LOCUS       NM_212494                718 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cutA divalent cation tolerance homolog (Cuta),
            transcript variant 1, mRNA.
ACCESSION   NM_212494 XM_215338
VERSION     NM_212494.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Liang,D., Nunes-Tavares,N., Xie,H.Q., Carvalho,S., Bon,S. and
            Massoulie,J.
  TITLE     Protein CutA undergoes an unusual transfer into the secretory
            pathway and affects the folding, oligomerization, and secretion of
            acetylcholinesterase
  JOURNAL   J Biol Chem 284 (8), 5195-5207 (2009)
   PUBMED   19049969
  REMARK    GeneRIF: Protein CutA undergoes an unusual transfer into the
            secretory pathway and affects the folding, oligomerization, and
            secretion of acetylcholinesterase.
REFERENCE   3  (bases 1 to 718)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 718)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   5  (bases 1 to 718)
  AUTHORS   Arnesano,F., Banci,L., Benvenuti,M., Bertini,I., Calderone,V.,
            Mangani,S. and Viezzoli,M.S.
  TITLE     The evolutionarily conserved trimeric structure of CutA1 proteins
            suggests a role in signal transduction
  JOURNAL   J Biol Chem 278 (46), 45999-46006 (2003)
   PUBMED   12949080
  REMARK    GeneRIF: comparative x-ray crystallography analysis suggests CutA1
            proteins have a role in signal transduction through allosteric
            communications between subunits.
REFERENCE   6  (bases 1 to 718)
  AUTHORS   Perrier,A.L., Cousin,X., Boschetti,N., Haas,R., Chatel,J.M.,
            Bon,S., Roberts,W.L., Pickett,S.R., Massoulie,J., Rosenberry,T.L.
            and Krejci,E.
  TITLE     Two distinct proteins are associated with tetrameric
            acetylcholinesterase on the cell surface
  JOURNAL   J Biol Chem 275 (44), 34260-34265 (2000)
   PUBMED   10954708
REFERENCE   7  (bases 1 to 718)
  AUTHORS   Navaratnam,D.S., Fernando,F.S., Priddle,J.D., Giles,K., Clegg,S.M.,
            Pappin,D.J., Craig,I. and Smith,A.D.
  TITLE     Hydrophobic protein that copurifies with human brain
            acetylcholinesterase: amino acid sequence, genomic organization,
            and chromosomal localization
  JOURNAL   J Neurochem 74 (5), 2146-2153 (2000)
   PUBMED   10800960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883042.1.
            
            On Sep 11, 2009 this sequence version replaced NM_212494.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               BX883042.1         37122-37253
            133-341             BX883042.1         37469-37677
            342-401             BX883042.1         37797-37856
            402-447             BX883042.1         37965-38010
            448-497             BX883042.1         38104-38153
            498-718             BX883042.1         38396-38616
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..718
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /note="cutA divalent cation tolerance homolog"
                     /db_xref="GeneID:294288"
                     /db_xref="RGD:1303306"
     exon            1..132
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..624
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein CutA; brain acetylcholinesterase
                     putative membrane anchor; divalent cation tolerant protein
                     CUTA"
                     /codon_start=1
                     /product="protein CutA isoform 1 precursor"
                     /protein_id="NP_997659.2"
                     /db_xref="GeneID:294288"
                     /db_xref="RGD:1303306"
                     /translation="MNWGRALGVLLGGGATLLLSFLCMPALLPVASRLLLLPRALLSM
                     ASGSPPSQPSPASGSGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQIT
                     SIYEWKGKIEEDSEVLMMIKTQSSLVPALTEFVRSVHPYEVAEVIALPVEQGNPPYLH
                     WVHQVTESVSGSGKALP"
     exon            133..341
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..401
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..447
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..497
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..718
                     /gene="Cuta"
                     /gene_synonym="CutA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggagacc gctccgctcg gggctcccga tccttcctcg gtgaaatgag cggcctttga
       61 tctctccttt tctctaccag cgcgggctgc atgaactggg ggcgggcgct cggcgtccta
      121 ctcggcggag gggccacgct gctcctgtcg tttctttgca tgcctgccct actgccggtg
      181 gcttcccgcc ttctattgct accccgagct ctgctgtcca tggcttctgg aagccctccg
      241 tcccagccgt cgccggcctc gggctccggc tacgttccag gatcagtctc tgcagccttt
      301 gtcacttgtc cgaacgaaaa agtcgccaag gagattgcca gggcagtggt agagaagcgc
      361 ctggcagcct gcgtcaacct catcccgcag atcacatcca tctatgaatg gaaaggaaag
      421 atcgaggaag atagtgaggt gctgatgatg attaaaacac aaagctccct ggtccctgct
      481 ctgacagagt ttgtccgatc tgtgcaccct tatgaagttg ccgaggtgat cgcactgccc
      541 gtggagcagg ggaatccccc gtatctgcac tgggtgcacc aggtcacgga atcagtgtca
      601 ggctctggca aggccctacc atgacaagcc ctgttcccgc cacagcttcc tctgctcaat
      661 gctcttgggc ttccacatga tgactgagcc cctaataaat cctctcctgc tctccagg
//
