LOCUS       NP_001178511            2513 aa            linear   ROD 31-MAR-2024
DEFINITION  cullin-9 [Rattus norvegicus].
ACCESSION   NP_001178511 XP_002730043 XP_006244580
VERSION     NP_001178511.2
DBSOURCE    REFSEQ: accession NM_001191582.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2513)
  AUTHORS   Li,Z., Pei,X.H., Yan,J., Yan,F., Cappell,K.M., Whitehurst,A.W. and
            Xiong,Y.
  TITLE     CUL9 mediates the functions of the 3M complex and ubiquitylates
            survivin to maintain genome integrity
  JOURNAL   Mol Cell 54 (5), 805-819 (2014)
   PUBMED   24793696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 21, 2021 this sequence version replaced
            XP_006244580.1, NP_001178511.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.23732.1,
                                           SRR26643298.47876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     Protein         1..2513
                     /product="cullin-9"
                     /note="p53-associated parkin-like cytoplasmic protein"
                     /calculated_mol_wt=280436
     Region          366..440
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          1159..1289
                     /region_name="APC10-like"
                     /note="APC10-like DOC1 domains in E3 ubiquitin ligases
                     that mediate substrate ubiquitination; cl02148"
                     /db_xref="CDD:382862"
     Site            order(1185,1213,1219,1221,1281)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176482"
     Region          <1585..1804
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          1856..1936
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; smart00884"
                     /db_xref="CDD:214883"
     Region          2061..2113
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Site            order(2063,2066,2081,2083,2086,2089,2108,2113)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:438286"
     Region          2139..2212
                     /region_name="BRcat_RBR_CUL9"
                     /note="BRcat domain found in cullin-9 (CUL-9) and similar
                     proteins; cd20347"
                     /db_xref="CDD:439008"
     Region          2220..2277
                     /region_name="Rcat_RBR_CUL9"
                     /note="Rcat domain found in cullin-9 (CUL-9) and similar
                     proteins; cd20359"
                     /db_xref="CDD:439020"
     CDS             1..2513
                     /gene="Cul9"
                     /gene_synonym="Parc; RGD1562008"
                     /coded_by="NM_001191582.4:62..7603"
                     /db_xref="GeneID:316228"
                     /db_xref="RGD:1562008"
ORIGIN      
        1 mvgeqragdl mvplgprlqa ypeelirqrp ghdghpeyli rwrvlkcsee gkvsleeekt
       61 eyllmwlsap evyancpmll rersvskgpq yeptgevgsf prdpggldel amaemeddvr
      121 alvrraarql aeggasnltv avlhtihvls ayasigpltg vfretgaldl lmhmlcspep
      181 qirrsagkml qalaahdags rahvllslsq hegieqhmdf dsrytllelf aettsteehc
      241 malegihlpq lpgkllfslv krylcvtsll dqlnnspesg agdqsspclp keksrgqrel
      301 efsmavgnli selvrsmgwa rnlseqgalp prpsrsifqp clsgpplllp tivttprkpg
      361 rafrgrsefs srsgygeyvq qtvqpgmrvr ilddyeeisa gdegefqqsn ngvppvqvfw
      421 qstgrtywvh whmleilgpe eatrepasaa vekgagatal gtacpswdrk pahglyslpy
      481 lqpesqksee pgyltqgeww ellffikkld lceqqpifqn lhekldkavg ektlgeisvp
      541 iemaegvlqv lsnrfegsnl cdllnshiyt kygrlpkepg rlppsrghsc tsepeegses
      601 aasfsekees pkaeaepaga kpespkaqsd sqlfnqllvt egmalapetq aaatemartl
      661 rgpgprssld qhvaavlatv qissldtnlq lsglgalsqa veevterdhp lvrpdrslre
      721 klvktlvdll tnqvgekmvv vlalrllyll mtkhewrplf areggiyavl icmqeyktsv
      781 lvqqaglaal kmlaiansse vptfvtgrds iqplfdtqmt reifasidsa trpgseslll
      841 svpaavvlml ntegcssavr ngllllnlll cnhhtlgdqi itqelrdtlf rhsgiapgte
      901 pmpttrtilm mllsrysepw gsperaalet pstqgqdgsp eslirslvgd lsaelfldle
      961 rvlchegspq gamtpllkrl qqetqpflll lrtldapgpn rallltvlrv mtrlldypet
     1021 mvlpwhevle pclnclngps sdsevvqelt cflhrlalmh kdyavvlccl gakealskvl
     1081 dkhstqllla selrhlvtec ekyaqlytnl tssllaaciq mvlgqiedhr rtykpinipf
     1141 fdvflrhlcq gssvevkedr cwekvevssn phraskltdr npktywesng stgshsitlh
     1201 mhrgvlirql tllvasedss ymparvvvfg gdsvgciste lntvnvvpsa srvtllenls
     1261 rfwpiiqiri krcqqggidt rvrgvevlgp kptfwplfre qlcrrtclfy tiraqawsrd
     1321 iaedrqrllq lyprlnrvlr heqnfadrfl pddeaaqalg ktcwealvsp lvqnitspda
     1381 ggvsslgwll dqylehreka rsrqgqaasf asqvrrlchl lvhveappgp spepssqpls
     1441 kssksqdgsp apapvrpstt lrnitqcwla vvqgqasrfl asawrasdfv prycdlyerl
     1501 qragselfgp raaftlalrs gfsgallqqs fltaahiseq farhidqqiq ggllggaagv
     1561 emlgrlqrhl epimvlsgle lattfehfyq yymadrllsl gsswlegavl eqiglcfpnr
     1621 lpqlmlqslr tseelqrgfl lfqlqqldrq lleqgeqeew klerleeedr gqetgrellt
     1681 edpgpaisvl vlsprcwpvs plcylhqprk hlptefcdal dgfssfyshs qhypvldmgp
     1741 hrrlqwtwlg raelqfgdqt lhvstvqmwl llnfnqteev sveillrnsg lspellhqal
     1801 lpltsdsgpl tleeaqdfpq ggvlrlrepr sqtheevlwl ippqtylsve kdegrtleqk
     1861 rnllscllvr ilkahgekgl hidqlvclvl eawqkgpnpp grlgrsaavg vacsstdvls
     1921 cilhllgqgy verrddrpqv lmyatpepmg hcrgqadvpf cgnqstetsk pspeavvala
     1981 slqlpagrtm spqeveglme qtvrqvqetl nlepdvaqhl layshwgteq llqsysedpe
     2041 plllaaglrv pqpqevparp dqcpvcispl gpnddspslc clhccckscw neylttrieq
     2101 nfvlnctcpi adcpaqptga firnivsspe viskyekall rgyvescsnl twctnpqgcd
     2161 rilcrqglgs gttcskcgwa scfncsfpea hypascghms qwvddggyyd gmsveaqskh
     2221 lakliskrcp scqapiekne gclhmtcarc nhgfcwrclr swkpshkdyy ncsamvskaa
     2281 rqekrfqdyn erctfhhqar efavnlrnqa saihevpppk sftflqdacr aleqarkvla
     2341 yacvysfysq gteymdvveq qtenlelhtn alqilleetl lrcqdlassl rllradclst
     2401 gtellrriqe rllailqhst qdfrvglqsp svetrevkgs nvpsdqpqgs sglevedeee
     2461 eeeeeeeedv pewqhefdee ldndsfsyde esenldretf ffgdedddde syd
//
