LOCUS       NP_446312               1504 aa            linear   ROD 31-MAR-2024
DEFINITION  homeobox protein cut-like 1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_446312 XP_008758482 XP_008767387
VERSION     NP_446312.1
DBSOURCE    REFSEQ: accession NM_053860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1504)
  AUTHORS   Zuo,X., Chen,Z., Cai,J., Gao,W., Zhang,Y., Han,G., Pu,L., Wu,Z.,
            You,W., Qin,J., Dai,X., Shen,H., Wu,J. and Wang,X.
  TITLE     5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma
            Progression Through FoxO6 in AKT-Dependent and Independent Manners
  JOURNAL   Hepatology 69 (5), 2031-2047 (2019)
   PUBMED   30561038
REFERENCE   2  (residues 1 to 1504)
  AUTHORS   Wang,J., Wang,Y., Sun,D., Ren,F., Pang,S. and Xu,S.
  TITLE     CUTL1 induces epithelial-mesenchymal transition in non-small cell
            lung cancer
  JOURNAL   Oncol Rep 37 (5), 3068-3074 (2017)
   PUBMED   28405678
REFERENCE   3  (residues 1 to 1504)
  AUTHORS   Fletcher,E., Wade,J., Georgala,P.A., Gillespie,T.L., Price,D.J.,
            Pilley,E. and Becher,J.C.
  TITLE     Oxygen flux reduces Cux1 positive neurons and cortical growth in a
            gestational rodent model of growth restriction
  JOURNAL   Ann Anat 210, 84-93 (2017)
   PUBMED   27986613
  REMARK    GeneRIF: hyperoxia resulted in a reduction of neurons expressing
            Cux1
REFERENCE   4  (residues 1 to 1504)
  AUTHORS   Xu,J. and Li,P.
  TITLE     Expression of EAP1 and CUX1 in the hypothalamus of female rats and
            relationship with KISS1 and GnRH
  JOURNAL   Endocr J 63 (8), 681-690 (2016)
   PUBMED   27250217
  REMARK    GeneRIF: In arcuate nucleus of hypothalamus, CUX1 gene was
            co-expressed in the kisspeptin neurons.
REFERENCE   5  (residues 1 to 1504)
  AUTHORS   Krug,S., Kuhnemuth,B., Griesmann,H., Neesse,A., Muhlberg,L.,
            Boch,M., Kortenhaus,J., Fendrich,V., Wiese,D., Sipos,B.,
            Friemel,J., Gress,T.M. and Michl,P.
  TITLE     CUX1: a modulator of tumour aggressiveness in pancreatic
            neuroendocrine neoplasms
  JOURNAL   Endocr Relat Cancer 21 (6), 879-890 (2014)
   PUBMED   25248790
REFERENCE   6  (residues 1 to 1504)
  AUTHORS   Gingras,H., Cases,O., Krasilnikova,M., Berube,G. and Nepveu,A.
  TITLE     Biochemical characterization of the mammalian Cux2 protein
  JOURNAL   Gene 344, 273-285 (2005)
   PUBMED   15656993
REFERENCE   7  (residues 1 to 1504)
  AUTHORS   Luong,M.X., van der Meijden,C.M., Xing,D., Hesselton,R.,
            Monuki,E.S., Jones,S.N., Lian,J.B., Stein,J.L., Stein,G.S.,
            Neufeld,E.J. and van Wijnen,A.J.
  TITLE     Genetic ablation of the CDP/Cux protein C terminus results in hair
            cycle defects and reduced male fertility
  JOURNAL   Mol Cell Biol 22 (5), 1424-1437 (2002)
   PUBMED   11839809
REFERENCE   8  (residues 1 to 1504)
  AUTHORS   Ellis,T., Gambardella,L., Horcher,M., Tschanz,S., Capol,J.,
            Bertram,P., Jochum,W., Barrandon,Y. and Busslinger,M.
