LOCUS       NM_001399207            5431 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CXADR, Ig-like cell adhesion molecule (Cxadr),
            transcript variant 1, mRNA.
ACCESSION   NM_001399207 XM_006248000
VERSION     NM_001399207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5431)
  AUTHORS   Lam,W.Y., Cheung,A.C., Tung,C.K., Yeung,A.C., Ngai,K.L., Lui,V.W.,
            Chan,P.K. and Tsui,S.K.
  TITLE     miR-466 is putative negative regulator of Coxsackie virus and
            Adenovirus Receptor
  JOURNAL   FEBS Lett 589 (2), 246-254 (2015)
   PUBMED   25497012
  REMARK    GeneRIF: Subsequent experiments also proved that both the
            rno-miR-466d and the human hsa-miR-466, which are orthologs of the
            miR-467 gene family, could effectively down-regulate the levels of
            rat and human CAR protein expression, respectively
REFERENCE   2  (bases 1 to 5431)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5431)
  AUTHORS   Chen,M., Kato,T., Higuchi,M., Yoshida,S., Yako,H., Kanno,N. and
            Kato,Y.
  TITLE     Coxsackievirus and adenovirus receptor-positive cells compose the
            putative stem/progenitor cell niches in the marginal cell layer and
            parenchyma of the rat anterior pituitary
  JOURNAL   Cell Tissue Res 354 (3), 823-836 (2013)
   PUBMED   24057874
  REMARK    GeneRIF: CAR-positive cells are pituitary stem/progenitor cells and
            compose putative stem/progenitor cell niches in the MCL and
            parenchyma.
REFERENCE   4  (bases 1 to 5431)
  AUTHORS   Su,L., Mruk,D.D. and Cheng,C.Y.
  TITLE     Regulation of the blood-testis barrier by coxsackievirus and
            adenovirus receptor
  JOURNAL   Am J Physiol Cell Physiol 303 (8), C843-C853 (2012)
   PUBMED   22875787
  REMARK    GeneRIF: CAR is not only a structural protein: it is involved in
            conferring the phosphorylation status of other adhesion proteins at
            the blood-testis barrier.
REFERENCE   5  (bases 1 to 5431)
  AUTHORS   Borovjagin,A.V., Dong,J., Passineau,M.J., Ren,C., Lamani,E.,
            Mamaeva,O.A., Wu,H., Keyser,E., Murakami,M., Chen,S. and
            MacDougall,M.
  TITLE     Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like
            cells
  JOURNAL   PLoS One 6 (10), e24281 (2011)
   PUBMED   22003382
REFERENCE   6  (bases 1 to 5431)
  AUTHORS   Cohen,C.J., Shieh,J.T., Pickles,R.J., Okegawa,T., Hsieh,J.T. and
            Bergelson,J.M.
  TITLE     The coxsackievirus and adenovirus receptor is a transmembrane
            component of the tight junction
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 15191-15196 (2001)
   PUBMED   11734628
REFERENCE   7  (bases 1 to 5431)
  AUTHORS   Cohen,C.J., Gaetz,J., Ohman,T. and Bergelson,J.M.
  TITLE     Multiple regions within the coxsackievirus and adenovirus receptor
            cytoplasmic domain are required for basolateral sorting
  JOURNAL   J Biol Chem 276 (27), 25392-25398 (2001)
   PUBMED   11316797
REFERENCE   8  (bases 1 to 5431)
  AUTHORS   Honda,T., Saitoh,H., Masuko,M., Katagiri-Abe,T., Tominaga,K.,
            Kozakai,I., Kobayashi,K., Kumanishi,T., Watanabe,Y.G., Odani,S. and
            Kuwano,R.
  TITLE     The coxsackievirus-adenovirus receptor protein as a cell adhesion
            molecule in the developing mouse brain
  JOURNAL   Brain Res Mol Brain Res 77 (1), 19-28 (2000)
   PUBMED   10814828
REFERENCE   9  (bases 1 to 5431)
  AUTHORS   Fechner,H., Haack,A., Wang,H., Wang,X., Eizema,K., Pauschinger,M.,
            Schoemaker,R., Veghel,R., Houtsmuller,A., Schultheiss,H.P.,
            Lamers,J. and Poller,W.
