LOCUS       NM_013156               1382 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Rattus norvegicus cathepsin L (Ctsl), mRNA.
ACCESSION   NM_013156
VERSION     NM_013156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Wang,H., Liu,H., Cheng,H., Xue,X., Ge,Y., Wang,X. and Yuan,J.
  TITLE     Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic
            Membranous Nephropathy through Regulating the TRPC6/CatL Pathway
  JOURNAL   Am J Nephrol 55 (3), 345-360 (2024)
   PUBMED   38330925
  REMARK    GeneRIF: Klotho Stabilizes the Podocyte Actin Cytoskeleton in
            Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL
            Pathway.
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Shen,X., Zhao,Y.F., Xu,S.Q., Wang,L., Cao,H.M., Cao,Y., Zhu,Y.,
            Wang,Y. and Liang,Z.Q.
  TITLE     Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb
            and regulation of cell cycle proteins
  JOURNAL   Acta Pharmacol Sin 40 (11), 1394-1403 (2019)
   PUBMED   31444477
  REMARK    GeneRIF: Cathepsin L induces apoptosis in rotenone-treated PC-12
            cells via activation of B-Myb protein.
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Szumska,J., Batool,Z., Al-Hashimi,A., Venugopalan,V., Skripnik,V.,
            Schaschke,N., Bogyo,M. and Brix,K.
  TITLE     Treatment of rat thyrocytes in vitro with cathepsin B and L
            inhibitors results in disruption of primary cilia leading to
            redistribution of the trace amine associated receptor 1 to the
            endoplasmic reticulum
  JOURNAL   Biochimie 166, 270-285 (2019)
   PUBMED   31302164
  REMARK    GeneRIF: The results revealed that cathepsin B and L activity is
            required for maintenance of a fully differentiated state of
            thyrocytes featuring Taar1-bearing primary cilia.
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Kubo,A., Shirato,I., Hidaka,T., Takagi,M., Sasaki,Y., Asanuma,K.,
            Ishidoh,K. and Suzuki,Y.
  TITLE     Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli
            of Rats With Puromycin Aminonucleoside Nephrosis
  JOURNAL   J Histochem Cytochem 66 (12), 863-877 (2018)
   PUBMED   30052474
  REMARK    GeneRIF: In contrast to the weak levels of cathepsin L in normal
            glomeruli, on days 4 and 8, strong immunostaining was detected in
            almost all podocytes when proteinuria and pathological changes of
            the podocytes developed. Cathepsin L was reduced after day 28, but
            remained in a focal and segmental manner. Cystatin B, an
            intracellular inhibitor, was not detected in podocytes.
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Zhou,X., Paushter,D.H., Feng,T., Sun,L., Reinheckel,T. and Hu,F.
  TITLE     Lysosomal processing of progranulin
  JOURNAL   Mol Neurodegener 12 (1), 62 (2017)
   PUBMED   28835281
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   Mason,R.W. and Massey,S.D.
  TITLE     Surface activation of pro-cathepsin L
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1659-1666 (1992)
   PUBMED   1482371
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   Cataldo,A.M., Paskevich,P.A., Kominami,E. and Nixon,R.A.
  TITLE     Lysosomal hydrolases of different classes are abnormally
            distributed in brains of patients with Alzheimer disease
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 10998-11002 (1991)
   PUBMED   1837142
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2509]
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Erickson-Lawrence,M., Zabludoff,S.D. and Wright,W.W.
  TITLE     Cyclic protein-2, a secretory product of rat Sertoli cells, is the
            proenzyme form of cathepsin L
  JOURNAL   Mol Endocrinol 5 (12), 1789-1798 (1991)
   PUBMED   1791830
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Ishidoh,K., Kominami,E., Suzuki,K. and Katunuma,N.
  TITLE     Gene structure and 5'-upstream sequence of rat cathepsin L
  JOURNAL   FEBS Lett 259 (1), 71-74 (1989)
   PUBMED   2599113
REFERENCE   10 (bases 1 to 1382)
  AUTHORS   Dahlmann,B., Kuehn,L., Heinrich,P.C., Kirschke,H. and
            Wiederanders,B.
