LOCUS       NM_001398643            3045 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cortactin (Cttn), transcript variant 1, mRNA.
ACCESSION   NM_001398643 XM_006230622
VERSION     NM_001398643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3045)
  AUTHORS   Palia,P., Adams,A., Sriram,A. and Vogl,A.W.
  TITLE     Cortactin knockdown results in disruption of basal TBCs and alters
            turnover of Sertoli cell ESs in Rattus norvegicusdagger
  JOURNAL   Biol Reprod 105 (5), 1330-1343 (2021)
   PUBMED   34426822
  REMARK    GeneRIF: Cortactin knockdown results in disruption of basal TBCs
            and alters turnover of Sertoli cell ESs in Rattus norvegicusdagger.
REFERENCE   2  (bases 1 to 3045)
  AUTHORS   Szabo,L.E., Marcello,G.M., Suth,M., Sotonyi,P. and Racz,B.
  TITLE     Distribution of cortactin in cerebellar Purkinje cell spines
  JOURNAL   Sci Rep 11 (1), 1375 (2021)
   PUBMED   33446758
  REMARK    GeneRIF: Distribution of cortactin in cerebellar Purkinje cell
            spines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3045)
  AUTHORS   Kim,J.Y., Hwang,H.G., Lee,J.Y., Kim,M. and Kim,J.Y.
  TITLE     Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal
            migration and dendrite morphogenesis during cerebral cortex
            development
  JOURNAL   Mol Brain 13 (1), 105 (2020)
   PUBMED   32711564
  REMARK    GeneRIF: Cortactin deacetylation by HDAC6 and SIRT2 regulates
            neuronal migration and dendrite morphogenesis during cerebral
            cortex development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3045)
  AUTHORS   Parkinson,G.T., Chamberlain,S.E.L., Jaafari,N., Turvey,M.,
            Mellor,J.R. and Hanley,J.G.
  TITLE     Cortactin regulates endo-lysosomal sorting of AMPARs via direct
            interaction with GluA2 subunit
  JOURNAL   Sci Rep 8 (1), 4155 (2018)
   PUBMED   29515177
  REMARK    GeneRIF: These results demonstrate that cortactin maintains
            GluA2/A3 levels by directing receptors away from lysosomes, and
            that disrupting GluA2-cortactin interactions to target GluA2/A3 to
            lysosomes is an essential component of LTD expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3045)
  AUTHORS   Kubo,Y., Baba,K., Toriyama,M., Minegishi,T., Sugiura,T., Kozawa,S.,
            Ikeda,K. and Inagaki,N.
  TITLE     Shootin1-cortactin interaction mediates signal-force transduction
            for axon outgrowth
  JOURNAL   J Cell Biol 210 (4), 663-676 (2015)
   PUBMED   26261183
  REMARK    GeneRIF: The shootin1-cortactin interaction participates in
            netrin-1-induced F-actin adhesion coupling and in the promotion of
            traction forces for axon outgrowth.
REFERENCE   6  (bases 1 to 3045)
  AUTHORS   Hattan,D., Nesti,E., Cachero,T.G. and Morielli,A.D.
  TITLE     Tyrosine phosphorylation of Kv1.2 modulates its interaction with
            the actin-binding protein cortactin
  JOURNAL   J Biol Chem 277 (41), 38596-38606 (2002)
   PUBMED   12151401
REFERENCE   7  (bases 1 to 3045)
  AUTHORS   Okamoto,P.M., Gamby,C., Wells,D., Fallon,J. and Vallee,R.B.
  TITLE     Dynamin isoform-specific interaction with the shank/ProSAP
            scaffolding proteins of the postsynaptic density and actin
            cytoskeleton
  JOURNAL   J Biol Chem 276 (51), 48458-48465 (2001)
   PUBMED   11583995
REFERENCE   8  (bases 1 to 3045)
  AUTHORS   Gallagher,A.R., Cedzich,A., Gretz,N., Somlo,S. and Witzgall,R.
  TITLE     The polycystic kidney disease protein PKD2 interacts with Hax-1, a
            protein associated with the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4017-4022 (2000)
   PUBMED   10760273
REFERENCE   9  (bases 1 to 3045)
  AUTHORS   Kessels,M.M., Engqvist-Goldstein,A.E. and Drubin,D.G.
