LOCUS       NM_017183               1319 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), mRNA.
ACCESSION   NM_017183
VERSION     NM_017183.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Gao,F., Wei,M., Wang,M., Yang,Y., Duan,X., Yang,L. and Sun,L.
  TITLE     The Role and Mechanism of Spinal NF-kappaB-CXCL1/CXCR2 in Rats with
            Nucleus Pulposus-induced Radicular Pain
  JOURNAL   Spine (Phila Pa 1976) 49 (7), E87-E99 (2024)
   PUBMED   38098294
  REMARK    GeneRIF: The Role and Mechanism of Spinal NF-kappaB-CXCL1/CXCR2 in
            Rats with Nucleus Pulposus-induced Radicular Pain.
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Ju,C., Yuan,F., Wang,L., Zang,C., Ning,J., Shang,M., Ma,J., Li,G.,
            Yang,Y., Chen,Q., Jiang,Y., Li,F., Bao,X. and Zhang,D.
  TITLE     Inhibition of CXCR2 enhances CNS remyelination via modulating
            PDE10A/cAMP signaling pathway
  JOURNAL   Neurobiol Dis 177, 105988 (2023)
   PUBMED   36603746
  REMARK    GeneRIF: Inhibition of CXCR2 enhances CNS remyelination via
            modulating PDE10A/cAMP signaling pathway.
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Zhang,Y.L., Teng,F., Han,X., Li,P.B., Yan,X., Guo,S.B. and Li,H.H.
  TITLE     Selective blocking of CXCR2 prevents and reverses atrial
            fibrillation in spontaneously hypertensive rats
  JOURNAL   J Cell Mol Med 24 (19), 11272-11282 (2020)
   PUBMED   32812337
  REMARK    GeneRIF: Selective blocking of CXCR2 prevents and reverses atrial
            fibrillation in spontaneously hypertensive rats.
REFERENCE   4  (bases 1 to 1319)
  AUTHORS   Wang,D., Chen,X., Fu,M., Xu,H. and Li,Z.
  TITLE     Tacrolimus increases the expression level of the chemokine receptor
            CXCR2 to promote renal fibrosis progression
  JOURNAL   Int J Mol Med 44 (6), 2181-2188 (2019)
   PUBMED   31638188
  REMARK    GeneRIF: the present study suggested that tacrolimus increases the
            level of chemokine receptor CXCR2 to promote renal fibrosis
            progression, which is one of the potential mechanisms underlying
            tacrolimusinduced nephrotoxicity.
REFERENCE   5  (bases 1 to 1319)
  AUTHORS   Piotrowska,A., Rojewska,E., Pawlik,K., Kreiner,G., Ciechanowska,A.,
            Makuch,W., Nalepa,I. and Mika,J.
  TITLE     Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP
            CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain
            Following Peripheral Nerve Injury
  JOURNAL   Front Immunol 10, 2198 (2019)
   PUBMED   31616413
  REMARK    GeneRIF: Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling
            by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic
            Pain Following Peripheral Nerve Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1319)
  AUTHORS   Burger,M., Burger,J.A., Hoch,R.C., Oades,Z., Takamori,H. and
            Schraufstatter,I.U.
  TITLE     Point mutation causing constitutive signaling of CXCR2 leads to
            transforming activity similar to Kaposi's sarcoma herpesvirus-G
            protein-coupled receptor
  JOURNAL   J Immunol 163 (4), 2017-2022 (1999)
   PUBMED   10438939
REFERENCE   7  (bases 1 to 1319)
  AUTHORS   Lippert,U., Artuc,M., Grutzkau,A., Moller,A., Kenderessy-Szabo,A.,
            Schadendorf,D., Norgauer,J., Hartmann,K., Schweitzer-Stenner,R.,
            Zuberbier,T., Henz,B.M. and Kruger-Krasagakes,S.
  TITLE     Expression and functional activity of the IL-8 receptor type CXCR1
            and CXCR2 on human mast cells
  JOURNAL   J Immunol 161 (5), 2600-2608 (1998)
   PUBMED   9725262
REFERENCE   8  (bases 1 to 1319)
  AUTHORS   Gobl,A.E., Huang,M.R., Wang,S., Zhou,Y. and Oberg,K.
  TITLE     Molecular cloning and characterization of a cDNA encoding the rat
            interleukin-8 receptor
  JOURNAL   Biochim Biophys Acta 1326 (2), 171-177 (1997)
   PUBMED   9218548
REFERENCE   9  (bases 1 to 1319)
  AUTHORS   Dunstan,C.A., Salafranca,M.N., Adhikari,S., Xia,Y., Feng,L. and
            Harrison,J.K.
