LOCUS       NM_001114401            5935 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cortactin binding protein 2 (Cttnbp2), mRNA.
ACCESSION   NM_001114401 XM_001058537 XM_347230
VERSION     NM_001114401.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5935)
  AUTHORS   Shih,P.Y., Hsieh,B.Y., Tsai,C.Y., Lo,C.A., Chen,B.E. and Hsueh,Y.P.
  TITLE     Autism-linked mutations of CTTNBP2 reduce social interaction and
            impair dendritic spine formation via diverse mechanisms
  JOURNAL   Acta Neuropathol Commun 8 (1), 185 (2020)
   PUBMED   33168105
  REMARK    GeneRIF: Autism-linked mutations of CTTNBP2 reduce social
            interaction and impair dendritic spine formation via diverse
            mechanisms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5935)
  AUTHORS   Shih,P.Y., Lee,S.P., Chen,Y.K. and Hsueh,Y.P.
  TITLE     Cortactin-binding protein 2 increases microtubule stability and
            regulates dendritic arborization
  JOURNAL   J Cell Sci 127 (Pt 16), 3521-3534 (2014)
   PUBMED   24928895
  REMARK    GeneRIF: Cttnbp2 increases microtubule stability and regulates
            dendritic arborization.
REFERENCE   3  (bases 1 to 5935)
  AUTHORS   Chen,Y.K. and Hsueh,Y.P.
  TITLE     Cortactin-binding protein 2 modulates the mobility of cortactin and
            regulates dendritic spine formation and maintenance
  JOURNAL   J Neurosci 32 (3), 1043-1055 (2012)
   PUBMED   22262902
  REMARK    GeneRIF: This sst=udy demonistrated that Cortactin-binding protein
            2 modulates the mobility of cortactin and regulates dendritic spine
            formation and maintenance.
REFERENCE   4  (bases 1 to 5935)
  AUTHORS   Thomas,J.W., Touchman,J.W., Blakesley,R.W., Bouffard,G.G.,
            Beckstrom-Sternberg,S.M., Margulies,E.H., Blanchette,M.,
            Siepel,A.C., Thomas,P.J., McDowell,J.C., Maskeri,B., Hansen,N.F.,
            Schwartz,M.S., Weber,R.J., Kent,W.J., Karolchik,D., Bruen,T.C.,
            Bevan,R., Cutler,D.J., Schwartz,S., Elnitski,L., Idol,J.R.,
            Prasad,A.B., Lee-Lin,S.Q., Maduro,V.V., Summers,T.J., Portnoy,M.E.,
            Dietrich,N.L., Akhter,N., Ayele,K., Benjamin,B., Cariaga,K.,
            Brinkley,C.P., Brooks,S.Y., Granite,S., Guan,X., Gupta,J.,
            Haghighi,P., Ho,S.L., Huang,M.C., Karlins,E., Laric,P.L.,
            Legaspi,R., Lim,M.J., Maduro,Q.L., Masiello,C.A., Mastrian,S.D.,
            McCloskey,J.C., Pearson,R., Stantripop,S., Tiongson,E.E.,
            Tran,J.T., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D.,
            Wiggins,L.S., Young,A.C., Zhang,L.H., Osoegawa,K., Zhu,B., Zhao,B.,
            Shu,C.L., De Jong,P.J., Lawrence,C.E., Smit,A.F., Chakravarti,A.,
            Haussler,D., Green,P., Miller,W. and Green,E.D.
  TITLE     Comparative analyses of multi-species sequences from targeted
            genomic regions
  JOURNAL   Nature 424 (6950), 788-793 (2003)
   PUBMED   12917688
REFERENCE   5  (bases 1 to 5935)
  AUTHORS   Ohoka,Y. and Takai,Y.
  TITLE     Isolation and characterization of cortactin isoforms and a novel
            cortactin-binding protein, CBP90
  JOURNAL   Genes Cells 3 (9), 603-612 (1998)
   PUBMED   9813110
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DP000027.1.
