LOCUS       NM_001106951            3821 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cullin 4B (Cul4b), mRNA.
ACCESSION   NM_001106951 XM_001058651 XM_228689
VERSION     NM_001106951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3821)
  AUTHORS   Wang,X., Xue,Q., Duan,Q., Sun,Z., Wu,Y., Yang,S., Xu,P., Cao,H.,
            Liao,F., Wang,X. and Miao,C.
  TITLE     Circ_0011058 alleviates RA pathology through the
            circ_0011058/miR-335-5p/CUL4B signal axis
  JOURNAL   Autoimmunity 57 (1), 2299587 (2024)
   PUBMED   38254314
  REMARK    GeneRIF: Circ_0011058 alleviates RA pathology through the
            circ_0011058/miR-335-5p/CUL4B signal axis.
REFERENCE   2  (bases 1 to 3821)
  AUTHORS   Li,W., Liu,J., Ji,L., Tang,Y., Qin,J., Zhao,H., Cheng,X., Tian,M.,
            Jin,G. and He,H.
  TITLE     MiR-674-5p Suppresses the Proliferation and Migration of Glioma
            Cells by Targeting Cul4b
  JOURNAL   Neurochem Res 47 (3), 679-691 (2022)
   PUBMED   34779995
  REMARK    GeneRIF: MiR-674-5p Suppresses the Proliferation and Migration of
            Glioma Cells by Targeting Cul4b.
REFERENCE   3  (bases 1 to 3821)
  AUTHORS   Miao,C., Chang,J., Zhang,G., Yu,H., Zhou,L., Zhou,G. and Zhao,C.
  TITLE     CUL4B promotes the pathology of adjuvant-induced arthritis in rats
            through the canonical Wnt signaling
  JOURNAL   J Mol Med (Berl) 96 (6), 495-511 (2018)
   PUBMED   29626254
  REMARK    GeneRIF: CUL4B expression is up-regulated in synovium and FLS from
            adjuvant-induced arthritis (AIA) rats. Increased CUL4B promotes the
            canonical Wnt signaling and promotes the pathogenesis of AIA rats.
            Decreased miR-101-3p contributes to disordered CUL4B.
REFERENCE   4  (bases 1 to 3821)
  AUTHORS   Uehara,T., Minoshima,Y., Sagane,K., Sugi,N.H., Mitsuhashi,K.O.,
            Yamamoto,N., Kamiyama,H., Takahashi,K., Kotake,Y., Uesugi,M.,
            Yokoi,A., Inoue,A., Yoshida,T., Mabuchi,M., Tanaka,A. and Owa,T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   5  (bases 1 to 3821)
  AUTHORS   Badertscher,L., Wild,T., Montellese,C., Alexander,L.T., Bammert,L.,
            Sarazova,M., Stebler,M., Csucs,G., Mayer,T.U., Zamboni,N., Zemp,I.,
            Horvath,P. and Kutay,U.
  TITLE     Genome-wide RNAi Screening Identifies Protein Modules Required for
            40S Subunit Synthesis in Human Cells
  JOURNAL   Cell Rep 13 (12), 2879-2891 (2015)
   PUBMED   26711351
REFERENCE   6  (bases 1 to 3821)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3821)
  AUTHORS   Miranda-Carboni,G.A., Krum,S.A., Yee,K., Nava,M., Deng,Q.E.,
            Pervin,S., Collado-Hidalgo,A., Galic,Z., Zack,J.A., Nakayama,K.,
            Nakayama,K.I. and Lane,T.F.
  TITLE     A functional link between Wnt signaling and SKP2-independent p27
            turnover in mammary tumors
  JOURNAL   Genes Dev 22 (22), 3121-3134 (2008)
   PUBMED   19056892
REFERENCE   8  (bases 1 to 3821)
  AUTHORS   Abbas,T., Sivaprasad,U., Terai,K., Amador,V., Pagano,M. and
            Dutta,A.
  TITLE     PCNA-dependent regulation of p21 ubiquitylation and degradation via
            the CRL4Cdt2 ubiquitin ligase complex
  JOURNAL   Genes Dev 22 (18), 2496-2506 (2008)
   PUBMED   18794347
REFERENCE   9  (bases 1 to 3821)
  AUTHORS   Dooley,S., Hamzavi,J., Ciuclan,L., Godoy,P., Ilkavets,I.,
            Ehnert,S., Ueberham,E., Gebhardt,R., Kanzler,S., Geier,A.,
            Breitkopf,K., Weng,H. and Mertens,P.R.
