LOCUS       NM_145672                554 bp    mRNA    linear   ROD 06-JUL-2023
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 9 (Cxcl9), mRNA.
ACCESSION   NM_145672
VERSION     NM_145672.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 554)
  AUTHORS   Xu H, Yu AL, Zhao DP, Meng GY, Wang L, Shan M, Hu NX and Liu YL.
  TITLE     Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat
            pathway and suppresses Schwann cell-mediated Th17 cell migration by
            reducing CXCL9/10 expression
  JOURNAL   Innate Immun 28 (5), 155-163 (2022)
   PUBMED   35548957
  REMARK    GeneRIF: Ursolic acid inhibits Th17 cell differentiation via
            STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17
            cell migration by reducing CXCL9/10 expression.
REFERENCE   2  (bases 1 to 554)
  AUTHORS   Shi G, Zhang Z, Ma S, Li Y, Du S, Chu Y, Li Y, Tang X, Yang Y, Chen
            Z, Wang Z and Wu H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   3  (bases 1 to 554)
  AUTHORS   Yang Y, Shen C, Li J, Yuan J, Wei J, Huang F, Wang F, Li G, Li Y,
            Xing L, Peng L, Yang M, Cao M, Zheng H, Wu W, Zou R, Li D, Xu Z,
            Wang H, Zhang M, Zhang Z, Gao GF, Jiang C, Liu L and Liu Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   4  (bases 1 to 554)
  AUTHORS   Fraser DD, Cepinskas G, Slessarev M, Martin C, Daley M, Miller MR,
            O'Gorman DB, Gill SE, Patterson EK and Dos Santos CC.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 554)
  AUTHORS   Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Moller
            R, Jordan TX, Oishi K, Panis M, Sachs D, Wang TT, Schwartz RE, Lim
            JK, Albrecht RA and tenOever BR.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   6  (bases 1 to 554)
  AUTHORS   Valbuena G, Bradford W and Walker DH.
  TITLE     Expression analysis of the T-cell-targeting chemokines CXCL9 and
            CXCL10 in mice and humans with endothelial infections caused by
            rickettsiae of the spotted fever group
  JOURNAL   Am J Pathol 163 (4), 1357-1369 (2003)
   PUBMED   14507644
REFERENCE   7  (bases 1 to 554)
  AUTHORS   Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and
            Oppenheim JJ.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
REFERENCE   8  (bases 1 to 554)
  AUTHORS   Fine JS, Rojas-Triana A, Jackson JV, Engstrom LW, Deno GS, Lundell
            DJ and Bober LA.
  TITLE     Impairment of leukocyte trafficking in a murine pleuritis model by
            IL-4 and IL-10
  JOURNAL   Inflammation 27 (4), 161-174 (2003)
   PUBMED   14527170
REFERENCE   9  (bases 1 to 554)
  AUTHORS   Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S,
            Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F,
            Romagnani S, Serio M and Romagnani P.
  TITLE     An alternatively spliced variant of CXCR3 mediates the inhibition
            of endothelial cell growth induced by IP-10, Mig, and I-TAC, and
            acts as functional receptor for platelet factor 4
  JOURNAL   J Exp Med 197 (11), 1537-1549 (2003)
   PUBMED   12782716
REFERENCE   10 (bases 1 to 554)
  AUTHORS   Belperio JA, Keane MP, Burdick MD, Lynch JP 3rd, Xue YY, Li K, Ross
            DJ and Strieter RM.
  TITLE     Critical role for CXCR3 chemokine biology in the pathogenesis of
            bronchiolitis obliterans syndrome
  JOURNAL   J Immunol 169 (2), 1037-1049 (2002)
   PUBMED   12097412
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF537208.1.
            
            On Jun 3, 2007 this sequence version replaced NM_145672.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF537208.1, FQ224849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..554
                     /gene="Cxcl9"
                     /gene_synonym="Mig; Scyb9"
                     /note="C-X-C motif chemokine ligand 9"
                     /db_xref="GeneID:246759"
                     /db_xref="RGD:628798"
     exon            1..155
                     /gene="Cxcl9"
                     /gene_synonym="Mig; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..472
                     /gene="Cxcl9"
                     /gene_synonym="Mig; Scyb9"
                     /note="monokine induced by gamma interferon; chemokine
                     (C-X-C motif) ligand 9; small inducible cytokine B9; C-X-C
                     motif chemokine 9"
                     /codon_start=1
                     /product="C-X-C motif chemokine 9 precursor"
                     /protein_id="NP_663705.1"
                     /db_xref="GeneID:246759"
                     /db_xref="RGD:628798"
                     /translation="MKSVALFLMGIIFLDHCGVRGTLVIRNQRCSCISTSQGTFHYKS
                     LKDLKQFAPSPNCNKTEIIATLKNGDQTCLDPDSARVKKLMKEWEKKISQKKKQKRGK
                     NHQRSKKTRKAKTPHHPESKKTA"
     exon            156..282
                     /gene="Cxcl9"
                     /gene_synonym="Mig; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     exon            283..367
                     /gene="Cxcl9"
                     /gene_synonym="Mig; Scyb9"
                     /inference="alignment:Splign:2.1.0"
     exon            368..554
                     /gene="Cxcl9"
                     /gene_synonym="Mig; Scyb9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcctaaat aaatatgacc accaagaaca tgttctctga agacattctc agccttgact
       61 ccagcacggt gacttaatag agctcggctc tgccatgaag tccgttgctc tattcctcat
      121 gggcatcatc ttcctggatc actgtggagt tcgaggaacc ctagtgataa ggaatcagcg
      181 atgctcctgc atcagcacca gccaaggcac attccactac aaatccctca aagacctcaa
      241 acagtttgcc ccaagcccta actgcaacaa aactgaaatc atcgctacac tgaagaacgg
      301 agatcaaacc tgcctagacc cagattcagc aagggtgaag aagctgatga aagaatggga
      361 gaaaaagatc agccaaaaga aaaagcaaaa gagggggaaa aaccatcaaa ggagcaagaa
      421 aacccgaaaa gctaaaacac cccaccatcc ggagtcaaag aagactgcat aagagaccac
      481 tttaccaaca agcgctctgc atctaaacgg cttttagatc atactaaaac gccttccctt
      541 taatacacaa ctcg
//