            
            On or before Feb 10, 2008 this sequence version replaced
            XM_347230.3, XM_001058537.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132268
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..5935
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /note="cortactin binding protein 2"
                     /db_xref="GeneID:282587"
                     /db_xref="RGD:628691"
     exon            1..171
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..5040
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /note="brain specific cortactin-binding protein CBP90"
                     /codon_start=1
                     /product="cortactin-binding protein 2"
                     /protein_id="NP_001107873.1"
                     /db_xref="GeneID:282587"
                     /db_xref="RGD:628691"
                     /translation="MATDSASCEPDLSRAPGDAEGATAEAAKKEFDVDTLSKSELRML
                     LSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKPV
                     CTNPLSILEAVMAHCRKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAAHLE
                     EERGKNKHVVLMLVKECKQLSGKVVEEAQKLEEVMVKLEEEKKKTSELEDQLSAEKQR
                     SAGMEAQLEKQLFEFDTEREQLRAKLTREEAHTTDLKEEIDKMKKMMEQMKKGNDGKP
                     GLSLPRKTKDKRLASISVATEGPVTRSVACQTDVVTESTDPVKKLPLSVPIKPSTGSP
                     LVSTNTKGNVGPSALLIRPGIDRQASHSDLGPSPPTALPSSASRIEENGPSAGNAPDL
                     SNSTPSTPSGTAPAAAQTLGAAPQNHSQAPPVHSLHSPCANTHPGLNPRIQAARFRFQ
                     GNANDPDQNGNNTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGASSRLG
                     ASPGGDAGTCPPVGRTGLKTPGAARVDRGNPPPIPPKKPGLSQTPSPPHPQLRASNAG
                     AKVDNKIVASPPSTLPQGTKVVNEENVPKSSSPQLPPKPSIDLTVASAGCPVSALATS
                     QVGAWPAETPGLNQPACTDSSLVIPTTVAFRSSINPVSASSRSPGASDSLLVTASGWS
                     PSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYCCEDSHSALYS
                     AAKNGHTDCVRLLLNAEARVDAADKNGFTPLCVAAAQGHFECIELLTAYNANINHSAA
                     GGQTPLYLACKTGNKECIKLLLEAGTDRSIKTRDGWTPIHAAVDTGNVDSLKLLMYHR
                     VPAPGNSLSAEEPKSGLFSLNGGESPPGSSKPVVPADLINHADKEGWTAAHIAASKGF
                     KNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIQPSN
                     DGSDDFECEHTICTLNIRKQTSWEDFSKAVSQALTNHFQAISSDGCWGLEDGTLNNTT
                     DSCIGLGTSSIQSIMLGSIPWSTGQSFSQSPWDFMKKKKVEQVTVLLSGPQEGCLSSV
                     TYTSMIPLQMLQNYLRLVEQYHNVIFHGPEGSLQDYIANQLALCMKHRQMAAGFPCEI
                     VRAEVDSGFSKEQLVDVFISNACLIPVKQFPVKKKIIVILENLEKSSLSELLGDFLAP
                     LENRSTESPCTFQKGNGTSECYYFHENCFLLGTLAKACLQGSDLLVQQHFRWVQLRWD
                     CEPSQGLLQRFLRRKAVSKFRGQLPAPCDPVCKIVDWVISVWRQLNSCLARLGTPEAL
                     LGPKYFLSCPVVPGHAQATVKWMSKLWNAIIAPRVQEAILSRAAMNKQPGARQTASKK
                     HPSQGQQAVVRAALSILLNKAILHGCPLPRTELDQQIADFKGGSFPLSIVSSYSKKKG
                     ESAAWRKVNTSPRKKPGHFSSPMWNKPDLKHEGMRNKSVPHLNINRSSSLSKQQSLEN
                     DLSMTLTLDHRLSLGSDDEADLVKELQSMCSSKSESDISKIADSREDLRTFDSSRTNP
                     VTSAPVNLRMPVPQKEASPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKVAQCSQ
                     NTKRSSSSSSNTRQLEINNNSKEENWNVDKHEHVEKRNK"
     exon            172..279
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..501
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..2128
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2332
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2432
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2583
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2835
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2953
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3229
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3325
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3405
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3492
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3592
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3745
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3933
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4112
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4113..4318
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4495
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..4559
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..4692
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4791
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4792..5935
                     /gene="Cttnbp2"
                     /gene_synonym="Cbp90; Cortbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccagcagc gggttaagcg ccgcccgcgc cgagagagct gagccctgcc gccgctccga
       61 gctcgcattc ggatccgcta gagcaggaag atggcgacgg acagcgcgag ctgcgagccc
      121 gacttgtccc gcgccccggg cgacgcggag ggggccacgg cggaggcggc gaaaaaggag
      181 tttgatgtgg acaccctcag caaatcagag ctgcggatgc tcctcagtgt gatggaaggt
      241 gaactagaag ccagagacct cgtgattgag gccctgcggg ctcgcaggaa ggaggtgttc
      301 atccaggaac gttatgggag atttaatcta aacgaccctt tcctggcact ccagagagac
      361 tatgaagcgg gtgctggtga caaagagaag ccagtctgca ccaacccact ctccattctt
      421 gaagccgtca tggcccactg cagaaaaatg caagaaagaa tgtccgcaca gctggctgcc
      481 gctgagagta ggcagaaaaa gttggagatg gaaaagctcc agcttcaggc ccttgaacag
      541 gagcacaaga agctggctgc ccacctggag gaagagaggg gcaagaacaa gcacgtggtc
      601 ctgatgctgg tgaaggagtg caagcagctc tcaggcaaag tcgtagagga agctcagaag
      661 ctggaggaag tcatggtgaa attggaggag gaaaagaaaa agacaagtga gttagaagac
      721 cagctctccg ctgagaaaca gagaagcgct ggaatggaag ctcagctgga gaaacagctc
      781 tttgagtttg atacggaacg ggagcagctg cgggccaagc tgacccgaga agaagcacac
      841 accaccgacc tcaaagagga gatagacaag atgaagaaaa tgatggagca aatgaagaaa
      901 ggcaacgatg ggaagcccgg actctccctc ccccggaaga caaaagataa gcgactggct
      961 tccatatctg tggcaacaga agggcctgtg acaaggtctg ttgcttgcca gacagatgta
     1021 gtgacagaaa gcactgaccc tgtgaagaaa ttgcctttgt ctgtacccat aaaaccttcc
     1081 acagggagcc ccctagtttc cacaaacaca aaagggaatg tgggccccag tgccctgctg