  TITLE     Expression of coxsackie adenovirus receptor and alphav-integrin
            does not correlate with adenovector targeting in vivo indicating
            anatomical vector barriers
  JOURNAL   Gene Ther 6 (9), 1520-1535 (1999)
   PUBMED   10490761
REFERENCE   10 (bases 1 to 5431)
  AUTHORS   Tomko,R.P., Xu,R. and Philipson,L.
  TITLE     HCAR and MCAR: the human and mouse cellular receptors for subgroup
            C adenoviruses and group B coxsackieviruses
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3352-3356 (1997)
   PUBMED   9096397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006248000.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.37383.1,
                                           SRR26643429.40426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000011.1  30469778-30469940
            164-330             JAXUCZ010000011.1  30492063-30492229
            331-535             JAXUCZ010000011.1  30496117-30496321
            536-691             JAXUCZ010000011.1  30500367-30500522
            692-814             JAXUCZ010000011.1  30501214-30501336
            815-953             JAXUCZ010000011.1  30501872-30502010
            954-5431            JAXUCZ010000011.1  30503054-30507531
FEATURES             Location/Qualifiers
     source          1..5431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..5431
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /note="CXADR, Ig-like cell adhesion molecule"
                     /db_xref="GeneID:89843"
                     /db_xref="RGD:619794"
     exon            1..163
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1218
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; coxsackievirus and adenovirus receptor homolog;
                     rCAR; CAR; coxsackie virus and adenovirus receptor"
                     /codon_start=1
                     /product="coxsackievirus and adenovirus receptor homolog
                     isoform 1 precursor"
                     /protein_id="NP_001386136.1"
                     /db_xref="GeneID:89843"
                     /db_xref="RGD:619794"
                     /translation="MALLLCFVLLCGVADFTSSLSITTPEQRIEKAKGETAYLPCKFT
                     LEPEDQGPLDIEWLISPSDNQKVDQVIILYSGDKIYDNYYPDLKGRVHFTSNDVKSGD
                     ASINVTNLQLSDIGTYQCKVKKAPGVANRKFLLTVLVKPSGTRCFVDGSGEIGNDFKL
                     KCEPKEGSLPLQYEWQKLSDSQKMPTPWLAEMTSPVISVKNASSEYSGTYSCTVQNRV
                     GSDQCMLRLDVVPPSNRAGTIAGAVIGTLLALVLIGAILFCCHKKRREEKYEKEVHHD
                     IREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERAPQSPT
                     LAPAKVAAPNLSRMGAVPVMIPAQSKDGSIV"
     exon            164..330
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..535
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..691
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..814
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..953
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..5431
                     /gene="Cxadr"
                     /gene_synonym="Car1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggtgc cttcgctgct gccaccgccg ggagccagtc gggagtgtac caggctctgg
       61 aaaaagcagg gctacccgag ctgagagcgt ttacctgcaa gctacggccc ggcagctccc
      121 atggcgctcc tactgtgctt cgtgctcctg tgcggtgtcg cggatttcac cagcagtttg
