LOCUS       NM_053647               1104 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 2 (Cxcl2), mRNA.
ACCESSION   NM_053647 XM_346458
VERSION     NM_053647.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1104)
  AUTHORS   Zhang,Y., Li,C., Wang,Z., Wang,T., Zhou,Y. and Zheng,L.
  TITLE     Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic
            Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3
            Inflammasome Activation
  JOURNAL   Biol Pharm Bull 46 (5), 672-683 (2023)
   PUBMED   37121693
  REMARK    GeneRIF: Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic
            Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3
            Inflammasome Activation.
REFERENCE   2  (bases 1 to 1104)
  AUTHORS   Asami,Y., Sasaki,H., Harada,A., Hanazawa,K., Kobayashi,T., Mori,G.
            and Yajima,Y.
  TITLE     Rat peri-implant soft tissue specifically expressed CXCL2 on
            titanium implant during wound healing
  JOURNAL   J Biomed Mater Res A 110 (4), 899-908 (2022)
   PUBMED   34850541
  REMARK    GeneRIF: Rat peri-implant soft tissue specifically expressed CXCL2
            on titanium implant during wound healing.
REFERENCE   3  (bases 1 to 1104)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   4  (bases 1 to 1104)
  AUTHORS   Blanco-Melo,D., Nilsson-Payant,B.E., Liu,W.C., Uhl,S., Hoagland,D.,
            Moller,R., Jordan,T.X., Oishi,K., Panis,M., Sachs,D., Wang,T.T.,
            Schwartz,R.E., Lim,J.K., Albrecht,R.A. and tenOever,B.R.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   5  (bases 1 to 1104)
  AUTHORS   Deftu,A.T., Ciorescu,R., Gheorghe,R.O., Mihailescu,D. and
            Ristoiu,V.
  TITLE     CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and
            Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons
  JOURNAL   Neurochem Res 44 (9), 2215-2229 (2019)
   PUBMED   31422522
  REMARK    GeneRIF: CXCL2 inhibits axon outgrowth of dorsal root ganglia
            neurons.
REFERENCE   6  (bases 1 to 1104)
  AUTHORS   Driscoll,K.E., Hassenbein,D.G., Howard,B.W., Isfort,R.J., Cody,D.,
            Tindal,M.H., Suchanek,M. and Carter,J.M.
  TITLE     Cloning, expression, and functional characterization of rat MIP-2:
            a neutrophil chemoattractant and epithelial cell mitogen
  JOURNAL   J Leukoc Biol 58 (3), 359-364 (1995)
   PUBMED   7665992
REFERENCE   7  (bases 1 to 1104)
  AUTHORS   Feng,L., Xia,Y., Yoshimura,T. and Wilson,C.B.
  TITLE     Modulation of neutrophil influx in glomerulonephritis in the rat
            with anti-macrophage inflammatory protein-2 (MIP-2) antibody
  JOURNAL   J Clin Invest 95 (3), 1009-1017 (1995)
   PUBMED   7883948
REFERENCE   8  (bases 1 to 1104)
  AUTHORS   Nakagawa,H., Komorita,N., Shibata,F., Ikesue,A., Konishi,K.,
            Fujioka,M. and Kato,H.
  TITLE     Identification of cytokine-induced neutrophil chemoattractants
            (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by
            granulation tissue in culture: purification, complete amino acid
            sequences and characterization
  JOURNAL   Biochem J 301 (Pt 2) (Pt 2), 545-550 (1994)
   PUBMED   8043001
REFERENCE   9  (bases 1 to 1104)
  AUTHORS   Nakagawa,H., Ikesue,A., Hatakeyama,S., Kato,H., Gotoda,T.,
            Komorita,N., Watanabe,K. and Miyai,H.
  TITLE     Production of an interleukin-8-like chemokine by
            cytokine-stimulated rat NRK-49F fibroblasts and its suppression by
            anti-inflammatory steroids
  JOURNAL   Biochem Pharmacol 45 (7), 1425-1430 (1993)
   PUBMED   8471066
REFERENCE   10 (bases 1 to 1104)
  AUTHORS   Huang,S., Paulauskis,J.D., Godleski,J.J. and Kobzik,L.