     1141 attagaccag gtattgatag acaagcttcc cacagtgact tgggtccctc tccacctact
     1201 gccctaccgt caagtgcaag tagaattgag gaaaacggac caagtgcagg caatgcccct
     1261 gacctatcaa acagcacacc ctcaactcct agtggaactg cccctgctgc tgctcagaca
     1321 ctaggtgcag caccccagaa ccattcacaa gctcctcctg tgcacagttt acattcaccg
     1381 tgtgccaaca ctcatccagg tctcaaccca cgcatccaag cagctagatt tagatttcag
     1441 ggcaatgcaa atgacccaga ccagaatgga aataacactc aaagtcctcc ctccagagat
     1501 gtttctccta cgagtcgtga caacctagta gccaagcagc tagctcggaa tactgtgacc
     1561 caagcgctgt ccagatttac cagccctcaa gcaggtgctt cttcaaggct gggagcatct
     1621 ccaggaggcg atgctggcac ctgccctcca gttggtcgaa ccggtttaaa gactccaggg
     1681 gcagcacgag ttgacagagg aaatcctcct cctatccctc ccaaaaagcc agggctctcc
     1741 caaactcctt ctccaccaca ccctcaactg agggcctcca atgcaggggc caaagttgat
     1801 aacaaaattg tggcttcacc tccctctaca ttgccacaag ggaccaaggt agtaaatgag
     1861 gagaacgtcc ctaagtcatc ctcccctcag ctgccaccaa aaccatccat agatttaact
     1921 gtggcatctg caggctgtcc cgtttcggcc ctggccacgt ctcaggtggg tgcctggcct
     1981 gctgaaaccc ctggactgaa ccaacccgca tgtacagaca gctcccttgt cattcccacc
     2041 accgttgcct ttcgctcttc cataaaccct gttagtgcct catcccgtag ccccggtgcc
     2101 tcagacagcc tcttggtaac agcatcaggc tggtcaccct ccctaacccc tttgctaatg
     2161 agtggtggtc ctgcccccct ggctggcagg cccacccttc ttcagcaagc tgctgcccag
     2221 ggaaatgtca ctctattatc aatgctgctt aatgaagaag gactggacat aaattactgc
     2281 tgtgaagata gccattctgc cttgtattct gctgctaaga atggacatac agactgtgtg
     2341 cgattgctgc tgaatgcaga agcccgcgtc gacgctgctg ataaaaatgg cttcacaccc
     2401 ttgtgcgttg cagccgctca gggacatttt gaatgtatag aattactaac tgcatacaat
     2461 gccaacatta atcactctgc tgctggagga cagacacctc tgtacctggc ctgtaaaact
     2521 ggaaataagg aatgtatcaa actcctgctg gaagctggca ctgaccggag tataaaaacc
     2581 agagatggct ggacaccaat tcatgcagcc gtggacactg gtaatgtgga cagcctcaag
     2641 ctattgatgt accatagagt gccagcccct ggaaactctt tgagtgcaga agagcccaag
     2701 tcaggcttgt tcagcttgaa tggaggtgag agccctccag gttcatctaa gcctgtggtt
     2761 cctgcggacc tcattaacca cgctgacaaa gaaggctgga ctgctgccca tattgctgct
     2821 tccaaaggtt tcaagaactg cctagaaatc ttgtgtaggc atggagggct agagccggaa
     2881 aggagagaca agtgcaatcg gactgtgcat gatgttgcca ctgatgactg caagcatttg
     2941 ctggagaatc tgaatgctct taaaataccc ttaaggattt ccgtgggtga aattcaacca
     3001 agcaacgacg gttctgacga ctttgaatgt gaacacacaa tatgcacttt aaatatccgc
     3061 aaacagacat catgggaaga tttttcaaaa gcagtgagtc aggctctgac aaatcacttc
     3121 caagccatct cttctgatgg atgttggggt ctggaagatg ggacacttaa taacacgact
     3181 gactcctgca tcggtcttgg caccagcagc atacaatcca tcatgctagg aagtattccg
     3241 tggtcaactg gtcagagctt ttcccagtcc ccgtgggact tcatgaagaa gaagaaggtg
     3301 gagcaggtca cagtgctctt gtcaggtccc caagaaggct gcctcagtag tgtgacttat
     3361 acatccatga tcccacttca gatgctgcag aactacctca ggctggttga gcaatatcat
     3421 aatgtcattt tccatggccc agaaggaagc ttgcaagact acatagcaaa tcagcttgcc
     3481 ctctgcatga agcacagaca gatggctgca ggattcccct gtgaaatagt gagagctgag
