LOCUS       NM_022205               1726 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine receptor 4 (Cxcr4), mRNA.
ACCESSION   NM_022205
VERSION     NM_022205.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1726)
  AUTHORS   Lu,Q. and Tang,H.
  TITLE     Overexpression of HSP27 accelerates stress-induced gastric ulcer
            healing via the CXCL12/CXCR4 axis
  JOURNAL   Clin Exp Pharmacol Physiol 51 (5), e13857 (2024)
   PUBMED   38566371
  REMARK    GeneRIF: Overexpression of HSP27 accelerates stress-induced gastric
            ulcer healing via the CXCL12/CXCR4 axis.
REFERENCE   2  (bases 1 to 1726)
  AUTHORS   Wu,Y., Zhang,Z., Sun,X., Wang,J., Shen,H., Sun,X. and Wang,Z.
  TITLE     Stromal cell-derived factor-1 downregulation contributes to
            neuroprotection mediated by CXC chemokine receptor 4 interactions
            after intracerebral hemorrhage in rats
  JOURNAL   CNS Neurosci Ther 30 (2), e14400 (2024)
   PUBMED   37614198
  REMARK    GeneRIF: Stromal cell-derived factor-1 downregulation contributes
            to neuroprotection mediated by CXC chemokine receptor 4
            interactions after intracerebral hemorrhage in rats.
REFERENCE   3  (bases 1 to 1726)
  AUTHORS   Li,W., Liang,J., Li,S., Jiang,S., Song,M., Xu,S., Wang,L., Meng,H.,
            Zhai,D., Tang,L., Yang,Y. and Zhang,B.
  TITLE     The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and
            sciatic nerve demyelination in rats
  JOURNAL   Clin Exp Immunol 214 (2), 219-234 (2023)
   PUBMED   37497691
  REMARK    GeneRIF: The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell
            pyroptosis and sciatic nerve demyelination in rats.
REFERENCE   4  (bases 1 to 1726)
  AUTHORS   He,S., Chen,Z., Xue,C., Zhou,L., Li,C., Jiang,W., Lian,S., Shen,Y.,
            Liao,M. and Zhang,X.
  TITLE     MiR-9a-5p alleviates ventilator-induced lung injury in rats by
            inhibiting the activation of the MAPK signaling pathway via CXCR4
            expression downregulation
  JOURNAL   Int Immunopharmacol 112, 109288 (2022)
   PUBMED   36193608
  REMARK    GeneRIF: MiR-9a-5p alleviates ventilator-induced lung injury in
            rats by inhibiting the activation of the MAPK signaling pathway via
            CXCR4 expression downregulation.
REFERENCE   5  (bases 1 to 1726)
  AUTHORS   Zhu,D., Fan,T., Chen,Y., Huo,X., Li,Y., Liu,D., Cai,Y.,
            Cheung,C.W., Tang,J., Cui,J. and Xia,Z.
  TITLE     CXCR4/CX43 Regulate Diabetic Neuropathic Pain via Intercellular
            Interactions between Activated Neurons and Dysfunctional Astrocytes
            during Late Phase of Diabetes in Rats and the Effects of
            Antioxidant N-Acetyl-L-Cysteine
  JOURNAL   Oxid Med Cell Longev 2022, 8547563 (2022)
   PUBMED   35799894
  REMARK    GeneRIF: CXCR4/CX43 Regulate Diabetic Neuropathic Pain via
            Intercellular Interactions between Activated Neurons and
            Dysfunctional Astrocytes during Late Phase of Diabetes in Rats and
            the Effects of Antioxidant N-Acetyl-L-Cysteine.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1726)
  AUTHORS   Cheng,Z.J., Zhao,J., Sun,Y., Hu,W., Wu,Y.L., Cen,B., Wu,G.X. and
            Pei,G.
  TITLE     beta-arrestin differentially regulates the chemokine receptor
            CXCR4-mediated signaling and receptor internalization, and this
            implicates multiple interaction sites between beta-arrestin and
            CXCR4
  JOURNAL   J Biol Chem 275 (4), 2479-2485 (2000)
   PUBMED   10644702
REFERENCE   7  (bases 1 to 1726)
  AUTHORS   Orsini,M.J., Parent,J.L., Mundell,S.J., Marchese,A. and
            Benovic,J.L.
  TITLE     Trafficking of the HIV coreceptor CXCR4. Role of arrestins and
            identification of residues in the c-terminal tail that mediate
            receptor internalization
  JOURNAL   J Biol Chem 274 (43), 31076-31086 (1999)
   PUBMED   10521508
  REMARK    Erratum:[J Biol Chem 2000 Aug 18;275(33):25876. Marchese, Adriano
            [added]]
REFERENCE   8  (bases 1 to 1726)
  AUTHORS   Pleskoff,O., Sol,N., Labrosse,B. and Alizon,M.
  TITLE     Human immunodeficiency virus strains differ in their ability to
            infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin)
  JOURNAL   J Virol 71 (4), 3259-3262 (1997)
   PUBMED   9060691
REFERENCE   9  (bases 1 to 1726)
  AUTHORS   Nagasawa,T., Nakajima,T., Tachibana,K., Iizasa,H., Bleul,C.C.,
            Yoshie,O., Matsushima,K., Yoshida,N., Springer,T.A. and
            Kishimoto,T.
