LOCUS       NM_001017478            1730 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 16 (Cxcl16), mRNA.
ACCESSION   NM_001017478 XM_573130
VERSION     NM_001017478.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Liu,C., Wu,M., Qu,J., Huang,X., Zeng,Q. and Ha,M.
  TITLE     JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate
            cypermethrin-induced kidney damage
  JOURNAL   Ecotoxicol Environ Saf 238, 113582 (2022)
   PUBMED   35512476
  REMARK    GeneRIF: JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate
            cypermethrin-induced kidney damage.
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Blanco-Melo,D., Nilsson-Payant,B.E., Liu,W.C., Uhl,S., Hoagland,D.,
            Moller,R., Jordan,T.X., Oishi,K., Panis,M., Sachs,D., Wang,T.T.,
            Schwartz,R.E., Lim,J.K., Albrecht,R.A. and tenOever,B.R.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Wu,J., He,Y., Luo,Y., Zhang,L., Lin,H., Liu,X., Liu,B., Liang,C.,
            Zhou,Y. and Zhou,J.
  TITLE     MiR-145-5p inhibits proliferation and inflammatory responses of RMC
            through regulating AKT/GSK pathway by targeting CXCL16
  JOURNAL   J Cell Physiol 233 (4), 3648-3659 (2018)
   PUBMED   29030988
  REMARK    GeneRIF: miR-145-5p inhibited proliferation and inflammatory
            responses of RMCs through regulation of AKT/GSK pathway by
            targeting CXCL16
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Rabquer,B.J., Tsou,P.S., Hou,Y., Thirunavukkarasu,E., Haines,G.K.
            3rd, Impens,A.J., Phillips,K., Kahaleh,B., Seibold,J.R. and
            Koch,A.E.
  TITLE     Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and
            their receptors in systemic sclerosis
  JOURNAL   Arthritis Res Ther 13 (1), R18 (2011)
   PUBMED   21303517
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Dahl,C.P., Husberg,C., Gullestad,L., Waehre,A., Damas,J.K.,
            Vinge,L.E., Finsen,A.V., Ueland,T., Florholmen,G., Aakhus,S.,
            Halvorsen,B., Aukrust,P., Oie,E., Yndestad,A. and Christensen,G.
  TITLE     Increased production of CXCL16 in experimental and clinical heart
            failure: a possible role in extracellular matrix remodeling
  JOURNAL   Circ Heart Fail 2 (6), 624-632 (2009)
   PUBMED   19919988
  REMARK    GeneRIF: Report increased production of CXCL16 in experimental
            heart failure: a possible role in extracellular matrix remodeling.
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Schramme,A., Abdel-Bakky,M.S., Kampfer-Kolb,N., Pfeilschifter,J.
            and Gutwein,P.
  TITLE     The role of CXCL16 and its processing metalloproteinases ADAM10 and
            ADAM17 in the proliferation and migration of human mesangial cells
  JOURNAL   Biochem Biophys Res Commun 370 (2), 311-316 (2008)
   PUBMED   18373975
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Chandrasekar,B., Mummidi,S., Valente,A.J., Patel,D.N., Bailey,S.R.,
            Freeman,G.L., Hatano,M., Tokuhisa,T. and Jensen,L.E.
  TITLE     The pro-atherogenic cytokine interleukin-18 induces CXCL16
            expression in rat aortic smooth muscle cells via MyD88,
            interleukin-1 receptor-associated kinase, tumor necrosis factor
            receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase,
            Akt, c-Jun N-terminal kinase, and activator protein-1 signaling
  JOURNAL   J Biol Chem 280 (28), 26263-26277 (2005)
   PUBMED   15890643
  REMARK    GeneRIF: IL-18 induces CXCL16 expression via a MyD88,
            IRAK1-IRAK4-TRAF6, c-Src, PI3K, Akt, JNK, AP-1 pathway
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Shimaoka,T., Kume,N., Minami,M., Hayashida,K., Kataoka,H., Kita,T.
            and Yonehara,S.
  TITLE     Molecular cloning of a novel scavenger receptor for oxidized low
            density lipoprotein, SR-PSOX, on macrophages
  JOURNAL   J Biol Chem 275 (52), 40663-40666 (2000)
   PUBMED   11060282
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Matloubian,M., David,A., Engel,S., Ryan,J.E. and Cyster,J.G.
  TITLE     A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
  JOURNAL   Nat Immunol 1 (4), 298-304 (2000)
   PUBMED   11017100
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079312.1.
