LOCUS       NM_031560               1446 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus cathepsin K (Ctsk), mRNA.
ACCESSION   NM_031560
VERSION     NM_031560.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. doi:
            10.3389/fphar.2020.635927.. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Liu,N., Zhang,T., Cao,B.R., Luan,F.Y., Liu,R.X., Yin,H.R. and
            Wang,W.B.
  TITLE     Icariin possesses chondroprotective efficacy in a rat model of
            dexamethasone-induced cartilage injury through the activation of
            miR-206 targeting of cathepsin K
  JOURNAL   Int J Mol Med 41 (2), 1039-1047 (2018)
   PUBMED   29207029
  REMARK    GeneRIF: the present study identified icariin as a novel
            therapeutic agent in DXM-induced cartilage injury in rats, and
            revealed that the activation of miR-206 targeting of cathepsin K
            may be responsible for the chondroprotective efficacy of icariin
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Seto,S.P., Parks,A.N., Qiu,Y., Soslowsky,L.J., Karas,S., Platt,M.O.
            and Temenoff,J.S.
  TITLE     Cathepsins in Rotator Cuff Tendinopathy: Identification in Human
            Chronic Tears and Temporal Induction in a Rat Model
  JOURNAL   Ann Biomed Eng 43 (9), 2036-2046 (2015)
   PUBMED   25558848
  REMARK    GeneRIF: Cathepsins in Rotator Cuff Tendinopathy: Identification in
            Human Chronic Tears and Temporal Induction in a Rat Model.
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Anway,M.D., Wright,W.W., Zirkin,B.R., Korah,N., Mort,J.S. and
            Hermo,L.
  TITLE     Expression and localization of cathepsin k in adult rat sertoli
            cells
  JOURNAL   Biol Reprod 70 (3), 562-569 (2004)
   PUBMED   14585819
  REMARK    GeneRIF: cathepsin K, in both its secreted and lysosomal forms, may
            play a role in the degradation of Sertoli cell residual bodies
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Friedrichs,B., Tepel,C., Reinheckel,T., Deussing,J., von Figura,K.,
            Herzog,V., Peters,C., Saftig,P. and Brix,K.
  TITLE     Thyroid functions of mouse cathepsins B, K, and L
  JOURNAL   J Clin Invest 111 (11), 1733-1745 (2003)
   PUBMED   12782676
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Tepel,C., Bromme,D., Herzog,V. and Brix,K.
  TITLE     Cathepsin K in thyroid epithelial cells: sequence, localization and
            possible function in extracellular proteolysis of thyroglobulin
  JOURNAL   J Cell Sci 113 Pt 24, 4487-4498 (2000)
   PUBMED   11082042
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Xia,L., Kilb,J., Wex,H., Li,Z., Lipyansky,A., Breuil,V., Stein,L.,
            Palmer,J.T., Dempster,D.W. and Bromme,D.
  TITLE     Localization of rat cathepsin K in osteoclasts and resorption pits:
            inhibition of bone resorption and cathepsin K-activity by peptidyl
            vinyl sulfones
  JOURNAL   Biol Chem 380 (6), 679-687 (1999)
   PUBMED   10430032
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Lazner,F., Gowen,M., Pavasovic,D. and Kola,I.
  TITLE     Osteopetrosis and osteoporosis: two sides of the same coin
  JOURNAL   Hum Mol Genet 8 (10), 1839-1846 (1999)
   PUBMED   10469835
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078793.1.
            
            On Aug 8, 2004 this sequence version replaced NM_031560.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078793.1, FQ222438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1446
                     /gene="Ctsk"
                     /note="cathepsin K"
                     /db_xref="GeneID:29175"
                     /db_xref="RGD:61810"
     exon            1..72
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     exon            73..193
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1063
                     /gene="Ctsk"
                     /EC_number="3.4.22.38"
                     /codon_start=1
                     /product="cathepsin K precursor"
                     /protein_id="NP_113748.1"
                     /db_xref="GeneID:29175"
                     /db_xref="RGD:61810"
                     /translation="MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEI
                     SRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFS
                     NDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL
                     ALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKA
                     AKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNH
                     AVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM"
     exon            194..316
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     exon            317..472
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     exon            473..691
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     exon            692..857
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     exon            858..963
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1417
                     /gene="Ctsk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttagtct accattacag tagccacact tcttgtctga aaagagcata gacaacagat
       61 tctcaacagc aggatgtggg tgttcaagtt tttgctgcta cccgtggtga gctttgctct
      121 atccccggag gaaacgctgg acacgcagtg ggagctgtgg aagaagaccc acgggaagca
      181 gtacaacagc aaggtggatg aaatctctcg gcgtttaatt tgggaaaaaa acctgaagaa
      241 aatttctgtc cataatcttg aggcctctct tggtgcccat acgtatgagc tggccatgaa
      301 tcacctggga gacatgacca gcgaagaagt ggttcagaag atgactggac tcagagtgcc
      361 accttcgcgt tccttcagta atgacactct ctatacccca gagtgggaag gcagagtccc
      421 agactccatc gactatcgaa agaaaggcta tgttactcca gtcaaaaacc agggccagtg
      481 tggttcctgt tgggctttca gctctgcggg tgccctggag ggccaactca agaagaaaac
      541 tggcaaactc ttagctctga gtccccagaa tcttgtggac tgtgtgtctg agaactatgg
      601 ctgtggaggc ggctatatga ccactgcctt ccaatatgtg cagcagaatg gaggcattga
      661 ctctgaagac gcttacccgt atgtggggca ggatgaaagt tgtatgtata acgccacggc
      721 aaaggcagct aagtgcagag ggtacagaga gatccctgtg gggaacgaga aagccctgaa
      781 gagagcagtg gctcgggtag gacccgtctc tgtgtccatc gatgcaagct tgacatcttt
      841 ccaattttac agcagaggtg tgtactatga cgaaaactgc gaccgtgata atgtgaacca
      901 tgccgtgttg gtggtgggct atggcaccca gaagggaaat aagtactgga taattaaaaa
      961 cagctgggga gaaagctggg gaaacaaagg ctatgttctc ttggctcgga ataagaacaa
     1021 tgcctgtggc attaccaacc tggccagctt ccccaagatg tgattcaagc cagccagccc
     1081 atctgttctc acattccttc ctcaacagtg caagcgaacg gtggctttgg agtgacacct
     1141 ctgcttccct tctctccacc caaggccctt ttctttgtgg acacaactgg gcattttctg
     1201 agagttgtgg cctctgtgct gatagacgct ggagtcctcc agcaggctgg aggactaagg
     1261 tgaccttccc aagcccctgt cttctatata caccagtgca gatttcagtc ttccactgag
     1321 atgcacaaat ctattcatga ttctttgaca aacttacatg atgtaaaaaa tgtttccttc
     1381 tttgcatttg aaataaagta tctcgtttac aatttgaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaa
//
