LOCUS       NM_054005               2263 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CUB and zona pellucida-like domains 1 (Cuzd1),
            mRNA.
ACCESSION   NM_054005
VERSION     NM_054005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2263)
  AUTHORS   Santos,Y., Martinez,M., Sandoval,A., Rodriguez,A.A., Falcon,A.,
            Heimer de la Cotera,E.P., Aguilar,M.B., Flores,P., Felix,R. and
            Arreguin,R.
  TITLE     Arrhythmogenic effect of a crude extract from sea anemone
            Condylactis gigantea: possible involvement of rErg1 channels
  JOURNAL   Toxicon 67, 47-54 (2013)
   PUBMED   23499927
  REMARK    GeneRIF: The arrhythmogenic effect of a crude extract from sea
            anemone Condylactis gigantea possibly involves rErg1 channels.
REFERENCE   2  (bases 1 to 2263)
  AUTHORS   Safar,B. and Sands,D.
  TITLE     Perianal Crohn's disease
  JOURNAL   Clin Colon Rectal Surg 20 (4), 282-293 (2007)
   PUBMED   20011424
REFERENCE   3  (bases 1 to 2263)
  AUTHORS   Leong,C.T., Ng,C.Y., Ong,C.K., Ng,C.P., Ma,Z.S., Nguyen,T.H.,
            Tay,S.K. and Huynh,H.
  TITLE     Molecular cloning, characterization and isolation of novel spliced
            variants of the human ortholog of a rat estrogen-regulated
            membrane-associated protein, UO-44
  JOURNAL   Oncogene 23 (33), 5707-5718 (2004)
   PUBMED   15184879
  REMARK    Erratum:[Oncogene. 2004 Nov 18;23(54):8857]
REFERENCE   4  (bases 1 to 2263)
  AUTHORS   Imamura,T., Asada,M., Vogt,S.K., Rudnick,D.A., Lowe,M.E. and
            Muglia,L.J.
  TITLE     Protection from pancreatitis by the zymogen granule membrane
            protein integral membrane-associated protein-1
  JOURNAL   J Biol Chem 277 (52), 50725-50733 (2002)
   PUBMED   12401800
REFERENCE   5  (bases 1 to 2263)
  AUTHORS   Huynh,H., Ng,C.Y., Lim,K.B., Ong,C.K., Ong,C.S., Tran,E., Tuyen
            Nguyen,T.T. and Chan,T.W.
  TITLE     Induction of UO-44 gene expression by tamoxifen in the rat uterus
            and ovary
  JOURNAL   Endocrinology 142 (7), 2985-2995 (2001)
   PUBMED   11416020
REFERENCE   6  (bases 1 to 2263)
  AUTHORS   Chen,D., Xu,X., Zhu,L.J., Angervo,M., Li,Q., Bagchi,M.K. and
            Bagchi,I.C.
  TITLE     Cloning and uterus/oviduct-specific expression of a novel
            estrogen-regulated gene (ERG1)
  JOURNAL   J Biol Chem 274 (45), 32215-32224 (1999)
   PUBMED   10542259
  REMARK    Erratum:[J Biol Chem 2000 Feb 18;275(7):5248]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_054005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022147.1, BC090345.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               JAXUCZ010000001.1  195532399-195532733 c
            336-486             JAXUCZ010000001.1  195530492-195530642 c
            487-701             JAXUCZ010000001.1  195528138-195528352 c
            702-852             JAXUCZ010000001.1  195526784-195526934 c
            853-1070            JAXUCZ010000001.1  195526256-195526473 c
            1071-1243           JAXUCZ010000001.1  195524983-195525155 c
            1244-1635           JAXUCZ010000001.1  195522305-195522696 c
            1636-1904           JAXUCZ010000001.1  195520502-195520770 c
            1905-2263           JAXUCZ010000001.1  195519609-195519967 c
FEATURES             Location/Qualifiers
     source          1..2263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2263
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /note="CUB and zona pellucida-like domains 1"
                     /db_xref="GeneID:117179"
                     /db_xref="RGD:619771"
     exon            1..335
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2077
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /note="CUB and zona pellucida-like domain-containing
                     protein 1; estrogen-regulated protein 1;
                     uterus/ovary-specific protein 44; CUB and ZP
                     domain-containing protein 1; integral membrane-associated
                     protein 1; uterine-ovarian-specific gene 44;
                     estrogen-regulated gene 1"
                     /codon_start=1
                     /product="CUB and zona pellucida-like domain-containing
                     protein 1 precursor"
                     /protein_id="NP_446457.2"
                     /db_xref="GeneID:117179"
                     /db_xref="RGD:619771"
