LOCUS       NM_053860              12860 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cut-like homeobox 1 (Cux1), transcript variant 1,
            mRNA.
ACCESSION   NM_053860 XM_008760260 XM_008769165
VERSION     NM_053860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12860)
  AUTHORS   Zuo,X., Chen,Z., Cai,J., Gao,W., Zhang,Y., Han,G., Pu,L., Wu,Z.,
            You,W., Qin,J., Dai,X., Shen,H., Wu,J. and Wang,X.
  TITLE     5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma
            Progression Through FoxO6 in AKT-Dependent and Independent Manners
  JOURNAL   Hepatology 69 (5), 2031-2047 (2019)
   PUBMED   30561038
REFERENCE   2  (bases 1 to 12860)
  AUTHORS   Wang,J., Wang,Y., Sun,D., Ren,F., Pang,S. and Xu,S.
  TITLE     CUTL1 induces epithelial-mesenchymal transition in non-small cell
            lung cancer
  JOURNAL   Oncol Rep 37 (5), 3068-3074 (2017)
   PUBMED   28405678
REFERENCE   3  (bases 1 to 12860)
  AUTHORS   Fletcher,E., Wade,J., Georgala,P.A., Gillespie,T.L., Price,D.J.,
            Pilley,E. and Becher,J.C.
  TITLE     Oxygen flux reduces Cux1 positive neurons and cortical growth in a
            gestational rodent model of growth restriction
  JOURNAL   Ann Anat 210, 84-93 (2017)
   PUBMED   27986613
  REMARK    GeneRIF: hyperoxia resulted in a reduction of neurons expressing
            Cux1
REFERENCE   4  (bases 1 to 12860)
  AUTHORS   Xu,J. and Li,P.
  TITLE     Expression of EAP1 and CUX1 in the hypothalamus of female rats and
            relationship with KISS1 and GnRH
  JOURNAL   Endocr J 63 (8), 681-690 (2016)
   PUBMED   27250217
  REMARK    GeneRIF: In arcuate nucleus of hypothalamus, CUX1 gene was
            co-expressed in the kisspeptin neurons.
REFERENCE   5  (bases 1 to 12860)
  AUTHORS   Krug,S., Kuhnemuth,B., Griesmann,H., Neesse,A., Muhlberg,L.,
            Boch,M., Kortenhaus,J., Fendrich,V., Wiese,D., Sipos,B.,
            Friemel,J., Gress,T.M. and Michl,P.
  TITLE     CUX1: a modulator of tumour aggressiveness in pancreatic
            neuroendocrine neoplasms
  JOURNAL   Endocr Relat Cancer 21 (6), 879-890 (2014)
   PUBMED   25248790
REFERENCE   6  (bases 1 to 12860)
  AUTHORS   Gingras,H., Cases,O., Krasilnikova,M., Berube,G. and Nepveu,A.
  TITLE     Biochemical characterization of the mammalian Cux2 protein
  JOURNAL   Gene 344, 273-285 (2005)
   PUBMED   15656993
REFERENCE   7  (bases 1 to 12860)
  AUTHORS   Luong,M.X., van der Meijden,C.M., Xing,D., Hesselton,R.,
            Monuki,E.S., Jones,S.N., Lian,J.B., Stein,J.L., Stein,G.S.,
            Neufeld,E.J. and van Wijnen,A.J.
  TITLE     Genetic ablation of the CDP/Cux protein C terminus results in hair
            cycle defects and reduced male fertility
  JOURNAL   Mol Cell Biol 22 (5), 1424-1437 (2002)
   PUBMED   11839809
REFERENCE   8  (bases 1 to 12860)
  AUTHORS   Ellis,T., Gambardella,L., Horcher,M., Tschanz,S., Capol,J.,
            Bertram,P., Jochum,W., Barrandon,Y. and Busslinger,M.
