LOCUS       NM_022177               1880 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 12 (Cxcl12),
            transcript variant 1, mRNA.
ACCESSION   NM_022177
VERSION     NM_022177.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Zieger,K., Cao,C. and Engele,J.
  TITLE     Evaluating CXCL12 for Effects on Reactive Gene Expression in
            Primary Astrocytes
  JOURNAL   J Mol Neurosci 74 (2), 57 (2024)
   PUBMED   38802573
  REMARK    GeneRIF: Evaluating CXCL12 for Effects on Reactive Gene Expression
            in Primary Astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Lu,Q. and Tang,H.
  TITLE     Overexpression of HSP27 accelerates stress-induced gastric ulcer
            healing via the CXCL12/CXCR4 axis
  JOURNAL   Clin Exp Pharmacol Physiol 51 (5), e13857 (2024)
   PUBMED   38566371
  REMARK    GeneRIF: Overexpression of HSP27 accelerates stress-induced gastric
            ulcer healing via the CXCL12/CXCR4 axis.
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   Rintanalert,D., Ishida,Y., Huang,A.C., Hatano-Sato,K., Li,K.,
            Chantarawaratit,P.O., Usumi-Fujita,R., Hosomichi,J. and Ono,T.
  TITLE     SDF-1 involvement in orthodontic tooth movement after tooth
            extraction
  JOURNAL   Sci Rep 14 (1), 5048 (2024)
   PUBMED   38424199
  REMARK    GeneRIF: SDF-1 involvement in orthodontic tooth movement after
            tooth extraction.
            Erratum:[Sci Rep. 2024 Mar 14;14(1):6205. doi:
            10.1038/s41598-024-56881-x. PMID: 38485772]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   Wu,Y., Zhang,Z., Sun,X., Wang,J., Shen,H., Sun,X. and Wang,Z.
  TITLE     Stromal cell-derived factor-1 downregulation contributes to
            neuroprotection mediated by CXC chemokine receptor 4 interactions
            after intracerebral hemorrhage in rats
  JOURNAL   CNS Neurosci Ther 30 (2), e14400 (2024)
   PUBMED   37614198
  REMARK    GeneRIF: Stromal cell-derived factor-1 downregulation contributes
            to neuroprotection mediated by CXC chemokine receptor 4
            interactions after intracerebral hemorrhage in rats.
REFERENCE   5  (bases 1 to 1880)
  AUTHORS   Li,W., Liang,J., Li,S., Jiang,S., Song,M., Xu,S., Wang,L., Meng,H.,
            Zhai,D., Tang,L., Yang,Y. and Zhang,B.
  TITLE     The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and
            sciatic nerve demyelination in rats
  JOURNAL   Clin Exp Immunol 214 (2), 219-234 (2023)
   PUBMED   37497691
  REMARK    GeneRIF: The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell
            pyroptosis and sciatic nerve demyelination in rats.
REFERENCE   6  (bases 1 to 1880)
  AUTHORS   Pillarisetti,K. and Gupta,S.K.
  TITLE     Cloning and relative expression analysis of rat stromal cell
            derived factor-1 (SDF-1)1: SDF-1 alpha mRNA is selectively induced
            in rat model of myocardial infarction
  JOURNAL   Inflammation 25 (5), 293-300 (2001)
   PUBMED   11820456
  REMARK    GeneRIF: Cloning and relative expression analysis of SDF-1: SDF-1
            alpha mRNA is selectively induced in rat model of myocardial
            infarction.
REFERENCE   7  (bases 1 to 1880)
  AUTHORS   Oh,S.B., Tran,P.B., Gillard,S.E., Hurley,R.W., Hammond,D.L. and
            Miller,R.J.
  TITLE     Chemokines and glycoprotein120 produce pain hypersensitivity by
            directly exciting primary nociceptive neurons
  JOURNAL   J Neurosci 21 (14), 5027-5035 (2001)
   PUBMED   11438578
REFERENCE   8  (bases 1 to 1880)
  AUTHORS   Dubois-Laforgue,D., Hendel,H., Caillat-Zucman,S., Zagury,J.F.,
            Winkler,C., Boitard,C. and Timsit,J.
  TITLE     A common stromal cell-derived factor-1 chemokine gene variant is
            associated with the early onset of type 1 diabetes
  JOURNAL   Diabetes 50 (5), 1211-1213 (2001)
   PUBMED   11334429
REFERENCE   9  (bases 1 to 1880)
  AUTHORS   Gleichmann,M., Gillen,C., Czardybon,M., Bosse,F.,
            Greiner-Petter,R., Auer,J. and Muller,H.W.
  TITLE     Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine
            transcript with developmentally regulated expression in the nervous
            system
  JOURNAL   Eur J Neurosci 12 (6), 1857-1866 (2000)
   PUBMED   10886327
REFERENCE   10 (bases 1 to 1880)
  AUTHORS   Nagasawa,T., Nakajima,T., Tachibana,K., Iizasa,H., Bleul,C.C.,
            Yoshie,O., Matsushima,K., Yoshida,N., Springer,T.A. and
            Kishimoto,T.
