LOCUS       NM_001127301            2859 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cullin 4A (Cul4a), mRNA.
ACCESSION   NM_001127301 XM_001066808 XM_341464
VERSION     NM_001127301.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Jia,Y., Huo,X., Wu,L., Zhang,H., Xu,W. and Leng,H.
  TITLE     circSNTB2 and CUL4A Induces Dysfunction of Nucleus Pulposus Cells
            by Competitively Binding miR-665
  JOURNAL   Biochem Genet 62 (2), 968-986 (2024)
   PUBMED   37507642
  REMARK    GeneRIF: circSNTB2 and CUL4A Induces Dysfunction of Nucleus
            Pulposus Cells by Competitively Binding miR-665.
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Ye,N., Zhang,N., Zhang,Y., Qian,H., Wu,B. and Sun,Y.
  TITLE     Cul4a as a New Interaction Protein of PARP1 Inhibits Oxidative
            Stress-Induced H9c2 Cell Apoptosis
  JOURNAL   Oxid Med Cell Longev 2019, 4273261 (2019)
   PUBMED   31178959
  REMARK    GeneRIF: Authors identified that when combining with PARP1, Cul4a
            could reduce its expression, and the interaction was enhanced under
            oxidative stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Uehara,T., Minoshima,Y., Sagane,K., Sugi,N.H., Mitsuhashi,K.O.,
            Yamamoto,N., Kamiyama,H., Takahashi,K., Kotake,Y., Uesugi,M.,
            Yokoi,A., Inoue,A., Yoshida,T., Mabuchi,M., Tanaka,A. and Owa,T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Badertscher,L., Wild,T., Montellese,C., Alexander,L.T., Bammert,L.,
            Sarazova,M., Stebler,M., Csucs,G., Mayer,T.U., Zamboni,N., Zemp,I.,
            Horvath,P. and Kutay,U.
  TITLE     Genome-wide RNAi Screening Identifies Protein Modules Required for
            40S Subunit Synthesis in Human Cells
  JOURNAL   Cell Rep 13 (12), 2879-2891 (2015)
   PUBMED   26711351
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Tong,X., Zhang,D., Guha,A., Arthurs,B., Cazares,V., Gupta,N. and
            Yin,L.
  TITLE     CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by
            Promoting Ubiquitination-Dependent Degradation of the Mammalian
            CRY1
  JOURNAL   PLoS One 10 (10), e0139725 (2015)
   PUBMED   26431207
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Li,B., Jia,N., Kapur,R. and Chun,K.T.
  TITLE     Cul4A targets p27 for degradation and regulates proliferation, cell
            cycle exit, and differentiation during erythropoiesis
  JOURNAL   Blood 107 (11), 4291-4299 (2006)
   PUBMED   16467204
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Wertz,I.E., O'Rourke,K.M., Zhang,Z., Dornan,D., Arnott,D.,
            Deshaies,R.J. and Dixit,V.M.
  TITLE     Human De-etiolated-1 regulates c-Jun by assembling a CUL4A
            ubiquitin ligase
  JOURNAL   Science 303 (5662), 1371-1374 (2004)
   PUBMED   14739464
REFERENCE   8  (bases 1 to 2859)
  AUTHORS   Groisman,R., Polanowska,J., Kuraoka,I., Sawada,J., Saijo,M.,
            Drapkin,R., Kisselev,A.F., Tanaka,K. and Nakatani,Y.
  TITLE     The ubiquitin ligase activity in the DDB2 and CSA complexes is
            differentially regulated by the COP9 signalosome in response to DNA
            damage
  JOURNAL   Cell 113 (3), 357-367 (2003)
   PUBMED   12732143
REFERENCE   9  (bases 1 to 2859)
  AUTHORS   Li,B., Yang,F.C., Clapp,D.W. and Chun,K.T.
  TITLE     Enforced expression of CUL-4A interferes with granulocytic
            differentiation and exit from the cell cycle
  JOURNAL   Blood 101 (5), 1769-1776 (2003)
   PUBMED   12393421
REFERENCE   10 (bases 1 to 2859)
  AUTHORS   Li,B., Ruiz,J.C. and Chun,K.T.
  TITLE     CUL-4A is critical for early embryonic development
  JOURNAL   Mol Cell Biol 22 (14), 4997-5005 (2002)
   PUBMED   12077329
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166799.1.