  TITLE     Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated
            fibrogenesis and protects against liver damage
  JOURNAL   Gastroenterology 135 (2), 642-659 (2008)
   PUBMED   18602923
REFERENCE   10 (bases 1 to 3821)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473991.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058651.1, XM_228689.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..3821
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /note="cullin 4B"
                     /db_xref="GeneID:302502"
                     /db_xref="RGD:1564494"
     exon            1..104
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            105..179
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3034
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /codon_start=1
                     /product="cullin-4B"
                     /protein_id="NP_001100421.1"
                     /db_xref="GeneID:302502"
                     /db_xref="RGD:1564494"
                     /translation="MSRSTKSRERRENDANSEDNSSETSNQERRRCLQGPPRPPYPPL
                     LPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGN
                     TSTTPPTSAKKRKLNSSSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLG
                     VPVATSSHVPIQKKLRFEDTLEFVGFDTKMAEESSSSSSSSSPTAATSQQQQQQLKNK
                     SILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQ
                     KLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFR
                     EDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRA
                     HIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLNMLSDLQIYQDSFEQRFLQE
                     TNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLG
                     EHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVIN
                     PEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKY
                     VDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVD
                     AEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNIL
                     TMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGK
                     KELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPK
                     GKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVR
                     IMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA"
     exon            180..353
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            354..902
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1018
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1122
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1192
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1266
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1429
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1519
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1602
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1670
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1789
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1982
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2087
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2198
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2284
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2392
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2506
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2612
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2785
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2938
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3821
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagttgatgg cagacatctt cgagaaggtc tttgtgatcc tcgaggtttg agagcttcgt
       61 cgcatgaata ttagaacaaa acttttgttg atcctccagt gactccggca aaaagaggat
      121 gtcacgttca actaagtcta gagaaagaag agagaatgat gccaactcag aagataacag
      181 ttcagaaacc tccaatcaag agcgccgaag gtgtctccaa ggcccgcccc gtcctcccta
      241 tccacctctt ttacccccgg tgttccctcc cccaaccccc ccacctcaag tccggcggac
      301 ccgggggctt caggatctgg gagctatgaa aagtgtctgc ccaggcactt ccggtttttc
      361 ttcccccaat ccctctgctg cttctgctgc tgctcaggag gtcagatctg ccactgatgg
      421 taataccagc accactccgc ccacctctgc caagaagaga aagttaaaca gcagcagcag
