LOCUS       NM_030845                933 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus C-X-C motif chemokine ligand 1 (Cxcl1), mRNA.
ACCESSION   NM_030845
VERSION     NM_030845.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 933)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   2  (bases 1 to 933)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   3  (bases 1 to 933)
  AUTHORS   Kusumanchi,P., Liang,T., Zhang,T., Ross,R.A., Han,S., Chandler,K.,
            Oshodi,A., Jiang,Y., Dent,A.L., Skill,N.J., Huda,N., Ma,J., Yang,Z.
            and Liangpunsakul,S.
  TITLE     Stress-Responsive Gene FK506-Binding Protein 51 Mediates
            Alcohol-Induced Liver Injury Through the Hippo Pathway and
            Chemokine (C-X-C Motif) Ligand 1 Signaling
  JOURNAL   Hepatology 74 (3), 1234-1250 (2021)
   PUBMED   33710653
REFERENCE   4  (bases 1 to 933)
  AUTHORS   Shi,Y., Yi,Z., Zhao,P., Xu,Y. and Pan,P.
  TITLE     MicroRNA-532-5p protects against cerebral ischemia-reperfusion
            injury by directly targeting CXCL1
  JOURNAL   Aging (Albany NY) 13 (8), 11528-11541 (2021)
   PUBMED   33867350
  REMARK    GeneRIF: MicroRNA-532-5p protects against cerebral
            ischemia-reperfusion injury by directly targeting CXCL1.
REFERENCE   5  (bases 1 to 933)
  AUTHORS   Dahlquist,K.J.V., Voth,L.C., Fee,A.J. and Stoeckman,A.K.
  TITLE     An Autocrine Role for CXCL1 in Progression of Hepatocellular
            Carcinoma
  JOURNAL   Anticancer Res 40 (11), 6075-6081 (2020)
   PUBMED   33109545
  REMARK    GeneRIF: An Autocrine Role for CXCL1 in Progression of
            Hepatocellular Carcinoma.
REFERENCE   6  (bases 1 to 933)
  AUTHORS   Hanzawa,H., Haruyama,H., Watanabe,K. and Tsurufuji,S.
  TITLE     The three dimensional structure of rat cytokine CINC/Gro in
            solution by homonuclear 3D NMR
  JOURNAL   FEBS Lett 354 (2), 207-212 (1994)
   PUBMED   7957925
REFERENCE   7  (bases 1 to 933)
  AUTHORS   Konishi,K., Takata,Y., Yamamoto,M., Yomogida,K., Watanabe,K.,
            Tsurufuji,S. and Fujioka,M.
  TITLE     Structure of the gene encoding rat neutrophil chemo-attractant Gro
  JOURNAL   Gene 126 (2), 285-286 (1993)
   PUBMED   8482545
REFERENCE   8  (bases 1 to 933)
  AUTHORS   Huang,S., Paulauskis,J.D., Godleski,J.J. and Kobzik,L.
  TITLE     Expression of macrophage inflammatory protein-2 and KC mRNA in
            pulmonary inflammation
  JOURNAL   Am J Pathol 141 (4), 981-988 (1992)
   PUBMED   1415488
REFERENCE   9  (bases 1 to 933)
  AUTHORS   Huang,S., Paulauskis,J.D. and Kobzik,L.
  TITLE     Rat KC cDNA cloning and mRNA expression in lung macrophages and
            fibroblasts
  JOURNAL   Biochem Biophys Res Commun 184 (2), 922-929 (1992)
   PUBMED   1374243
REFERENCE   10 (bases 1 to 933)
  AUTHORS   Watanabe,K., Konishi,K., Fujioka,M., Kinoshita,S. and Nakagawa,H.
  TITLE     The neutrophil chemoattractant produced by the rat kidney
            epithelioid cell line NRK-52E is a protein related to the KC/gro
            protein
  JOURNAL   J Biol Chem 264 (33), 19559-19563 (1989)
   PUBMED   2684956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NM_030845.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M86536.1, D11444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840113 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000014.1  17479201-17479321   c
            122-245             JAXUCZ010000014.1  17478988-17479111   c
            246-326             JAXUCZ010000014.1  17478789-17478869   c
            327-933             JAXUCZ010000014.1  17477542-17478148   c
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..933
                     /gene="Cxcl1"
                     /gene_synonym="CINC-1; Gro1"
                     /note="C-X-C motif chemokine ligand 1"
                     /db_xref="GeneID:81503"
                     /db_xref="RGD:619869"
     exon            1..121
                     /gene="Cxcl1"
                     /gene_synonym="CINC-1; Gro1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..342
                     /gene="Cxcl1"
                     /gene_synonym="CINC-1; Gro1"
                     /note="growth-regulated alpha protein; C-X-C motif
                     chemokine 1; platelet-derived growth factor-inducible
                     protein KC; cytokine-induced neutrophil chemoattractant 1;
                     chemokine (C-X-C motif) ligand 1 (melanoma growth
                     stimulating activity, alpha)"
                     /codon_start=1
                     /product="growth-regulated alpha protein precursor"
                     /protein_id="NP_110472.2"
                     /db_xref="GeneID:81503"
                     /db_xref="RGD:619869"
                     /translation="MVSATRSLLCAALLLLATSRQATGAPVANELRCQCLQTVAGIHF
                     KNIQSLKVMPPGPHCTQTEVIATLKNGREACLDPEAPMVQKIVQKMLKGVPK"
     exon            122..245
                     /gene="Cxcl1"
                     /gene_synonym="CINC-1; Gro1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..326
                     /gene="Cxcl1"
                     /gene_synonym="CINC-1; Gro1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..933
                     /gene="Cxcl1"
                     /gene_synonym="CINC-1; Gro1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctaaaccag ctccagcact ccagactcca gccacactcc aacagagcac catggtctca
       61 gccacccgct cgcttctctg tgcagcgctg ctgctgctgg ccaccagccg ccaagccaca
      121 ggggcgcccg tcgccaatga gctgcgctgt cagtgcctgc agacagtggc agggattcac
      181 ttcaagaaca tccagagttt gaaggtgatg ccgccaggac cccactgcac ccaaaccgaa
      241 gtcatagcca cactcaagaa tggtcgcgag gcttgccttg accctgaagc ccccatggtt
      301 cagaagattg tccaaaagat gctaaagggt gtccccaagt aatggagaaa gaagatagat
      361 tgcaccgatg gcgtctgtct ggtgaacgct ggcttctgac aacactagtt ttacacattt
      421 tacgatttct attgagggtc ctatttattt tatgtattta tttattccac caagtgtgtg
      481 gtttttattt tacattaata tttaacgatg tggatgcgtt tcatcgatgg tcgttcaatt
      541 ccaattgtgc agtttaaaga tggtaggcgt taaatatctc gttaaattaa tatttattgg
      601 gagaccatta agtgtcaacc actgtgctag aaggtgttga gcgggaagaa gggcggagag
      661 atgagagtct gggatcgtgt tttgtgttag ggtgaggaaa tgtgtgagag gctatgtttg
      721 tatgttttga aaagaatgtt atttattgaa agttgtcttt catattttat ggtcaacatt
      781 gatgtgttga agcttccctt ggacatttta tgtctagttt gtagggcaca atgccctttt
      841 atattcttta accaatgctc cttctcgtct caggacagag aagttcaaag gactgttaca
      901 aatgaaataa aaataaaagt tttattaaaa aat
//
