LOCUS       NP_001100421             971 aa            linear   ROD 26-FEB-2024
DEFINITION  cullin-4B [Rattus norvegicus].
ACCESSION   NP_001100421 XP_001058651 XP_228689
VERSION     NP_001100421.1
DBSOURCE    REFSEQ: accession NM_001106951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 971)
  AUTHORS   Wang,X., Xue,Q., Duan,Q., Sun,Z., Wu,Y., Yang,S., Xu,P., Cao,H.,
            Liao,F., Wang,X. and Miao,C.
  TITLE     Circ_0011058 alleviates RA pathology through the
            circ_0011058/miR-335-5p/CUL4B signal axis
  JOURNAL   Autoimmunity 57 (1), 2299587 (2024)
   PUBMED   38254314
  REMARK    GeneRIF: Circ_0011058 alleviates RA pathology through the
            circ_0011058/miR-335-5p/CUL4B signal axis.
REFERENCE   2  (residues 1 to 971)
  AUTHORS   Li,W., Liu,J., Ji,L., Tang,Y., Qin,J., Zhao,H., Cheng,X., Tian,M.,
            Jin,G. and He,H.
  TITLE     MiR-674-5p Suppresses the Proliferation and Migration of Glioma
            Cells by Targeting Cul4b
  JOURNAL   Neurochem Res 47 (3), 679-691 (2022)
   PUBMED   34779995
  REMARK    GeneRIF: MiR-674-5p Suppresses the Proliferation and Migration of
            Glioma Cells by Targeting Cul4b.
REFERENCE   3  (residues 1 to 971)
  AUTHORS   Miao,C., Chang,J., Zhang,G., Yu,H., Zhou,L., Zhou,G. and Zhao,C.
  TITLE     CUL4B promotes the pathology of adjuvant-induced arthritis in rats
            through the canonical Wnt signaling
  JOURNAL   J Mol Med (Berl) 96 (6), 495-511 (2018)
   PUBMED   29626254
  REMARK    GeneRIF: CUL4B expression is up-regulated in synovium and FLS from
            adjuvant-induced arthritis (AIA) rats. Increased CUL4B promotes the
            canonical Wnt signaling and promotes the pathogenesis of AIA rats.
            Decreased miR-101-3p contributes to disordered CUL4B.
REFERENCE   4  (residues 1 to 971)
  AUTHORS   Uehara,T., Minoshima,Y., Sagane,K., Sugi,N.H., Mitsuhashi,K.O.,
            Yamamoto,N., Kamiyama,H., Takahashi,K., Kotake,Y., Uesugi,M.,
            Yokoi,A., Inoue,A., Yoshida,T., Mabuchi,M., Tanaka,A. and Owa,T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   5  (residues 1 to 971)
  AUTHORS   Badertscher,L., Wild,T., Montellese,C., Alexander,L.T., Bammert,L.,
            Sarazova,M., Stebler,M., Csucs,G., Mayer,T.U., Zamboni,N., Zemp,I.,
            Horvath,P. and Kutay,U.
  TITLE     Genome-wide RNAi Screening Identifies Protein Modules Required for
            40S Subunit Synthesis in Human Cells
  JOURNAL   Cell Rep 13 (12), 2879-2891 (2015)
   PUBMED   26711351
REFERENCE   6  (residues 1 to 971)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 971)
  AUTHORS   Miranda-Carboni,G.A., Krum,S.A., Yee,K., Nava,M., Deng,Q.E.,
            Pervin,S., Collado-Hidalgo,A., Galic,Z., Zack,J.A., Nakayama,K.,
            Nakayama,K.I. and Lane,T.F.
  TITLE     A functional link between Wnt signaling and SKP2-independent p27
            turnover in mammary tumors
  JOURNAL   Genes Dev 22 (22), 3121-3134 (2008)
   PUBMED   19056892
REFERENCE   8  (residues 1 to 971)
  AUTHORS   Abbas,T., Sivaprasad,U., Terai,K., Amador,V., Pagano,M. and
            Dutta,A.
  TITLE     PCNA-dependent regulation of p21 ubiquitylation and degradation via
            the CRL4Cdt2 ubiquitin ligase complex
  JOURNAL   Genes Dev 22 (18), 2496-2506 (2008)
   PUBMED   18794347
REFERENCE   9  (residues 1 to 971)
  AUTHORS   Dooley,S., Hamzavi,J., Ciuclan,L., Godoy,P., Ilkavets,I.,
            Ehnert,S., Ueberham,E., Gebhardt,R., Kanzler,S., Geier,A.,
            Breitkopf,K., Weng,H. and Mertens,P.R.
  TITLE     Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated
            fibrogenesis and protects against liver damage
  JOURNAL   Gastroenterology 135 (2), 642-659 (2008)
   PUBMED   18602923
REFERENCE   10 (residues 1 to 971)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473991.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001058651.1, XP_228689.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     Protein         1..971
                     /product="cullin-4B"
                     /calculated_mol_wt=110681
     Region          275..872
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          903..963
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; pfam10557"
                     /db_xref="CDD:463146"
     CDS             1..971
                     /gene="Cul4b"
                     /gene_synonym="RGD1564494"
                     /coded_by="NM_001106951.1:119..3034"
                     /db_xref="GeneID:302502"
                     /db_xref="RGD:1564494"
ORIGIN      
        1 msrstksrer rendansedn ssetsnqerr rclqgpprpp yppllppvfp pptpppqvrr
       61 trglqdlgam ksvcpgtsgf sspnpsaasa aaqevrsatd gntsttppts akkrklnsss
      121 sssssnssne redfdstsss stppqprdsa spstssfclg vpvatsshvp iqkklrfedt
      181 lefvgfdtkm aeesssssss ssptaatsqq qqqqlknksi lissvasvhh anglaksstt
      241 vssfanskpg sakklviknf kdkpklpeny tdetwqklke aveaiqnsts ikynleelyq
      301 avenlcsyki sanlykqlrq icedhikaqi hqfredslds vlflkkidrc wqnhcrqmim
      361 irsiflfldr tyvlqnsmlp siwdmglelf rahiisdqkv qtktidgill liererngea
      421 idrsllrsll nmlsdlqiyq dsfeqrflqe tnrlyaaegq klmqerevpe ylhhvnkrle
      481 eeadrlityl dqttqkslia svekqllgeh ltailqkgln slldenriqd lsllyqlfsr
      541 vrggvqvllq hwieyikafg stivinpekd ktmvqelldf kdkvdhiidt cflknekfin
      601 amkeafetfi nkrpnkpael iakyvdsklr agnkeatdee lekmldkimi ifrfiygkdv
      661 feafykkdla krllvgksas vdaeksmlsk lkhecgaaft sklegmfkdm elskdimiqf
      721 kqymqnqnvp gnieltvnil tmgywptyvp mevhlppemv klqeifktfy lgkhsgrklq
      781 wqstlghcvl kaefkegkke lqvslfqtlv llmfnegeef sleeikqatg iedgelrrtl
      841 qslacgkarv laknpkgkdi edgdkficnd dfkhklfrik inqiqmketv eeqastterv
      901 fqdrqyqida aivrimkmrk tlshnllvse vynqlkfpvk padlkkries lidrdymerd
      961 kenpnqynyi a
//
