LOCUS       NM_017320               1435 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cathepsin S (Ctss), mRNA.
ACCESSION   NM_017320
VERSION     NM_017320.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Oshima,E., Hayashi,Y., Xie,Z., Sato,H., Hitomi,S., Shibuta,I.,
            Urata,K., Ni,J., Iwata,K., Shirota,T. and Shinoda,M.
  TITLE     M2 macrophage-derived cathepsin S promotes peripheral nerve
            regeneration via fibroblast-Schwann cell-signaling relay
  JOURNAL   J Neuroinflammation 20 (1), 258 (2023)
   PUBMED   37946211
  REMARK    GeneRIF: M2 macrophage-derived cathepsin S promotes peripheral
            nerve regeneration via fibroblast-Schwann cell-signaling relay.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Sun,P., Lin,W., Weng,Y., Gong,J., Huang,Y., Tang,Y., Lin,C.,
            Chen,A. and Chen,Y.
  TITLE     Spinal Cathepsin S promotes visceral hypersensitivity via
            FKN/CX3CR1/p38 MAPK signaling pathways
  JOURNAL   Mol Pain 19, 17448069231179118 (2023)
   PUBMED   37347150
  REMARK    GeneRIF: Spinal Cathepsin S promotes visceral hypersensitivity via
            FKN/CX3CR1/p38 MAPK signaling pathways.
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Peng,K., Liu,H., Yan,B., Meng,X.W., Song,S.Y., Ji,F.H. and Xia,Z.
  TITLE     Inhibition of cathepsin S attenuates myocardial
            ischemia/reperfusion injury by suppressing inflammation and
            apoptosis
  JOURNAL   J Cell Physiol 236 (2), 1309-1320 (2021)
   PUBMED   32657442
  REMARK    GeneRIF: Inhibition of cathepsin S attenuates myocardial
            ischemia/reperfusion injury by suppressing inflammation and
            apoptosis.
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Bonfante,R., Napimoga,M.H., Macedo,C.G., Abdalla,H.B., Pieroni,V.
            and Clemente-Napimoga,J.T.
  TITLE     The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal
            Subnucleus Caudalis Signal Persistent Hypernociception in
            Temporomandibular Rat Joints
  JOURNAL   Neuroscience 391, 120-130 (2018)
   PUBMED   30248434
  REMARK    GeneRIF: Study shows that a persistent model of inflammatory
            hypernociception induced by arthritis in the temporomandibular
            joint elicited protein levels of P2X7 receptors, cathepsin S and
            fractalkine in the trigeminal subnucleus caudalis.
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Ji,C., Tang,M., Harrison,J., Paciorkowski,A. and Johnson,G.V.W.
  TITLE     Nuclear transglutaminase 2 directly regulates expression of
            cathepsin S in rat cortical neurons
  JOURNAL   Eur J Neurosci 48 (9), 3043-3051 (2018)
   PUBMED   30239049
  REMARK    GeneRIF: Knockdown of transglutaminase 2 resulted in a significant
            increase in cathepsin S expression, which preceded the loss of
            neuronal viability.
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Sukhova,G.K., Shi,G.P., Simon,D.I., Chapman,H.A. and Libby,P.
  TITLE     Expression of the elastolytic cathepsins S and K in human atheroma
            and regulation of their production in smooth muscle cells
  JOURNAL   J Clin Invest 102 (3), 576-583 (1998)
   PUBMED   9691094
REFERENCE   7  (bases 1 to 1435)
  AUTHORS   Nissler,K., Kreusch,S., Rommerskirch,W., Strubel,W., Weber,E. and
            Wiederanders,B.
  TITLE     Sorting of non-glycosylated human procathepsin S in mammalian cells
  JOURNAL   Biol Chem 379 (2), 219-224 (1998)
   PUBMED   9524075
REFERENCE   8  (bases 1 to 1435)
  AUTHORS   Riese,R.J., Wolf,P.R., Bromme,D., Natkin,L.R., Villadangos,J.A.,
            Ploegh,H.L. and Chapman,H.A.
  TITLE     Essential role for cathepsin S in MHC class II-associated invariant
            chain processing and peptide loading
  JOURNAL   Immunity 4 (4), 357-366 (1996)
   PUBMED   8612130
REFERENCE   9  (bases 1 to 1435)
  AUTHORS   Lemere,C.A., Munger,J.S., Shi,G.P., Natkin,L., Haass,C.,
            Chapman,H.A. and Selkoe,D.J.
  TITLE     The lysosomal cysteine protease, cathepsin S, is increased in
            Alzheimer's disease and Down syndrome brain. An immunocytochemical
            study
  JOURNAL   Am J Pathol 146 (4), 848-860 (1995)
   PUBMED   7717452
REFERENCE   10 (bases 1 to 1435)
  AUTHORS   Petanceska,S. and Devi,L.
