LOCUS       NM_001415775            2853 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cut-like homeobox 1 (Cux1), transcript variant 3,
            mRNA.
ACCESSION   NM_001415775 XM_008769168
VERSION     NM_001415775.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Zuo,X., Chen,Z., Cai,J., Gao,W., Zhang,Y., Han,G., Pu,L., Wu,Z.,
            You,W., Qin,J., Dai,X., Shen,H., Wu,J. and Wang,X.
  TITLE     5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma
            Progression Through FoxO6 in AKT-Dependent and Independent Manners
  JOURNAL   Hepatology 69 (5), 2031-2047 (2019)
   PUBMED   30561038
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Wang,J., Wang,Y., Sun,D., Ren,F., Pang,S. and Xu,S.
  TITLE     CUTL1 induces epithelial-mesenchymal transition in non-small cell
            lung cancer
  JOURNAL   Oncol Rep 37 (5), 3068-3074 (2017)
   PUBMED   28405678
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Fletcher,E., Wade,J., Georgala,P.A., Gillespie,T.L., Price,D.J.,
            Pilley,E. and Becher,J.C.
  TITLE     Oxygen flux reduces Cux1 positive neurons and cortical growth in a
            gestational rodent model of growth restriction
  JOURNAL   Ann Anat 210, 84-93 (2017)
   PUBMED   27986613
  REMARK    GeneRIF: hyperoxia resulted in a reduction of neurons expressing
            Cux1
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Xu,J. and Li,P.
  TITLE     Expression of EAP1 and CUX1 in the hypothalamus of female rats and
            relationship with KISS1 and GnRH
  JOURNAL   Endocr J 63 (8), 681-690 (2016)
   PUBMED   27250217
  REMARK    GeneRIF: In arcuate nucleus of hypothalamus, CUX1 gene was
            co-expressed in the kisspeptin neurons.
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Krug,S., Kuhnemuth,B., Griesmann,H., Neesse,A., Muhlberg,L.,
            Boch,M., Kortenhaus,J., Fendrich,V., Wiese,D., Sipos,B.,
            Friemel,J., Gress,T.M. and Michl,P.
  TITLE     CUX1: a modulator of tumour aggressiveness in pancreatic
            neuroendocrine neoplasms
  JOURNAL   Endocr Relat Cancer 21 (6), 879-890 (2014)
   PUBMED   25248790
REFERENCE   6  (bases 1 to 2853)
  AUTHORS   Gingras,H., Cases,O., Krasilnikova,M., Berube,G. and Nepveu,A.
  TITLE     Biochemical characterization of the mammalian Cux2 protein
  JOURNAL   Gene 344, 273-285 (2005)
   PUBMED   15656993
REFERENCE   7  (bases 1 to 2853)
  AUTHORS   Luong,M.X., van der Meijden,C.M., Xing,D., Hesselton,R.,
            Monuki,E.S., Jones,S.N., Lian,J.B., Stein,J.L., Stein,G.S.,
            Neufeld,E.J. and van Wijnen,A.J.
  TITLE     Genetic ablation of the CDP/Cux protein C terminus results in hair
            cycle defects and reduced male fertility
  JOURNAL   Mol Cell Biol 22 (5), 1424-1437 (2002)
   PUBMED   11839809
REFERENCE   8  (bases 1 to 2853)
  AUTHORS   Ellis,T., Gambardella,L., Horcher,M., Tschanz,S., Capol,J.,
            Bertram,P., Jochum,W., Barrandon,Y. and Busslinger,M.
