LOCUS       NM_001394590            1034 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 3 (Cxcl3), mRNA.
ACCESSION   NM_001394590 XM_006250721
VERSION     NM_001394590.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1034)
  AUTHORS   Ichinohe,N., Tanimizu,N., Ishigami,K., Yoshioka,Y., Fujitani,N.,
            Ochiya,T., Takahashi,M. and Mitaka,T.
  TITLE     CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells
            activate hepatocytic progenitor cell growth in rat liver
            regeneration
  JOURNAL   Stem Cell Res Ther 14 (1), 134 (2023)
   PUBMED   37194082
  REMARK    GeneRIF: CINC-2 and miR-199a-5p in EVs secreted by transplanted
            Thy1[+] cells activate hepatocytic progenitor cell growth in rat
            liver regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1034)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. doi:
            10.3389/fphar.2020.635927.. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1034)
  AUTHORS   Piotrowska,A., Rojewska,E., Pawlik,K., Kreiner,G., Ciechanowska,A.,
            Makuch,W., Nalepa,I. and Mika,J.
  TITLE     Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP
            CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain
            Following Peripheral Nerve Injury
  JOURNAL   Front Immunol 10, 2198 (2019)
   PUBMED   31616413
  REMARK    GeneRIF: Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling
            by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic
            Pain Following Peripheral Nerve Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1034)
  AUTHORS   Annamalai,P. and Thangam,E.B.
  TITLE     Local and Systemic Profiles of Inflammatory Cytokines in
            Carrageenan-induced Paw Inflammation in Rats
  JOURNAL   Immunol Invest 46 (3), 274-283 (2017)
   PUBMED   27967265
  REMARK    GeneRIF: this study shows elevated expression of CINC-2 at the site
            of inflammation as well as their significant reflection in the
            circulation, thereby suggesting their frontline role in
            carrageenan-induced acute inflammation
REFERENCE   5  (bases 1 to 1034)
  AUTHORS   Michalak,S., Wender,M., Michalowska-Wender,G. and Kozubski,W.
  TITLE     Blood-brain barrier breakdown and cerebellar degeneration in the
            course of experimental neoplastic disease. Are circulating
            Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) and
            -2alpha(CINC-2alpha) the involved mediators?
  JOURNAL   Folia Neuropathol 48 (2), 93-103 (2010)
   PUBMED   20602290
  REMARK    GeneRIF: The decreased serum concentration of CINC-1 as
            neuroprotective agent and increased CINC-2alpha in late stage of
            Morris hepatoma may be considered for their contribution to
            cerebellar degeneration.
REFERENCE   6  (bases 1 to 1034)
  AUTHORS   Shibata,F., Konishi,K. and Nakagawa,H.
  TITLE     Gene structure, cDNA cloning, and expression of the rat
            cytokine-induced neutrophil chemoattractant-2 (CINC-2) gene
  JOURNAL   Cytokine 10 (3), 169-174 (1998)
   PUBMED   9576061
REFERENCE   7  (bases 1 to 1034)
  AUTHORS   Nakagawa,H., Shiota,S., Takano,K., Shibata,F. and Kato,H.
  TITLE     Cytokine-induced neutrophil chemoattractant (CINC)-2 alpha, a novel
            member of rat GRO/CINCs, is a predominant chemokine produced by
            lipopolysaccharide-stimulated rat macrophages in culture
  JOURNAL   Biochem Biophys Res Commun 220 (3), 945-948 (1996)
   PUBMED   8607872
REFERENCE   8  (bases 1 to 1034)
  AUTHORS   Shibata,F., Kato,H., Konishi,K., Okumora,A., Ochiai,H.,
            Nakajima,K., Al-Mokdad,M. and Nakagawa,H.
  TITLE     Differential changes in the concentrations of cytokine-induced
            neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during
            rat lipopolysaccharide-induced inflammation
  JOURNAL   Cytokine 8 (3), 222-226 (1996)
   PUBMED   8833037
REFERENCE   9  (bases 1 to 1034)
  AUTHORS   Nakagawa,H., Komorita,N., Shibata,F., Ikesue,A., Konishi,K.,
            Fujioka,M. and Kato,H.
  TITLE     Identification of cytokine-induced neutrophil chemoattractants
            (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by
            granulation tissue in culture: purification, complete amino acid
            sequences and characterization
  JOURNAL   Biochem J 301 (Pt 2) (Pt 2), 545-550 (1994)
   PUBMED   8043001
REFERENCE   10 (bases 1 to 1034)
  AUTHORS   Nakagawa,H., Ikesue,A., Hatakeyama,S., Kato,H., Gotoda,T.,
            Komorita,N., Watanabe,K. and Miyai,H.