                     /translation="MEVTGRLFIWAILAVSCRAQLNSTAAEGRPRCTASLGGANLGET
                     HKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPL
                     LGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFSSGTTIPNCGGYLQT
                     LEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGP
                     STTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYASTYVQEVNTTSLS
                     CASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDH
                     TISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGK
                     YNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDF
                     ASPTYDLISSGCSRDETCKVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDH
                     TSRCNQGCVSRRKRDIPSYKWKTDSVIGPIRLKRDRLVNGDSGLLPQTHEAEISKQPL
                     SHLHLFSFMVLALNVVIVVTATVRHFLNRWKDHGYQKLQVY"
     exon            336..486
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            487..701
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            702..852
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1070
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1243
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1635
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1904
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2263
                     /gene="Cuzd1"
                     /gene_synonym="ERG1; Itmap1; Uo; UO-44; Utczp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgataggag ctctatgtag ctgctgagct ctgtgcagaa ttgggctggc tggcccatag
       61 ccctttgagg agcgacctgg aagggtgagt gctgtaccag gaactgctgg ccaggataca
      121 gctccacagc tgtggagctc tcaccagcac cacccttggt gtggccaaac cgacacgttt
      181 ccctagacac caggaagccg acaaaactca gaaaactata aaaagcctga gggctctgag
      241 gcaccctgcc aagatggagg tcactggaag gctgttcatt tgggccattt tagctgtctc
      301 ctgtagggca cagctcaatt ctacagcagc tgaaggcaga ccaagatgca cggccagtct
      361 gggaggggcc aatctgggag agacccacaa ggctctgatc ctaaatctca atgctgatga
      421 gaactgcact tggaccatag agagacctga aaacaggagc atcagaatca tcttctccca
      481 catccagttg gatccagaca gtcggtgtga aaatgaaagc attaaggtgt ttgatggacg
      541 ctccaccagt gggcctctgc taggggaggc ctgcagcaaa aatgacttcg tgcctgtgtt
      601 tgagtcatcg gccaattcac tgacgtttca gatagtcact gactggacaa gggttcaaag
      661 gagtgtcttt atcttctact atttcttttc ctctggtacc actattccaa actgcggtgg
      721 ttacctgcaa acattggaag gatccttcag cagccccaat tatccaaggc cacaccctga
      781 gctggcatac tgtgtgtggc acatacaagt ggagaaaggc tataagataa acttgaattt
      841 tacagagctc ttcctagaaa tggatgaata ctgccgattt gacttcatcg cagtctacga
      901 tggcccctct accacatcgg gcttgctcaa acaggtgtgc ggccgtggga cacctacctt
      961 tgagtcttcc tctgatgcca tgactgttgt gctgtctaca gattatgcca attcctacag
     1021 aggcttcttt gcttcctacg cttcaaccta cgtacaagag gtcaacacta catctttaag
     1081 ttgtgcttct gacaagatga gagtcatcat cagcaagtca tacctacagt cacttaacta
     1141 ccatgagagc aatttgcagc taaacgaccc gacttgcaga ccgagtgtat caaacgttgt
     1201 agagttctct atccctctgc atgaatgcgg tacaatcaaa aagatagagg accacactat
     1261 cagttatacg aacataatca ccttcaccca gtctccagaa tctgccgtga tcacccgaaa
     1321 gaggcacctt cagattgtgg tgacgtgtga gatggagtat aattcaactg tggagattct
     1381 gtacataacc gaagacgacg tcatacaaaa tcaaagtgtc ctgggcaaat acaacaccag
     1441 catggctctt tatgagtccg gctcctttga aaaccttata caggagtcac cgtattatgt
     1501 agatttgaac caaacccttt ttgtccaagc cactttgcac acctcagatc caagcctggt
     1561 ggtgtttctg gacacttgca gagcctctcc cacatccgac tttgcatctc caacctatga
     1621 cttaatcagc agcgggtgta gtcgagatga gacctgtaag gtgtacccct tatttgggca
     1681 ctacgggaga ttccagttca atgcctttaa attcttgaga catctgagtt ctgtgtatct
     1741 caagtgtaag attttgatct gtgataccag tgaccacaca tctcgctgca atcaaggctg
     1801 cgtctcaaga aggaaacgag atattccttc atacaaatgg aagactgatt ctgttatagg
     1861 accaattcgc ctgaagaggg accgacttgt aaatggagat tcaggacttc tgcctcaaac
     1921 acacgaagca gagatttcga agcagcctct cagccatctg cacctgtttt ccttcatggt
     1981 tcttgctctg aatgtggtga ttgtggtcac agccacagtg aggcattttc taaatcgatg
     2041 gaaggatcac ggataccaga agctgcaggt ctactagctg tggaccccaa gaaaggcctc
     2101 ttgtcctctt ctgggtggcc gatgaaaaag ttctctgtgc ctacgagggt taggactata
     2161 ccagaaaggc ctaaaagcag cgtgtgtacc gtcatgctcg tatcacagcc tcagtgtgtt
     2221 tcattatggg atagctgaaa tgaataaata gtatgtctgg tca
//
