LOCUS       NM_053415               1678 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine receptor 3 (Cxcr3), mRNA.
ACCESSION   NM_053415
VERSION     NM_053415.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1678)
  AUTHORS   Qin,J., Li,A., Huang,Y., Teng,R.H., Yang,Y. and Yao,Y.X.
  TITLE     CXCR3 contributes to neuropathic pain via ERK activation in the
            anterior cingulate cortex
  JOURNAL   Biochem Biophys Res Commun 531 (2), 166-171 (2020)
   PUBMED   32782146
  REMARK    GeneRIF: CXCR3 contributes to neuropathic pain via ERK activation
            in the anterior cingulate cortex.
REFERENCE   2  (bases 1 to 1678)
  AUTHORS   Chen,Y., Yin,D., Fan,B., Zhu,X., Chen,Q., Li,Y., Zhu,S., Lu,R. and
            Xu,Z.
  TITLE     Chemokine CXCL10/CXCR3 signaling contributes to neuropathic pain in
            spinal cord and dorsal root ganglia after chronic constriction
            injury in rats
  JOURNAL   Neurosci Lett 694, 20-28 (2019)
   PUBMED   30448292
  REMARK    GeneRIF: Study showed that CXCL10 and CXCR3 expression was induced
            predominantly in activated neurons after chronic constriction
            injury. And, it is likely that CXCL10/CXCR3 participates in
            neuropathic pain via the p-ERK pathway.
REFERENCE   3  (bases 1 to 1678)
  AUTHORS   Lang,S., Li,L., Wang,X., Sun,J., Xue,X., Xiao,Y., Zhang,M., Ao,T.
            and Wang,J.
  TITLE     CXCL10/IP-10 Neutralization Can Ameliorate
            Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in
            Rats
  JOURNAL   PLoS One 12 (1), e0169100 (2017)
   PUBMED   28046003
  REMARK    GeneRIF: chemokine CXCL10 promotes the development of experimental
            acute respiratory distress syndrome by binding to its receptor
            CXCR3
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1678)
  AUTHORS   Horiguchi,K., Fujiwara,K., Tsukada,T., Yoshida,S., Higuchi,M.,
            Tateno,K., Hasegawa,R., Takigami,S., Ohsako,S., Yashiro,T., Kato,T.
            and Kato,Y.
  TITLE     CXCL10/CXCR3 signaling mediates inhibitory action by
            interferon-gamma on CRF-stimulated adrenocorticotropic hormone
            (ACTH) release
  JOURNAL   Cell Tissue Res 364 (2), 395-404 (2016)
   PUBMED   26572542
  REMARK    GeneRIF: the present study leads to an assumption that CXCL10/CXCR3
            signaling mediates inhibition of the corticotropin-releasing
            factor-stimulated adrenocorticotropin-release by interferon-gamma.
REFERENCE   5  (bases 1 to 1678)
  AUTHORS   Xia,J.B., Mao,C.Z., Chen,Z.Y., Liu,G.H., Wu,H.Y., Zhou,D.C.,
            Park,K.S., Zhao,H., Kim,S.K., Cai,D.Q. and Qi,X.F.
  TITLE     The CXCL10/CXCR3 axis promotes cardiac microvascular endothelial
            cell migration via the p38/FAK pathway in a
            proliferation-independent manner
  JOURNAL   Exp Mol Pathol 100 (2), 257-265 (2016)
   PUBMED   26835911
  REMARK    GeneRIF: Dats show that CXCL10 chemokine treatment promoted the
            activation of p38 MAPK pathway through CXCR3 receptor signaling,
            thereby up-regulating focal adhesion kinase (FAK) activation and
            promoted cardiac microvascular endothelial cell migration.
REFERENCE   6  (bases 1 to 1678)
  AUTHORS   Lasagni,L., Francalanci,M., Annunziato,F., Lazzeri,E., Giannini,S.,
            Cosmi,L., Sagrinati,C., Mazzinghi,B., Orlando,C., Maggi,E.,
            Marra,F., Romagnani,S., Serio,M. and Romagnani,P.
  TITLE     An alternatively spliced variant of CXCR3 mediates the inhibition
            of endothelial cell growth induced by IP-10, Mig, and I-TAC, and
            acts as functional receptor for platelet factor 4
  JOURNAL   J Exp Med 197 (11), 1537-1549 (2003)
   PUBMED   12782716
REFERENCE   7  (bases 1 to 1678)
  AUTHORS   Belperio,J.A., Keane,M.P., Burdick,M.D., Lynch,J.P. 3rd, Xue,Y.Y.,
            Li,K., Ross,D.J. and Strieter,R.M.
  TITLE     Critical role for CXCR3 chemokine biology in the pathogenesis of
            bronchiolitis obliterans syndrome
  JOURNAL   J Immunol 169 (2), 1037-1049 (2002)
   PUBMED   12097412
REFERENCE   8  (bases 1 to 1678)
  AUTHORS   Jenh,C.H., Cox,M.A., Hipkin,W., Lu,T., Pugliese-Sivo,C.,
            Gonsiorek,W., Chou,C.C., Narula,S.K. and Zavodny,P.J.
  TITLE     Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist
            for the human CXCR3 receptor
  JOURNAL   Cytokine 15 (3), 113-121 (2001)
   PUBMED   11554781
REFERENCE   9  (bases 1 to 1678)
  AUTHORS   Wang,X., Li,X., Schmidt,D.B., Foley,J.J., Barone,F.C., Ames,R.S.
            and Sarau,H.M.