  TITLE     Production of an interleukin-8-like chemokine by
            cytokine-stimulated rat NRK-49F fibroblasts and its suppression by
            anti-inflammatory steroids
  JOURNAL   Biochem Pharmacol 45 (7), 1425-1430 (1993)
   PUBMED   8471066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Apr 28, 2021 this sequence version replaced XM_006250721.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.723992.1,
                                           SRR21887622.1502715.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345331,
                                           SAMN12840113 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000014.1  17573470-17573624   c
            156-279             JAXUCZ010000014.1  17573260-17573383   c
            280-363             JAXUCZ010000014.1  17573059-17573142   c
            364-1034            JAXUCZ010000014.1  17571900-17572570   c
FEATURES             Location/Qualifiers
     source          1..1034
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1034
                     /gene="Cxcl3"
                     /gene_synonym="Cinc-2; Cinc2; Gm1960"
                     /note="C-X-C motif chemokine ligand 3"
                     /db_xref="GeneID:171551"
                     /db_xref="RGD:621812"
     exon            1..155
                     /gene="Cxcl3"
                     /gene_synonym="Cinc-2; Cinc2; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..379
                     /gene="Cxcl3"
                     /gene_synonym="Cinc-2; Cinc2; Gm1960"
                     /note="C-X-C motif chemokine 3; MIP2-alpha/beta;
                     macrophage inflammatory protein 2-alpha/beta;
                     cytokine-induced neutrophil chemoattractant 2; chemokine
                     (C-X-C motif) ligand 3"
                     /codon_start=1
                     /product="C-X-C motif chemokine 3 precursor"
                     /protein_id="NP_001381519.1"
                     /db_xref="GeneID:171551"
                     /db_xref="RGD:621812"
                     /translation="MAPPTRRLLNAALLLLLLLMATSHQPSGTVVARELRCQCLKTLP
                     RVDFENIQSLTVTPPGPHCTQTEVIATLKDGQEVCLNPQAPRLQKIIQKLLKSDKSS"
     exon            156..279
                     /gene="Cxcl3"
                     /gene_synonym="Cinc-2; Cinc2; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     exon            280..363
                     /gene="Cxcl3"
                     /gene_synonym="Cinc-2; Cinc2; Gm1960"
                     /inference="alignment:Splign:2.1.0"
     exon            364..1034
                     /gene="Cxcl3"
                     /gene_synonym="Cinc-2; Cinc2; Gm1960"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccagatc gcgccagggc acttggcact agctcccgcg ctccagactc caaccacact
       61 tcagcccagc gccatggccc ctcccacccg ccggctcctc aatgctgcac tgcttctgct
      121 gcttctgctg atggccacca gccaccaacc ttcagggact gttgtggccc gtgagctgcg
      181 ctgtcagtgc ctgaagaccc taccaagggt tgattttgag aacatccaga gcttgacggt
      241 gacccctcca ggaccgcact gcacccagac agaagtcata gccactctca aggatggtca
      301 agaagtttgt ctcaaccctc aagctcccag gcttcagaaa atcatccaga agttactgaa
      361 gagtgacaag tccagctgag ctgggaaaag gggaagtctc ttgtacggtg atggaggacc
      421 tgcctcagaa gcagagcagc gatccatcca atgctgcctg gatgagcctc cgcctgcttg
      481 ctttaaacaa ctcctgagag ttcataccta tttatttccc ccaaattcta tgttaatatt
      541 ttacatgtag aaaaaaaaac ccctaagtgt ataattgaat ctacttgcaa gattgcatct
      601 tatttaaagt tatttaatgt caagtctaag tttaaccaat ccttattctt aatttgaagg
      661 ttaaaggttt ccagatcccc tcagggaatt gtattaatat ttctgaggca attttccccg
      721 gctgaccatt ttgatggcag ctggggtagt caggaaacag acaaacaagg tcgtctcagt
      781 gtaggaagag catatgtgca cgtctagttt gcaactttac aagattagca gctaatctta
      841 ttaagttatt tattgaagtg gtttttacag cgtcacagga atgatcgact ttgtgttgga
      901 gctctaagaa ttgtgatgta ctatatattc tttagacatg atgactattt aatgcctctt
      961 tgtcttagaa tggagaagtt taaatattta ttgttatttt tacaaataat ttgaaaataa
     1021 aatattgtaa aata
//