  TITLE     Molecular cloning and characterization of a murine pre-B-cell
            growth-stimulating factor/stromal cell-derived factor 1 receptor, a
            murine homolog of the human immunodeficiency virus 1 entry
            coreceptor fusin
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14726-14729 (1996)
   PUBMED   8962122
REFERENCE   10 (bases 1 to 1726)
  AUTHORS   Wong,M.L., Xin,W.W. and Duman,R.S.
  TITLE     Rat LCR1: cloning and cellular distribution of a putative chemokine
            receptor in brain
  JOURNAL   Mol Psychiatry 1 (2), 133-140 (1996)
   PUBMED   9118323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO557829.1 and BC089804.1.
            
            On Nov 23, 2005 this sequence version replaced NM_022205.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089804.1, DY315507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680424
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CO557829.1         1-20
            21-1726             BC089804.1         1-1706
FEATURES             Location/Qualifiers
     source          1..1726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1726
                     /gene="Cxcr4"
                     /note="C-X-C motif chemokine receptor 4"
                     /db_xref="GeneID:60628"
                     /db_xref="RGD:620465"
     exon            1..81
                     /gene="Cxcr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1125
                     /gene="Cxcr4"
                     /note="chemokine receptor (LCR1); LESTR; fusin; CXC-R4;
                     CXCR-4; SDF-1 receptor; stromal cell-derived factor 1
                     receptor; leukocyte-derived seven transmembrane domain
                     receptor; CXC chemokine receptor; chemokine (C-X-C motif)
                     receptor 4"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 4"
                     /protein_id="NP_071541.2"
                     /db_xref="GeneID:60628"
                     /db_xref="RGD:620465"
                     /translation="MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFI
                     IFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFG
                     KFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIP
                     ALLLTIPDIIFADVSQGDGRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCI
                     IISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLEVIKQGCEFESV
                     VHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGH
                     SSVSTESESSSFHSS"
     exon            82..1708
                     /gene="Cxcr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcagcagg tagcagtgac cctctgaggc gtttggtgct ccggtagcta ccagggctgg
       61 agagcgagca ttgccatgga aatatacact tcggataact actccgaaga agtagggtct
      121 ggagactatg actccaacaa ggaaccctgc ttccgggatg aaaacgaaaa cttcaacagg
      181 atcttcctgc ccaccatcta ttttatcatc ttcttgactg gcatagtggg caatgggttg
      241 gtaatcctgg tcatgggtta ccagaagaag ctgaggagca tgacagacaa gtaccggctg
      301 cacctgtccg tggctgacct cctctttgtc atcacactcc ccttctgggc agtggacgcc
      361 atggctgact ggtactttgg gaaattttta tgtaaggctg tgcatatcat ctacaccgtc
      421 aacctttaca gcagtgttct catcctggcc ttcatcagcc tggaccgcta ccttgccatt
      481 gtccacgcca ccaacagcca gaggccgagg aagctgctgg ctgaaaaggc cgtctatgtg
      541 ggtgtctgga tccccgccct cctcctgact atccctgaca tcatcttcgc cgatgtcagc
      601 cagggggacg gcaggtacat ctgtgaccgc ctttaccccg acagcctgtg gatggtggtg
      661 ttccagttcc agcacatcat ggtgggtctc atcctgccgg gcatcgtcat cctgtcctgt
      721 tactgcatca tcatctccaa gctgtcacac tccaagggcc accagaagcg caaggccctc
      781 aagactacgg tcatccttat cctggctttc tttgcctgct ggctaccgta ttacgtgggg
      841 atcagcatcg attccttcat ccttttggag gtcatcaagc aaggatgtga gttcgagagc
      901 gtcgtgcaca agtggatctc catcacggag gccctcgcct tcttccactg ttgcctgaac
      961 cccatcctct acgccttcct cggggccaaa ttcaagagct ccgcgcagca tgcactcaat
     1021 tccatgagca gaggctccag cctcaagatc ctttccaaag ggaaacgggg tggacactct
     1081 tccgtctcca cagagtcaga atcctcaagt tttcactcca gctaacactt acgcaaagac
     1141 atatataata tatatatata tatatatata tgacaaagaa ctttttttat gttacacatt
     1201 tcccagatat aaaagactga ccaatcttgt acagtttttt ttattgactg ttggagttta
     1261 tgtttctcta gtttttgtgt gtgtgtgtgt gtgtgaggtt tgacttaatt tatataaata
     1321 ttggtttttt tctgttgttt gtctgtttca cgtgaatgag tgtctaggca ggacctgtgg
     1381 ccaagttctt agtcgctgtg tgtctgtgtg taggactgta gagctgtaga ggaaggaact
     1441 gaacgctcca gaatgtgtgg taaatcggat aaagctagaa gtgaccctca gctgtcgctg
     1501 cataatctct tcgccccgcc caccccgttc ctgaattgtt tggttgtgct gtgtggtttc
     1561 tctgtagaag atggcactta aaaccaaagc ctgaaatggt atagaaatgc tgggtttttt
     1621 ctttcagttt tcaagggtgg attgatttca gtacctacaa atgtacagtc ttgtattatg
     1681 ttgttaataa aagtcaatgg taaacttgaa aaaaaaaaaa aaaaaa
//
