LOCUS       NM_001106923            4420 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cullin 3 (Cul3), mRNA.
ACCESSION   NM_001106923 XM_001063669 XM_001063729 XM_008767226 XM_217454
VERSION     NM_001106923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4420)
  AUTHORS   Chen,N., Liu,Y., Yu,H., Liu,S., Xiao,P., Jia,Z. and Zhang,Z.
  TITLE     The Role of Cullin 3 in Cerebral Ischemia-Reperfusion Injury
  JOURNAL   Neuroscience 514, 14-24 (2023)
   PUBMED   36720302
  REMARK    GeneRIF: The Role of Cullin 3 in Cerebral Ischemia-Reperfusion
            Injury.
REFERENCE   2  (bases 1 to 4420)
  AUTHORS   Chen,X., Ma,F., Zhai,N., Gao,F. and Cao,G.
  TITLE     Long non-coding RNA XIST inhibits osteoblast differentiation and
            promotes osteoporosis via Nrf2 hyperactivation by targeting CUL3
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   34036379
  REMARK    GeneRIF: Long noncoding RNA XIST inhibits osteoblast
            differentiation and promotes osteoporosis via Nrf2 hyperactivation
            by targeting CUL3.
REFERENCE   3  (bases 1 to 4420)
  AUTHORS   Jumeau,F., Chalmel,F., Fernandez-Gomez,F.J., Carpentier,C.,
            Obriot,H., Tardivel,M., Caillet-Boudin,M.L., Rigot,J.M., Rives,N.,
            Buee,L., Sergeant,N. and Mitchell,V.
  TITLE     Defining the human sperm microtubulome: an integrated genomics
            approach
  JOURNAL   Biol Reprod 96 (1), 93-106 (2017)
   PUBMED   28395323
REFERENCE   4  (bases 1 to 4420)
  AUTHORS   Zhang,Z., Turer,E., Li,X., Zhan,X., Choi,M., Tang,M., Press,A.,
            Smith,S.R., Divoux,A., Moresco,E.M. and Beutler,B.
  TITLE     Insulin resistance and diabetes caused by genetic or diet-induced
            KBTBD2 deficiency in mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (42), E6418-E6426 (2016)
   PUBMED   27708159
REFERENCE   5  (bases 1 to 4420)
  AUTHORS   Ferretti,L.P., Himmels,S.F., Trenner,A., Walker,C., von Aesch,C.,
            Eggenschwiler,A., Murina,O., Enchev,R.I., Peter,M., Freire,R.,
            Porro,A. and Sartori,A.A.
  TITLE     Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to
            fine-tune DNA-end resection
  JOURNAL   Nat Commun 7, 12628 (2016)
   PUBMED   27561354
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4420)
  AUTHORS   Zhang,D.D., Lo,S.C., Sun,Z., Habib,G.M., Lieberman,M.W. and
            Hannink,M.
  TITLE     Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for
            Cul3, targets Keap1 for degradation by a proteasome-independent
            pathway
  JOURNAL   J Biol Chem 280 (34), 30091-30099 (2005)
   PUBMED   15983046
REFERENCE   7  (bases 1 to 4420)
  AUTHORS   Furukawa,M. and Xiong,Y.
  TITLE     BTB protein Keap1 targets antioxidant transcription factor Nrf2 for
            ubiquitination by the Cullin 3-Roc1 ligase
  JOURNAL   Mol Cell Biol 25 (1), 162-171 (2005)
   PUBMED   15601839
REFERENCE   8  (bases 1 to 4420)
  AUTHORS   Furukawa,M., He,Y.J., Borchers,C. and Xiong,Y.
  TITLE     Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
            ligases
  JOURNAL   Nat Cell Biol 5 (11), 1001-1007 (2003)
   PUBMED   14528312
REFERENCE   9  (bases 1 to 4420)
  AUTHORS   Pintard,L., Kurz,T., Glaser,S., Willis,J.H., Peter,M. and
            Bowerman,B.
  TITLE     Neddylation and deneddylation of CUL-3 is required to target
            MEI-1/Katanin for degradation at the meiosis-to-mitosis transition
            in C. elegans
  JOURNAL   Curr Biol 13 (11), 911-921 (2003)
   PUBMED   12781129
REFERENCE   10 (bases 1 to 4420)
  AUTHORS   Singer,J.D., Gurian-West,M., Clurman,B. and Roberts,J.M.