  TITLE     Expression of macrophage inflammatory protein-2 and KC mRNA in
            pulmonary inflammation
  JOURNAL   Am J Pathol 141 (4), 981-988 (1992)
   PUBMED   1415488
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053647.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060092.1, U45965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680425, SAMN06680428
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000014.1  17467107-17467255   c
            150-273             JAXUCZ010000014.1  17466897-17467020   c
            274-357             JAXUCZ010000014.1  17466695-17466778   c
            358-1104            JAXUCZ010000014.1  17465210-17465956   c
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1104
                     /gene="Cxcl2"
                     /gene_synonym="Mip-2; Scyb2"
                     /note="C-X-C motif chemokine ligand 2"
                     /db_xref="GeneID:114105"
                     /db_xref="RGD:70069"
     exon            1..149
                     /gene="Cxcl2"
                     /gene_synonym="Mip-2; Scyb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..373
                     /gene="Cxcl2"
                     /gene_synonym="Mip-2; Scyb2"
                     /note="small inducible cytokine subfamily, member 2; C-X-C
                     motif chemokine 2; MIP2; CINC-3; cytokine-induced
                     neutrophil chemoattractant 3; macrophage inflammatory
                     protein 2; chemokine (C-X-C motif) ligand 2"
                     /codon_start=1
                     /product="C-X-C motif chemokine 2 precursor"
                     /protein_id="NP_446099.1"
                     /db_xref="GeneID:114105"
                     /db_xref="RGD:70069"
                     /translation="MAPPTRQLLNAVLVLLLLLATNHQGTGVVVASELRCQCLTTLPR
                     VDFKNIQSLTVTPPGPHCAQTEVIATLKDGHEVCLNPEAPLVQRIVQKILNKGKAN"
     exon            150..273
                     /gene="Cxcl2"
                     /gene_synonym="Mip-2; Scyb2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..357
                     /gene="Cxcl2"
                     /gene_synonym="Mip-2; Scyb2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..1104
                     /gene="Cxcl2"
                     /gene_synonym="Mip-2; Scyb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcacctc agggcctcca gcaagctccc tcctgtgctc aagactccaa ccactctttg
       61 gtccagagcc atggcccctc ccactcgcca gctcctcaat gctgtactgg tcctgctcct
      121 cctgctggcc accaaccatc agggtacagg ggttgttgtg gccagtgagc tgcgctgtca
      181 atgcctgacg accctaccaa gggttgactt caagaacatc cagagcttga cggtgacccc
      241 tccaggaccc cactgcgccc agacagaagt catagccact cttaaggatg gtcatgaagt
      301 ttgtctcaac cctgaagccc ccttggttca gaggatcgtc caaaagatac tgaacaaagg
      361 caaggctaac tgacctggga aggaagaaca tgggctcctg tacctcaacg ggcagaatca
      421 aagagaaaag aaacgaactg cacccaggaa gcctggatcg tacctgatgt gcctcgctgt
      481 ccgagagttt atctatttat ttatatatgt atttatttat ttattttcag tgcctagatg
      541 ttgttacgtt tactatgata tttaaagata tgcattggcc agctcactgt agtatcttaa
      601 gaggtcattt taatatgttg aagtttattg taataatgtt caatgtgttc agtcagcgtt
      661 attttactta tgtagttgga aggtgatgca tttttaaatc tatatttatt actttctggg
      721 gggggagggg gagttgggta ctgactacac cacctccaca ctgtgataga gattggggat
      781 gaggggtgtg ggggggcaaa cagacgcagt cagatggctt tcaaggcagg actgtgcctg
      841 tccacgtcat tttctgtaag ccccgagaag ggcgggacga ctgttatttc tgtctccgtg
      901 tttctacact atgtgtacaa catttctgat gctgaatgtt caacaatcgt aatgtgaata
      961 tcccctggac attctatgtc ttctctgtaa ggcacagtgc ctcgtttagc aattgttttg
     1021 tcatgctttc tcatgtcttg aagtggggac atttatttat tcatgtactt ttacaaataa
     1081 caaaaaaaaa taaaaacttt tact
//
