LOCUS       NM_133534               1326 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus C-X3-C motif chemokine receptor 1 (Cx3cr1), mRNA.
ACCESSION   NM_133534
VERSION     NM_133534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Yip,J.L.K., Xavier,S., Balasuriya,G.K., Hill-Yardin,E.L. and
            Spencer,S.J.
  TITLE     Macrophage regulation of the 'second brain': CD163 intestinal
            macrophages interact with inhibitory interneurons to regulate
            colonic motility - evidence from the Cx3cr1-Dtr rat model
  JOURNAL   Front Immunol 14, 1269890 (2023)
   PUBMED   37868978
  REMARK    GeneRIF: Macrophage regulation of the 'second brain': CD163
            intestinal macrophages interact with inhibitory interneurons to
            regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Zhou,Y., Zhang,L., Hao,Y., Yang,L., Fan,S. and Xiao,Z.
  TITLE     FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating
            thalamic-cortical network microglia in status epilepticus model
            rats
  JOURNAL   J Headache Pain 23 (1), 42 (2022)
   PUBMED   35382731
  REMARK    GeneRIF: FKN/CX3CR1 axis facilitates migraine-Like behaviour by
            activating thalamic-cortical network microglia in status
            epilepticus model rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Faridvand,Y., Nemati,M., Zamani-Gharehchamani,E., Nejabati,H.R.,
            Zamani,A.R.N., Nozari,S., Safaie,N., Nouri,M. and Jodati,A.
  TITLE     Dapagliflozin Protects H9c2 Cells Against Injury Induced by
            Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and
            NF-kappaB Activity
  JOURNAL   Curr Mol Pharmacol 15 (6), 862-869 (2022)
   PUBMED   34629047
  REMARK    GeneRIF: Dapagliflozin Protects H9c2 Cells Against Injury Induced
            by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and
            NF-kappaB Activity.
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Younesi,S., Spencer,S.J. and Sominsky,L.
  TITLE     Monocyte perturbation modulates the ovarian response to an immune
            challenge
  JOURNAL   Mol Cell Endocrinol 536, 111418 (2021)
   PUBMED   34339824
  REMARK    GeneRIF: Monocyte perturbation modulates the ovarian response to an
            immune challenge.
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Mao,M., Xu,Y., Zhang,X.Y., Yang,L., An,X.B., Qu,Y., Chai,Y.N.,
            Wang,Y.R., Li,T.T. and Ai,J.
  TITLE     MicroRNA-195 prevents hippocampal microglial/macrophage
            polarization towards the M1 phenotype induced by chronic brain
            hypoperfusion through regulating CX3CL1/CX3CR1 signaling
  JOURNAL   J Neuroinflammation 17 (1), 244 (2020)
   PUBMED   32819407
  REMARK    GeneRIF: MicroRNA-195 prevents hippocampal microglial/macrophage
            polarization towards the M1 phenotype induced by chronic brain
            hypoperfusion through regulating CX3CL1/CX3CR1 signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Maciejewski-Lenoir,D., Chen,S., Feng,L., Maki,R. and Bacon,K.B.
  TITLE     Characterization of fractalkine in rat brain cells: migratory and
            activation signals for CX3CR-1-expressing microglia
  JOURNAL   J Immunol 163 (3), 1628-1635 (1999)
   PUBMED   10415068
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Feng,L., Chen,S., Garcia,G.E., Xia,Y., Siani,M.A., Botti,P.,
            Wilson,C.B., Harrison,J.K. and Bacon,K.B.
  TITLE     Prevention of crescentic glomerulonephritis by immunoneutralization
            of the fractalkine receptor CX3CR1 rapid communication
  JOURNAL   Kidney Int 56 (2), 612-620 (1999)
   PUBMED   10432400
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Boddeke,E.W., Meigel,I., Frentzel,S., Biber,K., Renn,L.Q. and
            Gebicke-Harter,P.
  TITLE     Functional expression of the fractalkine (CX3C) receptor and its
            regulation by lipopolysaccharide in rat microglia
  JOURNAL   Eur J Pharmacol 374 (2), 309-313 (1999)
   PUBMED   10422773
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Haskell,C.A., Cleary,M.D. and Charo,I.F.
  TITLE     Molecular uncoupling of fractalkine-mediated cell adhesion and
            signal transduction. Rapid flow arrest of CX3CR1-expressing cells
            is independent of G-protein activation
  JOURNAL   J Biol Chem 274 (15), 10053-10058 (1999)
   PUBMED   10187784
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Harrison,J.K., Barber,C.M. and Lynch,K.R.