  TITLE     The transcriptional repressor CDP (Cutl1) is essential for
            epithelial cell differentiation of the lung and the hair follicle
  JOURNAL   Genes Dev 15 (17), 2307-2319 (2001)
   PUBMED   11544187
REFERENCE   9  (bases 1 to 12860)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   10 (bases 1 to 12860)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Nov 5, 2019 this sequence version replaced
            XM_008769165.2, XM_008760260.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.30599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000012.1  25743971-25744101
            132-242             JAXUCZ010000012.1  25825511-25825621
            243-290             JAXUCZ010000012.1  25902550-25902597
            291-369             JAXUCZ010000012.1  25920002-25920080
            370-507             JAXUCZ010000012.1  25939568-25939705
            508-631             JAXUCZ010000012.1  25942697-25942820
            632-708             JAXUCZ010000012.1  25950074-25950150
            709-775             JAXUCZ010000012.1  25952749-25952815
            776-824             JAXUCZ010000012.1  25970649-25970697
            825-929             JAXUCZ010000012.1  25977740-25977844
            930-1112            JAXUCZ010000012.1  25983026-25983208
            1113-1171           JAXUCZ010000012.1  25989922-25989980
            1172-1220           JAXUCZ010000012.1  25993603-25993651
            1221-1317           JAXUCZ010000012.1  25995449-25995545
            1318-1989           JAXUCZ010000012.1  25996561-25997232
            1990-2091           JAXUCZ010000012.1  25999861-25999962
            2092-2927           JAXUCZ010000012.1  26001055-26001890
            2928-3093           JAXUCZ010000012.1  26003923-26004088
            3094-3150           JAXUCZ010000012.1  26004724-26004780
            3151-3453           JAXUCZ010000012.1  26022262-26022564
            3454-3642           JAXUCZ010000012.1  26026228-26026416
            3643-3907           JAXUCZ010000012.1  26032120-26032384
            3908-12860          JAXUCZ010000012.1  26036804-26045756
FEATURES             Location/Qualifiers
     source          1..12860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..12860
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /note="cut-like homeobox 1"
                     /db_xref="GeneID:116639"
                     /db_xref="RGD:620618"
     exon            1..131
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..4583
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein cut-like 1; CCAAT displacement protein;
                     homeobox protein cux-1"
                     /codon_start=1
                     /product="homeobox protein cut-like 1 isoform 1"
                     /protein_id="NP_446312.1"
                     /db_xref="GeneID:116639"
                     /db_xref="RGD:620618"
                     /translation="MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKR
                     LIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDP
                     VPALDLGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREY
                     EQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKT
