaca cagctactgt gttcagaagg
     5101 attccgttcc acaattgaca agcagacatt tcaggacatg ggccaccaag tgtactccgt
     5161 tcccagcgtc ctcccattct gaactgtgca gttatcggtt acattttcta atagatattt
     5221 gtgtaaaggt gtatgtaagc ttgtgcagtt attttaaaaa gcagttttgg aaaaacagtg
     5281 tatttattaa agaaaaatca cttatggggc atgtacaaaa ctgtaaaaag aaattaaaaa
     5341 ccacttcaat ttgcccagta aagttgtttt tgtgaaattt ctgtgttgtt aaataaagga
     5401 ctttagtatt caaagtatct ccatttttcc atggcaaaat tttatttgtg ggatttaaat
     5461 taataaacac agttctgaaa atctaa
//