  TITLE     The transcriptional repressor CDP (Cutl1) is essential for
            epithelial cell differentiation of the lung and the hair follicle
  JOURNAL   Genes Dev 15 (17), 2307-2319 (2001)
   PUBMED   11544187
REFERENCE   9  (bases 1 to 2853)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   10 (bases 1 to 2853)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 29, 2022 this sequence version replaced XM_008769168.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1262026.1,
                                           SRR26360190.138667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000012.1  25743999-25744101
            104-214             JAXUCZ010000012.1  25825511-25825621
            215-262             JAXUCZ010000012.1  25902550-25902597
            263-341             JAXUCZ010000012.1  25920002-25920080
            342-479             JAXUCZ010000012.1  25939568-25939705
            480-603             JAXUCZ010000012.1  25942697-25942820
            604-680             JAXUCZ010000012.1  25950074-25950150
            681-747             JAXUCZ010000012.1  25952749-25952815
            748-796             JAXUCZ010000012.1  25970649-25970697
            797-901             JAXUCZ010000012.1  25977740-25977844
            902-1090            JAXUCZ010000012.1  25983020-25983208
            1091-1149           JAXUCZ010000012.1  25989922-25989980
            1150-1198           JAXUCZ010000012.1  25993603-25993651
            1199-1295           JAXUCZ010000012.1  25995449-25995545
            1296-1423           JAXUCZ010000012.1  26053723-26053850
            1424-1490           JAXUCZ010000012.1  26054837-26054903
            1491-1603           JAXUCZ010000012.1  26055551-26055663
            1604-1720           JAXUCZ010000012.1  26056550-26056666
            1721-1804           JAXUCZ010000012.1  26058613-26058696
            1805-1861           JAXUCZ010000012.1  26059369-26059425
            1862-1942           JAXUCZ010000012.1  26060229-26060309
            1943-2007           JAXUCZ010000012.1  26061410-26061474
            2008-2853           JAXUCZ010000012.1  26061652-26062497
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2853
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /note="cut-like homeobox 1"
                     /db_xref="GeneID:116639"
                     /db_xref="RGD:620618"
     exon            1..103
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2077
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     homeobox protein cut-like 1; CCAAT displacement protein;
                     homeobox protein cux-1"
                     /codon_start=1
                     /product="homeobox protein cut-like 1 isoform 3"
                     /protein_id="NP_001402704.1"
                     /db_xref="GeneID:116639"
                     /db_xref="RGD:620618"
                     /translation="MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKR
                     LIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDP
                     VPALDLGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREY
                     EQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKT
                     RTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ
                     LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQ
                     ISQLEQQLNAKNSTLKQLEEKLKGQADYEDVKKELTTLKSMEFAPSEGAGTQDSTKPL
                     EVLLLEKNRSLQSENATLRISNSDLSGRCAELQIHLTEATAKAVEQKELIARLEQDLS
                     TIQSIQRPDAEGASEQGLEKIPEPIKEATALFYGPSVSSSGTLPEGQVDSLLSIISSQ
                     RERFRTRNQELEAESRMAQHTIQALQSELDSLRADNIKLFEKIKFLQSYPGRGIGSDD
                     TELRYSSQYEERLDPFSSFSKRERQRKYLGLSPWDKATLGMGRLILSNKMARTIGFFY
                     TLFLHCLVFLVLYKLAWSESVERDCAATCAKKFADHLHKFHESDNGAAAGDLWQ"
     exon            104..214
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..262
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..341
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..479
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..603
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..680
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..747
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..796
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..901
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1090