                     RTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ
                     LASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQIS
                     QLEQQLNAKNSTLKQLEEKLKGQADYEDVKKELTTLKSMEFAPSEGAGTQDSTKPLEV
                     LLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGPLPASPPPQLPRNTGEQ
                     VSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQE
                     AGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIA
                     RQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLS
                     DEQNILALRSIQGRQRGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQASS
                     TASSGNSDDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILNPKLLSASPMST
                     VSTYPPLAISLKKTPAAPEASTSALPSAPALKKEAQDAPTLDPPGSADATPGVLRPVK
                     NELVRGSTWKDPWWNPVQPERRNLTTSEETKADETNASGKEKTGSSQPRAERSQLQGP
                     SATAEYWKEWPNAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPL
                     TPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPW
                     SKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSEST
                     PKTSASCSPAPESPMSSSESVKSLTELVQQPCPTIETSKEGKPPEPSDPPTSDSQPTT
                     PLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVS
                     DLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDS
                     QPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELA
                     TQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGD
                     SCDGVEAADTEEPGGNIVATKSQGGPAEVTAAPADREEATQPAEKAKAQPLSSGTPGQ
                     DDGEDAGRSRPPPEGLADAPAPVPNLAAPAAGEDAATSATAPAMATEAPGAARAGPAE
                     RSSALPSTSAPANAPARRPSSLQSLFGLPEAAGARDNPVRKKKAANLNSIIHRLEKAA
                     SREEPIEWEF"
     exon            132..242
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..290
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..369
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..507
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..631
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..708
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..775
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..824
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..929
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1112
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1171
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1220
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1317
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1989
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2091
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2927
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3093
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3150
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3453
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3642
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3907
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..12860
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctggcgg ctcctgaact ccagccccct ctctatcagc ctctcactcc gtctcaatat
