LOCUS       NM_001399981            3099 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus CWC22 spliceosome associated protein (Cwc22),
            mRNA.
ACCESSION   NM_001399981 XM_342453
VERSION     NM_001399981.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   Zhang,X., Yan,C., Zhan,X., Li,L., Lei,J. and Shi,Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Zhan,X., Yan,C., Zhang,X., Lei,J. and Shi,Y.
  TITLE     Structure of a human catalytic step I spliceosome
  JOURNAL   Science 359 (6375), 537-545 (2018)
   PUBMED   29301961
REFERENCE   3  (bases 1 to 3099)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   4  (bases 1 to 3099)
  AUTHORS   Barbosa,I., Haque,N., Fiorini,F., Barrandon,C., Tomasetto,C.,
            Blanchette,M. and Le Hir,H.
  TITLE     Human CWC22 escorts the helicase eIF4AIII to spliceosomes and
            promotes exon junction complex assembly
  JOURNAL   Nat Struct Mol Biol 19 (10), 983-990 (2012)
   PUBMED   22961380
REFERENCE   5  (bases 1 to 3099)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 19, 2022 this sequence version replaced XM_342453.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231579.1, FQ231274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000003.1  83271170-83271206   c
            38-169              JAXUCZ010000003.1  83261283-83261414   c
            170-240             JAXUCZ010000003.1  83257669-83257739   c
            241-351             JAXUCZ010000003.1  83256550-83256660   c
            352-597             JAXUCZ010000003.1  83254386-83254631   c
            598-726             JAXUCZ010000003.1  83252436-83252564   c
            727-895             JAXUCZ010000003.1  83249665-83249833   c
            896-949             JAXUCZ010000003.1  83249328-83249381   c
            950-1085            JAXUCZ010000003.1  83246348-83246483   c
            1086-1292           JAXUCZ010000003.1  83245923-83246129   c
            1293-1355           JAXUCZ010000003.1  83245776-83245838   c
            1356-1463           JAXUCZ010000003.1  83242067-83242174   c
            1464-1545           JAXUCZ010000003.1  83240599-83240680   c
            1546-1606           JAXUCZ010000003.1  83236587-83236647   c
            1607-1684           JAXUCZ010000003.1  83233868-83233945   c
            1685-1837           JAXUCZ010000003.1  83232915-83233067   c
            1838-1965           JAXUCZ010000003.1  83231176-83231303   c
            1966-2067           JAXUCZ010000003.1  83229878-83229979   c
            2068-2285           JAXUCZ010000003.1  83229569-83229786   c
            2286-3099           JAXUCZ010000003.1  83222400-83223213   c
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3099
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /note="CWC22 spliceosome associated protein"
                     /db_xref="GeneID:362153"
                     /db_xref="RGD:1565385"
     exon            1..37
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            38..169
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2863
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /note="CWC22 homolog, spliceosome-associated protein;
                     CWC22 spliceosome associated protein homolog"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor CWC22 homolog"
                     /protein_id="NP_001386910.1"
                     /db_xref="GeneID:362153"
                     /db_xref="RGD:1565385"
                     /translation="MKSSMAHMKQSSGHDRRESHNSYHRRSSSPEDRYTEQDRSPRDR
                     DYSDYSRSDYERSRRGYSYDDSMESRSRDREKRRERERDADHRKRSRKSPSPERRSPD
                     RGVSQSSTQEEPTSKKKKDEQDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSW
                     EALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAA
                     LVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCL
                     EMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQ
                     YMIEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNF
                     MENEEKYKVIKKEILDEGDSDSNTDQEAGSSEDEEEDEEEEEGEEEEGGQKVTIHDKT
                     EINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYEKF
                     FGLLAGRFCMLKKEYMESFESIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSV
                     LECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPR
                     NTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDAEQKKPVLTSSSSESSSGSD
                     SSDSDSDSSESSSESSSEASDSSSSSSQSSASAKGSRKKRQGKARGEEVDKLARSHQA
                     RDRRREGGREDQRHQEGRTERARSERHRAQHSRDADWRDPPAKHMEDRSHENSYNRVG
                     NGREQGSHREPEDRHGEPRKKRRERRDSFSENEKQRARNQDSDNVRRKDGSKSRERSR
                     KHSGHKGDDDDRYQNGAERRWEKPSRYAEHSRESKRSQDRRREKSPTKHK"
     exon            170..240
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            241..351
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            352..597