  TITLE     Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src
            kinase target, with dynamic regions of the cortical actin
            cytoskeleton in response to Rac1 activation
  JOURNAL   Mol Biol Cell 11 (1), 393-412 (2000)
   PUBMED   10637315
REFERENCE   10 (bases 1 to 3045)
  AUTHORS   Ohoka,Y. and Takai,Y.
  TITLE     Isolation and characterization of cortactin isoforms and a novel
            cortactin-binding protein, CBP90
  JOURNAL   Genes Cells 3 (9), 603-612 (1998)
   PUBMED   9813110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XM_006230622.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061843.1, SRR26360194.968997.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000001.1  209064454-209064516 c
            64-160              JAXUCZ010000001.1  209059914-209060010 c
            161-247             JAXUCZ010000001.1  209058125-209058211 c
            248-321             JAXUCZ010000001.1  209057531-209057604 c
            322-451             JAXUCZ010000001.1  209055377-209055506 c
            452-562             JAXUCZ010000001.1  209051383-209051493 c
            563-617             JAXUCZ010000001.1  209050039-209050093 c
            618-728             JAXUCZ010000001.1  209048377-209048487 c
            729-839             JAXUCZ010000001.1  209046717-209046827 c
            840-950             JAXUCZ010000001.1  209046184-209046294 c
            951-1061            JAXUCZ010000001.1  209045317-209045427 c
            1062-1117           JAXUCZ010000001.1  209043846-209043901 c
            1118-1187           JAXUCZ010000001.1  209040082-209040151 c
            1188-1336           JAXUCZ010000001.1  209036127-209036275 c
            1337-1426           JAXUCZ010000001.1  209034152-209034241 c
            1427-1592           JAXUCZ010000001.1  209032960-209033125 c
            1593-1664           JAXUCZ010000001.1  209031223-209031294 c
            1665-3045           JAXUCZ010000001.1  209029048-209030428 c
FEATURES             Location/Qualifiers
     source          1..3045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3045
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /note="cortactin"
                     /db_xref="GeneID:60465"
                     /db_xref="RGD:619839"
     exon            1..63
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            64..160
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1801
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /note="isoform 1 is encoded by transcript variant 1; src
                     substrate cortactin"
                     /codon_start=1
                     /product="src substrate cortactin isoform 1"
                     /protein_id="NP_001385572.1"
                     /db_xref="GeneID:60465"
                     /db_xref="RGD:619839"
                     /translation="MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTV
                     QGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGH
                     EYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGG
                     KYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGK
                     TEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQ
                     SERQDSSAVGFDYKEKLAKHESQQDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAY
                     QKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAQERQEQEEARRKLE
                     EQARAKKQTPPASPSPQPAEDRPPSSPIYEDAAPLKAEPSYGSSEPEPEYSTEAAGLP
                     EASNQQGLAYTSEPVYETTEVPGHYQAEDDTYDGYESDLGITAIALYDYQAAGDDEIS
                     FDPDDVITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ"
     exon            161..247
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            248..321
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            322..451
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            452..562
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            563..617
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            618..728
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..839
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            840..950
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1061
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1117