       61 gtctcaagat ggcggccaat gtgggatcga tgtttcaata ttggaagcgc tttgatttac
      121 agcagctgca gagagaactt gatgccaccg caacagtatt ggcaaacagg caagatgaga
      181 gcgaacagtc cagaaagcgg ctcattgagc agagccgaga attcaagaag aacactccag
      241 aggatttacg caagcaggta gcaccactgc tcaagagctt ccaaggggag attgatgcac
      301 tgagtaaaag gagcaaagaa gcagaagcag ccttcttgac tgtgtacaag agactaattg
      361 atgttccaga tcccgtacca gccctggacc tcgggcaaca gctggaaata aaagtgcagc
      421 gtctacacga cattgaaaca gagaaccaga aacttaggga aacactagaa gagtacaaca
      481 aggagtttgc tgaagtgaaa aaccaagagg ttacgataaa agcacttaag gagaaaatcc
      541 gagaatacga gcagaccctg aagagtcagg ccgagaccat cgctctggag aaggagcaga
      601 agctacaaaa tgattttgca gagaaggaga gaaagctgca agagacacag atgtccacca
      661 cctcaaagct ggaggaagct gagcacaaac tccagactct gcaaacagcc ctggaaaaaa
      721 ctcgaacaga attatttgac ctgaaaacca aatacgatga agaaaccact gcaaaggccg
      781 acgagatcga gatgattatg actgaccttg aacgagccaa ccagagggca gaggtggcac
      841 agagagaggc agagacttta agggaacagc tttcatcggc caaccactct ctccaactgg
      901 cctcgcagat ccagaaggct ccagatgtgg ccatagaggt gctgacccga tccagcctgg
      961 aagtagagtt ggctgccaaa gagcgggaga ttgcccagct ggtggaagat gtgcagcgac
     1021 tccaggccag cctcaccaag ctgcgtgaga attccgccag ccagatctca cagctggagc
     1081 agcagctgaa cgccaagaat agcacactca aacaactgga agaaaaactc aaaggccagg
     1141 ctgactatga agatgtgaag aaagagttga ccactctgaa gtccatggag tttgcaccat
     1201 cggagggagc agggacacag gactcaacca agcccctgga ggttttactc ctggagaaga
     1261 accgctcgct gcagtccgag aatgccacgc tgcgcatctc caacagtgac ctgagcgggt
     1321 cagccaggag aaaagggaga gaccagcctg agagtcggcg cccgggaccc ttgccggcct
     1381 cccctcctcc tcagttgccc cgcaacacgg gggaacaggt ttccaatact aacggtacac
     1441 accacttctc accagcgggg ttaagtcaag actttttcag ctcaaacctg gccagcccca
     1501 gcctacccct ggcttctaca ggaaagtttg cactaaactc tcttctccag cgacagctaa
     1561 tgcagtcctt ctactccaag gccatgcagg aagccggaag cacaagcacc attttttcaa
     1621 caggtcctta cagcacaaac tccatatctt ccccaagtcc attacaacaa agcccagatg
     1681 taaatggcat ggccccatct cccagccaat cagaaagtgc tgggagcatc tcagagggtg
     1741 aggaaattga tacagcagaa atcgcccggc aggtcaaaga gcaactgatc aagcacaaca
     1801 ttggacagcg catttttgga cattacgtct tgggactatc tcaagggtct gtgagtgaga
     1861 ttctggcccg gccgaagccc tggaataagc tgactgtccg tggcaaggag ccattccaca
     1921 aaatgaagca gttcttgtct gatgagcaga acatcctggc acttcgaagc atccaaggca
     1981 gacagagagg taacatcacg acccggatcc gagcatctga gactggttct gatgaagcca
     2041 tcaagtccat cctagaacaa gccaagaggg aactccaagt gcagaaaacc gctgagccag
     2101 tccaggcgtc ttccacagcc agcagtggga actccgacga tgccatccgc tccatcctac
     2161 agcaggcccg ccgggaaatg gaggcccagc aggctgccct tgaccccgcc ttaaagccag
     2221 caccactgtc ccagcccgac ctcaccatcc tcaaccccaa gctcctgtct gcctcaccca
     2281 tgtctactgt gtccacttac ccccctcttg ccatctccct gaagaaaacc cctgcagcac
     2341 ctgaggccag tacctcagcc ttgcccagtg ccccagccct caaaaaagag gctcaggatg
     2401 cacccacact ggacccacca ggatcagctg atgctacccc gggggtactg aggccggtga
     2461 agaatgagct agtccgtggc agcacctgga aggatccttg gtggaaccct gtacagcctg
     2521 aaagaagaaa tcttaccact tccgaagaga ccaaggccga tgaaacaaat gcaagtggga
     2581 aagaaaagac aggcagcagc caacctcggg ctgagcgcag ccagcttcag ggaccctcgg
