LOCUS       NM_022214                939 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 6 (Cxcl6), mRNA.
ACCESSION   NM_022214 XM_001068757 XM_001072333 XM_039092389
VERSION     NM_022214.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Zheng,Y., Zhang,Y.M., Tang,Z.S., Du,J.K., Guo,D.W., Xu,Y.J.,
            Sheng,H., Lu,J.Q. and Ni,X.
  TITLE     Spatial learning and memory deficits induced by prenatal
            glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5
            signaling in rats
  JOURNAL   J Neuroinflammation 18 (1), 85 (2021)
   PUBMED   33810797
  REMARK    GeneRIF: Spatial learning and memory deficits induced by prenatal
            glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5
            signaling in rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Wu,Y.N., Liao,C.H., Chen,K.C. and Chiang,H.S.
  TITLE     CXCL5 Cytokine Is a Major Factor in Platelet-Rich Plasma's
            Preservation of Erectile Function in Rats After Bilateral Cavernous
            Nerve Injury
  JOURNAL   J Sex Med 18 (4), 698-710 (2021)
   PUBMED   33741291
  REMARK    GeneRIF: CXCL5 Cytokine Is a Major Factor in Platelet-Rich Plasma's
            Preservation of Erectile Function in Rats After Bilateral Cavernous
            Nerve Injury.
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Fang,Z.A., He,Y., Sun,C., Zhan,L., Zhou,G., Wei,B. and Sun,S.
  TITLE     Expression and potential role of CXCL5 in the pathogenesis of
            intrauterine adhesions
  JOURNAL   J Int Med Res 49 (3), 300060521997718 (2021)
   PUBMED   33752504
  REMARK    GeneRIF: Expression and potential role of CXCL5 in the pathogenesis
            of intrauterine adhesions.
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Zhang,Y., Zheng,Y., Xu,Y., Sheng,H. and Ni,X.
  TITLE     Corticotropin-Releasing Hormone Suppresses Synapse Formation in the
            Hippocampus of Male Rats via Inhibition of CXCL5 Secretion by Glia
  JOURNAL   Endocrinology 159 (2), 622-638 (2018)
   PUBMED   29126185
  REMARK    GeneRIF: CRH suppressed CXCL5 production in glia via CRHR1 in the
            hippocampus of male rats.
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Walley,K.R., Lukacs,N.W., Standiford,T.J., Strieter,R.M. and
            Kunkel,S.L.
  TITLE     Elevated levels of macrophage inflammatory protein 2 in severe
            murine peritonitis increase neutrophil recruitment and mortality
  JOURNAL   Infect Immun 65 (9), 3847-3851 (1997)
   PUBMED   9284162
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Goodman,R.B., Strieter,R.M., Martin,D.P., Steinberg,K.P.,
            Milberg,J.A., Maunder,R.J., Kunkel,S.L., Walz,A., Hudson,L.D. and
            Martin,T.R.
  TITLE     Inflammatory cytokines in patients with persistence of the acute
            respiratory distress syndrome
  JOURNAL   Am J Respir Crit Care Med 154 (3 Pt 1), 602-611 (1996)
   PUBMED   8810593
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Wakefield,T.W., Strieter,R.M., Wilke,C.A., Kadell,A.M.,
            Wrobleski,S.K., Burdick,M.D., Schmidt,R., Kunkel,S.L. and
            Greenfield,L.J.
  TITLE     Venous thrombosis-associated inflammation and attenuation with
            neutralizing antibodies to cytokines and adhesion molecules
  JOURNAL   Arterioscler Thromb Vasc Biol 15 (2), 258-268 (1995)
   PUBMED   7749835
  REMARK    Erratum:[Arterioscler Thromb Vasc Biol 1995 Apr;15(4):550]
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Colletti,L.M., Kunkel,S.L., Walz,A., Burdick,M.D., Kunkel,R.G.,
            Wilke,C.A. and Strieter,R.M.
  TITLE     Chemokine expression during hepatic ischemia/reperfusion-induced
            lung injury in the rat. The role of epithelial neutrophil
            activating protein
  JOURNAL   J Clin Invest 95 (1), 134-141 (1995)
   PUBMED   7814607
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Proost,P., Wuyts,A., Conings,R., Lenaerts,J.P., Billiau,A.,
            Opdenakker,G. and Van Damme,J.