  TITLE     Molecular cloning and characterization of a murine pre-B-cell
            growth-stimulating factor/stromal cell-derived factor 1 receptor, a
            murine homolog of the human immunodeficiency virus 1 entry
            coreceptor fusin
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14726-14729 (1996)
   PUBMED   8962122
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK475409.1, BC078737.1 and AF209976.1.
            
            On Sep 28, 2005 this sequence version replaced NM_022177.2.
            
            Transcript Variant: This variant (1) encodes the isoform alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF209976.1, BC078737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               CK475409.1         1-668
            669-1790            BC078737.1         668-1789
            1791-1880           AF209976.1         1741-1830
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1880
                     /gene="Cxcl12"
                     /gene_synonym="Sdf1"
                     /note="C-X-C motif chemokine ligand 12"
                     /db_xref="GeneID:24772"
                     /db_xref="RGD:3651"
     exon            1..142
                     /gene="Cxcl12"
                     /gene_synonym="Sdf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..351
                     /gene="Cxcl12"
                     /gene_synonym="Sdf1"
                     /note="isoform alpha precursor is encoded by transcript
                     variant 1; SDF-1 gamma; stromal cell-derived factor-1
                     gamma; Stromal cell-derived factor 1; chemokine (C-X-C
                     motif) ligand 12 (stromal cell-derived factor 1)"
                     /codon_start=1
                     /product="stromal cell-derived factor 1 isoform alpha
                     precursor"
                     /protein_id="NP_071513.1"
                     /db_xref="GeneID:24772"
                     /db_xref="RGD:3651"
                     /translation="MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHVARANV
                     KHLKILNTPNCALQIVARLKSNNRQVCIDPKLKWIQEYLDKALNK"
     exon            143..260
                     /gene="Cxcl12"
                     /gene_synonym="Sdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..1845
                     /gene="Cxcl12"
                     /gene_synonym="Sdf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcactttc actctccgtc cacctcggtg tcctcttgct gcccagctct gcagcctccg
       61 gcgcgccctc ccgcccacgc catggacgcc aaggtcgtcg ccgtgctggc cctggtgctg
      121 gccgcgctct gcatcagtga cggtaagcca gtcagcctga gctacagatg cccctgccga
      181 ttctttgaga gccatgtcgc cagagccaac gtcaaacatc tgaaaatcct caacactcca
      241 aactgtgccc ttcagattgt tgcaaggctg aaaagcaaca acagacaagt gtgcattgac
      301 ccgaaattaa agtggatcca agagtacctg gacaaagcct taaacaagta agcacaacag
      361 cccaaaggac tttccagtag acccctgagg aaggctgacc tccgtgggag aggaaagggc
      421 agtggtgggg aggagggcct gaaccctggc caggttggcc aatgggacgg cactgactgg
      481 ggtcatgctg agatttgcca gcacaaagac actccaccaa tagcatatgg tacgatattg
      541 ctacttatat tcatccgtgc cctcgcccgt gcacaatgga gcttttataa ctggggtttt
      601 tctaagaaat tgtattaccc taaccagtta gcttcatcct catcttcctc atcctcatcc
      661 tcatcctcat tttttaaaag cagtgattac ttcaaggtct gtattcggtt tgctttggag
      721 cttctcgctt ccctggggcc tctgggcaca gttacaggtg gtggcattgc tgggagccct
      781 ggggagtagc aaccttccac cagagcaggt ccgaggaatg ctgcagggct tgtcctgcag
      841 ggggcgctcc cggacagatt ccttgccgag agtcactcag ctcaaggttg ggcagaggct
      901 cctttttcca gttcagtgtc aggggtaggg aagcttcctt tagaaggtac ccctggggcc
      961 tgtgctcaga gaccctttcc tagccgttcc tgatctctgc ttgcctccaa aagcatgctt
     1021 caactggctt ccgcttctca cctctgtagc ctgacctgcc aatgctgcag tggaaggaag
     1081 gagaatgttt tggggggcgc ttcctccctc tcttcccttt gctttcctct cacttgggcc
     1141 ctttgtgaga tttctctttg gcctcctgta gaatggagcc agcccctcct ggataatgtg
     1201 agaacatgcc tagaattaac cacagaacac aagtctgaga attatccgaa acgcaatttt
     1261 aaatttgaaa actttgagga attggacttt tgcaattgcc cctgagtcct atatatttca
     1321 acagtggctc cgtgggctct gagttttcga atatcagaga tgaaaaaaat gaataagcca
     1381 gaatcttgcc gtgaagccac agtggggatt ctgggttcca atcagaaatg ggaacaagat
     1441 aaaaattgga tacgtcctaa tgatcacaga cggccctggt ggttttgata actatttgca
     1501 aggcattttt tacatatatt tttgtgcact ttttatgttt ctttggaaga caaatgtatt
     1561 tcagaatata tttgtagtca attcctatat ttgaagagaa gccatagtag tgtcagtaga
     1621 taacctctac ggtcttgaac tactggcgat ttgtaaagaa atatatatga catatagatg
     1681 tattgtagct tgccaatgtc agccagtgta tttttccact tgtaatgaaa ttgtatcaac
     1741 tgtgacacta tatgcactag caataaaatg ccaactgttt catgctgtaa gcctcctact
     1801 gtatgtggga atttatttac ctgaaataaa atctactagt tgttaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa
//