     2641 cgacagcaga gtactggaaa gagtggccca acgctgagtc cccatactcc cagagctcag
     2701 agctgagcct cactggagcc agccgcagtg agacacccca gaatagccca ctgccctctt
     2761 ccccaattgt gcccatggca aagccggcca agccttccgt gcccccgctg actcctgagc
     2821 agtatgaggt ctacatgtat caggaagtgg acaccatcga gctcactcgg caggtcaaag
     2881 agaagttggc caaaaatggc atttgccaga ggatctttgg ggagaaggta ctgggcctgt
     2941 cccagggcag cgtcagcgac atgctctcaa ggccaaaacc atggagcaaa ctgacccaga
     3001 aaggccgaga acccttcatc cggatgcagc tctggctgaa tggagagctg ggccaaggtg
     3061 ttctgcctgt gcaagggcaa caacaaggac cagtccttca ctcagtgacg tctctgcagg
     3121 accccctcca gcagggctgt gtgagttcag aaagcactcc aaagacctct gccagctgca
     3181 gccctgcccc tgagtcccca atgagttcca gcgaatctgt gaagagtctc actgagctgg
     3241 tccaacagcc ctgtcccacc attgagacca gtaaagaagg caaaccacca gaacccagtg
     3301 acccacccac ctcagactcc caacccacaa caccgctgcc tctctctgga cactcagccc
     3361 tcagcatcca agaattagta gccatgtctc ctgagctgga cacctatggc ataaccaaga
     3421 gggtcaaaga ggtgctgacg gacaacaacc tcggtcagcg cttatttgga gagaccattc
     3481 tggggctcac ccagggttct gtctccgacc tccttgcccg cccaaagccc tggcataagc
     3541 ttagtctgaa aggacgggag ccctttgtcc gcatgcagct atggctcaac gaccccaaca
     3601 atgtggagaa gctgatggat atgaagcgga tggagaagaa agcctacatg aagaggcgac
     3661 acagctctgt cagtgacagt cagccttgtg aacccccctc tgttggtatc gactatagcc
     3721 agggtgccag cccccagcca caacaccagc tgaagaaacc tcgagtggtc ctggctccag
     3781 aggagaagga agcactgaag cgagcatatc agcagaagcc atacccatca ccaaaaacca
     3841 tcgaggagct tgccacacaa ctcaacctga agactagcac cgtcatcaac tggttccata
     3901 attacaggtc tcggatccgc agagaactgt tcattgagga gattcaagcc ggaagccagg
     3961 gccaggccgg tgccagcgac tcaccttcag ctcgaagtag ccgggctgca cccagctctg
     4021 aaggcgacag ttgtgacggc gtggaagccg ctgacaccga ggagccaggt ggcaacatag
     4081 tggccaccaa gtctcaggga gggccggcag aggtgaccgc agccccggca gaccgggaag
     4141 aagcgacgca gccggccgag aaggcgaagg cacagccact atcctcgggg accccaggac
     4201 aagacgacgg tgaagacgca ggccggtcta ggccacctcc tgagggtctt gctgacgccc
     4261 cagcgcccgt gccaaacctc gccgcacccg cggccggaga ggacgccgct acctcagcca
     4321 ctgccccagc catggccact gaggcccctg gggcggccag ggccggccct gccgagagga
     4381 gttctgcgtt gccaagcacc agcgcgcctg ccaacgcgcc tgcgcgaagg cctagctctc
     4441 tgcagagcct ctttggtctg cctgaggcag cgggcgcccg ggacaacccg gtgcggaaga
     4501 agaaggccgc gaacttgaac agcatcatcc accgcctgga gaaggctgcc agccgggagg
     4561 agcccattga atgggagttc tgagggcgcc gggcctctgg gcctgaccag cagggcctcg
     4621 ccgggctagc caggcctact tgcgcctagc aggtccccca ggcctagtca gcactggcta
     4681 gtggtgggct ggggcaggcg ggtgcgtgga gggctgtgct gacccgaggc ctggacgtgt
     4741 tgcgcactta ccgccctgcg ggccacaggg caaaatcgcc ataggccaag gtgcatatag
     4801 aaaacaaagg agcattaagc ccaatctatg ttgtgttttc aaggaagaaa acggaaatgt
     4861 gtagtcaagc ttttttgtac cctgaagtgt tttttttttt taattgccct aagtgatttc
     4921 cacaggttct ggaataactc tttacagctt ttgccttgcg ccctcctctt tcgtgtgggc
     4981 tttaaaaaaa aaaaaaatca aacccacata ttaaaagggg gctttttatc tgccatctaa
     5041 tggcttcaga gcgataatac actattatct tcttaaacca ggaagggggg gattttttca
     5101 gaaaaattaa aaaagaaagt ttttgtagct gttcagttgc cactaagaga ttgcacagtc
     5161 aaaccgactc taaacacact agtttggatt cctaaatatt ttcaagaaaa gaatcttctc
