LOCUS       NM_134455               3057 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus C-X3-C motif chemokine ligand 1 (Cx3cl1), mRNA.
ACCESSION   NM_134455
VERSION     NM_134455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Ma,J., Wang,J., Kang,H., Ma,R. and Zhu,Z.
  TITLE     Expression and significance of Fractalkine/CX3CL1 in
            MPO-AAV-associated glomerulonephritis rats
  JOURNAL   BMC Nephrol 25 (1), 211 (2024)
   PUBMED   38937701
  REMARK    GeneRIF: Expression and significance of Fractalkine/CX3CL1 in
            MPO-AAV-associated glomerulonephritis rats.
            Erratum:[BMC Nephrol. 2024 Aug 1;25(1):249. doi:
            10.1186/s12882-024-03680-1.. PMID: 39090555]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Sivanesan,E., Sanchez,K.R., Zhang,C., He,S.Q., Linderoth,B.,
            Stephens,K.E., Raja,S.N. and Guan,Y.
  TITLE     Spinal Cord Stimulation Increases Chemoefficacy and Prevents
            Paclitaxel-Induced Pain via CX3CL1
  JOURNAL   Neuromodulation 26 (5), 938-949 (2023)
   PUBMED   37045646
  REMARK    GeneRIF: Spinal Cord Stimulation Increases Chemoefficacy and
            Prevents Paclitaxel-Induced Pain via CX3CL1.
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Zhou,Y., Zhang,L., Hao,Y., Yang,L., Fan,S. and Xiao,Z.
  TITLE     FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating
            thalamic-cortical network microglia in status epilepticus model
            rats
  JOURNAL   J Headache Pain 23 (1), 42 (2022)
   PUBMED   35382731
  REMARK    GeneRIF: FKN/CX3CR1 axis facilitates migraine-Like behaviour by
            activating thalamic-cortical network microglia in status
            epilepticus model rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Faridvand,Y., Nemati,M., Zamani-Gharehchamani,E., Nejabati,H.R.,
            Zamani,A.R.N., Nozari,S., Safaie,N., Nouri,M. and Jodati,A.
  TITLE     Dapagliflozin Protects H9c2 Cells Against Injury Induced by
            Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and
            NF-kappaB Activity
  JOURNAL   Curr Mol Pharmacol 15 (6), 862-869 (2022)
   PUBMED   34629047
  REMARK    GeneRIF: Dapagliflozin Protects H9c2 Cells Against Injury Induced
            by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and
            NF-kappaB Activity.
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Bai,X.J., Hao,L., Guo,Y.E., Shi,X.B. and Wu,W.P.
  TITLE     Bone marrow stromal cells reverse the microglia type from
            pro-inflammatory tumour necrosis factor a microglia to
            anti-inflammatory CD206 microglia of middle cerebral artery
            occlusion rats through triggering secretion of CX3CL1
  JOURNAL   Folia Neuropathol 59 (1), 20-31 (2021)
   PUBMED   33969675
  REMARK    GeneRIF: Bone marrow stromal cells reverse the microglia type from
            pro-inflammatory tumour necrosis factor a microglia to
            anti-inflammatory CD206 microglia of middle cerebral artery
            occlusion rats through triggering secretion of CX3CL1.
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Maciejewski-Lenoir,D., Chen,S., Feng,L., Maki,R. and Bacon,K.B.
  TITLE     Characterization of fractalkine in rat brain cells: migratory and
            activation signals for CX3CR-1-expressing microglia
  JOURNAL   J Immunol 163 (3), 1628-1635 (1999)
   PUBMED   10415068
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Haskell,C.A., Cleary,M.D. and Charo,I.F.
  TITLE     Molecular uncoupling of fractalkine-mediated cell adhesion and
            signal transduction. Rapid flow arrest of CX3CR1-expressing cells
            is independent of G-protein activation
  JOURNAL   J Biol Chem 274 (15), 10053-10058 (1999)
   PUBMED   10187784
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Schwaeble,W.J., Stover,C.M., Schall,T.J., Dairaghi,D.J.,
            Trinder,P.K., Linington,C., Iglesias,A., Schubart,A., Lynch,N.J.,
            Weihe,E. and Schafer,M.K.