     3541 gtggattcag gtttctccaa ggaacagcta gtagacgtgt tcatcagtaa tgcctgtctg
     3601 atcccagtaa agcagttccc tgttaagaag aaaataatcg tcatcttgga aaatttggaa
     3661 aaatcatcat tgtctgagtt actgggggac tttttggcac ctttggagaa tcgcagcact
     3721 gaaagcccat gcactttcca gaaaggaaat ggaacatctg aatgctatta tttccatgag
     3781 aactgctttc tgctgggaac cctcgccaag gcttgtctcc agggctctga cctgctggtg
     3841 cagcaacact tccgctgggt tcagctgcgc tgggattgcg agcccagtca aggactgctt
     3901 cagaggttcc tccgaagaaa agcagtcagc aagttcagag gtcagctgcc cgcaccctgt
     3961 gatcctgtgt gtaaaattgt ggactgggtt atctctgtct ggaggcagct caactcctgc
     4021 ctggcccgct tgggtacacc ggaagcactt cttggaccca agtatttcct gtcttgtcca
     4081 gtagtcccgg gacatgccca agcaacagtg aagtggatgt ctaagctgtg gaacgccatc
     4141 attgctcccc gagttcaaga agcaatactg tcaagagccg ccatgaacaa acaacctggt
     4201 gctaggcaga cagcttcgaa gaagcaccct agccaagggc agcaggctgt ggtgagggct
     4261 gctctcagca ttctgcttaa taaagccatt ctgcatggct gtccccttcc caggacagag
     4321 ctggaccagc agatagcaga cttcaaaggg ggaagtttcc ctctgtcaat agtttcaagt
     4381 tatagcaaga agaaaggaga gagtgcagcc tggagaaagg tgaacaccag tcctcgcaag
     4441 aaacctgggc acttctcctc acccatgtgg aacaagccag acctgaagca tgaaggtatg
     4501 agaaacaaga gtgtaccaca tctgaatatt aacaggagct cctctctgtc aaagcaacag
     4561 tccttagaga atgatctatc catgacattg actttggacc acagactctc tttgggttca
     4621 gatgatgagg cagatctggt caaagaactc cagagtatgt gttccagcaa atctgagtct
     4681 gatataagca agattgctga ttccagggaa gacttaagga catttgatag ttcaagaacc
     4741 aaccctgtga cttcagcacc tgttaacctg aggatgccag tgccacagaa ggaagccagt
     4801 cctctcagca gccatcaaac taccgaatgc agcaacagta aatccaagac tgagttgggt
     4861 gtctcaagag ttaaatcttt tcttcctgtt cctagaagta aagtcgccca gtgttcccag
     4921 aacaccaaaa gaagcagcag cagcagcagt aatacaaggc aactagaaat caataacaac
     4981 tccaaagaag agaattggaa cgtagacaaa cacgaacacg tagaaaaacg taacaaatag
     5041 gcctgcctac aacacctcca acaacgtgat caccttaacg tcttttgtat atttcatgca
     5101 gaaacaccaa gacaaagaag atgtaaatac cttaaaatga ataaaaccat tttcctgtaa
     5161 tataaaggac aggtgcggga ccactattca gccttttgta aagaatgtat ttataacctc
     5221 acattttttt ttctgttaat cctataggac taaactttga tcccatgaac ttacagcaac
     5281 ctttcaagta gtttttttat aatagaaaca ttgtaatcgt tttaatggag atgttcaggg
     5341 gtattaaagc agaagtgtct gtgtactgta tatttctatc tgtacatatg tacatatatg
     5401 tatattgaca gaagttgcat acatgtgtac aagattggct tagatgaaat gtgccagttt
     5461 gaatggagat gataatttta tgctcatctg atggggaatg actcgaatgg ggcaataaca
     5521 aaacatttct aaacagttat tttccattaa aagccatatg aagtattttg cctgttaaaa
     5581 ttctagtttt acattttgaa tcttttagtg gttacattgc catctggttg catcatgtat
     5641 atatatttac gcttcttaat ttgcattatg acttgtaaaa aatatgaaat tataatgcaa
     5701 taaaagtgtt atctttctta caaaactttt gtacctaagt ggatataaaa gttatctgca
     5761 tcaagaaaga catcaattaa atgaatttgg agttaacgcc ttcaatatat ttctaataac
     5821 acaccgataa taaaattaat attttctaga agtgtgtctt ataaaggaat ggtgaagtta
     5881 tttatccaat ttacggttaa ggtactttga tgccaaataa aattttgaac tagtg
//