     5221 gtttgaaact ttgaattaaa ataaaacaca tttactccac atatttttta acaaaaaaaa
     5281 gaaaaaaaaa gaaaagtcac atcaggaaaa atatctgatt ttgtggtagc tgacgtagtg
     5341 ttttcttgta cgtaactaga atcctgacat gtagtgcaca ttgatccata gctttaactg
     5401 actctgggct tttgctggcc agagtttgtt taatacactc cattctaggc caaatcagga
     5461 caaaaagaaa gatccgaatc taggtatttt ataatctgct ttttaacctc taaccgcaga
     5521 gcacgctgat cagacctcat atctcggagg tttaggagac aagttagaac tgtagcatgt
     5581 accggttcat tttgttttat ttatggtgtc tacgtctgtg ttggcacatc tgcgcatgtg
     5641 caagcgtcga aaggaaggaa atgtaggccg gcaaggtcac agcagttagt ccctcacgtg
     5701 caggcaacag tctgctcatc tttccttggc acagaaggca cctcacctca cgccactctc
     5761 cagggcacct aacagactga gccccccagg ggaagatgct ccctgggctt gggcagggct
     5821 ggcgcagcca tgcgcgcaca cactcttcct ctctcttctc atccccttcc caccacaagc
     5881 actgataacc ctatctactc gtgggaagct tccttccctg cagaagagag aacgctctat
     5941 ccccatccct gtagagctgg cccaaactca ccaaaatggt gatgctcttc aattccagac
     6001 cggaccattg gcccttcatt catttctcct ctcacaaggt tttttttatg cacagtttag
     6061 ggcaatctaa gtacaaatca aaagtctaac ttgtctcttg attcctcccg ttgtctttgt
     6121 gtatatgcgt gagtatagag gtggatgaaa gtgtgcgtgc gtgtgcgtgt gcagttttat
     6181 acgtctgtgt attttcttaa gtacctgtgc acacagagtg cactactgcc acctttttca
     6241 ataagctggt ttatcagtca tggcttctac aggttttgct aatttagact ccttattgcc
     6301 atatctttaa actaacaata gatgatttcg gtatatatct atattttttt ttgcttattt
     6361 ataggtgctg tattttatta tctgattgtt aggaagggat gaaaggggca aatattcttt
     6421 agagggatag actgccggca gtattgggta taatttacaa gatgtagctg tcatactgta
     6481 tattactgat tgaaaacttt ttgaccgtat tgtgtatcat tgaaactttt gtcttaggtc
     6541 aacatctttg gatgacattt taatggtgca ttcattattt cttaagttta attaattaat
     6601 agtacttttt tttatttggg agggtgggag ggagttctaa ttttaaaggc atctcccgct
     6661 agtacacctc agcgtgcttg ttatttttta gcttgtaggc tttgactgtc agacgtgaac
     6721 cccatttctt gcatgatgtt tggagcttat gtattttcat tcacagtctt tcaacctgca
     6781 gctgcaagcc cttagttgga gctttcacaa ctgtaagagt cgcgacacta aagacaatgc
     6841 ctttcatgaa tgagaagttc ccaggaggct ctaggaggct gggaggcagg cccctgctct
     6901 gtccttggat ggttgtatca cttctgagct tgagatgaga gttcacagtg gaggaacagg
     6961 agggaaaaca ggcccacctg gctctgtgct gagtgaggaa gagccctgca caccaggggc
     7021 attagggaca tggaggagca gggtcactcc acagaaacct caagggagcc tgtcgtcgtg
     7081 ggtgatggat cttaaattcc taactctcac tagagtgaga agcagagtta acaggaccga
     7141 ggagggtagt gtgtaagttt taaaggcatg tctgttactt aacaaatctg aggaaatgga
     7201 agtcgagggt ttttttccat cctggcagcc acaaggtagc agtgtaagac agcctttgac
     7261 tcttccaagc aagttggtca ttttcgttcc tttaattttt gaactaggtt cttgtcgatg
     7321 tccatcccgt ctcctgtgcc agactccatc tgggtgcttg ttacagtcac ttggttaggt
     7381 ttttgcttga gttctgtatt tgtattttct tatttattat tattgttatt attattatta
     7441 ttttaattga gatcccaact tgatggtgtt tggggttaag ctagcactgt ctgcagtttt
     7501 gctaagagtt gccagtagac agcacagaga cctggggttc catctccctc ctcaagtcct
     7561 ccctcccttc ccagtgtgag tccaagggtt catctttcat cttgaaaagc aatattcaag
     7621 tgccttgaac agcgctccct cgtgtggtga ccttccgctg gctggagacc caaacagtag
     7681 ctcccacaag cagccaccta tcctcttcat actctcagct taaaaagctg aattgtactc
