LOCUS       NM_001079698            2335 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus CXXC finger protein 1 (Cxxc1), mRNA.
ACCESSION   NM_001079698 XM_001053406 XM_001053476 XM_001053540 XM_238016
VERSION     NM_001079698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2335)
  AUTHORS   Tian H, Billings T and Petkov PM.
  TITLE     CXXC1 is not essential for normal DNA double-strand break formation
            and meiotic recombination in mouse
  JOURNAL   PLoS Genet 14 (10), e1007657 (2018)
   PUBMED   30365547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2335)
  AUTHORS   Long HK, Blackledge NP and Klose RJ.
  TITLE     ZF-CxxC domain-containing proteins, CpG islands and the chromatin
            connection
  JOURNAL   Biochem Soc Trans 41 (3), 727-740 (2013)
   PUBMED   23697932
  REMARK    Review article
REFERENCE   3  (bases 1 to 2335)
  AUTHORS   Shilatifard A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   4  (bases 1 to 2335)
  AUTHORS   Cho HM, Lee HA, Kim HY, Han HS and Kim IK.
  TITLE     Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically
            regulated during postnatal development of hypertension
  JOURNAL   Am J Hypertens 24 (12), 1286-1293 (2011)
   PUBMED   21814290
REFERENCE   5  (bases 1 to 2335)
  AUTHORS   Wu M, Wang PF, Lee JS, Martin-Brown S, Florens L, Washburn M and
            Shilatifard A.
  TITLE     Molecular regulation of H3K4 trimethylation by Wdr82, a component
            of human Set1/COMPASS
  JOURNAL   Mol Cell Biol 28 (24), 7337-7344 (2008)
   PUBMED   18838538
REFERENCE   6  (bases 1 to 2335)
  AUTHORS   Lee JH and Skalnik DG.
  TITLE     Wdr82 is a C-terminal domain-binding protein that recruits the
            Setd1A Histone H3-Lys4 methyltransferase complex to transcription
            start sites of transcribed human genes
  JOURNAL   Mol Cell Biol 28 (2), 609-618 (2008)
   PUBMED   17998332
REFERENCE   7  (bases 1 to 2335)
  AUTHORS   Lee JH, Tate CM, You JS and Skalnik DG.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   8  (bases 1 to 2335)
  AUTHORS   Lee JH and Skalnik DG.
  TITLE     CpG-binding protein is a nuclear matrix- and euchromatin-associated
            protein localized to nuclear speckles containing human trithorax.
            Identification of nuclear matrix targeting signals
  JOURNAL   J Biol Chem 277 (44), 42259-42267 (2002)
   PUBMED   12200428
REFERENCE   9  (bases 1 to 2335)
  AUTHORS   Voo KS, Carlone DL, Jacobsen BM, Flodin A and Skalnik DG.
  TITLE     Cloning of a mammalian transcriptional activator that binds
            unmethylated CpG motifs and shares a CXXC domain with DNA
            methyltransferase, human trithorax, and methyl-CpG binding domain
            protein 1
  JOURNAL   Mol Cell Biol 20 (6), 2108-2121 (2000)
   PUBMED   10688657
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128781.1.
            
            On or before Dec 10, 2006 this sequence version replaced
            XM_238016.4, XM_001053540.1, XM_001053476.1, XM_001053406.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2335
                     /gene="Cxxc1"
                     /note="CXXC finger protein 1"
                     /db_xref="GeneID:291440"
                     /db_xref="RGD:1310755"
     exon            1..56
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2036
                     /gene="Cxxc1"
                     /note="cpG-binding protein; CXXC finger 1 (PHD domain)"
                     /codon_start=1
                     /product="CXXC-type zinc finger protein 1"
                     /protein_id="NP_001073166.1"
                     /db_xref="GeneID:291440"
                     /db_xref="RGD:1310755"
                     /translation="MEGDGSDLEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCD
                     NCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKCRERDGSERDGSEP
                     RDEGGGRKRPASDPELQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQ
                     QQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRAR
                     ESYKYFPSSLSPVTPSEALPRPRRPPPTQQQPQQSQKLGRIREDEGTVLSSVVKEPPE
                     ATATPEPLSDEDLALDPDLYQDFCAGAFDDHVPWMSDAEESPFLDPALRKRAVKVKHV
                     KRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRAAQPGS
                     KYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQE
                     MERRFHELEAIILRAKQQAVREDEENNENDSDDTDLQIFCVSCGHPINPRVALRHMER
                     CYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADE
                     VCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQER
                     NVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR"
     exon            57..175
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            176..276
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..512
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..707
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..734
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..977
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1085
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1270
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1478
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1589
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1639
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1736
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1889
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2311
                     /gene="Cxxc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttcgcgg gttgctgcgc ggggtccaga gagggtgctc tgtgagcgga gatatggaag
       61 gagatggctc agacctggaa cctccagatg ctggggagga cagcaagtct gagaatgggg
      121 agaacgcccc catctactgc atctgtcgca aaccggacat caattgcttc atgattggat
      181 gtgacaactg caacgagtgg tttcatgggg actgcatccg catcaccgag aagatggcca
      241 aggccatccg ggaatggtac tgtcgcgagt gccgagagaa ggacccgaag ctggagattc
      301 gttaccgcca caaaaagtgc cgggagaggg atggcagtga gcgggacggc agtgagcccc
      361 gggatgaggg aggagggcgc aagaggcctg cttcagatcc agaactgcag cgccgggcag
      421 ggtcagggac aggggttggg gccatgcttg ctcggggctc tgcttcgccc cacaaatctt
      481 ctccacagcc cttggtggcc acacctagcc agcatcacca gcaacagcag cagcagcagc
      541 agcagcagca aatcaaacgg tcagctcgga tgtgtggtga gtgtgaggca tgccgacgca
      601 ctgaggactg tggccactgt gacttctgtc gtgacatgaa gaagtttggg ggccccaaca
      661 agatccggca gaagtgccgg cttcgccagt gtcagctgcg ggcacgggaa tcgtacaagt
      721 acttcccttc ctcgctctcg ccggtgacac cctcagaggc cctgccaagg ccccgccggc
      781 caccacccac tcaacagcag ccacagcaat cccagaagct ggggcgtatc cgtgaagatg
      841 aggggacagt gttgtcatca gtggttaagg agccaccaga ggctacagca acacctgagc
      901 cactctcaga tgaggaccta gcactggacc ctgatctgta ccaggatttc tgtgctgggg
      961 cctttgatga tcacgtacca tggatgagtg acgcagaaga gtccccgttc ctggatcctg
     1021 cactgaggaa gcgggcagta aaagtgaagc atgtgaagcg tcgagagaag aagtctgaga
     1081 agaagaagga ggagagatac aaacggcacc gacagaagca gaaacataaa gacaagtgga
     1141 aacacccaga gagggccgat gccaaggacc ctgcatctct accgcagtgc ctgggacctg
     1201 gctgtgtgcg cgccgcccag cctgggtcca agtattgttc agatgactgt ggcatgaagc
     1261 tggcagccaa ccgaatctat gagatcctcc cccagcgaat ccagcaatgg cagcaaagcc
     1321 cctgcatcgc cgaagagcac ggcaagaagc tccttgaacg gatccgccgt gagcagcaga
     1381 gtgcccgcac ccgccttcag gaaatggagc gcagattcca cgagcttgag gccatcatcc
     1441 ttcgtgctaa gcagcaagct gtgcgagagg acgaggagaa caatgagaat gacagcgatg
     1501 acaccgatct gcagatcttc tgtgtctcct gtgggcatcc catcaacccc cgagttgcct
     1561 tgcgtcacat ggagcgctgc tatgctaagt atgagagcca gacatccttt gggtccatgt
     1621 accccacacg cattgagggg gctacccgac tcttctgtga tgtctacaat cctcagagca
     1681 aaacatactg taagaggctc caggtgctat gtcctgagca ctcacgggac cccaaagtgc
     1741 cagctgatga ggtctgtggg tgtccacttg tacgcgatgt ctttgagctt acaggtgact
     1801 tctgccgcct gcccaagcgc cagtgtaatc gccattactg ctgggagaag cttcggcgag
     1861 cagaagtgga cttggagcgc gtgcgggtgt ggtacaagct ggacgagctg tttgagcagg
     1921 aacgtaatgt tcgcacagcc atgaccaaca gagcaggatt gcttgccctg atgctgcacc
     1981 aaaccatcca acacgatcca cttactaccg accttcgctc tagtgctgac cgctgaaagt
     2041 caccagccca gagcctctca gccctgcatt cagtcaggga ggggctctgc atttcagctc
     2101 gctcttcctc cgttcatctg tttattctac cacccttagt tttcttctta ccatccatgt
     2161 tttggcttct gtttgccctt atcagaaggg tctctgcttt ccctttgtct cctctccata
     2221 gtcagtgctg ggtgaaagtc aagtttactc agccttgcct ataccctccc ccaaaataaa
     2281 caggttttgt taataaaatt ttgaacaaga aaaaaaaaaa aaaaaaaaaa aaaaa
//