  TITLE     Neuronal expression of fractalkine in the presence and absence of
            inflammation
  JOURNAL   FEBS Lett 439 (3), 203-207 (1998)
   PUBMED   9845323
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Harrison,J.K., Jiang,Y., Chen,S., Xia,Y., Maciejewski,D.,
            McNamara,R.K., Streit,W.J., Salafranca,M.N., Adhikari,S.,
            Thompson,D.A., Botti,P., Bacon,K.B. and Feng,L.
  TITLE     Role for neuronally derived fractalkine in mediating interactions
            between neurons and CX3CR1-expressing microglia
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10896-10901 (1998)
   PUBMED   9724801
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Pan,Y., Lloyd,C., Zhou,H., Dolich,S., Deeds,J., Gonzalo,J.A.,
            Vath,J., Gosselin,M., Ma,J., Dussault,B., Woolf,E., Alperin,G.,
            Culpepper,J., Gutierrez-Ramos,J.C. and Gearing,D.
  TITLE     Neurotactin, a membrane-anchored chemokine upregulated in brain
            inflammation
  JOURNAL   Nature 387 (6633), 611-617 (1997)
   PUBMED   9177350
  REMARK    Erratum:[Nature 1997 Sep 4;389(6646):100]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134455.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030358.2, BC070938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000019.1  10242731-10242820   c
            91-211              JAXUCZ010000019.1  10237678-10237798   c
            212-3057            JAXUCZ010000019.1  10233334-10236179   c
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..3057
                     /gene="Cx3cl1"
                     /gene_synonym="Cx3c; Scyd1"
                     /note="C-X3-C motif chemokine ligand 1"
                     /db_xref="GeneID:89808"
                     /db_xref="RGD:620458"
     exon            1..90
                     /gene="Cx3cl1"
                     /gene_synonym="Cx3c; Scyd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1202
                     /gene="Cx3cl1"
                     /gene_synonym="Cx3c; Scyd1"
                     /note="small inducible cytokine subfamily D, 1;
                     neurotactin; C-X3-C motif chemokine 1; chemokine (C-X3-C
                     motif) ligand 1; small-inducible cytokine D1; CX3C
                     membrane-anchored chemokine; fractalkine"
                     /codon_start=1
                     /product="fractalkine precursor"
                     /protein_id="NP_604450.2"
                     /db_xref="GeneID:89808"
                     /db_xref="RGD:620458"
                     /translation="MAPSQLAWLLRLAAFFHLCTLLAGQHLGMTKCNITCHKMTSPIP
                     VTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNGGK
                     FEKRVDNVTPRITSTTRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPA
                     AVTGSFPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSAVYQSGSSLWAEEKATES
                     PPTIALSTQVSTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVHTDIFQDRGP
                     GSTVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKLSVFITPVPDSQAAT
                     RRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVLVP
                     V"
     exon            91..211
                     /gene="Cx3cl1"
                     /gene_synonym="Cx3c; Scyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..3057
                     /gene="Cx3cl1"
                     /gene_synonym="Cx3c; Scyd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcactccag ccatccagcc atggctccct cacagctcgc gtggctgctg cgcctggccg
       61 cgttctttca tctgtgtact ctgctggcgg gtcagcacct cggcatgacg aaatgcaaca
      121 tcacgtgcca caagatgacc tcgccaatcc cggtgacctt gctcatccac tatcaactga