     7741 ctcccccaga gggaaaaaat gattccacat aaaacactaa cacttcatca caggccactg
     7801 ttccatttca aatgctgttt tcttaattgg aggcagtaat cctaactagg tctcacgcca
     7861 ttgcccagtt ggctaagtgg gagcccacca tgaaatcgat gctcacatca acccccttga
     7921 cacctcttgc ttcatgccaa gtccccttac ggcctctgaa gtggcaggaa tatgggttct
     7981 tagacgcccg cccactcact tccactctga cctggctccc attcaccatc tcctcgaaac
     8041 attagtcagt tgagatgtct gaccactgta tattaggctt ctctcttaaa aaaataaaat
     8101 ttaaaaatgc aggcacatag ctgaagttca tatcttccta gctagccacc ttgaaagtgc
     8161 ttatgactgt atcccggctt tgaatcaggg cagactccag gggctgtagt gctaggtatt
     8221 cagccacact gaaaatgagg ccggaagata gctgtcaacc ttcgaggaca gatgcttctg
     8281 ctcagtgtct gtctctttgg taagcttccc tctgatgggc atctctcttc ttgtttaaag
     8341 tcagatctgg tagatggccc agaacatagc agggctgtga gctgagtgac tctgaatgct
     8401 tgtggccaat agagtccctg accgttgcca cgccatagac ctacatagcc catctgcctc
     8461 tacagccagg gccaaattca actgtggagc ctatgaggaa gcttagcagg aagcagcttg
     8521 tatccaatgc aaaaggggtg cactcttggc atcaactaag caccccaagg ttgtgtagct
     8581 gtgaaagccc cagaggtggg gagtcagagt acagataacc agcatcagag atgccctccc
     8641 ttgccatagc aagactttgt ctcttcggag ctgcaggctc ttgaacagca aggctcagtg
     8701 gattctaggc accttggaat ggtttggttc ctgtcacatg ctcctgcttt ccacctgctg
     8761 ccctggactg cagtcattcc agtcagaccc ctgaggctgt gagccatcct tgcagaggtc
     8821 agggagcaca tggatgcagt ggaaggctct tggctgtgtt cctcctgtcc ttcaatgtct
     8881 cccctttctg tctcttctac ctcaccactt gatgtcactc agagttgtga agcaagtggc
     8941 ctgggggagg ggggtgctta agaggctgca agtttgatag ctcatctcga ttggcaggtg
     9001 tgctttctgc ctccttcagt gagcacatcc tcaagtgctg tctggagtct gctaagcaca
     9061 gggattttcc tcttggcttc cagctgttct tgaaattccg gcagttgttg ggtctgtagg
     9121 caggagtggt ctccaacctc agaaattctt gtcttttgct cggccttccc acacagctgt
     9181 cagactccat cacagccatt tcttcagccc tgggttatcc ccaaacaata tgagcacact
     9241 tccccaggaa ctgtggctgt ccgtgtctct agaccttacc atgagctctg ctttacaaac
     9301 agctgtctcc aggacagaaa gggtcagaca gttttctacc ccaccatgca tttgtgatcc
     9361 caaaagaaca tgccagtttc tgttccctgt gggaggaaag cagctcccaa gacagccggt
     9421 ggacctgggt catacctgct ctgatgacca gagcgtgtac ctgtaggcat agggaactat
     9481 gttttatttt gttgttccca tcatgaatgt taaattcacc agacgcagct gctgctgcag
     9541 tttctctggg acttaactga atcaggagaa ggctttatgg ccactttggc ccaggaggcc
     9601 tgagactcta agtgacttgg ttccatctcc cagaggtgct acccaccagt ctgaccagta
     9661 aacttgcatg ctaagagaat gggctgatga gaaattttca ttcttgtcac ttctgccagt
     9721 gcttttcaga tggaaactac caggaaagtc agagtaggga caagcttctc agtaaaggat
     9781 acagttccag ccagtggaag agacagttta ggaacagcaa aggaaaagcc aggattcccc
     9841 gtgtaccact tgaggacctg cttcttcacc aaaccccatc ccactcctgt gccccccact
     9901 actcctctcc tgcccccttc cctccaaaga gtccacagcc acatcttcag tggcatatcg
     9961 agttttcatt tttggacaaa gtgacattta gctttaacaa gacatttcca aagctcctgg
    10021 tctcctttga aatgctgact ttaaaagttc agcattgttg ccaaggatgc gggggagggg
    10081 ctaatgaaag aaagacttag attatgcatg aatgtgcacg ccccgtccct cagttattca
    10141 aatttcaaat gcctttgagt tgcttttcat agatgggttt agtttgctca tgttaagtag
    10201 tctgttactg taatttttgt agtattctgg ctttaatttc taccacaaat atgctatgta
    10261 ctaagctttc tgtgatcaga aaggaaaggt gccttaaatc ccaataccac gcctctatcc
