LOCUS       NM_139089               1134 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 10 (Cxcl10), mRNA.
ACCESSION   NM_139089
VERSION     NM_139089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Zhang,Z., Zhu,Z., Zuo,X., Wang,X., Ju,C., Liang,Z., Li,K.,
            Zhang,J., Luo,L., Ma,Y., Song,Z., Li,X., Li,P., Quan,H., Huang,P.,
            Yao,Z., Yang,N., Zhou,J., Kou,Z., Chen,B., Ding,T., Wang,Z. and
            Hu,X.
  TITLE     Photobiomodulation reduces neuropathic pain after spinal cord
            injury by downregulating CXCL10 expression
  JOURNAL   CNS Neurosci Ther 29 (12), 3995-4017 (2023)
   PUBMED   37475184
  REMARK    GeneRIF: Photobiomodulation reduces neuropathic pain after spinal
            cord injury by downregulating CXCL10 expression.
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Huang,X., Yang,C. and Huang,M.
  TITLE     Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in
            rats with depressive-like behaviors
  JOURNAL   J Chem Neuroanat 132, 102283 (2023)
   PUBMED   37146769
  REMARK    GeneRIF: Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10
            axis in rats with depressive-like behaviors.
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Xu,H., Yu,A.L., Zhao,D.P., Meng,G.Y., Wang,L., Shan,M., Hu,N.X. and
            Liu,Y.L.
  TITLE     Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat
            pathway and suppresses Schwann cell-mediated Th17 cell migration by
            reducing CXCL9/10 expression
  JOURNAL   Innate Immun 28 (5), 155-163 (2022)
   PUBMED   35548957
  REMARK    GeneRIF: Ursolic acid inhibits Th17 cell differentiation via
            STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17
            cell migration by reducing CXCL9/10 expression.
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Wahyuni,T., Tanaka,S., Igarashi,R., Miyake,Y., Yamamoto,A.,
            Mori,S., Kametani,Y., Tomimatsu,M., Suzuki,S., Yokota,K., Okada,Y.,
            Maeda,M., Obana,M. and Fujio,Y.
  TITLE     CXCL10 is a novel anti-angiogenic factor downstream of p53 in
            cardiomyocytes
  JOURNAL   Physiol Rep 10 (9), e15304 (2022)
   PUBMED   35542987
  REMARK    GeneRIF: CXCL10 is a novel anti-angiogenic factor downstream of p53
            in cardiomyocytes.
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   Abdullah,F., Ovadia,P., Feuerstein,G., Neville,L.F., Morrison,R.,
            Mathiak,G., Whiteford,M. and Rabinovici,R.
  TITLE     The novel chemokine mob-1: involvement in adult respiratory
            distress syndrome
  JOURNAL   Surgery 122 (2), 303-312 (1997)
   PUBMED   9288136
REFERENCE   7  (bases 1 to 1134)
  AUTHORS   Wang,X., Yue,T.L., Ohlstein,E.H., Sung,C.P. and Feuerstein,G.Z.
  TITLE     Interferon-inducible protein-10 involves vascular smooth muscle
            cell migration, proliferation, and inflammatory response
  JOURNAL   J Biol Chem 271 (39), 24286-24293 (1996)
   PUBMED   8798675
REFERENCE   8  (bases 1 to 1134)
  AUTHORS   Taub,D.D., Longo,D.L. and Murphy,W.J.
  TITLE     Human interferon-inducible protein-10 induces mononuclear cell
            infiltration in mice and promotes the migration of human T
            lymphocytes into the peripheral tissues and human peripheral blood
            lymphocytes-SCID mice
  JOURNAL   Blood 87 (4), 1423-1431 (1996)
   PUBMED   8608232
REFERENCE   9  (bases 1 to 1134)
  AUTHORS   Angiolillo,A.L., Sgadari,C., Taub,D.D., Liao,F., Farber,J.M.,
            Maheshwari,S., Kleinman,H.K., Reaman,G.H. and Tosato,G.
  TITLE     Human interferon-inducible protein 10 is a potent inhibitor of
            angiogenesis in vivo
  JOURNAL   J Exp Med 182 (1), 155-162 (1995)
   PUBMED   7540647
REFERENCE   10 (bases 1 to 1134)
  AUTHORS   Liang,P., Averboukh,L., Zhu,W. and Pardee,A.B.