  TITLE     Identification and molecular characterization of rat CXCR3:
            receptor expression and interferon-inducible protein-10 binding are
            increased in focal stroke
  JOURNAL   Mol Pharmacol 57 (6), 1190-1198 (2000)
   PUBMED   10825390
REFERENCE   10 (bases 1 to 1678)
  AUTHORS   Agostini,C., Cassatella,M., Zambello,R., Trentin,L., Gasperini,S.,
            Perin,A., Piazza,F., Siviero,M., Facco,M., Dziejman,M., Chilosi,M.,
            Qin,S., Luster,A.D. and Semenzato,G.
  TITLE     Involvement of the IP-10 chemokine in sarcoid granulomatous
            reactions
  JOURNAL   J Immunol 161 (11), 6413-6420 (1998)
   PUBMED   9834133
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF223642.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF223642.1, FQ125480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1678
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1678
                     /gene="Cxcr3"
                     /gene_synonym="Gpr9"
                     /note="C-X-C motif chemokine receptor 3"
                     /db_xref="GeneID:84475"
                     /db_xref="RGD:621528"
     exon            1..160
                     /gene="Cxcr3"
                     /gene_synonym="Gpr9"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1252
                     /gene="Cxcr3"
                     /gene_synonym="Gpr9"
                     /note="CXC-R3; CXCR-3; IP-10 receptor;
                     interferon-inducible protein 10 receptor; G
                     protein-coupled receptor 9; chemokine (C-X-C motif)
                     receptor 3"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 3"
                     /protein_id="NP_445867.1"
                     /db_xref="GeneID:84475"
                     /db_xref="RGD:621528"
                     /translation="MYLEVSERQVLDASDIAFLLENSTSPYDYGENESDFSDSPPCPQ
                     DFSLNFDRTFLPVLYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLV
                     LTLPLWAVDAAAQWVFGSGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYR
                     RDPWVRVALTCIVVWGLCVLFALPDFIFLSASHDQRLNATHCQYNFPQVGRTALRVLQ
                     LVAGFLMPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVVAFAVCWTPYHLVVLV
                     DILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFKEQMWMLLMR
                     LGRSDQRGPQRQPSSSRRESSWSETTEASYLGL"
     exon            161..1663
                     /gene="Cxcr3"
                     /gene_synonym="Gpr9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattaccct ttggaagagg ctgtgctgag ccgtgaaatc ttcacttcct ctgttcacgg
       61 caagttccca accacaagtg ccaaaggcag agaagcaggc agcacgagac ctgaccccag
      121 cagccacagc cagagcagca gccaagccat gtaccttgag gtcagtgaac gtcaagtgct
      181 agatgcctcg gacattgcct ttcttctgga aaacagcaca tctccctacg attatgggga
      241 aaacgaaagc gacttctctg actccccgcc ctgcccacag gacttcagcc tgaactttga
      301 cagaaccttc ctgccagtcc tctacagcct cctctttttg ctggggctgc taggcaatgg
      361 ggcagtggct gctgtgctac tgagccagcg cactgccctg agcagcacag acaccttcct
      421 gctccacctg gctgtggccg atgtactgct ggtactaacc ctcccactgt gggcagtaga
      481 tgctgctgcc cagtgggttt tcggctctgg tctctgcaaa gtggcaggtg ccctgttcaa
      541 catcaacttc tacgcagggg ccttcctgct ggcctgtata agctttgacc gctacctgag
      601 catagtgcat gccacccaga tctaccgcag ggacccctgg gtacgtgtag ccctcacctg
      661 cattgttgtg tggggtctct gtgtgctctt tgccctccca gatttcatct tcctgtcagc
      721 cagccatgat cagcgcctca atgccaccca ttgccagtac aacttcccac aggtgggtcg
      781 gactgctctg cgtgtactgc agctagtggc tggtttcctg atgccccttc tagtcatggc
      841 ctactgctat gcccatatcc tggctgtgct gctggtctcc agaggccaga ggcgctttcg
      901 agctatgagg ctagtggtgg tggtggtggt ggcctttgcc gtctgctgga ccccctatca
      961 cctggtggtg ttagtggata tccttatgga cgtgggagtt ttggcccgca actgtggtcg
     1021 agaaagccat gtggacgtag ccaagtcagt cacctcaggc atgggctaca tgcactgctg
     1081 cctcaatcca ctgctctatg cctttgtggg agtgaagttc aaagaacaaa tgtggatgtt
     1141 gctcatgcgc ctgggccgct ctgaccagag aggaccgcag cggcagcctt catcttcacg
     1201 gagagaatca tcctggtctg agacaactga ggcctcctac ttgggcttgt aattcaggaa
     1261 tgcaactgga gcctgtgcaa cccaagtcct aacacactcc aggctcttct ccttgtagtt
     1321 gggctagctc taacttaccc ataactttgc tgctgggact cagtgacagc tcagcatatc
     1381 caggtctcct gagaaccact ctcagctcca aggacagcag cacctttact gagccatgcc
     1441 ctgcctccgc tgttttagaa ctagttgcct ggagccccac cacccttcta aattagcaga
     1501 tagcactcag ccatccctgt gtgagaagag gaagagacaa atagcactga aggccaggcc
     1561 ttgctcagca ctgaatgtgt ttatggtctc caatatctca acatgtgccc aattttatgg
     1621 ctagaaaccc tgcttaaact ttcaataaac aagataatga ggaaaaaaaa aaaaaaaa
//