    10321 ctatggaaaa tatatcagaa gcacagtgcc aggaagcatt gggacttccg ttggcaaaat
    10381 aggacaccat tcagcaagac acatccaagt ggcacggggc tgcttttgtt tgctaattcc
    10441 ttttttttct cccaacctat aattatcttt tgtttgttgt ttattttatt tttttttata
    10501 gttcgcttta aacaggaagc acttaataga tggctctgtg tcaaagctct gtgcaatgga
    10561 aatcatgttg cttttgtttg gggggtttgt tttgtttttc ttttcttgtt ttaaaaagat
    10621 agcgttattg cacaccaaat gaactcctaa gtaagcttta gaaccaggat cgattcaggt
    10681 cgtggatggg tatgttcact gtagttctgt gtgttcatga accgacgggc aagctggcct
    10741 cccttggcca ctgaggctca gccctgagcc ctgggtcatg gctgcctggg tcccaacggg
    10801 gaaccttccc ggatgtctga ccccacagtc gacccttgaa gcacttaacc ctctctttgt
    10861 ggagatagac cgactgctac tgatctgtca gcgtactcga gggtgattat aaaaggatgt
    10921 ttctttaaga aagaaaagat atttctatcc tcttctaatt tattattagg ttaatcattt
    10981 aagtacttat caggagtgtg ttgtcatttt gtgttgttgt tgccaatgct tttgctgtca
    11041 ctccagtggt taactgtccc ttgctcccca cctctctcct ccccatccca gagtccaaag
    11101 aggtctgggc ccagcagtgg gagacatgag ggacagaagg gagtcctcca gcacaatcag
    11161 acacctgtct ccctagtacc actcaaaacc tggcggtctc tacatatctt aactgttcaa
    11221 tcgagagagt tgacaaacaa agctacccac gtcaggcagc actgggggga ggcttgctcc
    11281 cagaggcgct gcaatgcagt gagaaaaaca gaaaagccaa gttcaagttc ccccaaagcc
    11341 tcctagagcc tctgttaaaa cttctgggtt catgaatgtt tgacgagcct ggatcagaag
    11401 agaggcaggc agtcaggccg tcaccctgaa ctggaaggtg gtttctcagt ggtccccaca
    11461 ggtgaccacg gcattgattt tcactgtcag ttgtctttcc ttgcattcaa agttagccaa
    11521 aagcatcttt tgaggcaaca ggtatttcct agcactggag gtggctagag ggccctcacc
    11581 tggagcctgg gttgagagaa acctccatcc tcccatatca ggagaagtgg agaaaggact
    11641 ttccatggct ggaaattccg ccagcaacaa gcccccgttg cttgctcagt ggagggtagg
    11701 ggatgtgaga ctgacctcta cctgggtggg ggggggcaaa cttaaaaaag aggctcaccc
    11761 cagggacagg tgaagggcct gctcactgct aggcagggca ggatacctgc ttctacccta
    11821 acggtccact gagcccaaat ccaaatttct ttctgtatct tatctttccc attctttgaa
    11881 atctgggggg caggtcctac tcatctcttt gggggtaaaa tatctcccat aaaattgccc
    11941 caatcccccc aagggttttt atttttctta gtctatgcat ttctctctct gaatctctct
    12001 aattctctcc tcccacccca aacacacaaa atagacatct catgtcccac cctctgagac
    12061 cacccctgcc tcagaaaaat gccggacatt ttgaagacat gagaatgcat ttaaaaaaaa
    12121 aaaaaaaagc cttcaagcat tttgaaaata gcttgtcata agctgacagt ggggaggaat
    12181 cagctccatg attttcctga gtcccttccc ataggacaag agacctagct ctttgcgttt
    12241 gtgcaataac tacttgctag gagagcgggt agcaccaccc tcctctagac tactaacaca
    12301 gcacaagaca cacgtcagcc cttcctaagc ccctccccca tcatgtgtta cattttagca
    12361 gtatttactt tttttttctg tcaggcacta agtcttaggt gtttatagag cttgtgtgtt
    12421 aatacaatca cggatcttat cattttattt taatcctcac caagacccaa ttgaccaaaa
    12481 agaagcaaga ggaagaaaaa gaaattgtaa aagatgtctc tctccttttt tttttttttt
    12541 ttttttgtac aagtagcttt gagaagcctt gtgttgctgt gaccatctcc tatcacagtc
    12601 ttgattttct tgtgatttgt ttttggcatt taagagttgg tcccggctgg cgtgggggtg
    12661 ggggtggggg aggcacccgt cggcccctca gcgccgtccc ttgtctttgg ttagccatac
    12721 gaaatgtttg ttctctgcac tgtcccacgg tccctattat gatacggaga agcaatatca
    12781 ccgaagctca caccatgtat tattcctcac tagcacccta ggtgtgatca ttgaagtaaa
    12841 tatcttttat acaaacacaa
//