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1149
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1198
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1295
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1423
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1490
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1603
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1720
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1804
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1861
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1942
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2007
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2853
                     /gene="Cux1"
                     /gene_synonym="CDP; CDP2; Cutl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctatca gcctctcact ccgtctcaat atgtctcaag atggcggcca atgtgggatc
       61 gatgtttcaa tattggaagc gctttgattt acagcagctg cagagagaac ttgatgccac
      121 cgcaacagta ttggcaaaca ggcaagatga gagcgaacag tccagaaagc ggctcattga
      181 gcagagccga gaattcaaga agaacactcc agaggattta cgcaagcagg tagcaccact
      241 gctcaagagc ttccaagggg agattgatgc actgagtaaa aggagcaaag aagcagaagc
      301 agccttcttg actgtgtaca agagactaat tgatgttcca gatcccgtac cagccctgga
      361 cctcgggcaa cagctggaaa taaaagtgca gcgtctacac gacattgaaa cagagaacca
      421 gaaacttagg gaaacactag aagagtacaa caaggagttt gctgaagtga aaaaccaaga
      481 ggttacgata aaagcactta aggagaaaat ccgagaatac gagcagaccc tgaagagtca
      541 ggccgagacc atcgctctgg agaaggagca gaagctacaa aatgattttg cagagaagga
      601 gagaaagctg caagagacac agatgtccac cacctcaaag ctggaggaag ctgagcacaa
      661 actccagact ctgcaaacag ccctggaaaa aactcgaaca gaattatttg acctgaaaac
      721 caaatacgat gaagaaacca ctgcaaaggc cgacgagatc gagatgatta tgactgacct
      781 tgaacgagcc aaccagaggg cagaggtggc acagagagag gcagagactt taagggaaca
      841 gctttcatcg gccaaccact ctctccaact ggcctcgcag atccagaagg ctccagatgt
      901 ggagcaggcc atagaggtgc tgacccgatc cagcctggaa gtagagttgg ctgccaaaga
      961 gcgggagatt gcccagctgg tggaagatgt gcagcgactc caggccagcc tcaccaagct
     1021 gcgtgagaat tccgccagcc agatctcaca gctggagcag cagctgaacg ccaagaatag
     1081 cacactcaaa caactggaag aaaaactcaa aggccaggct gactatgaag atgtgaagaa
     1141 agagttgacc actctgaagt ccatggagtt tgcaccatcg gagggagcag ggacacagga
     1201 ctcaaccaag cccctggagg ttttactcct ggagaagaac cgctcgctgc agtccgagaa
     1261 tgccacgctg cgcatctcca acagtgacct gagcgggcgc tgtgcggagc tgcagatcca
     1321 tctcactgag gccacagcca aggccgttga gcagaaggag ctgatcgctc gcttggagca
     1381 ggacctcagc accatccagt ccatccaacg ccctgatgct gagggagctt ccgagcaagg
     1441 cctagagaag attccagagc ccatcaagga ggccacagct ctgttttatg gaccctcagt
     1501 gtcatccagt gggaccctcc cagaaggtca ggtggactcc ctactttcca tcatctccag
     1561 ccaaagggaa cgtttccgca cccggaacca agagctggag gctgagagcc gtatggccca
     1621 gcacaccatc caggccctgc agagcgagct ggacagcctg cgtgccgaca acatcaagct
     1681 ttttgagaag atcaagttct tgcagagtta ccctggccgg ggtatcggca gtgacgacac
     1741 ggagctgcgg tactcctccc agtacgagga acgcctggac cctttctcct ccttcagcaa
     1801 gagggagcgg cagagaaaat acctgggcct gagcccctgg gacaaggcca cacttggcat
     1861 ggggcgtctg attctctcca acaaaatggc ccgcaccatt ggcttcttct acaccttgtt
     1921 cctgcactgt ctggtctttc tggtgctgta caagctggca tggagtgaga gcgtggagag
     1981 agactgtgct gccacctgcg ccaagaagtt cgccgatcat ctgcacaaat tccatgagag
     2041 tgacaatgga gcagcagctg gcgacttatg gcagtgaccc ccaggctcac tggagatgta
     2101 ttggctgcta ccctgtccct tgcttgatca gctgcttcta atgacatagc cttccccttc
     2161 cccccacaaa aaaatccccc acggaaactg tctctgtcct catccaacag ctgccggaag
     2221 ctcagagcct ctagaacccc tttcaaaggt tgtcacaacc ccattggagc cccaaggttc
     2281 aaacaacccc tagcaaccag ctagggtgga ctccctgagt ctctgccctc ggtctagtca
     2341 cctgacctgg gctccaccca catcagaacc tctagccctg gtggcagagc tttctgactg
     2401 tgatacagat tgtcagcacc cactccggca ttcctatagg ctctcgtagg accctgccac
     2461 ataataaaat aggtgggagt cttctgggcc ccagacttct catccgccct cttccccggc
     2521 agggcgggag gcggctttga tacaacctta accgcagtct ccaagtcagg gagccccaga
     2581 gggcgggatg gtttccacta ccccttccct gcacccagtc catgatttga gttctgcttg
     2641 cttctttggc aaaatatttt ggtttctaga agaggaagtc tctccaatga ggtccctgtg
     2701 cctcaggcac cacagacatg gtcccagagg ccccagcaaa acttgtcctg ggccatgata
     2761 gcaaggccaa ctctcaggac ctcagatctt cctccgctgg atttgatctt tttcttcagc
     2821 ttcgcatgaa ataaagaatc attgcagcca cca
//
