LOCUS       NM_183330               1355 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cathepsin Z (Ctsz), mRNA.
ACCESSION   NM_183330
VERSION     NM_183330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Obermajer,N., Doljak,B., Jamnik,P., Fonovic,U.P. and Kos,J.
  TITLE     Cathepsin X cleaves the C-terminal dipeptide of alpha- and
            gamma-enolase and impairs survival and neuritogenesis of neuronal
            cells
  JOURNAL   Int J Biochem Cell Biol 41 (8-9), 1685-1696 (2009)
   PUBMED   19433310
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Leichsenring,A., Backer,I., Wendt,W., Andriske,M., Schmitz,B.,
            Stichel,C.C. and Lubbert,H.
  TITLE     Differential expression of Cathepsin S and X in the spinal cord of
            a rat neuropathic pain model
  JOURNAL   BMC Neurosci 9, 80 (2008)
   PUBMED   18700000
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Lu,J., Qian,J., Keppler,D. and Cardoso,W.V.
  TITLE     Cathespin H is an Fgf10 target involved in Bmp4 degradation during
            lung branching morphogenesis
  JOURNAL   J Biol Chem 282 (30), 22176-22184 (2007)
   PUBMED   17500053
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Nakazono,E., Kamata,Y. and Yamafuji,K.
  TITLE     Determination of the mRNA sequence of cathepsin Y, a cysteine
            endopeptidase from rat spleen, 1 and confirmation of its ubiquitous
            expression
  JOURNAL   Biol Chem 383 (12), 1971-1975 (2002)
   PUBMED   12553736
  REMARK    GeneRIF: completion of the mRNA sequence resulted in the omission
            of the strangely attached C-terminal peptide from cathepsin Y
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Sakamoto,E., Sakao,Y., Taniguchi,Y. and Yamafuji,K.
  TITLE     Cathepsin Y (a novel thiol enzyme) produces kinin potentiating
            peptide from the component protein of rat plasma
  JOURNAL   Immunopharmacology 45 (1-3), 207-214 (1999)
   PUBMED   10615013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_183330.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023781.2, SRR26643296.12192.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               JAXUCZ010000003.1  183653621-183653847 c
            228-391             JAXUCZ010000003.1  183653064-183653227 c
            392-571             JAXUCZ010000003.1  183648504-183648683 c
            572-722             JAXUCZ010000003.1  183644614-183644764 c
            723-888             JAXUCZ010000003.1  183644131-183644296 c
            889-1355            JAXUCZ010000003.1  183643077-183643543 c
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..1355
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /note="cathepsin Z"
                     /db_xref="GeneID:252929"
                     /db_xref="RGD:708479"
     exon            1..227
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..999
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /EC_number="3.4.18.1"
                     /note="cathepsin Y; cathepsin X"
                     /codon_start=1
                     /product="cathepsin Z precursor"
                     /protein_id="NP_899159.1"
                     /db_xref="GeneID:252929"
                     /db_xref="RGD:708479"
                     /translation="MASSGSVQQLRLVLLMLLLAGAARASLYFRPGQTCYRPLHRDHL
                     ALLGRRTYPRPHEYLSPADLPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSA
                     LADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLPVWEYAHKHGIPDETCNNYQ
                     AKDQECDKFNQCGTCTEFKECHTIQNYTLWRVGDYGSLSGREKMMAEIYANGPISCGI
                     MATERMSNYTGGIYTEYQNQAIINHIISVAGWGVSNDGIEYWIVRNSWGEPWGERGWM
                     RIVTSTYKGGTGSSYNLAIEEACTFGDPIV"
     exon            228..391
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /inference="alignment:Splign:2.1.0"
     exon            392..571
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /inference="alignment:Splign:2.1.0"
     exon            572..722
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /inference="alignment:Splign:2.1.0"
     exon            723..888
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1355
                     /gene="Ctsz"
                     /gene_synonym="CATX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggcctgc ggatcgggtc aagaggttga aggtgctgtg cgtgatccag gatccaagtt
       61 ggcccccgga gcaggagcat ggcgtcgtcg ggatcggtgc agcagctgcg gctggtgctg
      121 ctgatgttgc tgctggccgg tgcggcacgg gccagcctct acttccgccc gggccagacc
      181 tgctaccgac cccttcacag ggaccacctg gctctgctgg ggcgcaggac ctatcctcgg
      241 ccacatgagt acctgtcccc agcggatctc cccaagaact gggactggag gaatgtgaac
      301 ggtgtcaact atgccagcgt cacgaggaat cagcatatcc cacagtactg tggttcttgc
      361 tgggcccacg gcagcaccag tgccttggca gatcgcatca acatcaagag aaaaggtgca
      421 tggccctcca ccctgttgtc ggtgcagaat gtcatcgact gcggcaatgc tggttcttgt
      481 gaggggggca atgaccttcc ggtgtgggag tatgcccaca agcatggcat ccccgatgag
      541 acctgcaaca actaccaggc caaggaccaa gaatgtgaca agtttaacca gtgtgggacc
      601 tgcactgaat tcaaagagtg ccacaccatc cagaattata ccctctggag agtgggtgac
      661 tatggctccc tgtccgggag ggagaagatg atggcagaga tctacgccaa tggtcccatc
      721 agctgcggga taatggcaac cgagaggatg tctaactaca ctggaggcat ctatactgag
      781 taccagaacc aggccattat caaccacatc atctctgtag ccggctgggg tgtcagcaat
      841 gatggcatcg agtattggat tgtccgcaat tcatggggcg agccctgggg tgagcgaggc
      901 tggatgagaa ttgtgaccag cacctataag ggagggacag gttccagcta caacctcgcc
      961 attgaggagg cctgcacatt tggggacccc attgtctagg tagatgtccc tggaagcaac
     1021 actgtgaacc atgatgagga ggggtgatta tcgacactgg atatgtccat tcagctagaa
     1081 acagtggccc tcatgtggac acgaggacca gagtgtgggc tgcaccccga gaggtgatag
     1141 gaaaggatga gccacaacta cactggaacc ctccaccttc agacctgctt ccctccaccc
     1201 acagacctgc ttcctcctcc accgtgccct gcaggcctac ctccagccgc cagagaggac
     1261 agctatggtc taggacagtt ctggtgttac cctggagtcc acgggagggg aactagtcca
     1321 gactgcctga gatgagtaaa gtatctggcg tcacc
//