  TITLE     ATP-activated, high-molecular-mass proteinase-I from rat skeletal
            muscle is a cysteine proteinase-alpha 1-macroglobulin complex
  JOURNAL   Biochim Biophys Acta 991 (2), 253-262 (1989)
   PUBMED   2470410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y00697.1.
            
            On Aug 30, 2012 this sequence version replaced NM_013156.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00697.1, FQ218649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1382              Y00697.1           5-1386
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1382
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /note="cathepsin L"
                     /db_xref="GeneID:25697"
                     /db_xref="RGD:2448"
     exon            1..62
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..199
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1078
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /EC_number="3.4.22.15"
                     /note="MEP; CP-2; cyclic protein 2; major excreted
                     protein; cathepsin L1; procathepsin L"
                     /codon_start=1
                     /product="procathepsin L preproprotein"
                     /protein_id="NP_037288.1"
                     /db_xref="GeneID:25697"
                     /db_xref="RGD:2448"
                     /translation="MTPLLLLAVLCLGTALATPKFDQTFNAQWHQWKSTHRRLYGTNE
                     EEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKK
                     GRLFQEPLMLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLIS
                     LSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYA
                     VANDTGFVDIPQQEKALMKPVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDH
                     GVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIVN
                     "
     exon            200..322
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..469
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..694
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..857
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..975
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1373
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1372
                     /gene="Ctsl"
                     /gene_synonym="CATHL; CatL; Ctsl1"
ORIGIN      
        1 ccgcggcgac ctccggggat ccgagtttgc agactacgtg tgtgcgcagc tagccacctc
       61 aggtgtttga accatgaccc ctttactcct cctggctgtc ctctgcttgg gaacagcctt
      121 agccactcca aaatttgatc aaacgtttaa tgcacagtgg caccagtgga agtccacaca
      181 cagaagactg tatggcacga atgaggaaga gtggaggaga gcagtgtggg agaagaacat
      241 gaggatgatc cagctacaca atggggagta cagcaacggg aagcacggct ttaccatgga
      301 gatgaacgcc ttcggtgaca tgaccaatga ggaattcagg cagatagtga atggctatcg
      361 ccaccagaag cacaagaagg gaaggttatt tcaggaacct ctgatgctgc agatccccaa
      421 gactgtggac tggagagaaa agggttgtgt gactcctgtg aagaatcagg gccagtgtgg
      481 ttcttgctgg gcttttagcg catcgggttg cctagaagga cagatgttcc ttaagactgg
      541 caaactgatc tcactgagtg aacagaacct tgtggactgt tctcacgatc aaggcaatca
      601 gggctgtaat ggaggcctga tggattttgc tttccagtac attaaggaaa atggaggtct
      661 ggactcagag gagtcttatc cctatgaagc aaaggatgga tcttgtaaat acagagctga
      721 gtatgctgtg gctaacgaca cagggtttgt ggatatccct cagcaagaga aagccctcat
      781 gaagcctgta gcgacggtgg ggcctatttc tgttgccatg gatgcaagcc atccgtctct
      841 ccagttctat agttcaggta tctactatga acccaactgt agcagcaagg acctcgacca
      901 tggggttctg gtggttggct atggttatga aggaacagat tcaaataagg ataaatactg
      961 gcttgtcaaa aacagctggg gtaaagaatg gggtatggat ggctacatca aaatagccaa
     1021 agaccggaac aaccactgcg gacttgccac cgcagccagc tatcctatcg tgaattgatg
     1081 gacagcgata ataaggactg acggacacta catccgaagg agttcatctt aaaactgacc
     1141 aaacccgtct ctgagtgaga ccatggtact tgaatcgttc aggatccaag tcacgattta
     1201 aattctgttg acatttttac atgggttaaa tgttaccact acttaaaact cctgttataa
     1261 acagctttat aatattggac acttaatgct taattctgat tctggaatat ttgttttata
     1321 aaagttgtat aaaactttct ttacctttta aaaataaatt ttagctcagt gcaaaaaaaa
     1381 aa
//
