LOCUS       NM_022683               2704 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cullin 5 (Cul5), mRNA.
ACCESSION   NM_022683
VERSION     NM_022683.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Weems,J.C., Slaughter,B.D., Unruh,J.R., Boeing,S., Hall,S.M.,
            McLaird,M.B., Yasukawa,T., Aso,T., Svejstrup,J.Q., Conaway,J.W. and
            Conaway,R.C.
  TITLE     Cockayne syndrome B protein regulates recruitment of the Elongin A
            ubiquitin ligase to sites of DNA damage
  JOURNAL   J Biol Chem 292 (16), 6431-6437 (2017)
   PUBMED   28292928
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Simo,S. and Cooper,J.A.
  TITLE     Rbx2 regulates neuronal migration through different cullin 5-RING
            ligase adaptors
  JOURNAL   Dev Cell 27 (4), 399-411 (2013)
   PUBMED   24210661
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Schenkova,K., Lutz,J., Kopp,M., Ramos,S. and Rivero,F.
  TITLE     MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of
            RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a
            predominantly nuclear dimeric protein
  JOURNAL   J Mol Biol 422 (5), 659-673 (2012)
   PUBMED   22709582
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Johnson,A.E., Le,I.P., Andresen,B.T., Stodola,J., Dewey,G.L.,
            Dean,S.B., Resau,J., Haak,P., Ruch,T., Sartor,A., Lazdins,I.,
            Barney,C.C. and Burnatowska-Hledin,M.A.
  TITLE     VACM-1/cul5 expression in vascular tissue in vivo is induced by
            water deprivation and its expression in vitro regulates aquaporin-1
            concentrations
  JOURNAL   Cell Tissue Res 349 (2), 527-539 (2012)
   PUBMED   22581383
  REMARK    GeneRIF: VACM-1 mRNA and protein levels were significantly higher
            in rat mesenteric arteries, skeletal muscle and the heart ventricle
            but not in the heart atrium from 24-h water-deprived rats when
            compared to the controls.
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Le,I.P., Schultz,S., Andresen,B.T., Dewey,G.L., Zhao,P.,
            Listenberger,L., Deen,P.M., Buchwalter,A., Barney,C.C. and
            Burnatowska-Hledin,M.A.
  TITLE     Aquaporin-2 levels in vitro and in vivo are regulated by VACM-1, a
            cul 5 gene
  JOURNAL   Cell Physiol Biochem 30 (5), 1148-1158 (2012)
   PUBMED   23171819
  REMARK    GeneRIF: the data demonstrate that VACM-1 is involved in the
            regulation of AQP2 protein concentration and may play a role in
            regulating water balance.
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Ceremuga,T.E., Yao,X.L., Alam,H.B. and McCabe,J.T.
  TITLE     Alterations of cullin-5 mRNA levels in the rat central nervous
            system following hemorrhagic shock
  JOURNAL   Neurol Res 25 (2), 211-216 (2003)
   PUBMED   12635525
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Ceremuga,T.E., Yao,X.L., Xia,Y., Mukherjee,D. and McCabe,J.T.
  TITLE     Osmotic stress increases cullin-5 (cul-5) mRNA in the rat cerebral
            cortex, hypothalamus and kidney
  JOURNAL   Neurosci Res 45 (3), 305-311 (2003)
   PUBMED   12631466
  REMARK    GeneRIF: Cullin-5 mRNA levels are significantly increased in the
            rat cerebral cortex, hypothalamus and kidney following 48 h of
            water deprivation.
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Ceremuga,T.E., Yao,X.L. and McCabe,J.T.
  TITLE     Vasopressin-activated calcium-mobilizing (VACM-1) receptor mRNA is
            present in peripheral organs and the central nervous system of the
            laboratory rat
  JOURNAL   Endocr Res 27 (4), 433-445 (2001)
   PUBMED   11794467
  REMARK    GeneRIF: transcript encoding vasopressin-activated
            calcium-mobilizing (VACM-1) receptor appears to be ubiquitously
            expressed in various tissues of the laboratory rat
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Burnatowska-Hledin, Zeneberg,A., Roulo,A., Grobe,J., Zhao,P.,
            Lelkes,P.I., Clare,P. and Barney,C.
  TITLE     Expression of VACM-1 protein in cultured rat adrenal endothelial
            cells is linked to the cell cycle
  JOURNAL   Endothelium 8 (1), 49-63 (2001)
   PUBMED   11409851
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Hurbin,A., Orcel,H., Ferraz,C., Moos,F.C. and Rabie,A.