      181 agtatcacta cacctgaaca gaggatcgaa aaagctaaag gggaaactgc ctatctaccc
      241 tgcaagttta ctcttgaacc cgaagaccag ggaccactgg acattgaatg gctgatatcc
      301 ccgtccgata accagaaagt ggatcaagtg atcattttgt attctggaga caaaatttat
      361 gataactact atccggatct gaaaggacga gtacacttta cgagtaacga cgtcaagtct
      421 ggtgacgcat cgataaatgt gaccaatctg cagttgtccg atattggcac ttaccagtgc
      481 aaagtgaaga aagctcctgg ggttgcaaat agaaaatttc tgctgacagt tcttgttaag
      541 ccttcaggta caaggtgctt cgtggatggc tcgggagaga ttggaaatga cttcaagcta
      601 aagtgtgaac ccaaagaagg ttccctccca ctgcagtatg aatggcagaa attgtcagat
      661 tcccagaaaa tgcctactcc atggctagca gaaatgactt caccggttat atctgtgaaa
      721 aatgccagtt ctgagtattc tgggacctac agttgcacag tccaaaacag agtgggctct
      781 gatcagtgta tgctacgact agatgttgtc cctccctcca acagagctgg aacgatcgcg
      841 ggagctgtca tagggacgct gcttgccctt gtgctcatcg gggccatcct cttctgctgt
      901 cataaaaaac gcagagaaga gaagtacgag aaggaagtgc atcacgacat cagggaagat
      961 gtgcctcctc cgaagagtcg gacatccacc gccaggagct acatcggcag caaccattcc
     1021 tccctggggt ccatgtcccc ttccaacatg gaagggtatt ccaagaccca gtataaccaa
     1081 gtccccagtg aagactttga acgtgctcct cagagtccga ctctggcacc cgctaaggta
     1141 gctgccccta atctaagtcg aatgggagcg gttcctgtga tgatcccagc acagagcaag
     1201 gatgggtcta tagtatagaa ttctgcacct ctcttctccg ctttccatgg ttcgattctt
     1261 ctcttgacat atcagtactt attctaaatt ttgttaacag tagcccatgt atatgtatgt
     1321 gtgtgtatat atgtgtaagt atgtatacat acatacacat atatacataa acacacacac
     1381 acacacacac acacacacac acacacgtga agaaatttat aaggaacatg ctccgtaaga
     1441 atttttggtt atagtaaata ataaaggctg aagagtaatg acattgacca actggaaatt
     1501 ttaccaagtt gatttctaag ggcacctaaa caataatgcc cttatatcct gagaaagata
     1561 tagcactttg agtatgatgt catgggtcaa gaaatttgtg aatttacgga cgtaccaagt
     1621 tgattcttga accatctgaa aacgatactt tgtagttcct accattattt gtagggtatc
     1681 tgtctcattt atttatgtct ctcaaaaaga aatccatgga aaaacctact taatgtaaga
     1741 atttgttttt atagtctgaa gtgtattcca ttatttgtaa gagtaggaga cctgacagtg
     1801 ttttaaaaat gcctagtttt atttctaagt ctttcacgat cactgatgac acgatttctt
     1861 ttctttcttt ttttcttttg ttgttttgag attgggcctc agtgtgttcg ttgcctaggc
     1921 tggcctcaaa tcatgatcct cctgcttcag cttcttgaat gctgggctga ctagtctgta
     1981 tcagttcctt aagtatttaa cctagagact acagcagcca cagaaagtag taaccttttg
     2041 tgcactacaa aaagaagcac ctttcagctt cggtagcatt tgcctctgct acacacagag
     2101 gtgaaacact cgatgctcca cgggtcgggg gaggaagagg aggaggagcg acgcggaggt
     2161 ctgcgcctcg gggcctgtgg acctcagcag aactgaccag gcagagtggg agtgccaggt
     2221 ttatcagtct gcagctaaac actggccttc tattttaggt gatgtttttg caattgggaa
     2281 ggaaggaagg aaacaaggaa ggaaggaggt agggaaggaa ggaaaactgt taattctctt
     2341 atctgacagt aatggatgag aattcttaaa ttatttttaa atttgtgttt ttgttttgtc
     2401 gtagaccgta ctgcatagtt taagttatag aaacatataa tctagacttt tgatttggag
     2461 tgcggttcct ggaggctatt tttctcagag tcaatgaaca aatatatttg aggcaagtta
     2521 agtgtcttcc actagtcctg aattccggac ttgggcagtg tgcttggtga cctgcggcca
     2581 aacctgcctc cctctagtgg tcagaaatca agtttgagtc ttagttttgt gaaagtgact
     2641 tactcttaaa agaaatttaa aaaggagtaa agggaatact cctatctgcc aaatgtatta
     2701 aatatagttt tcgtaggaaa aaaaaagtga atttattgta tatcccttaa gattgtgagg
     2761 gagtgtgtgt agagtgtaat gagccagcat tttctttata gtagataagg tctgttataa