  TITLE     Cullin-3 targets cyclin E for ubiquitination and controls S phase
            in mammalian cells
  JOURNAL   Genes Dev 13 (18), 2375-2387 (1999)
   PUBMED   10500095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XM_008767226.3, NM_001106923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.49722.1,
                                           SRR26643429.34433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000009.1  89118273-89118427   c
            156-353             JAXUCZ010000009.1  89099652-89099849   c
            354-467             JAXUCZ010000009.1  89080237-89080350   c
            468-628             JAXUCZ010000009.1  89066176-89066336   c
            629-743             JAXUCZ010000009.1  89065503-89065617   c
            744-972             JAXUCZ010000009.1  89063629-89063857   c
            973-1118            JAXUCZ010000009.1  89059962-89060107   c
            1119-1295           JAXUCZ010000009.1  89058995-89059171   c
            1296-1466           JAXUCZ010000009.1  89057755-89057925   c
            1467-1574           JAXUCZ010000009.1  89057196-89057303   c
            1575-1699           JAXUCZ010000009.1  89054338-89054462   c
            1700-1796           JAXUCZ010000009.1  89053746-89053842   c
            1797-1931           JAXUCZ010000009.1  89052680-89052814   c
            1932-2118           JAXUCZ010000009.1  89047560-89047746   c
            2119-2264           JAXUCZ010000009.1  89045154-89045299   c
            2265-4420           JAXUCZ010000009.1  89040987-89043142   c
FEATURES             Location/Qualifiers
     source          1..4420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..4420
                     /gene="Cul3"
                     /note="cullin 3"
                     /db_xref="GeneID:301555"
                     /db_xref="RGD:1308190"
     exon            1..155
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2396
                     /gene="Cul3"
                     /codon_start=1
                     /product="cullin-3"
                     /protein_id="NP_001100393.2"
                     /db_xref="GeneID:301555"
                     /db_xref="RGD:1308190"
                     /translation="MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEI
                     QRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFL
                     QTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDH
                     LRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQ
                     MESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTI
                     VEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGE
                     GKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFI
                     DDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDS
                     EKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVL
                     TTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGP
                     VKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPE
                     RELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQG
                     ESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVV
                     IKKRIEGLIEREYLARTPEDRKVYTYVA"
     exon            156..353
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..467
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..628
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..743
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..972
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1118
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1295
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1466
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1574
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1699
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1796
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1931
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2118
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2264
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..4420
                     /gene="Cul3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccct cccgccttca atgtgacacc ggcgcctcgg agtgcgagcc gcagccgccg
       61 ccgccgccgc cggggagggg ccgagcacca tgtcgaatct gagcaaaggc acgggcagcc
      121 ggaaggacac caagatgcgg atccgggcct ttccgatgac catggatgaa aaatatgtaa
      181 acagcatttg ggaccttctg aaaaatgcaa ttcaagaaat ccagcgtaag aataacagtg
      241 gtcttagttt tgaggagctc tatagaaatg catatacaat ggttttgcat aaacatggag
      301 aaaagctcta cactggacta agagaagttg ttactgaaca tctcataaat aaggtgcgag
      361 aagatgtact aaattcattg aataacaact ttcttcaaac actaaatcaa gcttggaatg
      421 atcatcaaac agccatggtg atgattagag acatactaat gtatatggac cgtgtatatg
      481 tacaacagaa taatgtagaa aatgtctaca atttgggatt aataattttt cgagatcaag