            
            On Apr 29, 2005 this sequence version replaced XM_573130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079312.1, DQ025528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1730
                     /gene="Cxcl16"
                     /note="C-X-C motif chemokine ligand 16"
                     /db_xref="GeneID:497942"
                     /db_xref="RGD:1562928"
     exon            1..356
                     /gene="Cxcl16"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1030
                     /gene="Cxcl16"
                     /note="C-X-C motif chemokine 16; small-inducible cytokine
                     B16; transmembrane chemokine CXCL16; chemokine (C-X-C
                     motif) ligand 16"
                     /codon_start=1
                     /product="C-X-C motif chemokine 16 precursor"
                     /protein_id="NP_001017478.1"
                     /db_xref="GeneID:497942"
                     /db_xref="RGD:1562928"
                     /translation="MRRGFGPLALTLFLFFFALLTLPGDGNQGSVAGSCYCDRTIPSG
                     TQIPPATLNHMRKYLKTFHRCQFFIRFQLQSKSVCGGSQDQWVRELVNCFEHKQCGIG
                     HGQSFHHQKHVPQASTRIPEATEGKPPDTSTAVQFQSTQQSTFPSGAPSLNKELTRHW
                     ETTILPSGYGLEARPVAEANEKQHKQQKEPGAGAGTQALVPVLSLLAIVFFLVAAMVC
                     VLCNRRVTRQSSSGLQLCYTPVEPRPQGL"
     exon            357..495
                     /gene="Cxcl16"
                     /inference="alignment:Splign:2.1.0"
     exon            496..578
                     /gene="Cxcl16"
                     /inference="alignment:Splign:2.1.0"
     exon            579..980
                     /gene="Cxcl16"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1707
                     /gene="Cxcl16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggagtct cgagtcggaa ggagctccgc cttccggggc agggatgtgt gtgtcccccg
       61 actgggagct gggcgcagcg cgggctcccc ggtactgacc agacggtcgg ttcaggacag
      121 cgcgcggggg acagaaggcg ccaccacctc gcgccccctc ccttcctgag cttggcacag
      181 atcagcgcct ccgcaaagca tcagccaggg tgaagtgaaa gcaatagaga atctgctgga
      241 tgtcggctag gtgacctggc ctcaacaagc tccgcagcgg cctgagatga ggcggggctt
      301 tggacccttg gcccttacac tcttcctttt cttctttgcg ctgctgactc tgccaggcga
      361 tggcaaccag ggcagtgtcg ctggaagttg ctactgtgat cgtacaattc cttctggcac
      421 ccagataccg cctgctactt tgaatcatat gcgaaaatat ctgaaaacgt tccatcgctg
      481 tcaattcttt atcaggttcc agttgcagtc caagagtgtg tgtggaggaa gccaagacca
      541 gtgggtccgt gaactagtga actgctttga gcacaaacaa tgtggaatcg gtcatgggca
      601 gagttttcac caccaaaaac atgtgcctca agccagtacc cggatccctg aggccacaga
      661 agggaaacct ccagacacaa gcacggctgt acagtttcag agcacccagc agtccacttt
      721 tccatctgga gcaccatcct tgaacaaaga gctcacccgc cactgggaaa caaccattct
      781 cccttcaggc tatggtctgg aggctaggcc tgtggctgag gcaaatgaga aacagcacaa
      841 acagcaaaaa gaaccaggag ctggtgctgg cacacaagcc ttggtgccgg tgctatccct
      901 cctggccatc gtcttcttcc tcgtggcagc catggtctgt gtgctgtgca acaggagagt
      961 gactcggcag agctcttcag gtttgcagct ctgttataca cctgttgaac caagacccca
     1021 gggcctgtag caagaatgga agctcgtgag agatgatgtg ggagaggtgg cagacagact
     1081 ggcaggctag gctccatcaa cgaactgaat ctgagctcat tttttctggt gatgttttga
     1141 atcaaagtag ccattatgta atctaggaca gctttgaact acagagcctg tgccccgacc
     1201 tcctagattc tgggattata gatatatcct actgcatctg ccctcgtcta ctttcataaa
     1261 taaggtataa attttcaggt ttttgttttg tttagcgaag atcttattta gcccaagcca
     1321 acctcaaatt ccctatgtat ctctaggtcc cctgcctcct tacacactca ctaaacgctt
     1381 ttctttttgg tttgtttgag acagggtttc actattcagc cttgacagtc ctagaactca
     1441 gaaaggtctg cctttctgca gtgttgggat taaaggactg cccttgggaa accctcttta
     1501 caactaataa catctgcata gcccctctgc cctagccttt cccctgcctc taataaaatg
     1561 taatactctc aagtatgtgg tccaaaagtg cagtcagagg tggagtgtaa agttcgaggt
     1621 tcaacctgcc cattaacaga ttaattttaa aaagtgtctg ctttttacat tgtgtaacaa
     1681 taaactggac aaattctatg tttttaaaaa aaaaaaaaaa aaaaaaaaaa
//
