LOCUS       NM_053303               1165 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine receptor 5 (Cxcr5), mRNA.
ACCESSION   NM_053303
VERSION     NM_053303.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1165)
  AUTHORS   Yi,H., Zhu,B., Zheng,C., Ying,Z. and Cheng,M.
  TITLE     CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte
            activation in rats by targeting NLRP3
  JOURNAL   Neuroreport 35 (6), 406-412 (2024)
   PUBMED   38526919
  REMARK    GeneRIF: CXCL13/CXCR5 promote chronic postsurgical pain and
            astrocyte activation in rats by targeting NLRP3.
REFERENCE   2  (bases 1 to 1165)
  AUTHORS   Cao,J., Hu,C., Ding,Z., Chen,J., Liu,S. and Li,Q.
  TITLE     Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats
  JOURNAL   Curr Mol Med 24 (7), 940-949 (2024)
   PUBMED   37622691
  REMARK    GeneRIF: Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats.
REFERENCE   3  (bases 1 to 1165)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
REFERENCE   4  (bases 1 to 1165)
  AUTHORS   Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
            Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
            Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
            Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   5  (bases 1 to 1165)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   6  (bases 1 to 1165)
  AUTHORS   Luther,S.A., Ansel,K.M. and Cyster,J.G.
  TITLE     Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7
            ligands in lymph node development
  JOURNAL   J Exp Med 197 (9), 1191-1198 (2003)
   PUBMED   12732660
REFERENCE   7  (bases 1 to 1165)
  AUTHORS   Kouba,M., Vanetti,M., Wang,X., Schafer,M. and Hollt,V.
  TITLE     Cloning of a novel putative G-protein-coupled receptor (NLR) which
            is expressed in neuronal and lymphatic tissue
  JOURNAL   FEBS Lett 321 (2-3), 173-178 (1993)
   PUBMED   8386678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X71463.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_053303.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CV074888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1165
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="C-X-C motif chemokine receptor 5"
                     /db_xref="GeneID:29363"
                     /db_xref="RGD:62010"
     CDS             1..1125
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="chemokine (C-X-C motif) receptor 5; CXC-R5; CXCR-5;
                     neurolymphatic receptor; burkitt lymphoma receptor 1
                     homolog; chemochine (C-X-C motif) receptor 5"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 5"
                     /protein_id="NP_445755.1"
                     /db_xref="GeneID:29363"
                     /db_xref="RGD:62010"
                     /translation="MNSPISLDMGAITYNMDDLYKELAIYSNSTEIPLQDSIFCSTEE
                     GPLLTSFKTIFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLL
                     VFILPFAVAEGSVGWVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAVHAY
                     RRRRLLSIHITCSTIWLAGFLFALPELLFAKVVQPHNNESLPQCIFSQENEAETRAWF
                     ASRFLYHTGGFLLPMLVMAWCYVGVVHRLLQAQRRPQRQKAVRVAILVTSIFLLCWSP
                     YHIVIFLDTLERLKAVNSSCELSGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSD
                     LSRLLTKLGCAGPASLCQLFPGWRKSSLSESENATSLTTF"
     exon            1..57
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /inference="alignment:Splign:2.1.0"
     exon            58..1165
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaactccc cgatatcgct agacatgggc gccatcacct acaacatgga cgatctgtac
       61 aaggaactgg ccatctacag taacagcacg gagatccccc tacaggacag tatcttctgt
      121 tctacagagg aggggcccct actgacttcc tttaagacga tattcatgcc tgtggcctac
      181 agcctcatct tcctcctggg tatgatggga aacatcctcg tactggtaat cctggagagg
      241 caccggcaca ctcggagctc aacggagacc ttcctgttcc acctggcagt agccgacctt
      301 ctcttggtct tcatcttgcc ttttgcagtg gctgagggct ctgtgggttg ggtcctaggg
      361 accttcctct gcaaaactgt gatcgccctg cacaagatca atttctactg cagcagcctg
      421 ctgctggcct gcatagctgt cgaccgttat ctggccatcg tccatgcggt ccacgcctac
      481 cgccgccgcc gtctcctctc tatccacatc acctgctcga ctatttggct agccggcttc
      541 ctatttgcct tgccagaact cctctttgcc aaggttgtcc aacctcataa caacgagtcc
      601 ttaccacagt gcatcttctc ccaagaaaat gaagccgaaa ctagagcctg gttcgcctcc
      661 cggtttctct accacactgg gggcttcctg ctaccgatgc tcgtgatggc ctggtgttat
      721 gtgggagtgg tacacaggct attgcaggcc cagcggcgcc ctcagaggca gaaggcagtc
      781 agggtggcca tcttggtgac aagcatcttc cttctctgct ggtcacccta ccacattgtc
      841 atcttcctcg atacactgga aaggctgaag gctgtgaaca gcagttgcga attgagtggc
      901 tacctctcag tggctatcac cttatgtgaa ttcctgggcc tggctcactg ctgtctcaat
      961 cccatgctct acaccttcgc tggcgtaaag ttccgcagtg acttgtctcg gcttctgacc
     1021 aagctgggct gtgctggccc ggcctccctt tgtcagctct ttccgggctg gcgcaagagc
     1081 agtctctctg agtcagagaa cgctacttct cttaccacct tctagatccc ggggtctcag
     1141 cccccggctc tgtttctgtt ttcct
//