      541 ttgtacggta tgggtgtatt agggatcatc ttcggcaaac tttattggat atgattgcca
      601 gagagaggaa aggagaagtt gtagacagag gagcaataag aaatgcttgc cagatgttaa
      661 tgattttagg tcttgaagga agatcagtct atgaggaaga ttttgaggct ccttttttgg
      721 aaatgtctgc agaatttttt cagatggaaa gccagaaatt tttagcagaa aacagtgctt
      781 cagtatatat aaagaaagta gaagctagga ttaatgagga aatagagcgg gtgatgcact
      841 gtctcgacaa atccacagaa gagcctattg tgaaggtggt ggagagggaa ctcatttcca
      901 agcacatgaa gactattgta gaaatggaaa attctgggct agtacatatg ctgaaaaatg
      961 ggaagacaga agaccttgct tgtatgtaca aattatttag tcgtgtgcca aatggtttga
     1021 agacaatgtg tgaatgtatg agttcttatt tgagggaaca aggaaaagcc cttgtttctg
     1081 aggaaggaga agggaagaat cctgttgact atatccaggg cttattggat ctgaagagta
     1141 ggtttgatcg cttccttcaa gaatccttca ataatgaccg actctttaaa cagactattg
     1201 ctggggactt tgagtatttc ttaaacctca actccaggtc tcctgaatac ctctcattat
     1261 ttattgatga taagctgaaa aagggagtca aagggctaac agaacaggaa gtagaaacga
     1321 tattggataa ggcaatggtc ctttttaggt ttatgcaaga aaaagatgta tttgaacgtt
     1381 actataaaca acatctggca agaagactgc tcacaaataa aagtgtttct gatgactctg
     1441 aaaaaaatat gatttctaaa ttaaagactg agtgtggatg tcaattcaca tcgaaactgg
     1501 aaggaatgtt tagggatatg agcatctcaa acacaactat ggatgagttc aggcaacatc
     1561 tacaggcaac gggggtatct ttaggtggag ttgatctcac agtccgggtt ctcacaacgg
     1621 gatattggcc tactcagtca gccacaccaa agtgcaacat cccacctgct ccaagacatg
     1681 cttttgagat atttagacgg ttctatttag ccaaacacag tggtcggcag ctcacactcc
     1741 agcatcacat gggttctgca gatctcaatg ccacctttta tggtccagtt aaaaaggaag
     1801 atggatctga ggttggtgtt ggcggtgcac aagtaactgg ttctaataca cggaagcaca
     1861 tactgcaagt ctccactttc cagatgacca tattaatgct ttttaataat agagagaaat
     1921 acacatttga ggaaattcaa caagagactg atatccctga aagagaactt gttagagccc
     1981 tccagtccct cgcctgtggt aaaccaacac agcgggtcct cacaaaagaa cccaagtcca
     2041 aggagataga aagtggccac atatttacag ttaatgatca attcacatcc aaactacaca
     2101 gagtcaagat tcaaacagtt gcagccaaac aaggtgaatc tgacccagaa aggaaagaaa
     2161 caagacagaa agtagatgat gacagaaaac acgagataga agctgctata gtgcggataa
     2221 tgaagtctag gaagaagatg cagcacaatg ttttagtagc agaggtaact cagcaactga
     2281 aggctcgatt cttaccaagt ccagttgtta ttaagaaacg tattgaagga cttattgaga
     2341 gagaatattt ggcacgaaca cctgaggatc gcaaagtata cacatacgta gcataaaatg
     2401 cattcagaaa tttgatttat tcttggactg tactcttcgc atggactggg aagttctttt
     2461 aaatcctact attaagacga ccatctcttc tgttaaattg cagtacatgt tatagaccac
     2521 tcagatcaag cctctactcc ctctgagagt tttcaacatc agttgattga gcttcaggct
     2581 ttccaacgtt atccctgtag agatcatctt tacagttcct cgggaaaatg tgaatgtgcc
     2641 gcgttttgtt ttcaatattg tatgaaaaca ggaaaaaaaa taaaacaaat ttagaaaaca
     2701 cagctcatta aaataaaatt gttggatttc atttccccag gtcttcagtg ttgctgtaag
     2761 tgtgtttctg tagtgttgct tactacactt tgcgcattgt gtaagttggg gagcaagaat
     2821 ggcaaaagag acagaattcc cagtcctctt gctctgcttg tgacgtttcc ttagctggtg
     2881 ttgtttacag gtttgctaag tatacagaga cccagacgta cagttggcgc atgctctacc
     2941 ctaccacttg cacttactgt ctcagcctta cgaccaagga cctttgtttg gacatcagta
     3001 cataccctga gttgtttttc tctattgtaa tctgaggttt tccaaattaa gttctaagat
     3061 gattaggttt tgctctgagt tatttctaga gaaagaaaat attttagtat gtataaattg
     3121 tacaataatt ttttgctgtt gtacttactg ctaatagtgg attgtatagg gtggtgtttt
     3181 tatttcattt attgtagaca aaataaatga atttagtatt cacatacaca ctaactgaag
     3241 tatgtcagag cacaaaggtg gcagctggtt atatttaatt cagttccttt gaaaagcaca
     3301 tccattctac catttgttta taaatacatc ccccaccccc cacacacagt ttaaatatat
     3361 attttggtga agctgtggta caccattaat tgtttcaaaa tgcaatctaa agatgcaata
     3421 aatagattac cttgatagtt tgaaggaatt cttcagttct tgcagctgtg ttttggaaag
     3481 tgttaagcaa tatttttcaa acgtggatat ttagctatcc attgtcctct gaagagtcat
     3541 gttcgtgttt tcaaagatgt gctttgtgct ggagattcgt gtccgttact ctgtgcttcc
     3601 aactatcact gacgttttct acctgattga tctgccaagg attatagttt gctttaactt
     3661 cagagtattt ttatcttcca ttttatttaa ttttgttcct tttttttctt aaaagataat
     3721 gttttagata tgtaattggg gaaaaccact agatttctgt cagaaaaatg aaatgttact
     3781 gagttcaagt aaccaactct ccattgaata tcaatactgt tgatatactt attagaatgt
     3841 atgtctcaga agatggtttg tgttaaattt atgaagttac aataactgaa ttctaatatg
     3901 gattaaaagc tccacataaa tattttcccc atgcgtcttg gattataatt ttccttttag
     3961 acttggtttt gttgcattta aatttgctct tatatgcact gaatggttga agtcttatga
     4021 tcttaatctc tacatgtttc ccacctttac atgaggcagt gaaggtgtgg ccagtataca
     4081 ccttgctgta cttgcacagg tacagtggga cactgaagaa ttgctttcgg tgtaattgga
     4141 atttttacta aggaggctgc tcttaacagt ttggaagtaa gggcagctca gctgtacaga
     4201 tcaggttcgg tgtatatgta gggacataaa ggtttgctgc ttgttctggt agatgcttgc
     4261 ttctgggtta aagtagattt atcggttggg caatgctggc tctgctacct tacaaaattc
     4321 ctgtgatgca tttggtattt ctcagcagta ggtcatggac atttttatcc tctaaatgtt
     4381 ttaaaagaat gatgtgatga gatgtttttg tgacttgaat
//
