LOCUS       NP_001102097             776 aa            linear   ROD 24-JUN-2024
DEFINITION  cullin-1 [Rattus norvegicus].
ACCESSION   NP_001102097 XP_001069456 XP_342680
VERSION     NP_001102097.1
DBSOURCE    REFSEQ: accession NM_001108627.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 776)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 776)
  AUTHORS   Reiterer,V., Figueras-Puig,C., Le Guerroue,F., Confalonieri,S.,
            Vecchi,M., Jalapothu,D., Kanse,S.M., Deshaies,R.J., Di Fiore,P.P.,
            Behrends,C. and Farhan,H.
  TITLE     The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits
            SCFFBXW7 function
  JOURNAL   EMBO J 36 (3), 260-273 (2017)
   PUBMED   28007894
  REMARK    Erratum:[EMBO J. 2018 Mar 15;37(6):e99170. doi:
            10.15252/embj.201899170. PMID: 29545456]
REFERENCE   3  (residues 1 to 776)
  AUTHORS   Chu,W.K., Payne,M.J., Beli,P., Hanada,K., Choudhary,C. and
            Hickson,I.D.
  TITLE     FBH1 influences DNA replication fork stability and homologous
            recombination through ubiquitylation of RAD51
  JOURNAL   Nat Commun 6, 5931 (2015)
   PUBMED   25585578
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 776)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   5  (residues 1 to 776)
  AUTHORS   Hirano,A., Yumimoto,K., Tsunematsu,R., Matsumoto,M., Oyama,M.,
            Kozuka-Hata,H., Nakagawa,T., Lanjakornsiripan,D., Nakayama,K.I. and
            Fukada,Y.
  TITLE     FBXL21 regulates oscillation of the circadian clock through
            ubiquitination and stabilization of cryptochromes
  JOURNAL   Cell 152 (5), 1106-1118 (2013)
   PUBMED   23452856
REFERENCE   6  (residues 1 to 776)
  AUTHORS   Kim,J., Kim,J.H., Lee,S.H., Kim,D.H., Kang,H.Y., Bae,S.H., Pan,Z.Q.
            and Seo,Y.S.
  TITLE     The novel human DNA helicase hFBH1 is an F-box protein
  JOURNAL   J Biol Chem 277 (27), 24530-24537 (2002)
   PUBMED   11956208
REFERENCE   7  (residues 1 to 776)
  AUTHORS   Zheng,N., Schulman,B.A., Song,L., Miller,J.J., Jeffrey,P.D.,
            Wang,P., Chu,C., Koepp,D.M., Elledge,S.J., Pagano,M., Conaway,R.C.,
            Conaway,J.W., Harper,J.W. and Pavletich,N.P.
  TITLE     Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase
            complex
  JOURNAL   Nature 416 (6882), 703-709 (2002)
   PUBMED   11961546
REFERENCE   8  (residues 1 to 776)
  AUTHORS   Heissmeyer,V., Krappmann,D., Hatada,E.N. and Scheidereit,C.
  TITLE     Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated
            ubiquitination and degradation for the NF-kappaB precursor p105 and
            IkappaBalpha
  JOURNAL   Mol Cell Biol 21 (4), 1024-1035 (2001)
   PUBMED   11158290
REFERENCE   9  (residues 1 to 776)
  AUTHORS   Morimoto,M., Nishida,T., Honda,R. and Yasuda,H.
  TITLE     Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances
            the activity of SCF(skp2) toward p27(kip1)
  JOURNAL   Biochem Biophys Res Commun 270 (3), 1093-1096 (2000)
   PUBMED   10772955
REFERENCE   10 (residues 1 to 776)
  AUTHORS   Dealy,M.J., Nguyen,K.V., Lo,J., Gstaiger,M., Krek,W., Elson,D.,
            Arbeit,J., Kipreos,E.T. and Johnson,R.S.
  TITLE     Loss of Cul1 results in early embryonic lethality and dysregulation
            of cyclin E
  JOURNAL   Nat Genet 23 (2), 245-248 (1999)
   PUBMED   10508527
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161932.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001069456.1, XP_342680.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     Protein         1..776
                     /product="cullin-1"
                     /calculated_mol_wt=89561
     Region          21..660
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          706..768
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; pfam10557"
                     /db_xref="CDD:463146"
     CDS             1..776
                     /gene="Cul1"
                     /coded_by="NM_001108627.2:255..2585"
                     /db_xref="GeneID:362356"
                     /db_xref="RGD:1308157"
ORIGIN      
        1 mssnrsqnph glkqigldqi wddlragiqq vytrqsmaks rymelythvy nyctsvhqsn
       61 qargagvpps kskkgqtpgg aqfvglelyk rlkeflknyl tnllkdgedl mdesvlkfyt
      121 qqwedyrfss kvlngicayl nrhwvrrecd egrkgiyeiy slalvtwrdc lfrplnkqvt
      181 navlklieke rngetintrl isgvvqsyve lglneddafa kgptltvyke sfesqfladt
      241 erfytreste flqqnpvtey mkkaearlle eqrrvqvylh estqdelark ceqvliekhl
      301 eifhtefqnl ldadknedlg rmynlvsriq dglgelkkll ethihnqgla aiekcgeaal
      361 ndpkmyvqtv ldvhkkynal vmsafnndag fvaaldkacg rfinnnavtk maqssskspe
      421 llarycdsll kkssknpeea eledtlnqvm vvfkyiedkd vfqkfyakml akrlvhqnsa
      481 sddaeasmis klkqacgfey tsklqrmfqd igvskdlneq fkkhltnsep ldldfsiqvl
      541 ssgswpfqqs ctfalpsele rsyqrftafy asrhsgrklt wlyqlskgel vtncfknryt
      601 lqastfqmai llqynteday tvqqltdstq ikmdilaqvl qillkskllv ledenanvde
      661 velkpdtlik lylgyknkkl rvninvpmkt eqkqeqetth knieedrkll iqaaivrimk
      721 mrkvlkhqql lgevltqlss rfkprvpvik kcidilieke ylervdgekd tysyla
//