            
            On or before May 11, 2008 this sequence version replaced
            XM_341464.3, XM_001066808.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166799.1, FQ210009.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2859
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /note="cullin 4A"
                     /db_xref="GeneID:361181"
                     /db_xref="RGD:1563853"
     exon            1..165
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2297
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /codon_start=1
                     /product="cullin-4A"
                     /protein_id="NP_001120773.1"
                     /db_xref="GeneID:361181"
                     /db_xref="RGD:1563853"
                     /translation="MADEGPRKGSVSALMGRTNGLTKPAALASGPAKPGGTGGSRKLV
                     IKNFRDRPRLPDNYTQDTWRKLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTL
                     YKQLRQVCEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
                     VLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLL
                     SMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRVIT
                     YLDHSTQKPLIACVEKQLLGEHLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKGGQH
                     ALLQHWSEYIKTFGTTIVINPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMKE
                     SFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFE
                     AFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHF
                     KQHMQNQSAPGPIDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRK
                     LQWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSEL
                     RRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADFKHKLFRIKINQIQMKETVEEQV
                     STTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLI
                     DRDYMERDKDSPNQYHYVA"
     exon            166..281
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            282..385
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            386..455
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            456..529
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            530..692
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            693..782
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            783..865
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            866..933
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1052
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1245
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1350
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1461
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1547
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1655
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1769
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1875
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2048
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2201
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2845
                     /gene="Cul4a"
                     /gene_synonym="RGD1563853"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgtccgg cccagccatg gcggacgagg gccctcggaa gggcagcgtc tcggctctca
       61 tgggccgcac caacggcctc accaagcccg cggcgttggc cagtggcccc gccaaaccgg
      121 gaggcacggg cggctccagg aagctggtca tcaagaactt ccgagacagg ccgcggctgc
      181 ctgacaacta cactcaggac acgtggcgga agcttcacga agcggtcaag gccatccaga
      241 gcagcacatc catcaggtac aacctggagg aactgtacca ggctgttgag aatctgtgct
      301 ctcacaaagt ctcccccacg ctctacaagc agctgcggca ggtctgtgaa gaccatgtcc
      361 aggcccagat cctccccttc agagaagact cactagacag cgttttgttt ctgaagaaga
      421 ttaacacatg ctggcaagat cactgcagac aaatgatcat gatcagaagc atcttcctgt
      481 ttctggaccg cacctacgtc ctccagaact ccatgctgcc ttccatctgg gacatgggcc
      541 tagagctgtt taggaaccat atcatcagtg acaggatggt gcaaagcaag accattgatg
      601 ggatcctgct gctgattggg cgtgaacgaa gtggtgaggc tgtggacagg agtctgcttc
      661 gcagtctgtt gagcatgctc tcagatctcc aggtctacaa agactcattc gaactgaagt
      721 tcttggaaga gactaactgt ctgtacgctg ctgaaggcca gcggctgatg caagacaggg
      781 aggttccaga ataccttaac catgtgagta aacgtctaga agaggaagca gaccgagtga
      841 tcacttactt agaccacagc acacaaaaac cgttgattgc ctgtgtggag aaacagttgt
      901 taggagaaca tttgacagca attcttcaga aagggcttga gcagctgctg gatgagaaca
      961 gggtgcccga cctcacacag atgtaccagc tcttcagccg ggtgaaaggg ggccagcacg
     1021 cactgctgca gcactggagc gagtacatca agacctttgg gacaaccatt gtcatcaatc
     1081 ctgagaaaga caaagacatg gtccaagacc tgctggactt taaggacaaa gtggaccacg
     1141 tggtggaggt gtgcttccag aggaacgagc gcttcatcaa cctgatgaag gagtcctttg
     1201 agacgttcat aaacaagaga ccaaacaagc cggcagagct cattgccaag cacgtggatt
     1261 caaagttacg agcaggcaac aaggaagcaa cagacgagga gctggagagg atcctggaca
     1321 agatcatgat tctgttccga ttcatccacg gtaaagatgt ctttgaagca ttttataaga
     1381 aagacttagc aaaaaggctg ctagtgggga agagcgcgtc ggtggacgcg gagaagtcca
     1441 tgctgtccaa gctgaagcat gagtgtggag cagcttttac cagcaagctg gagggcatgt
     1501 tcaaggacat ggagctgtcc aaagacatca tggttcactt caagcagcat atgcagaacc
     1561 aaagtgcacc aggccccatc gacctcacgg tgaacatcct caccatgggc tactggccta
     1621 catacacacc catggaagtg cacctccctc cagagatggt cagacttcag gaagtattca
     1681 agacgttcta cctgggcaag cacagtggcc ggaagctgca gtggcagacg acgctgggac
     1741 acgctgtgtt gaaggcggac tttaaggagg ggaagaagga gttccaggtg tccctgttcc
     1801 agacgctcgt gctgctcatg ttcaacgagg gcgacgggtt cagcttcgaa gaaatcaaaa
     1861 tggccaccgg catagaggac agtgagttgc gaagaacact gcagtctctc gcctgtggta
     1921 aagcccgggt cctgattaaa agtcccaaag ggaaggaggt ggaagacgga gataagttca
     1981 tcttcaatgc agacttcaaa cacaagttgt tcagaataaa gatcaatcaa atccagatga
     2041 aggaaaccgt tgaagaacag gttagcacca cagagagagt gttccaggac agacagtacc
     2101 agatcgacgc tgctatagtc agaataatga aaatgaggaa gacacttggt cataatcttc
     2161 tagtttctga attatacaat cagctgaaat ttccagtaaa gcctggagat ttgaaaaaga
     2221 ggattgagtc acttatagac agagactata tggaacgaga caaagacagt ccaaatcagt
     2281 accactacgt ggcgtgacgc agcggccgat ggccgtctcg cagtgagaca cactagaagc
     2341 acctgagagt atgacgctgc tgtgctgttt ccgggttcct gcagctgccc cgactctgga
     2401 cgctgggatt cgaagcagag gatgtggctc ttggctcatg cttcccgggc gcaaggactt
     2461 tgcggtgaca ccgtctttcc tccccgctcc ttccttcctc tacttcttta tcgtttctgt
     2521 tactctgact ttgcgttgag aagctccttc acaagctctt gttcctctgg cagaaggcca
     2581 cgggcctgct ttgttgtatg tgtgattgtg gggcacagtg gaaataccct agatgctgtg
     2641 ttcgtcccca gatgaagact cagagagagc gccctgggct gccaggcact gggaagagcc
     2701 tgtccaggct gccactcagc tctctcaccc tgagcattgg cctctttgca gtgtatttca
     2761 gaacgctgga aactttggct tctgtaaatc aggtttctaa gtgaggtccc tgatgtgcca
     2821 agaggacatc atgtctgtca tgagaaaaaa aaaaaaaaa
//