     2821 aagatttcat taactaacta caaagccttt cccctaggga actggtctct gttaatctct
     2881 tcaggtgctg tgcttgtaaa tgctacatta taaattaacg ttggcatgca tttacggtta
     2941 ggcagaatgt tgtgtatcct ttttaatggt gagtttaaac cgaatgtcca tgtaatggat
     3001 tagtgtacag ttttacatat tcggaggcat tttttaaaag taggtttaaa cctcacataa
     3061 aactactttt tatatttgtg ttgttctcat ctgtgccttt ttaggtaatt taatttctac
     3121 agtgacttta tggtgcctat gagctagcta tcacctacct gaaaggtgct tagaggtgag
     3181 ggtactgttt tcaaaagcac atcactgtgg ctcccttctc ccccgagtct cagtcttgcc
     3241 ttttctcctc tgctcttttt gatgtcactt aagcgatatc attgtttatt aggattgaaa
     3301 agacattcac accctcagta cactttggcc gtgtttctag tttataacca tagccacgtt
     3361 tgactcttag atgtttggca tttttataag atattacaag aataaattgg aatgtagagc
     3421 ttaatggttt ttaggtaatg aagaagatgc taggtagaaa ttactacaaa ggcagatgtg
     3481 tggaatcttt tcctttccat agactttgta tttattgaaa ggcaaacaaa acccagagta
     3541 tccaactatc tttagtccag atttgtagca actataatct gaaagagaaa cttgtttaaa
     3601 aacaaacaaa acaaaacaaa acactgtgaa aaccaacagg cctggagggt atacaattag
     3661 cgacatagtt aaattttagg ctttggtctg cagctcttct cattgaagtc tcagtttacc
     3721 caaaggtcag acaagtacta gtaatttccc caacaattct cactgattgt agttgaacca
     3781 gggagcaagt atttgctcta gaagtcaact agtcaacagc tcatggactt ggttggtgta
     3841 atcttatcta gagatccagt tcagggccag ctctgtcctc acagcagagg tttggatccc
     3901 actctctacg tgagacttaa cacacatgtt aatgttcccc ggggtaatct ggagagaagt
     3961 gccaccacag attccatagt ctgtgttctg aatacagaac agctatgagt tttattatta
     4021 ttgataacct cagtagcatt ttcctgatcg aaagcctccc ctgctgctca gtctgctgtt
     4081 gagttccatc attcccagtt aaatagacaa acacttcctt aacttcgagt taccgaccaa
     4141 ggatttgtta gtatggaaac acagaccgag tgtgtttact aggagaatcc atatagatta
     4201 tggagatgcc tagtttctgt tacatgtgac tgtgcacatg tatgatccca gaactcacag
     4261 gcacaggaag atcatggatt tgaggccagt agccagttca aaacaaggct gcactgagag
     4321 ctccaagacc tggacattga cctcattagt acagtaattt gactgaggtt tgactctaag
     4381 ttcttttaag aaatgaactt gagcctgtgc cctggggatt cgactatgtg gagaggcaag
     4441 tgaacttttt gactaacaag agctcagtgc atggagttgg ctgttctttc ctgtgtgact
     4501 tattaaataa ctactgtctc tgtgtacagc atgtaaattt gaagctatgt gaatgttcgt
     4561 agggttctgt ttttttctaa aatattttca acagtgttta gagtgctctc agctgcctta
     4621 tttcagtgtg aacagaaaat gttcctactt tatgtggtga atgctttaaa tgtgtcactt
     4681 acagaatagt gtgtaggaaa aggctggcac aattttaagt ggtttgcaac attattatat
     4741 atgtacatat atgtttataa cattcttgtg tttcatagta taaatgttca gggcaagttt
     4801 taatatttca aatgcctctg gatattccag caataaaggc aaaatgttct gcagtcaaat
     4861 ttctcgtttg cctacttttg acactaaaat aatctgtatt tgagcaaggt tccttttgaa
     4921 aatattacag aaagagggaa taaatacatt tgtgaattgt ggtttttttc tcctttagga
     4981 aggccagcca tttgtttacc ttccagaact tgaccctaag ctctaagttc aagcttaaaa
     5041 aatatgtccc agtttgtaat ttagagatag aggccatccg ttgagcttgg catttattca
     5101 gacactaaca agtctgccga agttgagctt tgggagttct gctaatttgt ctaatgacac
     5161 aggtgctaag agaaccacaa ttcaccaatt gacctttctt gttcctaatt gtgaattttg
     5221 gcaataaaca cagttgtatt aagaatacta atttgacacc cacatttgca aagtattgat
     5281 agtgtcagtt tcagatcttg tatttcagat atctggctta catacccaac gatgcagatt
     5341 ttaaagtttg taagaacaac tttgtttaaa aacagaaact tgctcttagc tttgtgaccg
     5401 tgtacttttg aaataaaacg aagaaagtcg t
//