  TITLE     cDNA cloning of a G-protein-coupled receptor expressed in rat
            spinal cord and brain related to chemokine receptors
  JOURNAL   Neurosci Lett 169 (1-2), 85-89 (1994)
   PUBMED   8047298
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133534.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04808.1, DN956036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676789, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000008.1  128677009-128677066 c
            59-1326             JAXUCZ010000008.1  128663361-128664628 c
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1326
                     /gene="Cx3cr1"
                     /gene_synonym="Rbs11"
                     /note="C-X3-C motif chemokine receptor 1"
                     /db_xref="GeneID:171056"
                     /db_xref="RGD:620137"
     exon            1..58
                     /gene="Cx3cr1"
                     /gene_synonym="Rbs11"
                     /inference="alignment:Splign:2.1.0"
     exon            59..1326
                     /gene="Cx3cr1"
                     /gene_synonym="Rbs11"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1132
                     /gene="Cx3cr1"
                     /gene_synonym="Rbs11"
                     /note="chemokine (C-X3-C) receptor 1; C-X3-C CKR-1;
                     fractalkine receptor; chemokine (C-X3-C motif) receptor 1"
                     /codon_start=1
                     /product="CX3C chemokine receptor 1"
                     /protein_id="NP_598218.1"
                     /db_xref="GeneID:171056"
                     /db_xref="RGD:620137"
                     /translation="MPTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSIFYSLVFT
                     FGLVGNLLVVLALTNSRKSKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAM
                     CKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAIL
                     VASPQFMFTKRKDNECLGDYPEVLQEIWPVLRNSEVNILGFVLPLLIMSFCYFRIVRT
                     LFSCKNRKKARAIRLILLVVVVFFLFWTPYNIVIFLETLKFYNFFPSCGMKRDLRWAL
                     SVTETVAFSHCCLNPFIYAFAGEKFRRYLRHLYNKCLAVLCGRPVHAGFSTESQRSRQ
                     DSILSSLTHYTSEGEGSLLL"
ORIGIN      
        1 gtgggactgg gtgagtggct ggcacttcct gcagaagtcc ccgtccccag ctgctcagga
       61 cctcaccatg cctacctcct tcccggaatt ggatctagag aactttgagt atgatgactc
      121 tgctgaggcc tgttatttgg gtgacatcgt ggcctttggg accatcttcc tatctatttt
      181 ctactccctt gtcttcacgt tcggtctggt ggggaatctg ttggtggtcc tcgccctcac
      241 caacagccgg aagtccaaga gcatcactga catctacctc ctgaacctgg ccttgagcga
      301 cctgctcttt gtggccactt tgcccttctg gactcactac ctcatcagcc atgagggcct
      361 ccacaacgcc atgtgcaagc tcacgactgc tttcttcttc attggcttct ttgggggcat
      421 attcttcatc accgtcatca gcatcgaccg gtacctcgcc atcgtcctgg ccgccaactc
      481 catgaacaac cggacagtgc aacacggcgt caccatcagt ctgggcgtct gggcggcggc
      541 catcttagtg gcgtcgcccc agttcatgtt cacaaagaga aaggacaacg aatgtttggg
      601 tgattacccc gaggtcctgc aggaaatctg gcccgtgctc cgcaactcgg aggtcaacat
      661 cctgggcttc gtcctgccct tgcttatcat gagcttttgc tacttccgca tcgtccggac
      721 gctgttttcc tgcaagaacc ggaagaaggc cagagccatt aggctcatcc tcttggtggt
      781 tgttgtcttc ttcctcttct ggacgcctta caacatcgtg attttcctgg agactctcaa
      841 attctacaac ttcttcccta gttgtggcat gaagagggac ctgaggtggg cccttagtgt
      901 gacggagaca gtggcgttta gccactgctg cctcaacccc tttatctacg ctttcgctgg
      961 ggaaaagttc agaaggtacc tgagacacct gtacaacaag tgcctggccg tcctgtgcgg
     1021 tcgtcctgtc cacgccggct tctcaacaga gtcccagagg agcaggcagg acagcattct
     1081 gagcagcttg actcactaca caagcgaggg agagggatct ctcctgctct gaaggggtct
     1141 ccccgacccc gactctacta agaacccaga gttcctgcat ctgactctgt gtaatgaaaa
     1201 cagattcaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacccc
     1261 gctcctcctg cattttatgt gcaagaaata cggaccaggt acctgcaaat caatcccaca
     1321 gtgttt
//
