LOCUS       NP_001386142             745 aa            linear   ROD 30-MAR-2024
DEFINITION  cullin-2 [Rattus norvegicus].
ACCESSION   NP_001386142 XP_006254134
VERSION     NP_001386142.1
DBSOURCE    REFSEQ: accession NM_001399213.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 745)
  AUTHORS   Choy,M.K., Movassagh,M., Bennett,M.R. and Foo,R.S.
  TITLE     PKB/Akt activation inhibits p53-mediated HIF1A degradation that is
            independent of MDM2
  JOURNAL   J Cell Physiol 222 (3), 635-639 (2010)
   PUBMED   19950214
REFERENCE   2  (residues 1 to 745)
  AUTHORS   Semenza,G.L.
  TITLE     Regulation of oxygen homeostasis by hypoxia-inducible factor 1
  JOURNAL   Physiology (Bethesda) 24, 97-106 (2009)
   PUBMED   19364912
  REMARK    Review article
REFERENCE   3  (residues 1 to 745)
  AUTHORS   Ferguson,J.E. 3rd, Wu,Y., Smith,K., Charles,P., Powers,K., Wang,H.
            and Patterson,C.
  TITLE     ASB4 is a hydroxylation substrate of FIH and promotes vascular
            differentiation via an oxygen-dependent mechanism
  JOURNAL   Mol Cell Biol 27 (18), 6407-6419 (2007)
   PUBMED   17636018
REFERENCE   4  (residues 1 to 745)
  AUTHORS   Mekhail,K., Khacho,M., Carrigan,A., Hache,R.R., Gunaratnam,L. and
            Lee,S.
  TITLE     Regulation of ubiquitin ligase dynamics by the nucleolus
  JOURNAL   J Cell Biol 170 (5), 733-744 (2005)
   PUBMED   16129783
REFERENCE   5  (residues 1 to 745)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
REFERENCE   6  (residues 1 to 745)
  AUTHORS   Pan,Z.Q., Kentsis,A., Dias,D.C., Yamoah,K. and Wu,K.
  TITLE     Nedd8 on cullin: building an expressway to protein destruction
  JOURNAL   Oncogene 23 (11), 1985-1997 (2004)
   PUBMED   15021886
  REMARK    Review article
REFERENCE   7  (residues 1 to 745)
  AUTHORS   Ohh,M., Kim,W.Y., Moslehi,J.J., Chen,Y., Chau,V., Read,M.A. and
            Kaelin,W.G. Jr.
  TITLE     An intact NEDD8 pathway is required for Cullin-dependent
            ubiquitylation in mammalian cells
  JOURNAL   EMBO Rep 3 (2), 177-182 (2002)
   PUBMED   11818338
REFERENCE   8  (residues 1 to 745)
  AUTHORS   Kamura,T., Koepp,D.M., Conrad,M.N., Skowyra,D., Moreland,R.J.,
            Iliopoulos,O., Lane,W.S., Kaelin,W.G. Jr., Elledge,S.J.,
            Conaway,R.C., Harper,J.W. and Conaway,J.W.
  TITLE     Rbx1, a component of the VHL tumor suppressor complex and SCF
            ubiquitin ligase
  JOURNAL   Science 284 (5414), 657-661 (1999)
   PUBMED   10213691
REFERENCE   9  (residues 1 to 745)
  AUTHORS   Pause,A., Lee,S., Worrell,R.A., Chen,D.Y., Burgess,W.H.,
            Linehan,W.M. and Klausner,R.D.
  TITLE     The von Hippel-Lindau tumor-suppressor gene product forms a stable
            complex with human CUL-2, a member of the Cdc53 family of proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2156-2161 (1997)
   PUBMED   9122164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 4, 2022 this sequence version replaced XP_006254134.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.61137.1,
                                           SRR26360190.265167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     Protein         1..745
                     /product="cullin-2"
                     /calculated_mol_wt=86838
     Region          14..644
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          675..735
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; pfam10557"
                     /db_xref="CDD:463146"
     CDS             1..745
                     /gene="Cul2"
                     /coded_by="NM_001399213.1:179..2416"
                     /db_xref="GeneID:361258"
                     /db_xref="RGD:1310644"
ORIGIN      
        1 mslkprvvdf detwnklltt ikavvmleyv eratwndrfs diyalcvayp eplgerlyae
       61 tkiflenhvr hlykrvlese eqvlvmyhry weeyskgady mdclyrylnt qyikknklte
      121 adlqygyggv dmneplmeig elaldmwrkl mveplqnili rmllreiknd rggedpnqkv
      181 ihgvinsfvh veqykkkfpl kfyqgifvsp fltetgeyyk qeasnllqes ncsqymekvl
      241 grlkdeeirc rkylhpssyt kvihecqqrm vadhlqflhs echsiirher kndmanmyvl
      301 lravssglph mieelqrhih deglratsnl tqehmptlfv esvlevhgkf vqlintvlng
      361 dqhfmsaldk altsvvnyre pksvckapel lakycdnllk ksakgmtene vedkltsfit
      421 vfkyiddkdv fqkfyarmla krlihglsms mdseeamink lkqacgyeft sklhrmytdm
      481 svsadlnnkf nnfirnqdtv idlgisfqiy vlqagawplt qapsstfaip qeleksvqmf
      541 elfysqhfsg rkltwlhylc tgevkmnylg kpyvamvtty qmavllafnn setvsykelq
      601 dstqmnekel tktikslldv kminhdseke didaessfsl nmsfsskrtk fkittsmqkd
      661 tpqeleqtrs avdedrkmyl qaaivrimka rkvlrhnali qevisqsrar fnpsismikk
      721 cievlidkqy iersqasade ysyva
//