  TITLE     Ras activation of genes: Mob-1 as a model
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12515-12519 (1994)
   PUBMED   7809069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139089.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225221.1, FQ226479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000014.1  15989066-15989218
            154-280             JAXUCZ010000014.1  15989713-15989839
            281-370             JAXUCZ010000014.1  15990034-15990123
            371-1134            JAXUCZ010000014.1  15990500-15991263
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1134
                     /gene="Cxcl10"
                     /gene_synonym="IP-10; Scyb10"
                     /note="C-X-C motif chemokine ligand 10"
                     /db_xref="GeneID:245920"
                     /db_xref="RGD:620209"
     exon            1..153
                     /gene="Cxcl10"
                     /gene_synonym="IP-10; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..389
                     /gene="Cxcl10"
                     /gene_synonym="IP-10; Scyb10"
                     /note="small inducible cytokine B subfamily (Cys-X-Cys),
                     member 10; C-X-C motif chemokine 10; gamma-IP10; protein
                     Mob-1; small-inducible cytokine B10; interferon-inducible
                     protein 10; 10 kDa interferon gamma-induced protein;
                     chemokine (C-X-C motif) ligand 10; interferon-inducible
                     cytokine IP-10; small inducible cytokine B subfamily
                     (Cys-X-Cys) member 10"
                     /codon_start=1
                     /product="C-X-C motif chemokine 10 precursor"
                     /protein_id="NP_620789.2"
                     /db_xref="GeneID:245920"
                     /db_xref="RGD:620209"
                     /translation="MNPSAAVVLCLVLLSLSGTQGIPLARTVRCTCIDFHEQPLRPRA
                     IGKLEIIPASLSCPHVEIIATMKKNNEKRCLNPESEAIKSLLKAVSQRRSKRAP"
     exon            154..280
                     /gene="Cxcl10"
                     /gene_synonym="IP-10; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     exon            281..370
                     /gene="Cxcl10"
                     /gene_synonym="IP-10; Scyb10"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1134
                     /gene="Cxcl10"
                     /gene_synonym="IP-10; Scyb10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcggctga gctgcattcc aatcccagct acatccggag cccagctaca ttcgagccca
       61 gccacatccc gagccaacct tccagaagca ccatgaaccc aagtgctgct gtcgttctct
      121 gcctcgtgct gctgagtctg agtgggactc aagggatccc tctcgcaaga acggtgcgct
      181 gcacctgcat cgacttccat gaacagccgc tgagacccag ggccatagga aaacttgaaa
      241 tcattcctgc aagtctatcc tgtccgcatg ttgagatcat tgccacaatg aaaaagaaca
      301 atgagaagag gtgtctgaat ccggaatctg aggccatcaa gagcttattg aaagcggtga
      361 gccaaagaag gtctaaaaga gctccgtaac tagagagaag ccactcgcca cagtgctgag
      421 accgatggac agcagagaga cggtctctcc acctcccttt acccagtgtg cggctagtcc
      481 taactgtccc tgtttctcct gaccatggtc ccatcagctg ctactcccac tacagggtga
      541 tggacaaggc ctggtcctga gacaaaagta actccagcag caaggcttcc caattctcta
      601 agagctggtc cgaatcttcc ctcaggcagc tatgacggct ctcctagctc tgttctgtaa
      661 gctatgtgca ggtactaatc tcttcagcat gtgccatgcc ccagcctgct ccacacaccc
      721 tccttctccc tagctctaag ctcatcagtt ctgagttcac ctgagctcct ttatttcaaa
      781 tgcagtccag gtgagatggc aaatcaagtt tgtcagaaca aacttaccac caccttccca
      841 agggaatttc ataactcaga atactcacag gaacctagac atgcatgttt aaatattatt
      901 taatgaccga ctgtacaaag tggaactcct agatgtattt tttgtacgat tttcattgta
      961 tatgtaagaa cttgtgtggt taagtatgta tcaatgggta gttaaagttt acataggcaa
     1021 atgctttgaa tgctacatat tacaagatgt gttggatggt tttcaaaata aaatgtactg
     1081 tattgaatgt agtatgagac caaaaaagta ataaagtaat aataactgac atga
//
