LOCUS       NM_001108627            3023 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cullin 1 (Cul1), mRNA.
ACCESSION   NM_001108627 XM_001069456 XM_342679
VERSION     NM_001108627.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3023)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3023)
  AUTHORS   Reiterer,V., Figueras-Puig,C., Le Guerroue,F., Confalonieri,S.,
            Vecchi,M., Jalapothu,D., Kanse,S.M., Deshaies,R.J., Di Fiore,P.P.,
            Behrends,C. and Farhan,H.
  TITLE     The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits
            SCFFBXW7 function
  JOURNAL   EMBO J 36 (3), 260-273 (2017)
   PUBMED   28007894
  REMARK    Erratum:[EMBO J. 2018 Mar 15;37(6):e99170. doi:
            10.15252/embj.201899170. PMID: 29545456]
REFERENCE   3  (bases 1 to 3023)
  AUTHORS   Chu,W.K., Payne,M.J., Beli,P., Hanada,K., Choudhary,C. and
            Hickson,I.D.
  TITLE     FBH1 influences DNA replication fork stability and homologous
            recombination through ubiquitylation of RAD51
  JOURNAL   Nat Commun 6, 5931 (2015)
   PUBMED   25585578
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3023)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   5  (bases 1 to 3023)
  AUTHORS   Hirano,A., Yumimoto,K., Tsunematsu,R., Matsumoto,M., Oyama,M.,
            Kozuka-Hata,H., Nakagawa,T., Lanjakornsiripan,D., Nakayama,K.I. and
            Fukada,Y.
  TITLE     FBXL21 regulates oscillation of the circadian clock through
            ubiquitination and stabilization of cryptochromes
  JOURNAL   Cell 152 (5), 1106-1118 (2013)
   PUBMED   23452856
REFERENCE   6  (bases 1 to 3023)
  AUTHORS   Kim,J., Kim,J.H., Lee,S.H., Kim,D.H., Kang,H.Y., Bae,S.H., Pan,Z.Q.
            and Seo,Y.S.
  TITLE     The novel human DNA helicase hFBH1 is an F-box protein
  JOURNAL   J Biol Chem 277 (27), 24530-24537 (2002)
   PUBMED   11956208
REFERENCE   7  (bases 1 to 3023)
  AUTHORS   Zheng,N., Schulman,B.A., Song,L., Miller,J.J., Jeffrey,P.D.,
            Wang,P., Chu,C., Koepp,D.M., Elledge,S.J., Pagano,M., Conaway,R.C.,
            Conaway,J.W., Harper,J.W. and Pavletich,N.P.
  TITLE     Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase
            complex
  JOURNAL   Nature 416 (6882), 703-709 (2002)
   PUBMED   11961546
REFERENCE   8  (bases 1 to 3023)
  AUTHORS   Heissmeyer,V., Krappmann,D., Hatada,E.N. and Scheidereit,C.
  TITLE     Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated
            ubiquitination and degradation for the NF-kappaB precursor p105 and
            IkappaBalpha
  JOURNAL   Mol Cell Biol 21 (4), 1024-1035 (2001)
   PUBMED   11158290
REFERENCE   9  (bases 1 to 3023)
  AUTHORS   Morimoto,M., Nishida,T., Honda,R. and Yasuda,H.
  TITLE     Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances
            the activity of SCF(skp2) toward p27(kip1)
  JOURNAL   Biochem Biophys Res Commun 270 (3), 1093-1096 (2000)
   PUBMED   10772955
REFERENCE   10 (bases 1 to 3023)
  AUTHORS   Dealy,M.J., Nguyen,K.V., Lo,J., Gstaiger,M., Krek,W., Elson,D.,
            Arbeit,J., Kipreos,E.T. and Johnson,R.S.
  TITLE     Loss of Cul1 results in early embryonic lethality and dysregulation
            of cyclin E
  JOURNAL   Nat Genet 23 (2), 245-248 (1999)
   PUBMED   10508527
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161932.1.