  TITLE     Human and bovine granulocyte chemotactic protein-2: complete amino
            acid sequence and functional characterization as chemokines
  JOURNAL   Biochemistry 32 (38), 10170-10177 (1993)
   PUBMED   8399143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Mar 16, 2021 this sequence version replaced
            XM_039092389.1, NM_022214.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.526036.1,
                                           SRR21887620.120562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000014.1  17596222-17596417   c
            197-332             JAXUCZ010000014.1  17595959-17596094   c
            333-419             JAXUCZ010000014.1  17595756-17595842   c
            420-939             JAXUCZ010000014.1  17594959-17595478   c
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..939
                     /gene="Cxcl6"
                     /gene_synonym="Cxcl5"
                     /note="C-X-C motif chemokine ligand 6"
                     /db_xref="GeneID:60665"
                     /db_xref="RGD:708540"
     exon            1..196
                     /gene="Cxcl6"
                     /gene_synonym="Cxcl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..480
                     /gene="Cxcl6"
                     /gene_synonym="Cxcl5"
                     /note="C-X-C motif chemokine 5; cytokine LIX;
                     small-inducible cytokine B5; chemokine (C-X-C motif)
                     ligand 6 (granulocyte chemotactic protein 2); CXC
                     chemokine LIX; chemokine (C-X-C motif) ligand 5"
                     /codon_start=1
                     /product="C-X-C motif chemokine 5 precursor"
                     /protein_id="NP_071550.2"
                     /db_xref="GeneID:60665"
                     /db_xref="RGD:708540"
                     /translation="MSFQLRSSARIPSRSCSSFTLLAFLLLFTLPQHRAQAAPFSAMV
                     ATELRCVCLTLAPRINPKMIANLEVIPAGPHCPKVEVIAKLKNQKDNVCLDPEAPLIK
                     KVIQKILGSENKKTKRNALALVRSASTQ"
     exon            197..332
                     /gene="Cxcl6"
                     /gene_synonym="Cxcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            333..419
                     /gene="Cxcl6"
                     /gene_synonym="Cxcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            420..939
                     /gene="Cxcl6"
                     /gene_synonym="Cxcl5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accacagtgc tctatagagc cccaatctcc acacctcctc cagcatatcc cgaaccggtg
       61 cttcctggtc cccggatcct gtccacaatg agcttccagc tccgcagctc cgcccgcatc
      121 cctagccggt cctgctcgtc attcaccctg ctggcatttc tgctgctgtt cacactgcca
      181 cagcatcgag ctcaagctgc tcctttctcg gccatggttg caacggagct acgctgtgtt
      241 tgcttaacct tagctccaag aattaacccc aaaatgatcg ctaatttgga ggtgatccct
      301 gcaggtccac attgccccaa ggtggaagtc atagctaagt tgaagaacca gaaggataat
      361 gtttgtcttg acccagaagc tccgttgata aagaaagtca ttcagaaaat attgggcagt
      421 gaaaataaga aaacaaagcg gaatgcactt gcactggtca gatcagccag tactcaatag
      481 aaagatttct gaggactctg tacccaggga aggcaagaaa gaagggctgg ttctccccac
      541 ctgcggtttt tctttatgaa ctccctgctt tgaagaggaa agagaagtca ctgtccctga
      601 agcttcctgc tcattttagg agtgtatttt agcaaaatgt ttcctagtct ttcctatcta
      661 ttatactatt ggaaactgtg gtattttagt gtgtaagtca agaatcattg atggttaacc
      721 tttcaaaatg tcttgaattg aaggtgacta ttgcattgtg tcttcagaaa atgtgtgtgt
      781 gtgtgtgtgt gtgtgtgtgt gtgcatgtaa tttgtagtgc ctttgtaatg ttcatgtgaa
      841 tgctgtggct ttaacagacc agtgacattc acttagaagc tgttgatagg gacaccctca
      901 tcttctctct cacgaaatgg ggacctctct tcctgttgt
//