  TITLE     Identification of two rat genes orthologous to the human
            interleukin-8 receptors
  JOURNAL   J Biol Chem 271 (51), 32770-32776 (1996)
   PUBMED   8955112
REFERENCE   10 (bases 1 to 1319)
  AUTHORS   Holmes,W.E., Lee,J., Kuang,W.J., Rice,G.C. and Wood,W.I.
  TITLE     Structure and functional expression of a human interleukin-8
            receptor
  JOURNAL   Science 253 (5025), 1278-1280 (1991)
   PUBMED   1840701
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017183.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X77797.1, SRR26643284.12434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JAXUCZ010000009.1  83178645-83178753
            110-1319            JAXUCZ010000009.1  83183808-83185017
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1319
                     /gene="Cxcr2"
                     /gene_synonym="Cmkar2; Il8rb"
                     /note="C-X-C motif chemokine receptor 2"
                     /db_xref="GeneID:29385"
                     /db_xref="RGD:2906"
     exon            1..109
                     /gene="Cxcr2"
                     /gene_synonym="Cmkar2; Il8rb"
                     /inference="alignment:Splign:2.1.0"
     exon            110..1319
                     /gene="Cxcr2"
                     /gene_synonym="Cmkar2; Il8rb"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1208
                     /gene="Cxcr2"
                     /gene_synonym="Cmkar2; Il8rb"
                     /note="high affinity interleukin-8 receptor B; CXCR-2;
                     IL-8R B; GRO/MGSA receptor; CXC-R2; interleukin 8
                     receptor, beta; chemokine (C-X-C motif) receptor 2;
                     chemokine (C-X-C) receptor 2"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 2"
                     /protein_id="NP_058879.1"
                     /db_xref="GeneID:29385"
                     /db_xref="RGD:2906"
                     /translation="MGEIRVDNFSLEDFFSGDIDSYNYSSDPPFTLSDAAPCPSANLD
                     INRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPV
                     WAASKVNGWIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHL
                     VKFVCITMWFLSLVLSLPIFILRTTVKANPSTVVCYENIGNNTSKWRVVLRILPQTYG
                     FLLPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLM
                     RTKLIKETCERQNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLV
                     SKEFLAKEGRPSFVGSSSANTSTTL"
ORIGIN      
        1 tcacagctgt ctcactttct tccagttcaa ccagccctga cagctcccaa gccttgagtc
       61 acagagactt gggagccact ccactcccag catcgtagag ctacagcagg attaagttta
      121 cctcaaagat gggagaaatc agggtggata atttcagcct tgaagacttc ttcagtggag
      181 atattgacag ttacaattac agttctgacc cgccctttac tctgtcagat gctgccccat
      241 gcccctcagc gaacctagat atcaacaggt atgctgtggt tgtcatatac gttctggtga
      301 ctttgctgag tctcgtggga aactccctgg tgatgctggt catcttgtac aatcgaagca
      361 cctgctctgt caccgacgtc tacctgctga acctggccat tgctgatctg ttctttgccc
      421 tgaccttgcc tgtctgggct gcatctaaag taaatggatg gatttttggc tcattcctgt
      481 gcaaggtatt ctcgttcctg caggagatta ccttctacag cagtgttctg ttgctagcct
      541 gcatcagcat ggaccgctac ctggccatcg tccacgccac aagtacactg atccagaaga
      601 gacacttggt caagtttgtg tgcatcacca tgtggtttct ctcactagtt ctgtccctgc
      661 ccatcttcat tcttcggact actgttaagg caaacccttc taccgtagtc tgctatgaga
      721 atataggtaa taatacatcc aagtggaggg tggtactgcg catcctgcct cagacctatg
      781 gcttcctcct gccgctgctc atcatgctgt tctgctatgg gttcacactg cgcacgctct
      841 ttaaggccca catggggcag aagcaccggg ccatgcgggt catctttgct gtggtcctcg
      901 tcttcctgct ctgctggctt ccctacaaca ttgtcctgtt cacagacacc ctcatgagaa
      961 ccaagctgat caaggagacc tgtgaacgcc agaacgagat taacaaagct ttggaagcta
     1021 ctgagattct tggcttcctc cacagctgtc ttaaccccat catctatgcc tttattggcc
     1081 agaaatttcg ccatggactt ctcaagatca tggctaatta tggccttgtc agcaaggagt
     1141 tcttagccaa ggagggcagg ccttcttttg ttggctcttc ttcagcgaac acctccacta
     1201 ccctctaaga ctgtttactt aaactgtggc ccctctgggt tccttcttgt ccttcagcat
     1261 ggctcattac cagagactgt gatatttgaa ttgatgcagt tccctctaca gctacagga
//