  TITLE     Expression of the genes encoding the vasopressin-activated
            calcium-mobilizing receptor and the dual angiotensin II/vasopressin
            receptor in the rat central nervous system
  JOURNAL   J Neuroendocrinol 12 (7), 677-684 (2000)
   PUBMED   10849213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF135115.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135115.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2704
                     /gene="Cul5"
                     /note="cullin 5"
                     /db_xref="GeneID:64624"
                     /db_xref="RGD:621742"
     exon            1..167
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2486
                     /gene="Cul5"
                     /note="CUL-5; VACM-1; vasopressin-activated
                     calcium-mobilizing receptor 1; vasopressin-activated
                     calcium-mobilizing receptor protein"
                     /codon_start=1
                     /product="cullin-5"
                     /protein_id="NP_073174.1"
                     /db_xref="GeneID:64624"
                     /db_xref="RGD:621742"
                     /translation="MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLF
                     SDVHAVCLWDDKGSSKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFT
                     QCDILPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAM
                     KLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQA
                     PSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKET
                     ILAECQGMIKRNETEKLHLMFSLMDKVPGGIEPMLKDLEEHIISAGLADMVAAAETIT
                     TDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQK
                     GVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVF
                     MRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQ
                     AFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH
                     SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE
                     LPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFSLIKNAKVQK
                     RGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVE
                     ILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYMA"
     exon            168..277
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            278..377
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            378..554
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            555..696
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            697..842
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            843..923
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1017
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1148
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1256
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1321
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1454
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1586
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1710
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1886
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2048
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2167
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2291
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2704
                     /gene="Cul5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgacggc acgccgctcc ggcgtcccct gcatccctcg ctgcggcctg cggggtcctg
       61 ctgggaaccc cggcctctcg aggaggcctg gccccgagag ccgccaagtc tcgccgcgtc
      121 tcgcgagagt ccaagttgag aacatggcga cgtctaatct gttaaagaat aaaggttctc
      181 tccagtttga agacaagtgg gatttcatgc gtccaattgt tttgaagctt ttacgccagg
      241 aatctgtaac aaagcagcag tggtttgatc tgttttcgga tgtacatgct gtctgtctct
      301 gggatgataa aggctcatca aaaattcatc aggctttaaa agaagatatc cttgaattta
      361 ttaagcaagc acaggcacgc gtactgagcc atcaagatga cacagctttg ctaaaggcat
      421 atattgttga atggcgaaaa ttcttcaccc agtgcgatat tttaccaaaa cctttttgtc
      481 aactagaggt gactttattg ggtaaacaaa gcagcaataa aaaatcaaat atggaagaca
      541 gtattgttcg aaagctcatg cttgatacgt ggaatgagtc gattttttcg aatataaaga
      601 acagactcca ggatagtgca atgaagctgg tgcatgctga gagattaggg gaagcttttg
      661 attcccagct ggtcatagga gtgcgagagt cctatgttaa tctttgttct aatcctgagg
      721 acaagcttca gatctatagg gataattttg agaaggcata tttggactca acagagagat
      781 tttatagaac tcaggcaccc tcatatttac agcaaaatgg tgtacagaat tacatgaaat
      841 atgcagatgc taaattaaaa gaagaagaaa aaagagcact ccgatactta gaaacaagac
      901 gagaatgtaa ctctgttgaa gcactcatgg aatgctgtgt gaacgcactg gtgacctcat
      961 ttaaagagac tattttagca gaatgtcaag gcatgatcaa gcgaaatgaa actgaaaagt
     1021 tacatttgat gttttcactg atggacaaag ttcctggtgg gatcgagccc atgttgaagg
     1081 atctggagga gcacatcata agtgctggtc tagcagacat ggtggcagct gctgaaacca
     1141 tcaccactga ctctgagaag tatgtggaac aattacttac actgttcaat agattcagta
     1201 aactggtcaa agaagctttt caggatgatc ctcgtttcct tactgcaaga gataaggcgt
     1261 ataaagcagt tgttaatgat gctaccatat ttaaacttga attgcctttg aagcaaaaag
     1321 gagtggggtt gaaaactcag cctgagtcaa agtgccctga gttgcttgct aattactgtg
     1381 acatgttatt aaggaaaaca ccattaagca aaaaactaac ctctgaagag attgaagcaa
     1441 agcttaaaga agtgctcttg gtacttaaat atgtacaaaa caaagatgtt tttatgaggt
     1501 atcacaaagc tcatcttacc cgacgtctca tattggacat ctctgctgat agcgagattg
     1561 aagaaaacat ggtggagtgg ctaagagaag ttggtatgcc agcagattat gtgaacaaac
     1621 ttgctagaat gtttcaggac ataaaagtat ctgaagactt gaaccaagct tttaaagaaa
     1681 tgcataaaaa taataagttg gcattaccag ctgattcagt taatataaag attttgaatg
     1741 ctggtgcttg gtctagaagc tctgagaaag tctttgtctc acttcctact gaactggagg
     1801 atttgatacc tgaagtagaa gaattttaca aaaaaaatca tagtggtaga aaattacatt
     1861 ggcaccatct catgtcaaat ggaattataa catttaaaaa cgaagtaggt cagtacgatt
     1921 tggaagtaac cacgtttcag ttggctgtgt tgtttgcatg gaaccaaaga cctagagaga
     1981 aaatcagctt tgagaatcta aaacttgcaa cggaactccc tgatgctgaa cttagaagga
     2041 ctttatggtc tttagtagct tttcccaagc tcaaacggca agttttattg tacgaccctc
     2101 aagtcaattc acccaaagat tttacagaag gcaccctctt ctcagtcaac caggacttta
     2161 gtttaataaa aaatgcaaaa gtacagaaaa ggggaaaaat caatttgatt ggacgcttgc
     2221 agctcactac agaacggatg agagaagaag aaaatgaagg aatagttcaa ctaagaatat
     2281 taagaaccca ggaagccatc atacaaataa tgaaaatgag gaagaaaatt agcaatgctc
     2341 agctgcagac tgaattagta gaaattttga aaaacatgtt cttaccacag aagaaaatga
     2401 taaaagagca aatcgaatgg ctgatcgagc acaagtacat caggagggat gaggccgaca
     2461 tcaacacctt catatacatg gcgtagctga atccagcctg ccgcagctac acatctggag
     2521 acctgggcag aaggttgtcc caggctgagc tggaggaagg tttatttgga ctttgattac
     2581 ataaatatta aactctgcct taccttacaa agcgactata ttttgccagt cacattagtc
     2641 agcatgatgg caatcccttc atgttgcaca ctctttaaca gcatgctgtt ttgtggagaa
     2701 aatt
//