      481 cagtagcagc agtaacagta gtaacgagag agaagacttt gattccacct cttcctcctc
      541 cacccctcca caacccagag attcggcgtc cccttcaacc tcatccttct gcctcggggt
      601 tccagtggcc acttccagcc acgtacctat acagaagaag ctgcgttttg aagacaccct
      661 ggagtttgta gggtttgata cgaaaatggc tgaggaatct tcctcctcat cttcctcatc
      721 ttcaccaact gctgcaacct cacagcagca acagcagcaa cttaaaaata agagtatatt
      781 aatttcttcg gtggcttcag tgcaccatgc aaacggcctg gctaaatctt ctaccacggt
      841 ctctagcttt gctaacagca agcctggctc agctaagaag ttagtgatca agaactttaa
      901 agataagcct aaattaccag aaaactatac agatgagaca tggcaaaagc taaaagaagc
      961 agtggaagcc attcagaata gtacttcaat taagtacaat ttagaagaac tctaccaggc
     1021 tgtagaaaat ctttgttctt acaagatttc tgccaatttg tataagcagc tgaggcagat
     1081 ctgtgaagat cacatcaaag cacagattca tcagttcaga gaggattcat tggatagtgt
     1141 tctttttcta aaaaagattg atagatgctg gcaaaatcat tgtaggcaaa tgataatgat
     1201 caggagcatt tttttgtttc tggatagaac ttatgttctt cagaattcaa tgctgccctc
     1261 tatttgggac atgggattag agttatttag ggctcatatt ataagtgatc aaaaagtcca
     1321 gacaaaaaca atcgatggca tccttctctt gattgagaga gagcggaatg gtgaagcaat
     1381 tgatagaagt ttacttcgaa gccttttaaa tatgctgtct gacttgcaaa tttaccaaga
     1441 ctcttttgaa caacgatttt tgcaagaaac taatcggctt tatgcggccg aaggtcagaa
     1501 gttaatgcaa gaaagagagg ttcctgagta tcttcatcat gttaataaac gcctagaaga
     1561 agaagcagac agacttatta cttacttaga tcagaccacc cagaagtcac tgattgcttc
     1621 tgttgaaaaa caacttctag gtgaacactt aacagcaatt cttcagaaag gtttaaatag
     1681 cctccttgat gaaaaccgaa ttcaagatct gtctctcctg tatcagctct tcagtagagt
     1741 tcggggagga gttcaggttc tcctacagca ctggattgag tatatcaagg cttttggaag
     1801 taccattgtt attaatcctg aaaaagataa aactatggtt caagaattat tggactttaa
     1861 agataaagtt gaccatataa ttgatacctg ctttctgaaa aatgaaaaat ttatcaatgc
     1921 catgaaagaa gcatttgaaa ccttcattaa taaaagacca aataagccag ctgaactgat
     1981 agctaagtat gtggattcaa aacttcgtgc aggcaacaaa gaagctacag atgaagagct
     2041 tgagaaaatg ttggataaaa taatgattat atttagattt atctatggca aagatgtttt
     2101 tgaggccttc tataagaaag acttagccaa acgcctatta gttggcaaga gtgcatcagt
     2161 ggatgctgaa aaatcaatgc tgtccaaact gaaacacgaa tgtggagccg cttttaccag
     2221 caagcttgaa ggcatgttta aagacatgga gctttctaaa gatatcatga tccagttcaa
     2281 acagtatatg cagaaccaga atgtacctgg caatattgaa ttaactgtta atatcctgac
     2341 aatgggttat tggccaacat atgtgcctat ggaagtccat ttgccaccag agatggtgaa
     2401 gcttcaggaa attttcaaga cattttactt aggcaagcac agtggcagga aacttcaatg
     2461 gcaatcaacc ttgggacact gtgtgctaaa agctgaattt aaagagggca aaaaagaact
     2521 tcaggtctct ctttttcaaa ccctggtgct actaatgttt aatgaaggag aggagttcag
     2581 tttagaggag ataaagcaag ccactggaat agaggatgga gaattaagaa gaacactgca
     2641 gtcactagcc tgtggcaaag ctagagttct ggctaaaaat ccaaagggca aagatattga
     2701 agatggtgac aagtttattt gtaatgatga tttcaaacac aaactattca ggataaagat
     2761 caatcaaatc cagatgaaag aaacggttga agaacaagca agcactacag aaagagtatt
     2821 tcaagataga cagtaccaaa ttgatgctgc gatcgtccga attatgaaga tgagaaaaac
     2881 acttagccac aaccttcttg tttcagaagt ctacaatcag ctaaaatttc cagtaaaacc
     2941 tgctgatctt aagaagagaa tagaatccct aattgaccgg gactacatgg aaagagataa
     3001 agaaaaccca aatcagtaca actatattgc atagaatgtt ggttggcctt ggaacatttg
     3061 ttgtcatgcc gtagccaatg gataaactaa cttgttgaat ctcatgttat ttgacttctt
     3121 ttatacttcc gatgaccaaa tgaagcagtg tgtaatggga atagttgcgt ggacatttct
     3181 cagtggttaa catacccatt ttaaagagta atacttaacc tttaagaaga atgtcgttga
     3241 actctatgca tgttatttag tatgatgtgc agaaaactct ttaagaaagt acctgggtct
     3301 tcatgattcc tttttggaac tggggaagag atccctatgg ccattaaaag ggggagggtg
     3361 attcttatac atcatcaata aagcaaaagg tttatttgcc taaaagtcat ttaaagatac
     3421 ttaaactgca tgcaaatttt atttactgta cagaattctg gatgtattta tcaaatagaa
     3481 aaaccaccct ggacttggtt gttcacccat tttgtggttt cccttgaaaa gaaaagtaag
     3541 ttttcattgt tggcattctg ttacactgaa gagggaaaaa aaaccttatt tggaaacaag
     3601 tttttcacgt agggtaacag ttccttccat cataccttat atattcacag cctaaaggtt
     3661 tcccattatg actctgggat gtgtacagaa gacagctcca aattcactgt gctcattaac
     3721 aggaacttac taaaatagat caaatagaaa aattgctgat cttgtactat aagaacatag
     3781 taagggggga aaactcagtt ctttttatta gaactgaata c
//