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            598..726
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            727..895
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            896..949
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1085
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1292
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1355
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1463
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1545
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1606
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1684
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1837
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1965
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2067
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2285
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..3099
                     /gene="Cwc22"
                     /gene_synonym="RGD1565385"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacttccgg tgtgatggcg gcgcggtgga gctttaggtg acgtgtggag acagaaaact
       61 gacaaggaac tcagaccatt gagtacgtgt cacttagaaa aacctgaaga atctggttta
      121 tcgggtcagc cgacagcaga aaatgaaaag tagtatggca cacatgaaac agtcctctgg
      181 tcacgacaga agggagagcc acaattcata ccaccggagg agctcctccc cagaagacag
      241 atatacagag caagaccggt ccccccggga tagagactat tctgattaca gccggtcaga
      301 ctatgagcga tccagaagag gatactctta cgatgacagc atggaatcac gaagcaggga
      361 ccgagagaaa cgcagagaga gagagagaga cgcagaccat cggaaacggt cccggaaatc
      421 cccgtctccg gaaaggagga gcccagaccg aggagtgagc cagagttcta ctcaggaaga
      481 accgacatcg aagaagaaga aggatgagca ggacccgctg ctcacccgca ctgggggagc
      541 gtatatccct cctgcaaagc tcaggatgat gcaggagcag atcacggata aaaacagctt
      601 agcataccag aggatgagct gggaggctct gaagaaatcc atcaatggtc tcatcaacaa
      661 ggtcaacatc tcaaatataa gcatcattat ccaagagctc cttcaagaga acatcgttag
      721 agggagagga ttgctgtcca gatctgttct gcaagcacag agcgcttctc ccattttcac
      781 tcatgtttat gcagctttgg tggcgataat caactcaaag ttcccacaga ttggagaact
      841 gatcctcaag agactaattc tcaattttcg gaaaggatac cgaaggaacg ataagcaact
      901 ttgcctgact gcttcaaaat ttgtggcaca tcttattaac caaaatgtgg cacatgaggt
      961 tctgtgcctg gagatgctca ctttgctgct agagagacca accgatgaca gtgttgaagt
     1021 agctatcggc ttcctcaagg agtgtggtct caaattaacc caggtgtcac caaggggaat
     1081 caatgcaatc tttgaacgcc tgcgaaacat tctgcatgag tccgagattg acaaaagagt
     1141 ccagtacatg attgaagtga tgtttgctgt acggaaggat ggattcaagg accaccctgt
     1201 tattctggaa ggacttgact tagtggaaga ggatgatcag tttacacaca tgctcccctt
     1261 ggaggatgac tacaatccag aagatgttct taatgttttc aagatggatc ctaattttat
     1321 ggagaatgaa gagaagtaca aggttattaa aaaagaaatc cttgatgaag gagacagtga
     1381 ctcaaacaca gaccaggaag caggaagtag tgaagatgag gaggaggacg aggaagagga
     1441 agaaggtgaa gaagaggaag gaggacagaa agtaactatt catgataaaa cagaaatcaa
     1501 cctagtctcg tttcgccgta caatatatct tgctattcag tcaagtttag attttgaaga
     1561 atgtgcacac aagttgctga aaatggagtt tgctgagagc caaacaaaag aactctgcaa
     1621 catgatactt gattgctgtg cccaacaaag aacctatgaa aaattttttg gcttgttagc
     1681 tgggcggttt tgtatgctga aaaaagagta catggaatca tttgaaagta tattcaagga
     1741 acagtacgac accatccacc gcttagagac aaacaaattg agaaatgttg ctaagatgtt
     1801 cgctcacctt ttatacacag actcacttcc gtggagtgtt ctcgagtgta taaagctgag
     1861 tgaagagacg acgacatcat ccagtaggat ttttgtcaag atcttcttcc aggagctgtg
     1921 tgaatacatg ggtcttccta aactgaatgc gaggttaaag gatgaaactc ttcagccatt
     1981 ctttgaagga ctgttacccc gagacaaccc acgcaacacc cggtttgcca tcaacttctt
     2041 cacttccata ggtctcggag gattgacgga tgaacttcga gaacatctga aaaatacgcc
     2101 caaggtcatt gtagcccaga aaccagatgc tgagcagaag aaaccggtcc taacatcttc
     2161 atcttcagag tcttcctcgg ggtctgattc ctctgactca gattctgaca gcagcgagag
     2221 cagctcagag tcctccagtg aagcgagcga ctcctcctcc tccagcagtc agagctctgc
     2281 ctcagctaaa ggttcaagaa agaaaagaca aggaaaggcc agaggtgaag aagtagataa
     2341 gttagccagg agccaccagg cacgtgacag gcggcgagaa ggaggcagag aggaccaaag
     2401 gcatcaggaa gggaggactg agagagcaag gtctgaaaga cacagagctc agcactcacg
     2461 agatgcagac tggcgagatc ccccagcaaa gcacatggag gacagaagtc atgagaatag
     2521 ttacaacaga gttggcaatg gccgagaaca aggctcgcac agagagccag aagacaggca
     2581 tggcgagcca aggaagaagc ggcgagagag aagagattct ttttctgaaa atgagaagca
     2641 aagagcccga aatcaggaca gtgataatgt tagaagaaaa gatggctcca agtcaagaga
     2701 gaggagtagg aagcattctg gtcataaagg agatgatgac gacaggtatc agaacggtgc
     2761 cgagagacgc tgggaaaaac ctagcagata cgctgaacat tctagagaat cgaagagaag
     2821 tcaggaccgg aggagagaaa agtctccaac aaaacacaaa taactctaat gacaactgga
     2881 ctcgccttac attcagttca atgtcctttt tacattgatg gattttatag agaactctgt
     2941 ataaagtacc tgtttgtaaa ttttaaagat tttttttgac atgttttata attgatatat
     3001 ctcaaggttc tttgtgtaaa atcataaaga aaagggactc aacaaagggg taaatcttat
     3061 gttttgtgaa taaaaggaac aaatgttcat tgaatcatt
//