  TITLE     The transcriptional repressor CDP (Cutl1) is essential for
            epithelial cell differentiation of the lung and the hair follicle
  JOURNAL   Genes Dev 15 (17), 2307-2319 (2001)
   PUBMED   11544187
REFERENCE   9  (residues 1 to 1504)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   10 (residues 1 to 1504)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Nov 5, 2019 this sequence version replaced
            XP_008767387.1, XP_008758482.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.30599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     Protein         1..1504
                     /product="homeobox protein cut-like 1 isoform 1"
                     /note="homeobox protein cut-like 1; CCAAT displacement
                     protein; homeobox protein cux-1"
                     /calculated_mol_wt=164411
     Region          <17..368
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          404..464
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Region          520..557
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Region          556..632
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          670..691
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Region          <676..>941
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Site            734..742
                     /site_type="cleavage"
                     /note="Cleavage, by CTSL.
                     /evidence=ECO:0000250|UniProtKB:P39880; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Site            750
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39880; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Region          759..912
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Site            893
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Region          923..991
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1020..1094
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Site            1043
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39880; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Site            1053
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Region          1106..1183
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1196..1231
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Region          1229..1285
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Site            1254
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39880; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Region          1296..1476
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53565.2)"
     Region          1300..>1497
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Site            1321
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P53564; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Site            1457
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39880; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Site            1485
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39880; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     Site            1495
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P53565.2)"
     CDS             1..1504
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /coded_by="NM_053860.1:69..4583"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:116639"
                     /db_xref="RGD:620618"
ORIGIN      
        1 maanvgsmfq ywkrfdlqql qreldatatv lanrqdeseq srkrlieqsr efkkntpedl
       61 rkqvapllks fqgeidalsk rskeaeaafl tvykrlidvp dpvpaldlgq qleikvqrlh
      121 dietenqklr etleeynkef aevknqevti kalkekirey eqtlksqaet ialekeqklq
      181 ndfaekerkl qetqmsttsk leeaehklqt lqtalektrt elfdlktkyd eettakadei
      241 emimtdlera nqraevaqre aetlreqlss anhslqlasq iqkapdvaie vltrssleve
      301 laakereiaq lvedvqrlqa sltklrensa sqisqleqql naknstlkql eeklkgqady
      361 edvkkelttl ksmefapseg agtqdstkpl evllleknrs lqsenatlri snsdlsgsar
      421 rkgrdqpesr rpgplpaspp pqlprntgeq vsntngthhf spaglsqdff ssnlaspslp
      481 lastgkfaln sllqrqlmqs fyskamqeag ststifstgp ystnsissps plqqspdvng
      541 mapspsqses agsisegeei dtaeiarqvk eqlikhnigq rifghyvlgl sqgsvseila
      601 rpkpwnkltv rgkepfhkmk qflsdeqnil alrsiqgrqr gnittriras etgsdeaiks
      661 ileqakrelq vqktaepvqa sstassgnsd dairsilqqa rremeaqqaa ldpalkpapl
      721 sqpdltilnp kllsaspmst vstypplais lkktpaapea stsalpsapa lkkeaqdapt
      781 ldppgsadat pgvlrpvkne lvrgstwkdp wwnpvqperr nlttseetka detnasgkek
      841 tgssqpraer sqlqgpsata eywkewpnae spysqssels ltgasrsetp qnsplpsspi
      901 vpmakpakps vppltpeqye vymyqevdti eltrqvkekl akngicqrif gekvlglsqg
      961 svsdmlsrpk pwskltqkgr epfirmqlwl ngelgqgvlp vqgqqqgpvl hsvtslqdpl
     1021 qqgcvssest pktsascspa pespmssses vksltelvqq pcptietske gkppepsdpp
     1081 tsdsqpttpl plsghsalsi qelvamspel dtygitkrvk evltdnnlgq rlfgetilgl
     1141 tqgsvsdlla rpkpwhklsl kgrepfvrmq lwlndpnnve klmdmkrmek kaymkrrhss
     1201 vsdsqpcepp svgidysqga spqpqhqlkk prvvlapeek ealkrayqqk pypspktiee
     1261 latqlnlkts tvinwfhnyr srirrelfie eiqagsqgqa gasdspsars sraapssegd
     1321 scdgveaadt eepggnivat ksqggpaevt aapadreeat qpaekakaqp lssgtpgqdd
     1381 gedagrsrpp pegladapap vpnlaapaag edaatsatap amateapgaa ragpaerssa
     1441 lpstsapana parrpsslqs lfglpeaaga rdnpvrkkka anlnsiihrl ekaasreepi
     1501 ewef
//