      181 accaggagtc ctgcggcaag cgcgccatca tcctggagac gagacagcac agacacttct
      241 gtgctgaccc aaaggagaaa tgggtccaag acgccatgaa gcacctggac caccagaccg
      301 ctgccctgac tagaaatggt ggcaagtttg agaagcgtgt ggacaatgtg acacctagga
      361 tcacctcgac caccagggga ctgtccccaa ctgccctggc aaagcctgag tcagccacag
      421 tggaagacct tactttggaa ccgactgcta tttcccagga ggcccgaagg cccatgggga
      481 cttcccaaga gccaccagca gcagtgactg gatcgtttcc ctcaacttcc aaagctcagg
      541 atgcagggct tgccgccaag cctcagagca ctggaatttc tgaggtggct gctgtctcta
      601 ccaccatttg gccgagttct gctgtctacc aatctggatc tagcctctgg gccgaggaaa
      661 aagctactga atcccccccc actatagccc tgtctactca agtgtccacc acttcaagcc
      721 ccaagcagaa tgttgggtct gaaggccagc ccccatgggt ccaggagcag gactccactc
      781 cagagaaatc tccagggcct gaggagacaa acccagttca tactgatatt ttccaagaca
      841 gaggacctgg cagcacagtc catccctcag tggctcccac ctcctctgaa aagaccccca
      901 gcccagagct ggtggcctcg ggcagccagg ctcctaaggt agaggaaccc attcatgcca
      961 ctgcagatcc ccagaaactg agtgtgttta tcactcctgt ccctgactcc caggcagcca
     1021 cccggaggca ggcagtgggg ttactggcct ttcttggtct actcttctgt ctgggggtgg
     1081 ccatgtttgc ctaccagagc ctccagggct gtccccgcaa aatggcaggg gagatggtgg
     1141 aaggcctccg ctacgtcccc cgtagctgtg gcagtaactc gtacgtcctg gtgccggtgt
     1201 gagctgcctg cttgcctgcc cgtgtccaga gtgtgattca gacagctgtc tggggacccc
     1261 catcctcata cccaccttca tccacgctgg gagaatggga atgcagaagc tggatcctcc
     1321 aggggccatg tgctccaacc cccgaggagt ggccctggag gccaccctag accattattc
     1381 acttatcaga gacagacaga gcaggtggcc ttccagctcc cccatatttg aaagaatcct
     1441 ctgctgctgg ctggttagag gggcccttga catcccaaac tctatgagca attatttatt
     1501 ggattcccag cccctgagac acccgtttcc cgtgcgcacc gtggtccacc catcttacaa
     1561 gcagcaggcc aggcctctct gcctgtcccc tgacctcctc gtgtctcctg gctttgctgc
     1621 agtcgccagc cctgtctcct ccccggccag ctgcggtgct atctatcccg gtctctctct
     1681 cccgtgtaca gagccatcac caccatcacc accaacaact cgttctgtct ttgcttgcat
     1741 gaggttaatg ctgtgttttc tggagctctc tgggacggga gatgagcttc tgtgagggtt
     1801 taaagtgttc ctccccagac tttgatgtgc cgtgaaggca tgctgcctct gaaggaaggc
     1861 tctggtcccc actccgctgc cagcacaaca aagtgcccca cctgtaaagg aaaagagact
     1921 cggcccagag ctggcaaaaa cccatggccc tgacatcatc actttctctg agatctttgt
     1981 ccccatccct ggatgccacc ccccccccag cccttatcaa catgaatagt cactgccatt
     2041 ccactggact gacacttttg tatgctgtga ttctgagggc tggcaaggga tgacttgaga
     2101 gtgcagatcc taccccatgg gcccccaaat ggaggctgag ctggggacct gcaggaagag
     2161 aggccaactc agaaggctcc actgtgttct cactggcacc cctcccctgt gcaccaaggt
     2221 gacagtcaca ggtctgccct gcctgaagaa caagccacag aaggaagatt atgacaagtc
     2281 cctgggaggc caaggatcca gggcaaaccc ctggagtggc cacacaccca atttcagctt
     2341 agggacttgt gcatgtgtgt acttgcacag cccagatcat tcagaagctg ccagggtcct
     2401 ttcctacatc tgagagcgca gttcctgcca aggtctcacc ttcgcctcac ttcaggcagg
     2461 gccagaactc ccataacatt ctccaagagc cctgtgacgt gttctggaag ggactctgcc
     2521 ctgggcacaa agtgtctact gaagcagaga gcagcgcccc agcgccccag cgccccagcg
     2581 ccccagcggg agctgtaccg gcagaccacg cccctggggg gagggccctc cgttgcagct
     2641 ttccccaccc tgctctgaat agctccaacc gtcacctttg gagcctccca ggggcgggct
     2701 tcacccagcc agtgactcac tccttgatag gtggaagctc agaacaggtg gctctgtccc
     2761 agagtgagga agccagcccc ttggcgaccc ttctcttggg aagcttgtgg gaggctctgg
     2821 tctggctcca gagtactagt tgtaggcctg aggagcagca gcccgagtgc actatatcct
     2881 ggttccttcg gtggggagcc ttcaagggtt gggacaccca tggttggact ttgttggttc
     2941 ccgcgcctcg tgggccaaaa caatctgagg aggactttgg aaggagttgg tttttcaagc
     3001 atcattacca atgtctgtgc cattttgtat tttactaata aaattttaaa gtcttgt
//