  TITLE     Sequence analysis, tissue distribution, and expression of rat
            cathepsin S
  JOURNAL   J Biol Chem 267 (36), 26038-26043 (1992)
   PUBMED   1281481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 5, 2021 this sequence version replaced NM_017320.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231418.1, FQ218804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000002.1  185775396-185775520
            126-252             JAXUCZ010000002.1  185778151-185778277
            253-375             JAXUCZ010000002.1  185785347-185785469
            376-525             JAXUCZ010000002.1  185787981-185788130
            526-756             JAXUCZ010000002.1  185791234-185791464
            757-922             JAXUCZ010000002.1  185792890-185793055
            923-1025            JAXUCZ010000002.1  185795805-185795907
            1026-1435           JAXUCZ010000002.1  185803031-185803440
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1435
                     /gene="Ctss"
                     /note="cathepsin S"
                     /db_xref="GeneID:50654"
                     /db_xref="RGD:621513"
     exon            1..125
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1125
                     /gene="Ctss"
                     /EC_number="3.4.22.27"
                     /codon_start=1
                     /product="cathepsin S preproprotein"
                     /protein_id="NP_059016.2"
                     /db_xref="GeneID:50654"
                     /db_xref="RGD:621513"
                     /translation="MRTPAHAAIRRWLFWVPLVCSVTMEQLQRDPTLDHHWDLWKKTH
                     EKEYKDQNEEDVRRLIWEKNLKFIMLHNLEHSMGMHSYSVGMNHMGDMTPEEVIGYMG
                     SLRIPRHWNRSGTLKSSSNQTLPDSVDWREKGCVTNVKYQGSCGSCWAFSAVGALEGQ
                     LKLKTGKLVSLSAQNLVDCSTEEKYGNKGCGGGFMTEAFQYIIDNGGIDSEASYPYKA
                     MDEKCHYDPKNRAATCSRYIELPFGDEEALKEAVATKGPVSVGIDASHSSFFLYQSGV
                     YDDPSCTENVNHGVLVVGYGTLDGKDYWLVKNSWGLHFGDQGYIRMARNNKNHCGIAS
                     YCSYPEI"
     exon            126..252
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     exon            253..375
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     exon            376..525
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     exon            526..756
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     exon            757..922
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1025
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1435
                     /gene="Ctss"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcatgtg acaagctcca atttcttttt agagtcattt cgaccagcct cctgctgcct
       61 gggacatctt tagagtgagc accacacttc acggtgacca tgaggactcc tgctcatgcc
      121 gccatacgga gatggctgtt ttgggtgccc ctggtgtgct ctgtgacaat ggagcaactg
      181 cagagagacc ctaccctgga ccaccactgg gatctctgga agaaaacgca tgagaaggaa
      241 tacaaggatc agaatgaaga agacgtacga cgtctcatct gggaaaagaa tctcaagttt
      301 ataatgcttc acaatctgga acattctatg ggaatgcatt catacagtgt gggcatgaac
      361 cacatgggag acatgacacc tgaagaagtc ataggttata tgggctctct gagaattccc
      421 aggcactgga atagaagtgg cactctcaag tcaagctcta atcagacatt gcccgactct
      481 gtggactggc gagaaaaggg ctgcgtcact aatgtgaaat accagggctc ttgtggttcc
      541 tgctgggctt tcagcgccgt gggggccctt gaagggcagc tgaagctgaa aacggggaag
      601 ctggtgtctc tcagtgctca gaacctggtg gattgctcaa ccgaagaaaa gtacgggaat
      661 aaaggctgcg ggggtggctt catgaccgaa gctttccagt acatcatcga taacggaggc
      721 atcgactcag aagcttccta tccctacaaa gccatggatg aaaagtgtca ctatgaccca
      781 aaaaatcgag ctgccacgtg ttcaaggtac attgagctcc ccttcggcga tgaagaagct
      841 ctgaaagaag cagtggccac taaagggcct gtctctgtgg gcatcgacgc cagccattcc
      901 tccttcttcc tctaccaaag tggtgtctat gatgacccct cctgtaccga gaatgtgaat
      961 catggtgttc tcgtggttgg ctatgggact cttgatggga aagactactg gcttgtgaaa
     1021 aacagttggg gccttcactt tggtgatcaa ggatatattc ggatggcgag aaataacaaa
     1081 aatcactgcg ggattgctag ctattgctct tacccagaaa tctaaaccgt ttcttctttt
     1141 tctaatgggt cacaaagacg gaatacactc taatttaatt ttgtctgctc catccggagg
     1201 acccaagtgt gtcgtgatca gtgtgtacat actgtgctaa ctggcttaca gcttgtttgt
     1261 tttataactt tacctctctc tgaaaagtct gtaagcaagg acgcgctgag gatggagctg
     1321 gcagtctgtc ctagatattc tttctatgct tgcaccctgt cgtctaatgt gtctaataac
     1381 cctttgtaac acgatatccc caaagtgcct aataaaatct gtcatttcaa agctc
//