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1187
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1336
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1426
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1592
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1664
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..3045
                     /gene="Cttn"
                     /gene_synonym="Cttnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgagc gggcacaggg agcggcgggg cgcggcggga gcctggcgga ccctgctggt
       61 gcggtaatca ttgatcgtca cagatgccct cacattctgc cttggattcc tcggatacag
      121 acggactatt ctgagctgct tttcccagca aaagaaaaag atgtggaaag cttctgcagg
      181 ccatgctgtg tccatcaccc aggatgatgg gggagccgat gactgggaga ctgaccctga
      241 ttttgtgaac gatgtgagtg aaaaggaaca gagatggggc gccaaaaccg tgcagggatc
      301 ggggcaccag gaacacatca acatacacaa gcttcgagag aatgtcttcc aagaacacca
      361 gacactcaag gagaaggagc tggaaacggg acccaaggct tcccatggct atggcgggaa
      421 gtttggtgtg gagcaagata ggatggacaa atcagctgtg ggccatgagt accagtcaaa
      481 gctctccaag cactgctcac aagtggactc agtccggggc ttcggaggca agttcggtgt
      541 ccagatggac agggtggatc agtctgctgt aggctttgaa taccagggga agacggagaa
      601 gcacgcctcc cagaaagact actccagtgg tttcggtggc aaatatggag tgcaagctga
      661 ccgtgtagac aagagtgctg tgggctttga ctaccagggc aagacggaga agcacgagtc
      721 acagaaagat tactccaaag gttttggtgg caaatacgga attgacaagg acaaggtgga
      781 taaaagcgct gtgggctttg agtatcaagg caaaacagag aagcatgagt cccagaaaga
      841 ctatgtaaaa ggctttggag gaaagtttgg tgtgcagaca gacagacagg acaagtgtgc
      901 ccttggctgg gaccatcagg agaagctgca gctgcatgaa tcccaaaaag actataagac
      961 tggtttcgga ggcaaatttg gtgttcagtc cgagaggcag gactcctccg ctgtggggtt
     1021 tgattacaag gagaaattgg ccaagcacga gtcccagcaa gactatgcca aaggattcgg
     1081 cgggaagtat ggggtgcaga aggatcggat ggacaagaac gcatccacct ttgaagaagt
     1141 ggtccaggtg ccgtctgcct atcagaagac tgtccccatt gaggctgtga ccagcaaaac
     1201 cagtaatatt cgtgctaact ttgaaaacct ggcaaaggag agagagcagg aggacagacg
     1261 gaaggcagaa gccgagagag ctcagcggat ggcccaagaa aggcaggagc aggaggaggc
     1321 tcgaaggaag ctggaagagc aagccagagc caagaagcag acaccccctg catcccctag
     1381 tcctcagcca gctgaagaca gaccaccatc cagccccatc tatgaggatg cagctccgtt
     1441 gaaggccgag ccgagctacg gaagtagtga gcctgagcct gagtacagca ctgaggctgc
     1501 aggccttcct gaggccagca accagcaagg tctggcctac acatcagagc ctgtttacga
     1561 gaccacagag gttcctggcc actaccaagc agaggatgac acctacgatg ggtatgagag
     1621 tgacctgggc atcacagcca tcgccctgta tgactaccag gctgctggcg atgatgaaat
     1681 ctcctttgac cctgatgatg tcatcaccaa catagaaatg attgacgatg gctggtggcg
     1741 tggggtgtgc aagggcagat atgggctctt cccggccaac tatgtggagc tgcggcagta
     1801 gggtggccac ccagagccta ccagcaccag cactgggttc acactacatc gcgtctgcgt
     1861 gtgttgaatt ggtttctgct tccatttctg tttttgttct ttttccgaag gtggggaggg
     1921 gaatatacat attgccttta tatttaatac gtctgctgat gcttcggggc atgtcctgcc
     1981 acagaatttg ctaatgtctg atgatcatgt tcacagagaa catgggtgat tactttcagc
     2041 catccaggtg ttttagcttt gccaagccga ctgtggtacg tagccacttc agggcatgca
     2101 cttctcctga ggttggtggt acatgtggcc ttgtgcccac ttcccttcca tggcagtcgg
     2161 gttcccagga tggagacagt gctcctggag tggccactca gggaggaggc tctctgggat
     2221 ccagtgtttg gaagaagagg aagggcgtcc aaaggaaatc gaggtcccgg agcgttgacc
     2281 cttcgaggga agtcgtatct ttcagtcctg accatttgag ccaggatctg ggcttccttt
     2341 actccacctc ctcatctcaa ttcaacctga caccccagtc ctggttgacc cctttctcct
     2401 gctgccttgc cctgaagtgt tactttctcc cgtctgtatt cgaggtctgt agcacacaat
     2461 gcatctcaga gatgtgctgg ccacttatcc tgagcttggc ctgcgacatg ggagacttgg
     2521 ggagggagtc ttggacttgc tcatgactcc tgctcagcca gagtgagctg tgtggccagc
     2581 cacctggctg ggcagacaga taccttctcc ctgcaagcct ccagaaacat gctccctgtg
     2641 gggagctgtg ttctttttgc caaatatgtt caattatagt cagttgatag attaatgtgg
     2701 ctgaacacag gactgagtga actgatccac ctgggtgcct ccccagcatc cttgatcaac
     2761 tgtccctaag atgctttcaa agtgtctgag acaccaggag gctgggccac actggttata
     2821 cacagtcaag cgagcagcac agcatgtcct tgtagatgcg tccccacctc tgggacacat
     2881 gaggaccgat gcccgttttc tccccatgag ctttcctgta gaatccttgc ctttccgttg
     2941 ttaggttggg ttttctatat gaattatcat ctggaattct gtagcacacc ttataggtat
     3001 ggattttttt aaattaaata ttcagaataa actttttttg atcca
//