            
            On Apr 6, 2008 this sequence version replaced NM_001108627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3023
                     /gene="Cul1"
                     /note="cullin 1"
                     /db_xref="GeneID:362356"
                     /db_xref="RGD:1308157"
     exon            1..93
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..394
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2585
                     /gene="Cul1"
                     /codon_start=1
                     /product="cullin-1"
                     /protein_id="NP_001102097.1"
                     /db_xref="GeneID:362356"
                     /db_xref="RGD:1308157"
                     /translation="MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYME
                     LYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTN
                     LLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIY
                     SLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDA
                     FAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQ
                     VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLG
                     ELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFV
                     AALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVM
                     VVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMF
                     QDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRF
                     TAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQ
                     LTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRV
                     NINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSS
                     RFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA"
     exon            395..569
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..737
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..788
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..879
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1043
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1206
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1337
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1445
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1552
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1601
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1733
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1851
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1928
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2060
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2153
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2201
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2284
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2390
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2504
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..3006
                     /gene="Cul1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacgcgagg gcggcgggaa aacctggcgg aggattccgc acgtccggcg ggacctagtt
       61 cggcgtttgg gaagcagagg ccatggctcc caggtttgcc tgcaatgaga ctttaatctc
      121 tacacttaaa gaacattctt tctgagctgc tgtgaataaa tttggaatga tattgtctat
      181 tttcaactaa tggagaacta gctgcatctt gaacaaggat tgctgtattg gacaacttca
      241 gaacattgat caaaatgtca tcaaacagga gtcagaatcc tcatggactg aagcagatcg
      301 gtcttgacca gatctgggat gacctcagag ctggaattca gcaagtgtac accagacaaa
      361 gcatggcaaa gtccagatac atggagctct acactcatgt ttataactac tgtactagtg
      421 tgcatcagtc caaccaagcc cggggtgctg gagtccctcc ttccaagtca aaaaaggggc
      481 agactcctgg gggagctcag tttgtcggct tggagttata caagcgattg aaggagtttt
      541 tgaagaatta cttgacaaat cttcttaagg atggagaaga tttaatggat gagagtgtgc
      601 tgaagttcta cactcagcag tgggaagatt accgattctc cagcaaagtg ctgaatggaa
      661 tctgtgccta cctcaataga cattgggttc gtcgcgaatg tgatgaagga cgaaaaggaa
      721 tatatgaaat ctattcgctt gcgttggtga catggagaga ttgtttgttc aggccattga
      781 ataaacaggt aacaaatgct gttttaaaac tgattgagaa ggaaagaaat ggcgaaacca
      841 tcaatacaag actgattagt ggagttgtac aatcttatgt ggaattggga ctgaatgaag
      901 atgatgcatt tgcaaagggc cctacgttaa cagtgtataa agaatccttt gaatctcaat
      961 ttttggctga cacagagaga ttttatacca gagaaagtac tgaattctta cagcagaacc
     1021 cagttactga atatatgaaa aaggctgaag ctcgtctgct tgaggaacag cggagagttc
     1081 aggtttatct ccatgagagc acacaagatg agctagcacg gaaatgtgag caggtcctca
     1141 ttgaaaaaca cttggaaatt tttcacacag agtttcagaa tttgttggat gctgacaaga
     1201 atgaagattt gggccgcatg tataatcttg tatctagaat tcaggatggc ctaggagaat
     1261 tgaaaaaact actagagaca catattcata atcagggtct tgcggcaatt gagaagtgtg
     1321 gagaagctgc tctgaatgac cccaagatgt atgtgcagac agtgctggat gttcataaaa
     1381 aatacaatgc cctggtgatg tcagcattca acaacgatgc tggcttcgtg gctgcacttg
     1441 ataaggcttg tggtcgcttc ataaacaaca atgcagttac caaaatggcc cagtcatcca
     1501 gtaaatcccc tgagcttctt gctcggtact gtgactcctt gttgaagaaa agttctaaga
     1561 acccagaaga ggcagaacta gaagataccc tcaatcaagt gatggtggtc ttcaagtaca
     1621 tcgaggacaa agatgtattt cagaagttct atgcaaagat gcttgccaag agactggtac
     1681 atcagaacag tgcgagtgac gatgctgaag caagcatgat ctctaaatta aagcaagctt
     1741 gtggttttga gtacacttcc aaactccagc gaatgtttca agacattggt gtaagcaaag
     1801 atctaaatga acagttcaaa aagcacctga cgaattcaga accactggac ttggacttca
     1861 gtattcaggt cctgagttcc ggatcatggc cctttcagca gtcttgcacg tttgccttgc
     1921 cgtcagagtt ggagcgcagt taccaacggt ttacagcttt ctacgccagc cgtcacagtg
     1981 gcagaaaatt gacatggttg tatcaactgt ccaaagggga actagtcact aactgcttca
     2041 aaaacagata cactttgcag gcgtccacat tccagatggc catcctgctt cagtacaaca
     2101 cagaagacgc ctatactgtg cagcagctga ccgacagcac tcagattaaa atggacattt
     2161 tggcacaagt cctacagatt ttactgaagt caaaattgct ggtcttagaa gatgaaaatg
     2221 ccaatgttga tgaggtggaa ttgaagccag acaccttaat aaagttatat cttggttata
     2281 aaaataagaa attgagggtt aatatcaatg taccaatgaa aactgaacag aagcaggaac
     2341 aagaaaccac acacaaaaat atagaggaag accgcaaact actgattcag gcggccatcg
     2401 taagaatcat gaaaatgagg aaggttctga aacaccagca gttacttggt gaagtcctca
     2461 ctcagctgtc ctccaggttc aaacctcggg tcccagtgat caagaaatgc attgatattc
     2521 tcatcgaaaa agaatatttg gagcgagtcg atggtgagaa ggacacctac agttacttgg
     2581 cttaacccat ctagcagggt ctccgtgacc cacgagcaga tagttccagt gaataaagtg
     2641 gaaacaactc gagttcatag cagccagcct gccaccattt ggaccttcct ttttaaagct
     2701 gagaccacag tttccaccag ctggtctcaa gctacagcag gactgctcag gactgacaca
     2761 tttcagtctg taaacagacg ccaatgccat ttaccctaac tcacagacag aggggaaccg
     2821 aaccttccat gctgaggctg catgctaccg cacttaaatc aatacattgg ctccctggtt
     2881 aacagctgtc gtctgaggca gcacacgaga gcgagtctga atggacccac gtgtaatctg
     2941 ctatgaaaac catttgtata gtgtgtttca tttttttaat gtgtgaaaat aaagaaaatt
     3001 aaaggaaaaa aaaaaaaaaa aaa
//
